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RU2009136998A - Трансдермальная система мониторинга аналита и способы детекции аналита - Google Patents

Трансдермальная система мониторинга аналита и способы детекции аналита Download PDF

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RU2009136998A
RU2009136998A RU2009136998/14A RU2009136998A RU2009136998A RU 2009136998 A RU2009136998 A RU 2009136998A RU 2009136998/14 A RU2009136998/14 A RU 2009136998/14A RU 2009136998 A RU2009136998 A RU 2009136998A RU 2009136998 A RU2009136998 A RU 2009136998A
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monitoring system
hydrogel
analyte monitoring
transdermal analyte
transdermal
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RU2009136998/14A
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RU2444980C2 (ru
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Хань ЧУАН (US)
Хань ЧУАН
Джеймс П. ХЕРЛИ (US)
Джеймс П. ХЕРЛИ
Джозеф КОСТ (IL)
Джозеф КОСТ
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Эко Терапьютикс, Инк. (Us)
Эко Терапьютикс, Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A61B5/6833—Adhesive patches

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Hematology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

1. Трансдермальная система мониторинга аналита, включающая: сенсорное устройство, где сенсорное устройство содержит гидрогель и основную часть сенсора, содержащую множество электродов, где основная часть сенсора находится в жидкостной связи с гидрогелем, и где гидрогель содержит гигроскопическое вещество и фермент. ! 2. Система трансдермального мониторинга аналита по п.1, дополнительно включающая полупроницаемую мембрану, где мембрана находится в жидкостной связи с гидрогелем. ! 3. Трансдермальная система мониторинга аналита по п.2, в которой гидрогель и полупроницаемая мембрана образуют взаимопроницающую полимерную сетку. ! 4. Трансдермальная система мониторинга аналита по п.1, в которой гидрогель содержит полимер, выбранный из группы, состоящей из полиэтиленгликоль диакрилата (PEGDA), агарозы, полиэтиленгликоль диакрилата/полиэтиленимина (PEGDA-PEI), полиэтиленгликоль диакрилата-N-винил пирролидона (PEGDA-NVP), акрилата-полиэтиленгликоля-N-гидроксисукцинимида (A-PEG-N) и их смесей и сополимеров из них. !5. Трансдермальная система мониторинга аналита по п.1, в которой фермент является ферментом глюкозооксидазой. ! 6. Трансдермальная система мониторинга аналита по п.1, в которой фермент ковалентно иммобилизован в гидрогель. ! 7. Трансдермальная система мониторинга аналита по п.6, в которой фермент ковалентно иммобилизован в гидрогель с использованием A-PEG-N. ! 8. Трансдермальная система мониторинга аналита по п.1, в которой гигроскопическое вещество является отрицательно заряженным гигроскопическим веществом. ! 9. Трансдермальная система мониторинга аналита по п.9, в которой отрицательно заряженным гигроскопическим веществом

Claims (22)

1. Трансдермальная система мониторинга аналита, включающая: сенсорное устройство, где сенсорное устройство содержит гидрогель и основную часть сенсора, содержащую множество электродов, где основная часть сенсора находится в жидкостной связи с гидрогелем, и где гидрогель содержит гигроскопическое вещество и фермент.
2. Система трансдермального мониторинга аналита по п.1, дополнительно включающая полупроницаемую мембрану, где мембрана находится в жидкостной связи с гидрогелем.
3. Трансдермальная система мониторинга аналита по п.2, в которой гидрогель и полупроницаемая мембрана образуют взаимопроницающую полимерную сетку.
4. Трансдермальная система мониторинга аналита по п.1, в которой гидрогель содержит полимер, выбранный из группы, состоящей из полиэтиленгликоль диакрилата (PEGDA), агарозы, полиэтиленгликоль диакрилата/полиэтиленимина (PEGDA-PEI), полиэтиленгликоль диакрилата-N-винил пирролидона (PEGDA-NVP), акрилата-полиэтиленгликоля-N-гидроксисукцинимида (A-PEG-N) и их смесей и сополимеров из них.
5. Трансдермальная система мониторинга аналита по п.1, в которой фермент является ферментом глюкозооксидазой.
6. Трансдермальная система мониторинга аналита по п.1, в которой фермент ковалентно иммобилизован в гидрогель.
7. Трансдермальная система мониторинга аналита по п.6, в которой фермент ковалентно иммобилизован в гидрогель с использованием A-PEG-N.
8. Трансдермальная система мониторинга аналита по п.1, в которой гигроскопическое вещество является отрицательно заряженным гигроскопическим веществом.
9. Трансдермальная система мониторинга аналита по п.9, в которой отрицательно заряженным гигроскопическим веществом является натрий пирролидон карбоновая кислота (NaPCA).
10. Трансдермальная система мониторинга аналита по п.1, в которой сенсорное устройство включает, по меньшей мере, один канал или полость для снабжения гидрогеля кислородом.
11. Трансдермальная система мониторинга аналита по п.1, в которой фермент иммобилизован в гидрогель посредством нековалентной иммобилизации.
12. Способ увеличения детекции аналита при помощи трансдермальной системы мониторинга аналита, включающий:
(a) обработку участка кожи пользователя для повышения проницаемости;
(b) наложение трансдермальной системы мониторинга аналита по любому из пп.1-11.
13. Способ по п.12, дополнительно включающий после стадии (а) и перед стадией (b) протирку обработанного участка кожи субстратом, содержащим, по меньшей мере, один реагент, выбранный из группы, состоящей из воды, этанола, изопропанола и глицерина.
14. Способ по п.12, в котором участок кожи обрабатывают на стадии (a) способом, выбираемым из группы, состоящей из соскоба кожи при помощи липкой ленты, шлифовки, обработки наждачной бумагой, шлифовки абразивом, лазерной абляции, абляции СВЧ, химического пилинга, сонофореза, ионофореза, электропорации и нанесения агентов, повышающих проницаемость.
15. Способ по п.12, в котором субстрат выбирают из группы, состоящей из тампонов, тканого или нетканого материала, войлока или марли.
16. Способ по п.12, в котором субстрат содержит неорганический или органический растворитель.
17. Способ по п.16, в котором неорганический или органический растворитель выбирают из группы, состоящей из воды, этанола и изопропанола.
18. Способ по п.12, в котором субстрат содержит фосфатный буферный раствор, молочную кислоту, мыло или поверхностно-активное вещество.
19. Способ по п.12, в котором определяемый аналит является глюкозой в крови, лактатом или другими аналитами.
20. Способ увеличения чувствительности, стабильности или точности трансдермального сенсора аналита по любому из пп.1-11, включающий обеспечение увеличенной подачи кислорода к гидрогелю.
21. Способ по п.20, в котором источником кислорода является воздух.
22. Трансдермальный сенсор аналита по любому из пп.1-11 для применения в способе по любому из пп.20-21.
RU2009136998/14A 2007-03-07 2008-03-06 Трансдермальная система мониторинга аналита и способы детекции аналита RU2444980C2 (ru)

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US60/893,563 2007-03-07

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US (1) US8812071B2 (ru)
EP (1) EP2124723A1 (ru)
JP (3) JP5508861B2 (ru)
KR (2) KR101433550B1 (ru)
CN (1) CN101707875B (ru)
AU (1) AU2008222757B2 (ru)
CA (1) CA2680213C (ru)
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ZA (1) ZA200906959B (ru)

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