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PE20181336A1 - Anticuerpos que se unen a interleucina 8 (il-8) y sus usos - Google Patents

Anticuerpos que se unen a interleucina 8 (il-8) y sus usos

Info

Publication number
PE20181336A1
PE20181336A1 PE2018000378A PE2018000378A PE20181336A1 PE 20181336 A1 PE20181336 A1 PE 20181336A1 PE 2018000378 A PE2018000378 A PE 2018000378A PE 2018000378 A PE2018000378 A PE 2018000378A PE 20181336 A1 PE20181336 A1 PE 20181336A1
Authority
PE
Peru
Prior art keywords
hvr
seq
antibodies
bind interleukin
interleukin
Prior art date
Application number
PE2018000378A
Other languages
English (en)
Inventor
Tomoyuki Igawa
Atsuhiko Maeda
Genki Nakamura
Masaru Muraoka
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of PE20181336A1 publication Critical patent/PE20181336A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
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    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

Referido a un anticuerpo anti-IL-8 que se une a una interleucina-8 humana de manera dependiente de pH, caracterizado porque comprende como minimo una sustitucion de aminoacidos en uno de : a) HVR-H1 que comprende la secuencia de aminoacidos SEC ID NO: 67; b) HVR-H2 que comprende la SEC ID NO: 68; c) HVR-H3 que comprende la SEC ID NO: 69; d) HVR-L1 que comprende la SEC ID NO:70; e) HVR-L2 que comprende la SEC ID NO: 71; y f) HVR-L3 que comprende la SEC ID NO: 72. Tambien se refiere a composiciones, metodos y uso en el tratamiento de enfermedades o trastornos relacionados con la presencia excesiva de IL-8, tal como inhibidor de la angiogenesis.
PE2018000378A 2015-09-18 2016-08-05 Anticuerpos que se unen a interleucina 8 (il-8) y sus usos PE20181336A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2015185254 2015-09-18

Publications (1)

Publication Number Publication Date
PE20181336A1 true PE20181336A1 (es) 2018-08-21

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ID=56738152

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PE2018000378A PE20181336A1 (es) 2015-09-18 2016-08-05 Anticuerpos que se unen a interleucina 8 (il-8) y sus usos

Country Status (24)

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EP (1) EP3350202A1 (es)
JP (4) JP6266164B2 (es)
KR (4) KR20250016474A (es)
CN (2) CN113372443A (es)
AR (1) AR105634A1 (es)
AU (1) AU2016323088B2 (es)
BR (1) BR112018002432A2 (es)
CA (1) CA2993423C (es)
CL (1) CL2018000699A1 (es)
CO (1) CO2018004056A2 (es)
CR (1) CR20180217A (es)
HK (1) HK1252615A1 (es)
IL (2) IL258088B2 (es)
MA (1) MA42808A (es)
MX (2) MX2018003005A (es)
MY (1) MY203894A (es)
NZ (2) NZ777634A (es)
PE (1) PE20181336A1 (es)
PH (1) PH12018500386B1 (es)
RU (1) RU2728430C2 (es)
TW (5) TWI814162B (es)
UA (1) UA120981C2 (es)
WO (1) WO2017046994A1 (es)
ZA (1) ZA201800536B (es)

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TW202144395A (zh) 2020-02-12 2021-12-01 日商中外製藥股份有限公司 用於癌症之治療的抗cd137抗原結合分子
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