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PE20181451A1 - Anticuerpos neutralizadores del virus de inmunodeficiencia humana - Google Patents

Anticuerpos neutralizadores del virus de inmunodeficiencia humana

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Publication number
PE20181451A1
PE20181451A1 PE2018001115A PE2018001115A PE20181451A1 PE 20181451 A1 PE20181451 A1 PE 20181451A1 PE 2018001115 A PE2018001115 A PE 2018001115A PE 2018001115 A PE2018001115 A PE 2018001115A PE 20181451 A1 PE20181451 A1 PE 20181451A1
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PE
Peru
Prior art keywords
antigen
antibody
heavy chain
monoclonal antibody
binding
Prior art date
Application number
PE2018001115A
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English (en)
Inventor
Mini Balakrishnan
Brian A Carr
John Corbin
Craig S Pace
Nathan D Thomsen
Xue Zhang
Original Assignee
Gilead Sciences Inc
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Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of PE20181451A1 publication Critical patent/PE20181451A1/es

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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036Retroviridae, e.g. leukemia viruses
    • C07K16/1045Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00Immunoglobulins specific features
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Abstract

Referido a un anticuerpo monoclonal aislado, o fragmentado de union a antigeno del mismo, que comprende las regiones determinantes de complementariedad de cadena pesada 1-3 (CDR 1-3) establecidas en la SEQ ID NO: 362, 364 y 367 y las CDR de cadena liviana 1-3 establecidas en SEQ ID NO: 395, 396, y 397, donde el anticuerpo o fragmento de union a antigeno del mismo comprende entre cero y cuatro sustituciones de aminoacidos dentro de las CDR, y en donde el anticuerpo o fragmento de union a antigeno del mismo comprende: (a) una cadena pesada del alotipo de IgG1m17; (b) una cadena ligera Lambda2; (c) una region constante de cadena pesada que comprende sustituciones de aminoacidos, como: Ala en posicion 236, Aspen posicion 239, Leu en posicion 330, entre otros; (d) una region variable de cadena pesada que comprende uno o mas de: Ser-Ser-Val o Thr-Gly-Val en las posiciones 82a-82, Gln en la posicion 39, Asn en la posicion 60, entre otros; los cuales son anticuerpos anti-virus de inmunodeficiencia humana (anti-VIH). Tambien se refiere a un polinucleotido aislado que codifica el anticuerpo monoclonal o fragmento de union a antigeno, un vector, una celula y un vector; ademas se refiere a una composicion farmaceutica que comprende el anticuerpo monoclonal, y un metodo para producir el anticuerpo.
PE2018001115A 2015-12-15 2016-12-14 Anticuerpos neutralizadores del virus de inmunodeficiencia humana PE20181451A1 (es)

Applications Claiming Priority (1)

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US201562267652P 2015-12-15 2015-12-15

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PE20181451A1 true PE20181451A1 (es) 2018-09-12

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US (3) US10239935B2 (es)
EP (2) EP3992206A1 (es)
JP (4) JP6732915B2 (es)
KR (1) KR102165120B1 (es)
CN (2) CN109311967B (es)
AR (1) AR106991A1 (es)
AU (3) AU2016370591C1 (es)
BR (1) BR112018012164A2 (es)
CA (1) CA3008442C (es)
CL (1) CL2018001587A1 (es)
CO (1) CO2018006050A2 (es)
CR (1) CR20180321A (es)
CU (1) CU20180062A7 (es)
CY (1) CY1124756T1 (es)
DK (1) DK3390441T3 (es)
DO (2) DOP2018000146A (es)
EA (2) EA201891186A1 (es)
EC (1) ECSP18045028A (es)
ES (1) ES2897756T3 (es)
HU (1) HUE056243T2 (es)
IL (1) IL259832B (es)
LT (1) LT3390441T (es)
MA (1) MA44077A (es)
MX (2) MX2018007288A (es)
MY (2) MY196200A (es)
NZ (1) NZ743713A (es)
PE (1) PE20181451A1 (es)
PH (1) PH12018501281A1 (es)
PL (1) PL3390441T3 (es)
SA (1) SA518391778B1 (es)
SG (2) SG10202108793TA (es)
SI (1) SI3390441T1 (es)
SV (1) SV2018005710A (es)
TW (2) TWI735491B (es)
UA (1) UA125819C2 (es)
WO (1) WO2017106346A2 (es)
ZA (1) ZA201803783B (es)

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