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RU2010113976A - Применение glp-1 в качестве терапевтического средства - Google Patents

Применение glp-1 в качестве терапевтического средства Download PDF

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RU2010113976A
RU2010113976A RU2010113976/15A RU2010113976A RU2010113976A RU 2010113976 A RU2010113976 A RU 2010113976A RU 2010113976/15 A RU2010113976/15 A RU 2010113976/15A RU 2010113976 A RU2010113976 A RU 2010113976A RU 2010113976 A RU2010113976 A RU 2010113976A
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Russia
Prior art keywords
glu
disease
gly
ala
phe
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RU2010113976/15A
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Дориан БЕВЕК (DE)
Дориан БЕВЕК
Фабио КАВАЛЛИ (CH)
Фабио КАВАЛЛИ
Вера КАВАЛЛИ (CH)
Вера КАВАЛЛИ
Геральд БАХЕР (DE)
Геральд БАХЕР
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Мондобайотек Лабораториз Аг (Li)
Мондобайотек Лабораториз Аг
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Publication of RU2010113976A publication Critical patent/RU2010113976A/ru

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Abstract

1. Применение пептида His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ. !2. Применение по п.1, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из инфекции вирусом гепатита B, заболеваний, вызываемых инфекцией вирусом гепатита B, а именно острого гепатита, хронического гепатита, острой печеночной недостаточности, цирроза печени, злокачественной опухоли, ассоциированной с инфекцией вирусом гепатита B. ! 3. Применение пептида по п.1 или 2 для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста. ! 4. Применение пептида по п.1 или 2 для получения лиофилизированного состава или буферного жидкого состава. ! 5. Фармацевтическая композиция, содержащая пептид His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротектором, лиопротектором, эксципиентом и/или разбавителем. ! 6. Фармацевтическая композиция по п.5 в форме лиофилизата или жидкого буферного раствора. ! 7. Фармацевтическая композиция по п.5 или 6, пригодная для внутривенного введен�

Claims (9)

1. Применение пептида His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ.
2. Применение по п.1, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из инфекции вирусом гепатита B, заболеваний, вызываемых инфекцией вирусом гепатита B, а именно острого гепатита, хронического гепатита, острой печеночной недостаточности, цирроза печени, злокачественной опухоли, ассоциированной с инфекцией вирусом гепатита B.
3. Применение пептида по п.1 или 2 для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
4. Применение пептида по п.1 или 2 для получения лиофилизированного состава или буферного жидкого состава.
5. Фармацевтическая композиция, содержащая пептид His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротектором, лиопротектором, эксципиентом и/или разбавителем.
6. Фармацевтическая композиция по п.5 в форме лиофилизата или жидкого буферного раствора.
7. Фармацевтическая композиция по п.5 или 6, пригодная для внутривенного введения, перорального введения или для введения посредством ингаляции.
8. Фармацевтическая композиция по п.5 или 6 в форме состава искусственного материнского молока или заменителя материнского молока, пригодная для пероральной доставки новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
9. Фармацевтическая композиция по п.5 или 6, пригодная для лечения и/или профилактики злокачественной опухоли, аутоиммунного заболевания, фиброза, воспалительного заболевания, нейродегенеративного заболевания, инфекционного заболевания, заболевания легких, заболевания сердца и сосудов или болезней обмена веществ.
RU2010113976/15A 2007-09-11 2008-09-09 Применение glp-1 в качестве терапевтического средства RU2010113976A (ru)

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RU2010113967A (ru) 2011-10-20
CA2698852A1 (en) 2009-03-19
WO2009043522A2 (en) 2009-04-09
WO2009046866A3 (en) 2009-09-17
WO2009033797A3 (en) 2009-11-05
US20100311643A1 (en) 2010-12-09
JP2010539005A (ja) 2010-12-16
CA2698968A1 (en) 2009-03-19
WO2009039960A1 (en) 2009-04-02
RU2010114061A (ru) 2011-10-20
AU2008297885A1 (en) 2009-03-19
WO2009033710A1 (en) 2009-03-19
KR20100059861A (ko) 2010-06-04
JP5480140B2 (ja) 2014-04-23
WO2009043477A2 (en) 2009-04-09
EP2190447A2 (en) 2010-06-02
AU2008303922A1 (en) 2009-04-02
RU2010114036A (ru) 2011-10-20
WO2009033669A2 (en) 2009-03-19
WO2009043504A3 (en) 2009-10-29
WO2009043504A2 (en) 2009-04-09
CA2699083A1 (en) 2009-04-16
EP2187927A1 (en) 2010-05-26
US8193149B2 (en) 2012-06-05
RU2010113986A (ru) 2011-10-20
CA2698974A1 (en) 2009-03-19
EP2187930A2 (en) 2010-05-26
WO2009039964A2 (en) 2009-04-02
JP2010538986A (ja) 2010-12-16
KR20100063715A (ko) 2010-06-11
CA2699000A1 (en) 2009-04-02
AU2008306218A1 (en) 2009-04-09
WO2009033784A3 (en) 2009-11-05
WO2009046866A2 (en) 2009-04-16
KR20100057062A (ko) 2010-05-28

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