PE20160011A1 - Formulaciones combinadas de neosaxitoxina para una anestesia local prolongada - Google Patents
Formulaciones combinadas de neosaxitoxina para una anestesia local prolongadaInfo
- Publication number
- PE20160011A1 PE20160011A1 PE2015002008A PE2015002008A PE20160011A1 PE 20160011 A1 PE20160011 A1 PE 20160011A1 PE 2015002008 A PE2015002008 A PE 2015002008A PE 2015002008 A PE2015002008 A PE 2015002008A PE 20160011 A1 PE20160011 A1 PE 20160011A1
- Authority
- PE
- Peru
- Prior art keywords
- neosaxitoxin
- mcg
- formulations
- combined
- local anesthesia
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Rheumatology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Una unidad de dosificacion para el tratamiento o la prevencion del dolor en un sujeto humano despierto, sedado o anestesiado, caracterizada porque comprende una cantidad eficaz de entre 5 y 40 mcg de neosaxitoxina, un anestesico local que se selecciona del grupo que consiste en la bupivacaina, la levobupivacaina, la tetracaina y la ropivacaina, en una concentracion en el rango de entre 0,1% (1 mg/ml) y 0.5% (5 mg/ml), y epinefrina en una concentracion en el rango de entre 2 mcg/ml (1:500000 en la terminologia comun) y 10 mcg/ml (1:100000), de manera tal de proveer una concentracion minima eficaz de la neosaxitoxina de 0,1-1 mcg/ml en el sitio en el que se realiza la administracion
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361789054P | 2013-03-15 | 2013-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20160011A1 true PE20160011A1 (es) | 2016-02-10 |
Family
ID=50549480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015002008A PE20160011A1 (es) | 2013-03-15 | 2014-03-17 | Formulaciones combinadas de neosaxitoxina para una anestesia local prolongada |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US10314833B2 (es) |
| EP (2) | EP3492075B1 (es) |
| JP (1) | JP6313420B2 (es) |
| KR (4) | KR20220132666A (es) |
| CN (1) | CN105142625B (es) |
| AU (2) | AU2014232881B2 (es) |
| CA (2) | CA2906851C (es) |
| CL (1) | CL2015002534A1 (es) |
| CY (1) | CY1121606T1 (es) |
| DK (1) | DK2968225T3 (es) |
| ES (2) | ES2727292T3 (es) |
| HK (1) | HK1218384A1 (es) |
| HR (1) | HRP20190419T1 (es) |
| HU (1) | HUE042711T2 (es) |
| IL (1) | IL241346B (es) |
| LT (1) | LT2968225T (es) |
| MX (1) | MX390159B (es) |
| NZ (1) | NZ710890A (es) |
| PE (1) | PE20160011A1 (es) |
| PL (2) | PL2968225T3 (es) |
| PT (1) | PT2968225T (es) |
| RS (1) | RS58750B1 (es) |
| RU (2) | RU2015143665A (es) |
| SI (1) | SI2968225T1 (es) |
| TR (1) | TR201903411T4 (es) |
| WO (1) | WO2014145580A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20160011A1 (es) * | 2013-03-15 | 2016-02-10 | Childrens Medical Center | Formulaciones combinadas de neosaxitoxina para una anestesia local prolongada |
| US20170368176A1 (en) | 2014-12-15 | 2017-12-28 | The Children's Medical Center Corporation | Non-toxic topical anesthetic ophthalmic compositions |
| US11344498B2 (en) | 2015-10-08 | 2022-05-31 | The Children's Medical Center Corporation | Compositions and methods for on-demand high-efficiency triggerable anesthesia |
| US10117847B2 (en) | 2015-12-04 | 2018-11-06 | Ventis Pharma | Extended duration local anesthetic formulation |
| US10791651B2 (en) | 2016-05-31 | 2020-09-29 | Carbice Corporation | Carbon nanotube-based thermal interface materials and methods of making and using thereof |
| EP3717017A1 (en) * | 2017-12-01 | 2020-10-07 | The Children's Medical Center Corporation | Covalent anesthetic-polymer conjugates for prolonged local anesthesia |
| RU2701571C1 (ru) * | 2019-02-13 | 2019-09-30 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Казанский Государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ профилактики болевого синдрома после вмешательств на коленном суставе |
| WO2021141956A1 (en) * | 2020-01-06 | 2021-07-15 | Pacira Pharmaceuticals, Inc, | Treatment of pain associated with cesarean section surgery with sustained-release liposomal anesthetic compositions |
| CN115297854A (zh) | 2020-01-10 | 2022-11-04 | 帕西拉制药股份有限公司 | 通过蛛网膜下腔给予缓释脂质体麻醉组合物治疗疼痛 |
| CN115515581A (zh) | 2020-01-10 | 2022-12-23 | 帕西拉制药股份有限公司 | 通过给予缓释脂质体麻醉组合物治疗疼痛 |
| BR112023013685A2 (pt) | 2021-01-11 | 2023-11-14 | Pacira Pharmaceuticals Inc | Tratamento da dor no quadril com composições anestésicas lipossômicas de liberação sustentada |
| BR112023018896A2 (pt) | 2021-03-19 | 2023-10-10 | Pacira Pharmaceuticals Inc | Tratamento da dor em pacientes pediátricos por administração de composições anestésicas lipossômicas de liberação prolongada |
| US12226610B2 (en) | 2022-11-03 | 2025-02-18 | Pacira Pharmaceuticals, Inc. | Treatment of pain associated with total knee arthroplasty with sustained-release liposomal anesthetic compositions |
| US11918565B1 (en) | 2022-11-03 | 2024-03-05 | Pacira Pharmaceuticals, Inc. | Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions |
| WO2024151854A1 (en) * | 2023-01-13 | 2024-07-18 | Smilanich Michael D | Composition for local anesthesia and uses thereof |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
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| PE20160011A1 (es) * | 2013-03-15 | 2016-02-10 | Childrens Medical Center | Formulaciones combinadas de neosaxitoxina para una anestesia local prolongada |
-
2014
- 2014-03-17 PE PE2015002008A patent/PE20160011A1/es unknown
- 2014-03-17 CN CN201480015980.0A patent/CN105142625B/zh active Active
- 2014-03-17 RS RS20190594A patent/RS58750B1/sr unknown
- 2014-03-17 JP JP2016503385A patent/JP6313420B2/ja active Active
- 2014-03-17 AU AU2014232881A patent/AU2014232881B2/en active Active
- 2014-03-17 KR KR1020227032390A patent/KR20220132666A/ko not_active Ceased
- 2014-03-17 PL PL14719486T patent/PL2968225T3/pl unknown
- 2014-03-17 KR KR1020157029781A patent/KR20150131330A/ko not_active Ceased
- 2014-03-17 ES ES14719486T patent/ES2727292T3/es active Active
- 2014-03-17 CA CA2906851A patent/CA2906851C/en active Active
- 2014-03-17 DK DK14719486.4T patent/DK2968225T3/da active
- 2014-03-17 RU RU2015143665A patent/RU2015143665A/ru not_active Application Discontinuation
- 2014-03-17 KR KR1020217012549A patent/KR20210062693A/ko not_active Ceased
- 2014-03-17 SI SI201431117T patent/SI2968225T1/sl unknown
- 2014-03-17 CA CA3018668A patent/CA3018668C/en active Active
- 2014-03-17 TR TR2019/03411T patent/TR201903411T4/tr unknown
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