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PE20181363A1 - Variantes optimizadas de anticuerpos anti-vegf - Google Patents

Variantes optimizadas de anticuerpos anti-vegf

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Publication number
PE20181363A1
PE20181363A1 PE2018000425A PE2018000425A PE20181363A1 PE 20181363 A1 PE20181363 A1 PE 20181363A1 PE 2018000425 A PE2018000425 A PE 2018000425A PE 2018000425 A PE2018000425 A PE 2018000425A PE 20181363 A1 PE20181363 A1 PE 20181363A1
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PE
Peru
Prior art keywords
hvr
amino acid
acid sequence
glu
gln
Prior art date
Application number
PE2018000425A
Other languages
English (en)
Inventor
Patrick Koenig
Chingwei Vivian Lee
Karthikan Rajagopal
Amin Famili
Germaine Fuh
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20181363A1 publication Critical patent/PE20181363A1/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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Abstract

Se refiere a un anticuerpo aislado que se une especificamente al factor de crecimiento endotelial vascular (VEGF), caracterizado porque el anticuerpo comprende 6 regiones hipervariables (HVR): a) HVR - H1 comprende la secuencia de aminoacidos de DYWIH, b) HVR - 2 comprende la secuencia de aminoacidos GX1TPX2GGX3X4 X5YX6DSVX7X8 donde X1 es Ile o His, X2 es Ala o Arg, X3 es Try, Gln, o Glu, X6 es Ala o Glu, X7 es Lys o Glu, y X8 es Gly o Glu, c) HVR - 3 comprende la secuencia de aminoacidos FVFFLPYAMDY, d) HVR - L1 comprende la secuencia de aminoacidos RASQX1VSTAVA, en el que X1 es Asp o Arg, e) HVR - L2 comprende la secuencia de aminoacidos X1ASFLYS, e) HVR - L3 comprende la secuencia de aminoacidos de X1QGYGX2 en el que X1 es Gln, Asn, Gln, o Arg. Dichos anticuerpos anti - VEGF son usados para el tratamiento de trastornos asociados con la angiogenesis patologica con propiedades mejoradas como la afinidad de union, estabilidad y farmacocinetica
PE2018000425A 2015-09-23 2016-09-23 Variantes optimizadas de anticuerpos anti-vegf PE20181363A1 (es)

Applications Claiming Priority (2)

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US201562222698P 2015-09-23 2015-09-23
US201562271913P 2015-12-28 2015-12-28

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PE20181363A1 true PE20181363A1 (es) 2018-08-27

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EP (1) EP3353203A2 (es)
JP (2) JP6959912B2 (es)
KR (1) KR102725051B1 (es)
CN (2) CN108137681B (es)
AU (1) AU2016326666B2 (es)
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