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PE20130382A1 - Derivados de n-(imidazopirimidin-7-il)-heteroarilamida y su uso como inhibidores de pde10a - Google Patents

Derivados de n-(imidazopirimidin-7-il)-heteroarilamida y su uso como inhibidores de pde10a

Info

Publication number
PE20130382A1
PE20130382A1 PE2012001636A PE2012001636A PE20130382A1 PE 20130382 A1 PE20130382 A1 PE 20130382A1 PE 2012001636 A PE2012001636 A PE 2012001636A PE 2012001636 A PE2012001636 A PE 2012001636A PE 20130382 A1 PE20130382 A1 PE 20130382A1
Authority
PE
Peru
Prior art keywords
amide
lower alkyl
imidazopyrimidin
heteroarylamide
pde10a
Prior art date
Application number
PE2012001636A
Other languages
English (en)
Inventor
Sanchez Ruben Alvarez
Konrad Bleicher
Alexander Flohr
Luca Gobbi
Katrin Groebke Zbinden
Mathias Koerner
Bernd Kuhn
Jens-Uwe Peters
Markus Rudolph
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20130382A1 publication Critical patent/PE20130382A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A UN COMPUESTO DERIVADO DE N-(IMIDAZOPIRIMIDIN-7-IL)-HETEROARILAMIDA DE FORMULA (I) DONDE R1 ES FENILO O TIENILO OPCIONALMENTE SUSTUIDO CON OH, HALOGENO, ALQUILO INFERIOR, ENTRE OTROS; R2 ES UN HETEROARILO MONOCICLICO DE 5 O 6 ESLABONES QUE TIENE DE 1 A 3 HETEROATOMOS OPCIONALMENTE SUSTITUIDO CON NITRO, ALQUILO INFERIOR, ALCOXI INFERIOR, ENTRE OTROS; R8 ES HIDROGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-[(2-FLUOR-ETIL)-METIL-AMIDA]3-{[2-(3-FLUORMETOXIFENIL)-IMIDAZOL[1,2-a]PIRIMIDIN-7-IL]-AMIDA}DEL ACIDO 2-METIL-2H-PIRAZOL-3,4-DICARBOXILICO, 2-[(2-FENIL-IMIDAZO[1,2-a]PIRIMIDIN-7-IL)-AMIDA] 3-[(2,2,2-TRIFLUOR-ETIL)-AMIDA] DEL ACIDO PIRAZINA-2,3- DICARBOXILICO, ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA FOSFODIESTERASA 10A (PDE10A) SIENDO UTILES PARA EL TRATAMIENTO TERAPEUTICO Y/O PROFILACTICO DE LOS TRANSTORNOS PSICOTICOS, LA ESQUIZOFRENIA, TRANSTORNO DE LA ALUCINACION ENTRE OTROS.
PE2012001636A 2010-03-26 2011-03-23 Derivados de n-(imidazopirimidin-7-il)-heteroarilamida y su uso como inhibidores de pde10a PE20130382A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10158011 2010-03-26

Publications (1)

Publication Number Publication Date
PE20130382A1 true PE20130382A1 (es) 2013-03-30

Family

ID=43989818

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012001636A PE20130382A1 (es) 2010-03-26 2011-03-23 Derivados de n-(imidazopirimidin-7-il)-heteroarilamida y su uso como inhibidores de pde10a

Country Status (26)

Country Link
US (1) US8410117B2 (es)
EP (1) EP2552918B1 (es)
JP (1) JP5764196B2 (es)
KR (1) KR20130073876A (es)
CN (1) CN102791714B (es)
AR (1) AR080785A1 (es)
AU (1) AU2011231668A1 (es)
BR (1) BR112012024199A2 (es)
CA (1) CA2786213A1 (es)
CL (1) CL2012002497A1 (es)
CR (1) CR20120443A (es)
EC (1) ECSP12012174A (es)
ES (1) ES2478448T3 (es)
HK (1) HK1173440A1 (es)
IL (1) IL220932A0 (es)
MA (1) MA34069B1 (es)
MX (1) MX2012010880A (es)
NZ (1) NZ600927A (es)
PE (1) PE20130382A1 (es)
PH (1) PH12012501772A1 (es)
RU (1) RU2562066C2 (es)
SG (1) SG183824A1 (es)
TW (1) TWI478924B (es)
UA (1) UA108640C2 (es)
WO (1) WO2011117264A1 (es)
ZA (1) ZA201206257B (es)

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Publication number Publication date
CR20120443A (es) 2012-10-11
ZA201206257B (en) 2013-05-29
SG183824A1 (en) 2012-10-30
UA108640C2 (uk) 2015-05-25
TWI478924B (zh) 2015-04-01
RU2562066C2 (ru) 2015-09-10
KR20130073876A (ko) 2013-07-03
EP2552918A1 (en) 2013-02-06
IL220932A0 (en) 2012-09-24
AR080785A1 (es) 2012-05-09
CN102791714B (zh) 2015-03-25
CL2012002497A1 (es) 2013-03-22
TW201136937A (en) 2011-11-01
ECSP12012174A (es) 2012-10-30
US8410117B2 (en) 2013-04-02
EP2552918B1 (en) 2014-06-11
JP5764196B2 (ja) 2015-08-12
HK1173440A1 (en) 2013-05-16
US20110237564A1 (en) 2011-09-29
PH12012501772A1 (en) 2017-07-26
NZ600927A (en) 2013-08-30
CA2786213A1 (en) 2011-09-29
CN102791714A (zh) 2012-11-21
AU2011231668A1 (en) 2012-07-19
ES2478448T3 (es) 2014-07-22
RU2012143794A (ru) 2014-05-10
MX2012010880A (es) 2012-10-15
WO2011117264A1 (en) 2011-09-29
BR112012024199A2 (pt) 2016-07-05
MA34069B1 (fr) 2013-03-05
JP2013523673A (ja) 2013-06-17

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