+

SG10201601719RA - Anti-LAG-3 Antibodies - Google Patents

Anti-LAG-3 Antibodies

Info

Publication number
SG10201601719RA
SG10201601719RA SG10201601719RA SG10201601719RA SG10201601719RA SG 10201601719R A SG10201601719R A SG 10201601719RA SG 10201601719R A SG10201601719R A SG 10201601719RA SG 10201601719R A SG10201601719R A SG 10201601719RA SG 10201601719R A SG10201601719R A SG 10201601719RA
Authority
SG
Singapore
Prior art keywords
lag
antibodies
Prior art date
Application number
SG10201601719RA
Inventor
Cheng-I Wang
Siok Ping Yeo
Chia Yin Lee
Hsueh Ling Janice Oh
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Priority to SG10201601719RA priority Critical patent/SG10201601719RA/en
Priority to CN201780015245.3A priority patent/CN109219619A/en
Priority to KR1020187028534A priority patent/KR20180114218A/en
Priority to TW106107003A priority patent/TW201734042A/en
Priority to AU2017226965A priority patent/AU2017226965A1/en
Priority to JP2018546454A priority patent/JP2019517773A/en
Priority to PCT/EP2017/055060 priority patent/WO2017149143A1/en
Priority to EP17710682.0A priority patent/EP3423492A1/en
Priority to CA3015938A priority patent/CA3015938A1/en
Priority to US16/079,947 priority patent/US20190040136A1/en
Priority to SG11201807252QA priority patent/SG11201807252QA/en
Publication of SG10201601719RA publication Critical patent/SG10201601719RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG10201601719RA 2016-03-04 2016-03-04 Anti-LAG-3 Antibodies SG10201601719RA (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
SG10201601719RA SG10201601719RA (en) 2016-03-04 2016-03-04 Anti-LAG-3 Antibodies
CN201780015245.3A CN109219619A (en) 2016-03-04 2017-03-03 anti-LAG-3 antibody
KR1020187028534A KR20180114218A (en) 2016-03-04 2017-03-03 Anti-LAG-3 antibody
TW106107003A TW201734042A (en) 2016-03-04 2017-03-03 Anti-LAG-3 antibodies
AU2017226965A AU2017226965A1 (en) 2016-03-04 2017-03-03 Anti-LAG-3antibodies
JP2018546454A JP2019517773A (en) 2016-03-04 2017-03-03 Anti-LAG-3 antibody
PCT/EP2017/055060 WO2017149143A1 (en) 2016-03-04 2017-03-03 Anti-lag-3 antibodies
EP17710682.0A EP3423492A1 (en) 2016-03-04 2017-03-03 Anti-lag-3 antibodies
CA3015938A CA3015938A1 (en) 2016-03-04 2017-03-03 Anti-lag-3 antibodies
US16/079,947 US20190040136A1 (en) 2016-03-04 2017-03-03 Anti-lag-3 antibodies
SG11201807252QA SG11201807252QA (en) 2016-03-04 2017-03-03 Anti-lag-3 antibodies

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SG10201601719RA SG10201601719RA (en) 2016-03-04 2016-03-04 Anti-LAG-3 Antibodies

Publications (1)

Publication Number Publication Date
SG10201601719RA true SG10201601719RA (en) 2017-10-30

Family

ID=58277259

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201601719RA SG10201601719RA (en) 2016-03-04 2016-03-04 Anti-LAG-3 Antibodies
SG11201807252QA SG11201807252QA (en) 2016-03-04 2017-03-03 Anti-lag-3 antibodies

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201807252QA SG11201807252QA (en) 2016-03-04 2017-03-03 Anti-lag-3 antibodies

Country Status (10)

Country Link
US (1) US20190040136A1 (en)
EP (1) EP3423492A1 (en)
JP (1) JP2019517773A (en)
KR (1) KR20180114218A (en)
CN (1) CN109219619A (en)
AU (1) AU2017226965A1 (en)
CA (1) CA3015938A1 (en)
SG (2) SG10201601719RA (en)
TW (1) TW201734042A (en)
WO (1) WO2017149143A1 (en)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI756187B (en) 2015-10-09 2022-03-01 美商再生元醫藥公司 Anti-lag3 antibodies and uses thereof
JP7066696B2 (en) 2016-10-11 2022-05-13 アジェナス インコーポレイテッド Anti-LAG-3 antibody and its usage
MA46814B2 (en) 2017-02-10 2022-09-30 Regeneron Pharma Radiolabeled anti-lag3 antibodies for immuno-pet imaging
BR112019018759A2 (en) 2017-05-30 2020-05-05 Bristol-Myers Squibb Company compositions comprising a combination of an anti-lag-3 antibody, an inhibitor of the pd-1 pathway, and an immunotherapeutic agent
DK3631454T3 (en) 2017-05-30 2023-12-04 Bristol Myers Squibb Co TREATMENT OF LAYER-3 POSITIVE TUMORS
CA3065304A1 (en) 2017-05-30 2018-12-06 Bristol-Myers Squibb Company Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody
CN111954680B (en) 2017-11-10 2024-03-15 新加坡科技研究局 IL2 Rbeta/common gamma chain antibodies
WO2019179365A1 (en) * 2018-03-20 2019-09-26 WuXi Biologics Ireland Limited Novel anti-lag-3 antibody polypeptide
CN110343178B (en) 2018-04-03 2022-07-22 上海开拓者生物医药有限公司 Anti-human LAG-3 monoclonal antibody and application thereof
CA3100349A1 (en) * 2018-05-17 2019-11-21 The Board Of Trustees Of The Leland Stanford Junior University Receptor inhibition by phosphatase recruitment
EP3826660A1 (en) 2018-07-26 2021-06-02 Bristol-Myers Squibb Company Lag-3 combination therapy for the treatment of cancer
DK3866850T3 (en) 2018-10-19 2024-10-14 Bristol Myers Squibb Co COMBINATION THERAPY AGAINST MELANOMA
TW202031683A (en) 2018-11-09 2020-09-01 新加坡商優其洛伊生物私人有限公司 Il2rbeta/common gamma chain antibodies
TW202039557A (en) 2018-11-09 2020-11-01 新加坡商優其洛伊生物私人有限公司 Il2rbeta/common gamma chain antibodies
US12187800B2 (en) * 2018-11-22 2025-01-07 Suzhou Kanova Biopharmaceutical Co., Ltd. Anti-B7-H3 antibody
GB201906118D0 (en) * 2019-05-01 2019-06-12 Immutep S A Anti-LAG-3 binding molecules
EP3976832A1 (en) 2019-05-30 2022-04-06 Bristol-Myers Squibb Company Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy
JP2022534967A (en) 2019-05-30 2022-08-04 ブリストル-マイヤーズ スクイブ カンパニー Multiple tumor gene signatures and their uses
CN114174537A (en) 2019-05-30 2022-03-11 百时美施贵宝公司 Cell localization features and combination therapies
IL267614A (en) * 2019-06-24 2019-09-26 Lotem Michal Nucleic acid agents modulating slamf6 isoforms
WO2021024020A1 (en) 2019-08-06 2021-02-11 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
BR112022004316A2 (en) 2019-09-22 2022-06-21 Bristol Myers Squibb Co Quantitative spatial characterization for lag-3 antagonist therapy
WO2021092221A1 (en) 2019-11-06 2021-05-14 Bristol-Myers Squibb Company Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
WO2021092220A1 (en) 2019-11-06 2021-05-14 Bristol-Myers Squibb Company Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
BR112022008191A2 (en) 2019-11-08 2022-07-12 Bristol Myers Squibb Co LAG-3 ANTAGONIST THERAPY FOR MELANOMA
KR20220139915A (en) 2020-02-06 2022-10-17 브리스톨-마이어스 스큅 컴퍼니 IL-10 and its uses
KR102555328B1 (en) * 2020-02-06 2023-07-17 아주대학교산학협력단 T cell receptor-like antibody to CMV pp65 peptide presented by HLA-A*02 and uses thereof
MX2023000197A (en) 2020-07-07 2023-02-22 BioNTech SE THERAPEUTIC RNA FOR HPV POSITIVE CANCER.
US20230265188A1 (en) 2020-08-28 2023-08-24 Bristol-Myers Squibb Company Lag-3 antagonist therapy for hepatocellular carcinoma
US20230303700A1 (en) 2020-08-31 2023-09-28 Bristol-Myers Squibb Company Cell localization signature and immunotherapy
WO2022087402A1 (en) 2020-10-23 2022-04-28 Bristol-Myers Squibb Company Lag-3 antagonist therapy for lung cancer
WO2022120179A1 (en) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Multi-tumor gene signatures and uses thereof
CN114621345B (en) * 2020-12-10 2022-11-29 北京东方百泰生物科技股份有限公司 anti-LAG-3 monoclonal antibody, antigen binding fragment thereof and application thereof
WO2022135666A1 (en) 2020-12-21 2022-06-30 BioNTech SE Treatment schedule for cytokine proteins
WO2022135667A1 (en) 2020-12-21 2022-06-30 BioNTech SE Therapeutic rna for treating cancer
TW202245808A (en) 2020-12-21 2022-12-01 德商拜恩迪克公司 Therapeutic rna for treating cancer
JP2024501029A (en) 2020-12-28 2024-01-10 ブリストル-マイヤーズ スクイブ カンパニー Subcutaneous administration of PD1/PD-L1 antibodies
ES3023507T3 (en) 2020-12-28 2025-06-02 Bristol Myers Squibb Co Antibody compositions and methods of use thereof
WO2022165214A1 (en) 2021-01-29 2022-08-04 Board Of Regents, The University Of Texas System Methods of treating cancer with kinase inhibitors
AU2022246593A1 (en) 2021-03-29 2023-10-12 Juno Therapeutics, Inc. Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy
US20240279225A1 (en) 2021-04-08 2024-08-22 Board Of Regents, The University Of Texas System Compounds and methods for theranostic targeting of parp activity
WO2022240741A1 (en) 2021-05-12 2022-11-17 Dana-Farber Cancer Institute, Inc. Lag3 and gal3 inhibitory agents, xbp1, cs1, and cd138 peptides, and methods of use thereof
MX2024000674A (en) 2021-07-13 2024-02-07 BioNTech SE Multispecific binding agents against cd40 and cd137 in combination therapy for cancer.
TW202333802A (en) 2021-10-11 2023-09-01 德商拜恩迪克公司 Therapeutic rna for lung cancer
WO2023077090A1 (en) 2021-10-29 2023-05-04 Bristol-Myers Squibb Company Lag-3 antagonist therapy for hematological cancer
EP4469477A1 (en) 2022-01-26 2024-12-04 Bristol-Myers Squibb Company Combination therapy for hepatocellular carcinoma
JP2025507694A (en) 2022-02-25 2025-03-21 ブリストル-マイヤーズ スクイブ カンパニー Combination Therapy for Colorectal Cancer
WO2023168404A1 (en) 2022-03-04 2023-09-07 Bristol-Myers Squibb Company Methods of treating a tumor
US20250179170A1 (en) 2022-03-08 2025-06-05 Alentis Therapeutics Ag Use of anti-claudin-1 antibodies to increase t cell availability
EP4493575A1 (en) 2022-03-18 2025-01-22 Bristol-Myers Squibb Company Methods of isolating polypeptides
JP2025518785A (en) 2022-06-02 2025-06-19 ブリストル-マイヤーズ スクイブ カンパニー Antibody compositions and methods of use thereof
CN115651082A (en) * 2022-11-04 2023-01-31 西北农林科技大学 Preparation method and application of pig LAG3 monoclonal antibody
WO2024116140A1 (en) 2022-12-01 2024-06-06 Medimmune Limited Combination therapy for treatment of cancer comprising anti-pd-l1 and anti-cd73 antibodies
WO2024126457A1 (en) 2022-12-14 2024-06-20 Astellas Pharma Europe Bv Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and immune checkpoint inhibitors
IL321575A (en) 2022-12-21 2025-08-01 Bristol Myers Squibb Co Combination therapy for lung cancer
US20240299601A1 (en) 2023-02-17 2024-09-12 Regeneron Pharmaceuticals, Inc. Radiolabeled anti-lag3 antibodies for immuno-pet imaging
WO2024196952A1 (en) 2023-03-20 2024-09-26 Bristol-Myers Squibb Company Tumor subtype assessment for cancer therapy
WO2025038763A1 (en) 2023-08-15 2025-02-20 Bristol-Myers Squibb Company Ceramic hydroxyapatite chromatography flow through method
WO2025096478A1 (en) 2023-10-30 2025-05-08 Regeneron Pharmaceuticals, Inc. Stable antibody formulation comprising fianlimab
WO2025121445A1 (en) 2023-12-08 2025-06-12 Astellas Pharma Inc. Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2
WO2025120867A1 (en) 2023-12-08 2025-06-12 Astellas Pharma Inc. Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies
WO2025120866A1 (en) 2023-12-08 2025-06-12 Astellas Pharma Inc. Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2
WO2025145207A1 (en) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Combination therapy of kras inhibitor and treg-depleting agent
US20250269052A1 (en) 2024-02-27 2025-08-28 Bristol-Myers Squibb Company Anti-ceacam5 antibody drug conjugates
WO2025184208A1 (en) 2024-02-27 2025-09-04 Bristol-Myers Squibb Company Anti-ceacam5 antibodies and uses thereof

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0615451T3 (en) 1992-05-26 2006-04-24 Immunex Corp Hitherto unknown cytokine that binds to CD30
ITRM20010408A1 (en) 2001-07-10 2003-01-10 Univ Napoli Federico Ii CYTOTOXIC HUMAN MINI-ANTIBODY FOR CANCER CELLS THAT EXPRESS THE ERBB2 RECEPTOR.
KR100668538B1 (en) 2002-01-09 2007-01-16 메다렉스, 인코포레이티드 Human monoclonal antibodies against CD300
MXPA06008700A (en) 2004-02-06 2007-01-19 Morphosys Ag Anti-cd38 human antibodies and uses therefor.
SI2287195T1 (en) 2004-07-01 2019-08-30 Novo Nordisk A/S Pan-kir2dl nk-receptor antibodies and their use in diagnostik and therapy
SG10201912554TA (en) 2005-03-23 2020-02-27 Genmab As Antibodies against cd38 for treatment of multiple myeloma
CA3151350A1 (en) 2005-05-09 2006-11-16 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
TWI461436B (en) 2005-11-25 2014-11-21 Kyowa Hakko Kirin Co Ltd Human CD134 (OX40) human monoclonal antibody and method of making and using same
BRPI0714728A2 (en) 2006-08-04 2013-05-14 Astrazeneca Ab targeted binding agent, antibody, composition, isolated cell line isolated nucleic acid molecule, vector, host cell, methods for making a targeted binding agent, for isolating an antibody or antigen binding portion thereof, for making an antibody human monoclonal construct, to treat, prevent or alleviate the symptoms of a disorder, to inhibit the proliferation of a cancer cell, to inhibit an erbb2 activity in an erbb2 expressing cell, and to modulate an erbb2 activity in an erbb2 expressing cell. and non-human transgenic animal or transgenic plant
CA2669520C (en) 2006-11-13 2016-07-26 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Methods of treating cancer using sirna molecules directed against cd24
HRP20131113T1 (en) 2007-02-16 2014-01-17 Merrimack Pharmaceuticals, Inc. Antibodies against erbb3 and uses thereof
EP1987839A1 (en) * 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
US9244059B2 (en) * 2007-04-30 2016-01-26 Immutep Parc Club Orsay Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
KR20100093578A (en) 2007-11-30 2010-08-25 브리스톨-마이어스 스큅 컴퍼니 Anti-b7h4 monoclonal antibody-drug conjugate and methods of use
AR072999A1 (en) * 2008-08-11 2010-10-06 Medarex Inc HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE
PT4209510T (en) 2008-12-09 2024-04-02 Hoffmann La Roche Anti-pd-l1 antibodies and their use to enhance t-cell function
EP2478110B1 (en) 2009-09-16 2016-01-06 Immunomedics, Inc. Class i anti-cea antibodies and uses thereof
BR122016002916B8 (en) 2010-03-04 2021-05-25 Macrogenics Inc diabody, nucleic acid molecule, pharmaceutical composition and uses of diabody
CN103068850A (en) 2010-05-26 2013-04-24 明尼苏达大学评议会 Single -chain variable fragment anti-cd133 antibodies and uses thereof
PE20131403A1 (en) 2010-08-23 2014-01-10 Univ Texas ANTI-OX40 ANTIBODIES AND METHODS OF USING THEM
MX344773B (en) 2011-04-25 2017-01-06 Daiichi Sankyo Co Ltd Anti-b7-h3 antibody.
GB201116092D0 (en) 2011-09-16 2011-11-02 Bioceros B V Antibodies and uses thereof
ES2694153T3 (en) 2011-09-30 2018-12-18 Regeneron Pharmaceuticals, Inc. Antibodies anti-ErbB3 and uses thereof
WO2013067492A1 (en) 2011-11-03 2013-05-10 The Trustees Of The University Of Pennsylvania Isolated b7-h4 specific compositions and methods of use thereof
WO2014039983A1 (en) 2012-09-07 2014-03-13 The Trustees Of Dartmouth College Vista modulators for diagnosis and treatment of cancer
WO2014066532A1 (en) 2012-10-23 2014-05-01 Bristol-Myers Squibb Company Combination of anti-kir and anti-ctla-4 antibodies to treat cancer
CA2894689A1 (en) 2012-12-19 2014-06-26 Amplimmune, Inc. Anti-human b7-h4 antibodies and their uses
US9573988B2 (en) 2013-02-20 2017-02-21 Novartis Ag Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells
MA38498B1 (en) * 2013-03-15 2018-11-30 Glaxosmithkline Ip Dev Ltd Anti-lag-3 binding proteins
WO2014160627A1 (en) 2013-03-25 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd276 polypeptides, proteins, and chimeric antigen receptors
BR122023024195A2 (en) 2013-09-20 2023-12-26 Bristol-Myers Squibb Company USES OF ANTI-LAG-3 ANTIBODIES AND ANTI-PD-1 ANTIBODIES
SG10201805933TA (en) 2013-12-24 2018-08-30 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments

Also Published As

Publication number Publication date
TW201734042A (en) 2017-10-01
SG11201807252QA (en) 2018-09-27
CN109219619A (en) 2019-01-15
JP2019517773A (en) 2019-06-27
US20190040136A1 (en) 2019-02-07
WO2017149143A1 (en) 2017-09-08
EP3423492A1 (en) 2019-01-09
CA3015938A1 (en) 2017-09-08
KR20180114218A (en) 2018-10-17
AU2017226965A1 (en) 2018-10-11

Similar Documents

Publication Publication Date Title
ZA201900373B (en) Anti-tim-3 antibodies
IL259048A (en) Anti-ror1 antibodies
SG10201601719RA (en) Anti-LAG-3 Antibodies
GB201601073D0 (en) Antibodies
SG10201913864RA (en) Anti-LAG-3 Antibodies
GB201621439D0 (en) IL-11Ra Antibodies
IL253633A0 (en) Anti-transthyretin antibodies
GB201521391D0 (en) Antibodies
GB201521393D0 (en) Antibodies
GB201610044D0 (en) Antibodies
GB201521382D0 (en) Antibodies
PL3250593T3 (en) Anti-transthyretin antibodies
IL255323A0 (en) Anti-fcrn antibodies
GB201616699D0 (en) Antibodies
ZA201808317B (en) Anti-tnfrsf25 antibodies
GB201603291D0 (en) Antibodies
PT3484921T (en) Anti-il-22r antibodies
IL260083A (en) Anti-myl9 antibody
GB201509907D0 (en) Antibodies
GB201522394D0 (en) Antibodies
GB201503438D0 (en) Antibodies
IL284022A (en) Anti-transthyretin antibodies
GB201622197D0 (en) Antibodies
GB201620414D0 (en) Antibodies
GB201615224D0 (en) Antibodies
点击 这是indexloc提供的php浏览器服务,不要输入任何密码和下载