PE20181403A1 - Hidrolisis enzimatica parcial de triacilgliceroles - Google Patents
Hidrolisis enzimatica parcial de triacilglicerolesInfo
- Publication number
- PE20181403A1 PE20181403A1 PE2018001234A PE2018001234A PE20181403A1 PE 20181403 A1 PE20181403 A1 PE 20181403A1 PE 2018001234 A PE2018001234 A PE 2018001234A PE 2018001234 A PE2018001234 A PE 2018001234A PE 20181403 A1 PE20181403 A1 PE 20181403A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- isoform
- amino acid
- acid sequence
- triacilgliceroles
- Prior art date
Links
- 230000007071 enzymatic hydrolysis Effects 0.000 title 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 102000001708 Protein Isoforms Human genes 0.000 abstract 3
- 108010029485 Protein Isoforms Proteins 0.000 abstract 3
- 241000222175 Diutina rugosa Species 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 abstract 1
- 241000235058 Komagataella pastoris Species 0.000 abstract 1
- 101710084373 Lipase 1 Proteins 0.000 abstract 1
- 101710084376 Lipase 3 Proteins 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
- C11C1/02—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils
- C11C1/04—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils by hydrolysis
- C11C1/045—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils by hydrolysis using enzymes or microorganisms, living or dead
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE REFIERE A UNA CELULA HUESPED TAL COMO PICHIA PASTORIS QUE EXPRESA UN POLIPEPTIDO SELECCIONADO DE i) LA ISOFORMA LIPASA 1 DE CANDIDA RUGOSA QUE TIENE LA SECUENCIA DE AMINOACIDOS DE LA SEQ ID NO: 1, ii) LA ISOFORMA LIPASA 2 DE GEOTRICHUM CANDIDUM QUE TIENE LA SECUENCIA DE AMINOACIDOS DE LA SEQ ID NO: 3, Y iii) LA ISOFORMA LIPASA 3 DE CANDIDA RUGOSA QUE TIENE LA SECUENCIA DE AMINOACIDOS DE LA SEQ ID NO: 2; EN DONDE EL POLIPEPTIDO TIENE UNA IDENTIDAD DE 90% A 99% CON LA SECUENCIA DE AMINOACIDOS DE SEQ ID NO: 1, 2 O 3, E HIDROLIZA UN ENLACE ESTER DE UN TRIACILGLICEROL EN UN ACEITE QUE COMPRENDE AL MENOS UN ACIDO GRASO POLIINSATURADO DE CADENA LARGA (LC-PUFA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562272829P | 2015-12-30 | 2015-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20181403A1 true PE20181403A1 (es) | 2018-09-07 |
Family
ID=57838436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2018001234A PE20181403A1 (es) | 2015-12-30 | 2016-12-29 | Hidrolisis enzimatica parcial de triacilgliceroles |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11535875B2 (es) |
| EP (1) | EP3397771A2 (es) |
| JP (2) | JP2019500042A (es) |
| KR (1) | KR20180098386A (es) |
| CN (2) | CN116064263A (es) |
| BR (1) | BR112018013385A2 (es) |
| CA (1) | CA3009871A1 (es) |
| PE (1) | PE20181403A1 (es) |
| WO (1) | WO2017115322A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116064263A (zh) * | 2015-12-30 | 2023-05-05 | 帝斯曼知识产权资产管理有限公司 | 三酰基甘油的部分酶水解 |
| CN116134147A (zh) | 2020-07-27 | 2023-05-16 | 帝斯曼知识产权资产管理有限公司 | 脂肪酸视黄酯形成的减少 |
| EP4284905A1 (en) * | 2021-01-28 | 2023-12-06 | Novozymes A/S | Lipase with low malodor generation |
| WO2023275212A1 (en) * | 2021-07-01 | 2023-01-05 | Dsm Ip Assets B.V. | Sustainable production of retinyl fatty esters |
| AU2023393689A1 (en) * | 2022-12-14 | 2025-05-01 | Novozymes A/S | Improved lipase (gcl1) variants |
| CN120210158A (zh) * | 2025-05-29 | 2025-06-27 | 成都圆大生物科技有限公司 | 一株脂肪酶、编码基因Lip1.1及其基因工程菌与应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2679920A1 (fr) | 1991-08-02 | 1993-02-05 | Rhone Poulenc Rorer Sa | Levures recombinantes hautement stables pour la production de proteines recombinantes, leur preparation et leur utilisation. |
| DK0635574T3 (da) | 1993-07-23 | 2003-08-11 | Dsm Ip Assets Bv | Selektionsmarkørgenfri rekombinantstammer, en fremgangsmåde til fremstilling af disse og anvendelse af disse stammer |
| DK0979294T3 (en) | 1997-04-11 | 2015-08-31 | Dsm Ip Assets Bv | Gene conversion AS A TOOL FOR CONSTRUCTION OF RECOMBINANT INDUSTRIAL filamentous fungi |
| RU2230790C2 (ru) | 1998-05-19 | 2004-06-20 | Дсм Н.В. | Способ расширения 5-членного кольца соединения бета-лактама до 6-членного цефема |
| AU3042600A (en) | 1998-12-22 | 2000-07-12 | Dsm N.V. | Improved (in vivo) production of cephalosporins |
| EP1130100A1 (en) * | 2000-02-14 | 2001-09-05 | Unilever N.V. | Modified lipolytic enzymes and their use |
| CN100336906C (zh) | 2001-01-15 | 2007-09-12 | 广州市绿巨人生物环保技术有限公司 | 脂肪酶基因序列及其在酵母中的应用 |
| DE10149714A1 (de) * | 2001-10-09 | 2003-04-30 | Degussa | Esterase EstA aus Rhodococcus sp. |
| ATE512979T1 (de) * | 2002-02-19 | 2011-07-15 | Procter & Gamble | Neue lipase aus pilzen |
| WO2013043641A1 (en) * | 2011-09-21 | 2013-03-28 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Method for enrichment of eicosapentaenoic acid and docosahexaenoic acid in source oils |
| CN103421758A (zh) * | 2013-07-24 | 2013-12-04 | 浙江大学 | 利用水稻胚乳细胞作为生物反应器生产重组脂肪酶的方法 |
| US10415023B2 (en) * | 2013-12-10 | 2019-09-17 | Amano Enzyme Inc. | Modified lipase and use thereof |
| CN104726477B (zh) * | 2013-12-23 | 2018-02-13 | 中国农业大学 | 一种脂肪酶编码基因及其工程菌株 |
| CN104498450B (zh) * | 2014-12-18 | 2017-02-22 | 上海交通大学 | 褶皱假丝酵母脂肪酶1突变体及其基因 |
| CA3010288A1 (en) * | 2015-12-30 | 2017-07-06 | Dsm Ip Assets B.V. | Partial enzymatic hydrolysis of triacylglycerols |
| CN116064263A (zh) * | 2015-12-30 | 2023-05-05 | 帝斯曼知识产权资产管理有限公司 | 三酰基甘油的部分酶水解 |
| US10829748B2 (en) * | 2016-06-10 | 2020-11-10 | Dsm Ip Assets B.V. | Mutant lipase and use thereof |
-
2016
- 2016-12-29 CN CN202211111087.0A patent/CN116064263A/zh active Pending
- 2016-12-29 CN CN201680082770.2A patent/CN108884480A/zh active Pending
- 2016-12-29 JP JP2018534130A patent/JP2019500042A/ja active Pending
- 2016-12-29 EP EP16828786.0A patent/EP3397771A2/en not_active Withdrawn
- 2016-12-29 WO PCT/IB2016/058086 patent/WO2017115322A2/en not_active Ceased
- 2016-12-29 KR KR1020187021735A patent/KR20180098386A/ko not_active Ceased
- 2016-12-29 BR BR112018013385A patent/BR112018013385A2/pt not_active IP Right Cessation
- 2016-12-29 CA CA3009871A patent/CA3009871A1/en active Pending
- 2016-12-29 PE PE2018001234A patent/PE20181403A1/es unknown
- 2016-12-29 US US16/066,587 patent/US11535875B2/en active Active
-
2021
- 2021-12-03 JP JP2021196980A patent/JP2022046487A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3009871A1 (en) | 2017-07-06 |
| EP3397771A2 (en) | 2018-11-07 |
| CN108884480A (zh) | 2018-11-23 |
| BR112018013385A2 (pt) | 2018-12-04 |
| CN116064263A (zh) | 2023-05-05 |
| US11535875B2 (en) | 2022-12-27 |
| WO2017115322A2 (en) | 2017-07-06 |
| KR20180098386A (ko) | 2018-09-03 |
| JP2019500042A (ja) | 2019-01-10 |
| WO2017115322A3 (en) | 2017-08-10 |
| US20210207181A1 (en) | 2021-07-08 |
| JP2022046487A (ja) | 2022-03-23 |
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