PT976748E - Derivados de pirrolidina com actividade inibidora de fosfolipase a2 - Google Patents
Derivados de pirrolidina com actividade inibidora de fosfolipase a2Info
- Publication number
- PT976748E PT976748E PT98900741T PT98900741T PT976748E PT 976748 E PT976748 E PT 976748E PT 98900741 T PT98900741 T PT 98900741T PT 98900741 T PT98900741 T PT 98900741T PT 976748 E PT976748 E PT 976748E
- Authority
- PT
- Portugal
- Prior art keywords
- phospholipase
- inhibiting activity
- optionally substituted
- pirrolidine
- derivatives
- Prior art date
Links
- 102100037611 Lysophospholipase Human genes 0.000 title 1
- 108010058864 Phospholipases A2 Proteins 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Cosmetics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1796297 | 1997-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT976748E true PT976748E (pt) | 2004-03-31 |
Family
ID=11958379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98900741T PT976748E (pt) | 1997-01-31 | 1998-01-27 | Derivados de pirrolidina com actividade inibidora de fosfolipase a2 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6147100A (pt) |
| EP (1) | EP0976748B1 (pt) |
| JP (1) | JP3850450B2 (pt) |
| KR (1) | KR100354358B1 (pt) |
| CN (1) | CN1217942C (pt) |
| AT (1) | ATE255579T1 (pt) |
| AU (1) | AU719210B2 (pt) |
| BR (1) | BR9807132A (pt) |
| CA (1) | CA2277947C (pt) |
| DE (1) | DE69820248T2 (pt) |
| DK (1) | DK0976748T3 (pt) |
| ES (1) | ES2210710T3 (pt) |
| HU (1) | HUP0000965A3 (pt) |
| NO (1) | NO313881B1 (pt) |
| PL (1) | PL334915A1 (pt) |
| PT (1) | PT976748E (pt) |
| RU (1) | RU2198174C2 (pt) |
| TR (1) | TR199901847T2 (pt) |
| TW (1) | TW577875B (pt) |
| WO (1) | WO1998033797A1 (pt) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| CA2380206A1 (en) * | 1999-07-26 | 2001-02-01 | Shionogi & Co., Ltd. | Pharmaceutical compositions exhibiting thrombopoietin receptor agonism |
| AU781524B2 (en) | 1999-10-13 | 2005-05-26 | Johns Hopkins University School Of Medicine, The | Regulators of the hedgehog pathway, compositions and uses related thereto |
| CA2388468C (en) * | 1999-10-14 | 2011-01-25 | Curis, Inc. | Mediators of hedgehog signalling pathways, compositions and uses related thereto |
| US6552016B1 (en) | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| EP1240906A4 (en) * | 1999-10-22 | 2004-04-14 | Shionogi & Co | PROPHYLACTICS AND THERAPEUTICS AGAINST ARRHYTHMIA |
| US7361663B2 (en) | 1999-11-10 | 2008-04-22 | Aventis Pharmaceuticals Inc. | N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa |
| AU2155001A (en) * | 1999-11-10 | 2001-06-06 | Aventis Pharma Deutschland Gmbh | N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor xa |
| CA2418416A1 (en) * | 2000-08-07 | 2002-02-14 | Akzo Nobel N.V. | Sizing dispersion |
| MXPA03006510A (es) * | 2001-01-26 | 2003-10-15 | Shionogi & Co | Compuestos halogenados que muestran agonismo del receptor de trombopoyetina. |
| US20030073945A1 (en) * | 2001-10-17 | 2003-04-17 | Liang-Kuang Diang | Ozone hemodiafiltration device |
| US6867320B2 (en) * | 2002-02-21 | 2005-03-15 | Asahi Kasei Pharma Corporation | Substituted phenylalkanoic acid derivatives and use thereof |
| AU2003237397A1 (en) * | 2002-06-04 | 2003-12-19 | Sequenom, Inc. | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| AU2003248793A1 (en) * | 2002-06-27 | 2004-01-19 | Sequenom, Inc | Diagnosing predisposition to fat deposition and associated condition |
| US20050014158A1 (en) * | 2002-06-27 | 2005-01-20 | Adam Gail Isabel Reid | Therapeutic methods for reducing fat deposition and treating associated conditions |
| US20060276520A1 (en) * | 2002-11-13 | 2006-12-07 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
| AU2003302645A1 (en) * | 2002-11-29 | 2004-06-23 | Shionogi And Co., Ltd. | Synthesis of pyrrolidine compound and salt thereof |
| US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
| US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| US7781464B2 (en) * | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
| TW200503698A (en) * | 2003-04-08 | 2005-02-01 | Shionogi & Co | Composition for treating or preventing dermatitis |
| US7470807B2 (en) | 2003-08-14 | 2008-12-30 | Asahi Kasei Pharma Corporation | Substituted arylalkanoic acid derivatives and use thereof |
| US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
| US7207652B2 (en) * | 2003-10-17 | 2007-04-24 | Lexmark International, Inc. | Balanced satellite distributions |
| US20090215857A1 (en) * | 2005-09-13 | 2009-08-27 | Pfizer Products Inc. | Therapeutic Pyrrolidines |
| TWI461423B (zh) | 2008-07-02 | 2014-11-21 | Astrazeneca Ab | 用於治療Pim激酶相關病狀及疾病之噻唑啶二酮化合物 |
| EP2348856B1 (en) * | 2008-10-21 | 2013-08-14 | Merck Sharp & Dohme Corp. | 2,4-disubstituted pyrrolidine orexin receptor antagonists |
| ES2611150T3 (es) | 2010-06-18 | 2017-05-05 | The Whitehead Institute For Biomedical Research | PLA2G16 como diana para compuestos antivirales |
| WO2013018929A1 (en) | 2011-08-04 | 2013-02-07 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
| USD804651S1 (en) | 2017-01-10 | 2017-12-05 | Howard Loonan | Syringe |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986002073A1 (en) * | 1984-10-03 | 1986-04-10 | Takeda Chemical Industries, Ltd. | Thiazolidinedione derivatives, process for their preparation, and pharmaceutical composition containing same |
| US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| JP2826379B2 (ja) * | 1990-01-22 | 1998-11-18 | 三共株式会社 | チアゾリジン誘導体を有効成分とする肥満性高血圧症治療剤 |
| US5317016A (en) * | 1991-08-20 | 1994-05-31 | Shionogi Seiyaku Kabushiki Kaisha | Pyrrolidylthiocarbapenem derivative |
| FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| JPH05306224A (ja) * | 1992-04-24 | 1993-11-19 | Wakamoto Pharmaceut Co Ltd | ドーパミン β−ヒドロキシラーゼ阻害剤 |
| EP0586229A1 (en) * | 1992-09-01 | 1994-03-09 | Zeneca Limited | 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors |
| TW245716B (pt) * | 1992-12-28 | 1995-04-21 | Takeda Pharm Industry Co | |
| CA2151157A1 (en) * | 1993-10-15 | 1995-04-20 | Mitsuaki Ohtani | Oxazolinone derivatives having cytosolic phospholipase a2 inhibitor activity |
| JPH07138258A (ja) * | 1993-11-16 | 1995-05-30 | Taiho Yakuhin Kogyo Kk | チアゾリジンジオン誘導体又はその塩 |
| TW363959B (en) * | 1994-03-23 | 1999-07-11 | Sankyo Co | Thiazolidine and oxazolidine derivatives, their preparation and their medical use |
| AU707537B2 (en) * | 1995-07-31 | 1999-07-15 | Anthera Pharmaceuticals, Inc. | Pyrrolidine derivatives having phospholipase a2 inhibitory activity |
| JPH09176162A (ja) * | 1995-12-22 | 1997-07-08 | Toubishi Yakuhin Kogyo Kk | チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物 |
| AU2995497A (en) * | 1996-07-26 | 1997-11-19 | Dr. Reddy's Research Foundation | Thiazolidinedione compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions thereof |
| AU2930797A (en) * | 1997-05-02 | 1997-11-19 | Dr. Reddy's Research Foundation | Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| AU2823797A (en) * | 1997-05-02 | 1997-11-19 | Dr. Reddy's Research Foundation | Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
-
1998
- 1998-01-26 TW TW087101064A patent/TW577875B/zh not_active IP Right Cessation
- 1998-01-27 JP JP53270898A patent/JP3850450B2/ja not_active Expired - Fee Related
- 1998-01-27 KR KR1019997006741A patent/KR100354358B1/ko not_active Expired - Fee Related
- 1998-01-27 WO PCT/JP1998/000307 patent/WO1998033797A1/ja active IP Right Grant
- 1998-01-27 RU RU99119481/04A patent/RU2198174C2/ru not_active IP Right Cessation
- 1998-01-27 CA CA002277947A patent/CA2277947C/en not_active Expired - Fee Related
- 1998-01-27 HU HU0000965A patent/HUP0000965A3/hu unknown
- 1998-01-27 AT AT98900741T patent/ATE255579T1/de not_active IP Right Cessation
- 1998-01-27 CN CN988038021A patent/CN1217942C/zh not_active Expired - Fee Related
- 1998-01-27 PL PL98334915A patent/PL334915A1/xx not_active Application Discontinuation
- 1998-01-27 ES ES98900741T patent/ES2210710T3/es not_active Expired - Lifetime
- 1998-01-27 PT PT98900741T patent/PT976748E/pt unknown
- 1998-01-27 TR TR1999/01847T patent/TR199901847T2/xx unknown
- 1998-01-27 DE DE69820248T patent/DE69820248T2/de not_active Expired - Lifetime
- 1998-01-27 US US09/355,008 patent/US6147100A/en not_active Expired - Fee Related
- 1998-01-27 EP EP98900741A patent/EP0976748B1/en not_active Expired - Lifetime
- 1998-01-27 BR BR9807132-7A patent/BR9807132A/pt not_active Application Discontinuation
- 1998-01-27 DK DK98900741T patent/DK0976748T3/da active
- 1998-01-27 AU AU55775/98A patent/AU719210B2/en not_active Ceased
-
1999
- 1999-07-29 NO NO19993706A patent/NO313881B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TR199901847T2 (xx) | 2000-06-21 |
| NO313881B1 (no) | 2002-12-16 |
| KR20000070497A (ko) | 2000-11-25 |
| BR9807132A (pt) | 2000-01-25 |
| EP0976748A4 (en) | 2001-08-08 |
| ATE255579T1 (de) | 2003-12-15 |
| CN1217942C (zh) | 2005-09-07 |
| JP3850450B2 (ja) | 2006-11-29 |
| PL334915A1 (en) | 2000-03-27 |
| HUP0000965A2 (hu) | 2001-04-28 |
| AU719210B2 (en) | 2000-05-04 |
| TW577875B (en) | 2004-03-01 |
| CN1251587A (zh) | 2000-04-26 |
| DK0976748T3 (da) | 2004-03-22 |
| DE69820248D1 (de) | 2004-01-15 |
| AU5577598A (en) | 1998-08-25 |
| EP0976748B1 (en) | 2003-12-03 |
| HUP0000965A3 (en) | 2001-11-28 |
| DE69820248T2 (de) | 2004-09-23 |
| US6147100A (en) | 2000-11-14 |
| CA2277947A1 (en) | 1998-08-06 |
| CA2277947C (en) | 2004-09-21 |
| RU2198174C2 (ru) | 2003-02-10 |
| ES2210710T3 (es) | 2004-07-01 |
| EP0976748A1 (en) | 2000-02-02 |
| KR100354358B1 (ko) | 2002-09-28 |
| WO1998033797A1 (fr) | 1998-08-06 |
| NO993706D0 (no) | 1999-07-29 |
| NO993706L (no) | 1999-09-30 |
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