+

PE20170665A1 - Anticuerpos anti-tau humanizados - Google Patents

Anticuerpos anti-tau humanizados

Info

Publication number
PE20170665A1
PE20170665A1 PE2016002780A PE2016002780A PE20170665A1 PE 20170665 A1 PE20170665 A1 PE 20170665A1 PE 2016002780 A PE2016002780 A PE 2016002780A PE 2016002780 A PE2016002780 A PE 2016002780A PE 20170665 A1 PE20170665 A1 PE 20170665A1
Authority
PE
Peru
Prior art keywords
humanized anti
tau antibodies
nos
refers
amino acid
Prior art date
Application number
PE2016002780A
Other languages
English (en)
Inventor
Diljeet S Athwal
Francis J Carr
Tim West
Timothy D Jones
Robert George Edward Holgate
Original Assignee
C2N Diagnostics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C2N Diagnostics Llc filed Critical C2N Diagnostics Llc
Publication of PE20170665A1 publication Critical patent/PE20170665A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Optics & Photonics (AREA)

Abstract

Se refiere a un anticuerpo anti-tau que comprende: a) una region variable de cadena pesada (VH) con una secuencia de aminoacidos SEQ ID NOs: 5, 6, 7 y 8; y b) una region variable de cadena ligera (VL) con una secuencia de aminoacidos SEQ ID NOs: 1, 2, 3 y 4. Tambien se refiere a un vector, una celula huesped y a una composicion farmaceutica. Dicho anticuerpo es util en la profilaxis o tratamiento de una tauopatia en humanos
PE2016002780A 2014-06-27 2015-06-26 Anticuerpos anti-tau humanizados PE20170665A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462018436P 2014-06-27 2014-06-27
US201462080903P 2014-11-17 2014-11-17
US201562170036P 2015-06-02 2015-06-02
PCT/US2015/038002 WO2015200806A2 (en) 2014-06-27 2015-06-26 Humanized anti-tau antibodies

Publications (1)

Publication Number Publication Date
PE20170665A1 true PE20170665A1 (es) 2017-06-10

Family

ID=54938957

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016002780A PE20170665A1 (es) 2014-06-27 2015-06-26 Anticuerpos anti-tau humanizados

Country Status (27)

Country Link
US (2) US9957317B2 (es)
EP (1) EP3182987B1 (es)
JP (3) JP6626892B2 (es)
KR (1) KR102431596B1 (es)
CN (1) CN106659759B (es)
AU (2) AU2015279643B2 (es)
BR (1) BR112016030686A2 (es)
CA (2) CA2953809C (es)
CL (1) CL2016003346A1 (es)
CR (1) CR20170026A (es)
DO (1) DOP2016000335A (es)
EC (1) ECSP17005649A (es)
ES (1) ES2959528T3 (es)
IL (3) IL249734B (es)
MA (1) MA40229A (es)
MX (2) MX384790B (es)
MY (1) MY184540A (es)
NZ (1) NZ727919A (es)
PE (1) PE20170665A1 (es)
PH (2) PH12016502608A1 (es)
RU (1) RU2743152C2 (es)
SG (2) SG10201914067XA (es)
TW (3) TW202136296A (es)
UA (1) UA122771C2 (es)
UY (1) UY36194A (es)
WO (1) WO2015200806A2 (es)
ZA (1) ZA201608875B (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ739622A (en) 2012-07-03 2020-01-31 Univ Washington Antibodies to tau
SG10201707855YA (en) 2013-03-13 2017-10-30 Prothena Biosciences Ltd Tau immunotherapy
TW202136296A (zh) 2014-06-27 2021-10-01 美商Ｃ２Ｎ醫療診斷有限責任公司 人類化抗-tau抗體
CR20180013A (es) 2015-06-05 2018-12-06 Ac Immune Sa Anticuerpos anti-tau y métodos de uso.
US20200030445A1 (en) * 2015-06-12 2020-01-30 C2N Diagnostics, Llc Stable formulations of humanized anti-tau antibody
RS63580B1 (sr) 2016-04-18 2022-10-31 Faron Pharmaceuticals Oy Humanizovana antitela protiv clever-1 i njihova primena
PT3452507T (pt) * 2016-05-02 2022-12-20 Prothena Biosciences Ltd Imunoterapia anti-tau
MY197413A (en) 2016-05-02 2023-06-16 Prothena Biosciences Ltd Antibodies recognizing tau
US10889638B2 (en) 2016-05-02 2021-01-12 Prothena Biosciences Limited Antibodies recognizing tau
WO2018017370A1 (en) * 2016-07-20 2018-01-25 Anahit Ghochikyan Humanized anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies
KR20190050931A (ko) * 2016-09-10 2019-05-14 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 Cns의 질병 또는 손상의 치료를 위한 전신 조절 t 세포 수준 또는 활성 감소
AU2017335634A1 (en) 2016-09-27 2019-03-14 Cero Therapeutics, Inc. Chimeric engulfment receptor molecules
UA128383C2 (uk) 2016-12-07 2024-07-03 Дженентек, Інк. Антитіло до тау-білка та спосіб його застосування
KR20240035636A (ko) 2016-12-07 2024-03-15 제넨테크, 인크. 항-타우 항체 및 이의 이용 방법
EP3583123A1 (en) 2017-02-17 2019-12-25 Denali Therapeutics Inc. Anti-tau antibodies and methods of use thereof
JOP20180014A1 (ar) 2017-02-27 2019-01-30 Teijin Pharma Ltd جسم مضاد متوافق مع البشر لعلاج أو الوقاية من الاضطرابات الإدراكية، وعملية لإنتاجه، وعامل لعلاج أو الوقاية من الاضطرابات الإدراكية باستخدامه
TW202400231A (zh) 2017-03-28 2024-01-01 美商建南德克公司 治療神經退化性疾病之方法
CN110881274B (zh) 2017-05-02 2024-11-15 普罗塞纳生物科学有限公司 识别tau的抗体
US11708423B2 (en) 2017-09-26 2023-07-25 Cero Therapeutics, Inc. Chimeric engulfment receptor molecules and methods of use
UA126000C2 (uk) 2017-10-02 2022-07-27 Мерк Шарп Енд Дохме Корп. Хроманмонобактамові сполуки для лікування бактеріальних інфекцій
JOP20200074A1 (ar) 2017-10-16 2020-04-30 Eisai R&D Man Co Ltd أجسام مضادة ضد tau واستخداماتها
CN112004827A (zh) * 2018-03-23 2020-11-27 艾伯维德国有限责任两合公司 稳定的水性抗tau抗体调配物
US20210015865A1 (en) 2018-03-28 2021-01-21 Cero Therapeutics, Inc. Chimeric engulfment receptors and uses thereof for neurodegenerative diseases
US12291557B2 (en) 2018-03-28 2025-05-06 Cero Therapeutics Holdings, Inc. Chimeric TIM4 receptors and uses thereof
WO2020025703A1 (en) * 2018-08-01 2020-02-06 Imcheck Therapeutics Sas Anti-btn3a antibodies and their use in treating cancer or infectious disorders
TWI859197B (zh) 2019-03-03 2024-10-21 愛爾蘭商普羅帝納生物科學公司 識別ｔａｕ之抗體
JP2022528953A (ja) * 2019-04-05 2022-06-16 タウク３ バイオロジクス リミテッド 抗タウｃ３抗体及びその使用
CA3143811A1 (en) * 2019-07-15 2021-01-21 Seung-Yong Yoon Anti-tau antibody and use of same
CN114641490B (zh) 2019-08-06 2023-06-06 新旭生技股份有限公司 结合至病理性tau种类的抗体及其用途
KR20230023802A (ko) 2020-06-25 2023-02-17 머크 샤프 앤드 돔 엘엘씨 세린 413에서 인산화된 타우를 표적화하는 고친화도 항체
CL2021001380A1 (es) 2021-05-26 2022-01-14 Corporacion Centro Int De Biomedicina Icc Generación de un nuevo anticuerpo monoclonal sitio específico para la proteína tau y su uso como herramienta en biomarcadores específicos para la detección temprana de enfermedades neurodegenerativas y patologías involucradas con la proteína tau como alzheimer y otras demencias.
JP2024534151A (ja) 2021-08-27 2024-09-18 ジェネンテック， インコーポレイテッド タウ病態の治療方法
WO2023041805A1 (en) 2021-09-20 2023-03-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for improving the efficacy of hdac inhibitor therapy and predicting the response to treatment with hdac inhibitor
US20250034559A1 (en) 2021-11-17 2025-01-30 Voyager Therapeutics, Inc. Compositions and methods for the treatment of tau-related disorders
KR20240162497A (ko) 2022-03-14 2024-11-15 제넨테크, 인크. 음성 분석에 기반한 신경퇴행성 질환 예측
WO2023250326A1 (en) 2022-06-21 2023-12-28 Genentech, Inc. Detecting longitudinal progression of alzheimer's disease (ad) based on speech analyses
CN115724970B (zh) * 2022-07-27 2023-10-20 生工生物工程（上海）股份有限公司 一种特异性结合e-cad多肽的结合蛋白及其应用
TW202428602A (zh) 2022-09-15 2024-07-16 美商航海家醫療公司 Ｔａｕ結合化合物
WO2024133723A1 (en) 2022-12-22 2024-06-27 Institut National de la Santé et de la Recherche Médicale Methods for decreasing therapeutic acquired resistance to chemotherapy and/or radiotherapy
CN116375857A (zh) * 2023-03-30 2023-07-04 天津鸿宇泰生物科技有限公司 一种用于检测Tau蛋白的单链抗体及其制备方法和应用
CN119331085B (zh) * 2024-10-16 2025-03-14 中国科学院合肥物质科学研究院 沙贝冠状病毒广谱中和抗体及其应用

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01163661A (ja) 1987-10-02 1989-06-27 E I Du Pont De Nemours & Co ＩｇＧ捕捉抗体および多重単クローン性抗体検出系を用いたイムノアツセイ
AU2414092A (en) 1991-08-01 1993-03-02 Paul H. Voorheis Diagnostic method for alzheimer's disease
US5733734A (en) 1991-08-14 1998-03-31 The Trustees Of The University Of Pennsylvania Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
WO1993008302A1 (en) 1991-10-25 1993-04-29 Itt Automotive Europe Gmbh Monoclonal antibodies directed against the microtubule-associated protein tau
US5266331A (en) 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
EP0911390B1 (en) 1991-12-06 2009-08-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Protein kinases as tools for the diagnosis and treatment of Alzheimer's disease
US7408027B1 (en) 1991-12-06 2008-08-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften Tools for the diagnosis and treatment of Alzheimer's disease
JPH06239899A (ja) 1993-02-12 1994-08-30 Teijin Ltd ヒトタウ蛋白に対する抗体、並びに該抗体を利用する体液中のヒトタウ蛋白の測定方法
WO1996004309A1 (en) 1994-07-29 1996-02-15 Innogenetics N.V. Monoclonal antibodies specific for an epitope of a particular subclass or form of phosphorylated tau, hybridomas secreting them, antigen recognition of these antibodies and their applications
WO1997034145A1 (fr) 1996-03-13 1997-09-18 Mitsubishi Chemical Corporation Anticorps a proteine tau antiphosphorylee et procede de detection de la maladie d'alzheimer l'utilisant
AU5508798A (en) 1996-11-19 1998-06-10 Trustees Of The University Of Pennsylvania, The Diagnostic and therapeutic reagents for alzheimer's disease
US6797478B1 (en) 1998-03-05 2004-09-28 University Of Cincinnati Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies
AU772151B2 (en) 1998-09-08 2004-04-08 Innogenetics N.V. Tau as a marker for early CNS damage
US6972125B2 (en) * 1999-02-12 2005-12-06 Genetics Institute, Llc Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
US6589746B1 (en) 1999-10-21 2003-07-08 University Of Cincinnati Method of detecting axonally-derived protein tau in patients with traumatic CNS injury
JP4582874B2 (ja) 2000-07-13 2010-11-17 富士通株式会社 偏波モード分散補償方法および偏波モード分散補償装置
AT500379B8 (de) 2001-02-02 2009-08-15 Axon Neuroscience Tau-proteine
AR035119A1 (es) 2001-08-16 2004-04-14 Lilly Co Eli Anticuerpos humanos antagonistas anti-htnfsf13b
JP4063769B2 (ja) 2001-12-28 2008-03-19 中外製薬株式会社 タンパク質安定化方法
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
CN100482277C (zh) 2002-05-02 2009-04-29 惠氏控股公司 加利车霉素衍生物-载体缀合物
ES2304146T3 (es) 2002-07-12 2008-09-16 Axon Neuroscience Forschungs- Und Entwicklungs Gmbh Animales transgenicos que expresan la proteina tau truncada de la enfermedad de alzheimer.
AU2003257850A1 (en) 2002-08-14 2004-03-03 Mitsubishi Kagaku Iatron, Inc. ANTIBODY SPECIFIC TO CENTRAL Tau-PROTEIN
FI20030652A0 (fi) 2003-04-30 2003-04-30 Susann Eriksson Parannettu immunomääritys
CN1871259A (zh) 2003-08-22 2006-11-29 比奥根艾迪克Ma公司 具有改变的效应物功能的经改进的抗体和制备它的方法
WO2005073375A1 (en) * 2004-01-30 2005-08-11 Maxygen Holdings Ltd. Regulated stop codon readthrough
US7238788B2 (en) 2004-02-18 2007-07-03 University Of Iowa Foundation Antibodies to phosphorylated tau, methods of making and methods of use
US8026070B2 (en) 2005-02-19 2011-09-27 Peoplebio, Inc. Differential detection of multimeric and monomeric forms of multimer-forming polypeptides
WO2007019273A2 (en) 2005-08-04 2007-02-15 Albert Einstein College Of Medicine Of Yeshiva University Phosphorylation of tau by abl
ES2321996B1 (es) 2006-01-26 2010-03-05 Consejo Superior Investig. Cientificas Uso de compuestos que se unen al dominio de union a microtubulos de tau en la elaboracion de composiciones farmaceuticas, dichas composiciones farmaceuticas y su aplicacion en el tratamiento de tauopatias.
US8012936B2 (en) 2006-03-29 2011-09-06 New York University Tau fragments for immunotherapy
CN101622276B (zh) * 2006-07-18 2015-04-22 赛诺菲-安万特 用于治疗癌症的抗epha2的拮抗抗体
US20080220449A1 (en) 2007-02-08 2008-09-11 Oligomerix, Inc. Biomarkers and assays for Alzheimer's disease
DK2276485T3 (da) 2008-04-24 2014-10-13 Bristol Myers Squibb Co Anvendelse af epothilon d i behandling af tau-associerede sygdomme,herunder alzheimers sygdom
CN101307108B (zh) 2008-06-25 2012-04-04 南京川博生物技术有限公司 抗磷酸化Tau蛋白抗体及其在AD症异常磷酸化Tau蛋白水平测定上的用途
EP2342226B1 (en) * 2008-09-26 2016-06-22 Dana-Farber Cancer Institute, Inc. Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses thereof
WO2010096751A1 (en) 2009-02-23 2010-08-26 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating a disease mediated by soluble oligomeric amyloid beta
US9605054B2 (en) 2009-02-23 2017-03-28 The Board Of Trustees Of The University Of Illinois Composition and method for treating a tauopathy
UA107571C2 (xx) 2009-04-03 2015-01-26 Фармацевтична композиція
US8409584B2 (en) 2009-05-05 2013-04-02 New York University Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins
JP5917394B2 (ja) 2009-06-10 2016-05-11 ニューヨーク・ユニバーシティ 病理学的タウタンパク質の免疫学的標的化方法
US8609097B2 (en) * 2009-06-10 2013-12-17 Hoffmann-La Roche Inc. Use of an anti-Tau pS422 antibody for the treatment of brain diseases
CN102144341B (zh) 2009-06-17 2013-02-27 株式会社藤仓 多包层光纤、光纤模块、光纤激光器及光纤放大器
KR20130127547A (ko) 2009-07-30 2013-11-22 화이자 백신스 엘엘씨 항원성 타우 펩타이드 및 이의 용도
EP2470211B1 (en) 2009-08-28 2016-01-27 The Board of Regents of The University of Texas System Antibodies that bind tau oligomers
WO2011045166A1 (en) 2009-09-24 2011-04-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Fkbp52-tau interaction as a novel therapeutical target for treating the neurological disorders involving tau dysfunction
WO2011109112A2 (en) 2010-03-05 2011-09-09 Albert Einstein College Of Medicine Of Yeshiva University Method of detecting tau protein and tau fragments in serum
EP2560994B1 (en) * 2010-04-08 2016-10-12 JN Biosciences LLC Antibodies to cd122
SI2625198T1 (sl) 2010-10-07 2015-11-30 Ac Immune S.A. Epfl Innovation Park Protitelesa, ki prepoznavajo fosfo-tau
AU2013205313B2 (en) 2010-10-07 2016-05-19 Ac Immune S.A. Phosphospecific antibodies recognising tau
PL2627672T3 (pl) * 2010-10-11 2018-11-30 Biogen International Neuroscience Gmbh Ludzkie przeciwciała anty-tau
EP2670434B1 (en) 2011-01-31 2018-12-26 Tau Bio-Logic Corp. Treatment of tauopathies
US8697076B2 (en) 2011-04-27 2014-04-15 Northwestern University Antibodies selective for pathological tau dimers and prefibrillar pathological tau oligomers and their uses in treatment, diagnosis and monitoring of tauopathies
US20120321594A1 (en) 2011-05-06 2012-12-20 New York University Methods of controlling axon or dendrite development of neuronal cells
WO2012162179A1 (en) 2011-05-20 2012-11-29 Oligomerix, Inc. Tau protease compositions and methods of use
GB201111361D0 (en) 2011-07-04 2011-08-17 Nordic Bioscience As Biochemical markers for neurodegenerative conditions
GB201112056D0 (en) 2011-07-14 2011-08-31 Univ Leuven Kath Antibodies
US9926353B2 (en) 2011-07-19 2018-03-27 New York University Immunotherapeutic modulation of amyloidogenic disease using non-fibrillogenic, non-amyloidogenic polymerized proteins and peptides
RS56852B1 (sr) 2011-09-19 2018-04-30 Axon Neuroscience Se Terapija na osnovu proteina i dijagnoza patologije u kojoj posreduje tau u alchajmerovoj bolesti
CN108034005B (zh) 2011-10-07 2021-06-25 Ac免疫有限公司 识别Tau的磷酸化特异抗体
WO2013063086A1 (en) 2011-10-24 2013-05-02 Intellect Neurosciences, Inc. Compositions and methods for treatment of proteinopathies
AU2012328588C1 (en) * 2011-10-27 2015-12-03 Nkt Therapeutics Inc. Humanized antibodies to iNKT
CA3234629A1 (en) 2011-12-20 2013-06-27 Janssen Biotech, Inc. Anti-phf-tau antibodies and their uses
US20130251731A1 (en) * 2012-03-22 2013-09-26 The Trustees Of The University Of Pennsylvania Tau Acetylation in the Pathogenesis of Alzheimers Disease and Other Related Tauopathies
JP6293731B2 (ja) 2012-04-05 2018-03-14 エーシー イミューン エス．エー． ヒト化タウ抗体
WO2013177104A2 (en) 2012-05-21 2013-11-28 Felder Mitchell S Treatment for tauopathies
LT2857039T (lt) 2012-05-31 2020-03-10 Osaka City University Terapinis agentas arba profilaktinis agentas nuo demencijos
NZ739622A (en) * 2012-07-03 2020-01-31 Univ Washington Antibodies to tau
AU2013302540B2 (en) 2012-08-16 2018-02-15 Ipierian, Inc. Methods of treating a tauopathy
US20140056901A1 (en) 2012-08-21 2014-02-27 The Institute For Molecular Medicine Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies
CA2885924C (en) 2012-08-21 2022-12-13 Institute For Molecular Medicine, Inc. Compositions and methods related to diseases associated with deposits of amyloid, tau, and alpha-synuclein
JP6324974B2 (ja) 2012-10-12 2018-05-23 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ タウの毒性オリゴマー形態を特異的に認識する抗体ベースの試薬
US9910048B2 (en) 2012-12-03 2018-03-06 Washington University Method for detection of aggregates in biological samples
US8921150B2 (en) 2012-12-06 2014-12-30 Taiwan Semiconductor Manufacturing Co., Ltd. Process to achieve contact protrusion for single damascene via
US9200068B2 (en) 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy
WO2014096321A1 (en) 2012-12-21 2014-06-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies specific to tau phosphorylated at serine 422 and uses for the treatment and diagnosis of tauopathies
LT2935326T (lt) 2012-12-21 2020-12-10 Biogen Ma Inc. Žmogaus antikūnai prieš tau baltymą
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
SG10201707855YA (en) 2013-03-13 2017-10-30 Prothena Biosciences Ltd Tau immunotherapy
WO2014159244A2 (en) 2013-03-14 2014-10-02 Merck Patent Gmbh O-GlcNAc TAU ANTIBODY AND USE THEREOF
CA2903091C (en) 2013-03-15 2022-09-06 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
MX374811B (es) 2013-03-15 2025-03-06 Ac Immune Sa Anticuerpos anti-tau y métodos de uso.
TW202136296A (zh) 2014-06-27 2021-10-01 美商Ｃ２Ｎ醫療診斷有限責任公司 人類化抗-tau抗體

Also Published As

Publication number Publication date
MY184540A (en) 2021-04-01
BR112016030686A2 (pt) 2017-10-31
IL249734B (en) 2020-03-31
WO2015200806A3 (en) 2016-02-25
MX2021008888A (es) 2021-08-19
TWI734975B (zh) 2021-08-01
SG10201914067XA (en) 2020-03-30
RU2743152C2 (ru) 2021-02-15
ES2959528T3 (es) 2024-02-26
IL273656A (en) 2020-05-31
CR20170026A (es) 2017-06-16
CN106659759B (zh) 2022-04-15
NZ727919A (en) 2021-07-30
TW202136296A (zh) 2021-10-01
CA2953809C (en) 2020-09-29
TW201946931A (zh) 2019-12-16
US20180371066A1 (en) 2018-12-27
SG11201610862VA (en) 2017-01-27
AU2021204800A1 (en) 2021-08-05
KR102431596B1 (ko) 2022-08-12
CA2953809A1 (en) 2015-12-30
WO2015200806A2 (en) 2015-12-30
MX384790B (es) 2025-03-14
AU2015279643B2 (en) 2021-04-08
PH12016502608A1 (en) 2017-04-24
US9957317B2 (en) 2018-05-01
RU2017102514A3 (es) 2019-02-25
MA40229A (fr) 2021-06-02
CN106659759A (zh) 2017-05-10
IL273656B (en) 2022-01-01
JP2017521097A (ja) 2017-08-03
US20170058024A1 (en) 2017-03-02
AU2015279643A1 (en) 2017-01-19
DOP2016000335A (es) 2017-04-17
IL249734A0 (en) 2017-02-28
EP3182987B1 (en) 2023-09-27
RU2017102514A (ru) 2018-07-31
UA122771C2 (uk) 2021-01-06
CA3094638A1 (en) 2015-12-30
KR20170026390A (ko) 2017-03-08
MX2017000205A (es) 2017-08-22
CL2016003346A1 (es) 2017-07-21
JP2022050392A (ja) 2022-03-30
EP3182987A2 (en) 2017-06-28
TW201607956A (zh) 2016-03-01
JP2020054356A (ja) 2020-04-09
PH12021550023A1 (en) 2021-12-13
ECSP17005649A (es) 2018-04-30
EP3182987C0 (en) 2023-09-27
ZA201608875B (en) 2017-09-27
UY36194A (es) 2016-01-29
TWI664190B (zh) 2019-07-01
JP6626892B2 (ja) 2019-12-25
IL288649A (en) 2022-02-01
EP3182987A4 (en) 2018-01-24

Similar Documents

Publication Publication Date Title
PE20170665A1 (es) Anticuerpos anti-tau humanizados
ES2687282T3 (es) Anticuerpos humanizados ANTI-CD134 (OX40) y sus usos
PE20181805A1 (es) Composiciones y anticuerpos anti-tim-3
PE20150002A1 (es) Anticuerpos anti-fcrn
EA201890285A1 (ru) Антитела против pd-1, активируемые антитела против pd-1 и способы их применения
EA201991383A1 (ru) Антитела против ctla-4 и способы их применения
EA201991577A1 (ru) Новые антитела против рецептора трансферрина человека, способные преодолевать гематоэнцефалический барьер
EA201791029A1 (ru) Антитела против интерлейкина-33 и их применение
EA201891709A1 (ru) Антигенсвязывающие белки, связывающие pd-l1
PE20161032A1 (es) Anticuerpos anti-tau(ps422) humanizados y metodos de utilizacion
MX2021011167A (es) Anticuerpos humanizados anti grupo de diferenciacion 19 (cd19) humano y metodos de uso.
EA202092435A3 (ru) Моноклональные антитела против bcma
EA201891339A1 (ru) Водный фармацевтический препарат, который содержит антитело к pd-l1 авелумаб
PE20171103A1 (es) Anticuerpos heterodimericos que se unen a cd3 y cd38
EA201890630A1 (ru) Антитела против pd-1 и способы их применения
PE20180480A1 (es) Anticuerpos de factor xi y metodos de uso
PE20181326A1 (es) Anticuerpos que se unen especificamente a pd-1 y sus usos
CL2015001895A1 (es) Anticuerpos que se unen al tl1a y sus usos
BR112017003582A2 (pt) anticorpos, composições e usos
ES2670621T3 (es) Anticuerpos que se unen a OX40 y sus usos
PE20190208A1 (es) Anticuerpos que reconocen tau
MX375524B (es) Anticuerpos anti-axl.
PE20171107A1 (es) Anticuerpos mejorados contra il-6
AU2012249274A8 (en) Neutralizing antibodies to Nipah and Hendra virus
EA201692025A1 (ru) Доставка белков, осуществляемая на основе бактерий
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载