PE20130382A1 - Derivados de n-(imidazopirimidin-7-il)-heteroarilamida y su uso como inhibidores de pde10a - Google Patents
Derivados de n-(imidazopirimidin-7-il)-heteroarilamida y su uso como inhibidores de pde10aInfo
- Publication number
- PE20130382A1 PE20130382A1 PE2012001636A PE2012001636A PE20130382A1 PE 20130382 A1 PE20130382 A1 PE 20130382A1 PE 2012001636 A PE2012001636 A PE 2012001636A PE 2012001636 A PE2012001636 A PE 2012001636A PE 20130382 A1 PE20130382 A1 PE 20130382A1
- Authority
- PE
- Peru
- Prior art keywords
- amide
- lower alkyl
- imidazopyrimidin
- heteroarylamide
- pde10a
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A UN COMPUESTO DERIVADO DE N-(IMIDAZOPIRIMIDIN-7-IL)-HETEROARILAMIDA DE FORMULA (I) DONDE R1 ES FENILO O TIENILO OPCIONALMENTE SUSTUIDO CON OH, HALOGENO, ALQUILO INFERIOR, ENTRE OTROS; R2 ES UN HETEROARILO MONOCICLICO DE 5 O 6 ESLABONES QUE TIENE DE 1 A 3 HETEROATOMOS OPCIONALMENTE SUSTITUIDO CON NITRO, ALQUILO INFERIOR, ALCOXI INFERIOR, ENTRE OTROS; R8 ES HIDROGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-[(2-FLUOR-ETIL)-METIL-AMIDA]3-{[2-(3-FLUORMETOXIFENIL)-IMIDAZOL[1,2-a]PIRIMIDIN-7-IL]-AMIDA}DEL ACIDO 2-METIL-2H-PIRAZOL-3,4-DICARBOXILICO, 2-[(2-FENIL-IMIDAZO[1,2-a]PIRIMIDIN-7-IL)-AMIDA] 3-[(2,2,2-TRIFLUOR-ETIL)-AMIDA] DEL ACIDO PIRAZINA-2,3- DICARBOXILICO, ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA FOSFODIESTERASA 10A (PDE10A) SIENDO UTILES PARA EL TRATAMIENTO TERAPEUTICO Y/O PROFILACTICO DE LOS TRANSTORNOS PSICOTICOS, LA ESQUIZOFRENIA, TRANSTORNO DE LA ALUCINACION ENTRE OTROS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10158011 | 2010-03-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20130382A1 true PE20130382A1 (es) | 2013-03-30 |
Family
ID=43989818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2012001636A PE20130382A1 (es) | 2010-03-26 | 2011-03-23 | Derivados de n-(imidazopirimidin-7-il)-heteroarilamida y su uso como inhibidores de pde10a |
Country Status (26)
Country | Link |
---|---|
US (1) | US8410117B2 (es) |
EP (1) | EP2552918B1 (es) |
JP (1) | JP5764196B2 (es) |
KR (1) | KR20130073876A (es) |
CN (1) | CN102791714B (es) |
AR (1) | AR080785A1 (es) |
AU (1) | AU2011231668A1 (es) |
BR (1) | BR112012024199A2 (es) |
CA (1) | CA2786213A1 (es) |
CL (1) | CL2012002497A1 (es) |
CR (1) | CR20120443A (es) |
EC (1) | ECSP12012174A (es) |
ES (1) | ES2478448T3 (es) |
HK (1) | HK1173440A1 (es) |
IL (1) | IL220932A0 (es) |
MA (1) | MA34069B1 (es) |
MX (1) | MX2012010880A (es) |
NZ (1) | NZ600927A (es) |
PE (1) | PE20130382A1 (es) |
PH (1) | PH12012501772A1 (es) |
RU (1) | RU2562066C2 (es) |
SG (1) | SG183824A1 (es) |
TW (1) | TWI478924B (es) |
UA (1) | UA108640C2 (es) |
WO (1) | WO2011117264A1 (es) |
ZA (1) | ZA201206257B (es) |
Families Citing this family (41)
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MX2013009575A (es) | 2011-02-18 | 2014-10-14 | Exonhit Therapeutics Sa | Derivados de 6, 7-dialcoxi-3-isoquinolinol sustituidos como inhibidores de fosfodiesterasa 10 (pdei0a). |
EP2768833A4 (en) * | 2011-10-20 | 2015-04-15 | Sirtris Pharmaceuticals Inc | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS MODULATORS OF SIRTUINS |
AU2012325909B2 (en) | 2011-10-20 | 2016-06-09 | Glaxosmithkline Llc | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
KR20140077964A (ko) * | 2011-10-20 | 2014-06-24 | 글락소스미스클라인 엘엘씨 | 시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체 |
KR20150042847A (ko) * | 2012-08-17 | 2015-04-21 | 에프. 호프만-라 로슈 아게 | 피라졸 카르복시산 유도체의 제조 방법 |
WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
ES2603931T3 (es) * | 2012-11-07 | 2017-03-02 | F. Hoffmann-La Roche Ag | Compuestos de triazolo |
CN102964308B (zh) * | 2012-11-30 | 2015-03-18 | 中国药科大学 | 新型嘧啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途 |
NZ708593A (en) | 2013-02-27 | 2018-01-26 | Mochida Pharm Co Ltd | Novel pyrazole derivative |
CA2907605A1 (en) * | 2013-05-23 | 2014-11-27 | F. Hoffmann-La Roche Ag | 2-phenylimidazo[1,2-a]pyrimidines as imaging agents |
US10039764B2 (en) | 2013-07-12 | 2018-08-07 | University Of South Alabama | Treatment and diagnosis of cancer and precancerous conditions using PDE10A inhibitors and methods to measure PDE10A expression |
CN105579453B (zh) * | 2013-09-26 | 2017-12-22 | 豪夫迈·罗氏有限公司 | 作为成像工具的咪唑并[1,2‑a]吡啶‑7‑胺类 |
US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
PL408251A1 (pl) * | 2014-05-19 | 2015-11-23 | Celon Pharma Spółka Z Ograniczoną Odpowiedzialnością | Skondensowane pochodne triazolu jako inhibitory fosfodiesterazy 10A |
WO2016017711A1 (ja) * | 2014-07-30 | 2016-02-04 | 持田製薬株式会社 | ピラゾール誘導体の製造方法 |
ES2928164T3 (es) | 2015-10-19 | 2022-11-15 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
MY199220A (en) | 2015-11-19 | 2023-10-20 | Incyte Corp | Heterocyclic compounds as immunomodulators |
LT3394033T (lt) | 2015-12-22 | 2021-03-10 | Incyte Corporation | Heterocikliniai junginiai, kaip imunomoduliatoriai |
AR108396A1 (es) | 2016-05-06 | 2018-08-15 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
ES2905980T3 (es) | 2016-05-26 | 2022-04-12 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
MD3472167T2 (ro) | 2016-06-20 | 2023-02-28 | Incyte Corp | Compuși heterociclici ca imunomodulatori |
WO2018013789A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
ES2941716T3 (es) | 2016-08-29 | 2023-05-25 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
US20180179179A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
IL295660A (en) | 2016-12-22 | 2022-10-01 | Incyte Corp | Benzooxazole derivatives as immunomodulators |
EP3558989B1 (en) | 2016-12-22 | 2021-04-14 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
MX391980B (es) | 2016-12-22 | 2025-03-21 | Incyte Corp | Derivados de tetrahidro imidazo [4,5-c] piridina como inductores de internalización de ligando 1 de muerte programada (pd-l1). |
TWI674260B (zh) | 2017-02-01 | 2019-10-11 | 德商菲尼克斯製藥股份有限公司 | 芳基烴受體(AhR)調節劑化合物 |
TWI752155B (zh) * | 2017-02-01 | 2022-01-11 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
LT4212529T (lt) | 2018-03-30 | 2025-05-12 | Incyte Corporation | Heterocikliniai junginiai kaip imunomoduliatoriai |
US10618916B2 (en) | 2018-05-11 | 2020-04-14 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
WO2020094592A1 (en) | 2018-11-06 | 2020-05-14 | H. Lundbeck A/S | Compounds for treating negative symptoms and cognitive impairments |
TW202031250A (zh) | 2018-11-06 | 2020-09-01 | 丹麥商H 朗德貝克公司 | 用於治療負性症狀和認知損傷之pde10a抑制劑 |
WO2021030162A1 (en) | 2019-08-09 | 2021-02-18 | Incyte Corporation | Salts of a pd-1/pd-l1 inhibitor |
PE20221038A1 (es) | 2019-09-30 | 2022-06-17 | Incyte Corp | Compuestos de pirido[3,2-d] pirimidina como inmunomoduladores |
AU2020370958A1 (en) * | 2019-10-21 | 2022-06-09 | Sk Biopharmaceuticals Co., Ltd. | Use of imidazopyrimidine or imidazotriazine compounds for prevention, alleviation, or treatment of cognitive disorders, or for improving cognitive function |
TW202120504A (zh) | 2019-11-11 | 2021-06-01 | 美商英塞特公司 | Pd-1/pd-l1 抑制劑之鹽及結晶型 |
US11866434B2 (en) | 2020-11-06 | 2024-01-09 | Incyte Corporation | Process for making a PD-1/PD-L1 inhibitor and salts and crystalline forms thereof |
TW202233615A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Pd—1/pd—l1抑制劑之結晶形式 |
WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
CN115572282B (zh) * | 2021-07-05 | 2024-07-09 | 华东理工大学 | 含芳杂环结构的吡唑酰胺类化合物及其制备方法和应用 |
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ES8106502A1 (es) | 1980-07-17 | 1981-07-01 | Consejo Superior Investigacion | Procedimiento para la preparacion de 3(6 5)-formilpira- zol-4-carboxilatos de alquilo |
PL348924A1 (en) * | 1999-11-10 | 2002-06-17 | Ortho Mcneil Pharm Inc | Substituted 2−aryl−3−(heteroaryl)−imidazo[1,2−a |
EP1294723A1 (en) | 2000-05-24 | 2003-03-26 | MERCK SHARP & DOHME LTD. | 3-phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors |
US6596731B2 (en) * | 2001-03-27 | 2003-07-22 | Hoffmann-La Roche Inc. | Substituted imidazo[1,2-A] pyridine derivatives |
FR2825705B1 (fr) | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
BRPI0412636A (pt) * | 2003-07-30 | 2006-09-26 | S A L V A T Lab Sa | imidazopirimidinas substituìdas para a prevenção e tratamento de cáncer |
JP2007508241A (ja) | 2003-07-31 | 2007-04-05 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | Pde10a阻害剤を用いる糖尿病および関連障害の処置方法 |
WO2007034282A2 (en) * | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists |
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EP1964841A1 (en) * | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]azine and their use as pharmaceuticals |
DE102007048716A1 (de) * | 2007-10-11 | 2009-04-23 | Merck Patent Gmbh | Imidazo[1,2-a]pyrimidinderivate |
FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物 |
-
2011
- 2011-03-17 US US13/049,941 patent/US8410117B2/en not_active Expired - Fee Related
- 2011-03-22 TW TW100109761A patent/TWI478924B/zh active
- 2011-03-23 UA UAA201211970A patent/UA108640C2/uk unknown
- 2011-03-23 MX MX2012010880A patent/MX2012010880A/es active IP Right Grant
- 2011-03-23 MA MA35218A patent/MA34069B1/fr unknown
- 2011-03-23 RU RU2012143794/04A patent/RU2562066C2/ru not_active IP Right Cessation
- 2011-03-23 WO PCT/EP2011/054385 patent/WO2011117264A1/en active Application Filing
- 2011-03-23 CN CN201180013745.6A patent/CN102791714B/zh not_active Expired - Fee Related
- 2011-03-23 NZ NZ600927A patent/NZ600927A/xx not_active IP Right Cessation
- 2011-03-23 SG SG2012064044A patent/SG183824A1/en unknown
- 2011-03-23 KR KR1020127027825A patent/KR20130073876A/ko not_active Ceased
- 2011-03-23 ES ES11711068.4T patent/ES2478448T3/es active Active
- 2011-03-23 PH PH1/2012/501772A patent/PH12012501772A1/en unknown
- 2011-03-23 CA CA2786213A patent/CA2786213A1/en not_active Abandoned
- 2011-03-23 AR ARP110100945A patent/AR080785A1/es unknown
- 2011-03-23 BR BR112012024199A patent/BR112012024199A2/pt active Search and Examination
- 2011-03-23 JP JP2013501753A patent/JP5764196B2/ja not_active Expired - Fee Related
- 2011-03-23 PE PE2012001636A patent/PE20130382A1/es not_active Application Discontinuation
- 2011-03-23 EP EP11711068.4A patent/EP2552918B1/en not_active Not-in-force
- 2011-03-23 AU AU2011231668A patent/AU2011231668A1/en not_active Abandoned
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2012
- 2012-07-12 IL IL220932A patent/IL220932A0/en unknown
- 2012-08-20 ZA ZA2012/06257A patent/ZA201206257B/en unknown
- 2012-08-24 CR CR20120443A patent/CR20120443A/es unknown
- 2012-09-10 CL CL2012002497A patent/CL2012002497A1/es unknown
- 2012-09-24 EC ECSP12012174 patent/ECSP12012174A/es unknown
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2013
- 2013-01-15 HK HK13100592.7A patent/HK1173440A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CR20120443A (es) | 2012-10-11 |
ZA201206257B (en) | 2013-05-29 |
SG183824A1 (en) | 2012-10-30 |
UA108640C2 (uk) | 2015-05-25 |
TWI478924B (zh) | 2015-04-01 |
RU2562066C2 (ru) | 2015-09-10 |
KR20130073876A (ko) | 2013-07-03 |
EP2552918A1 (en) | 2013-02-06 |
IL220932A0 (en) | 2012-09-24 |
AR080785A1 (es) | 2012-05-09 |
CN102791714B (zh) | 2015-03-25 |
CL2012002497A1 (es) | 2013-03-22 |
TW201136937A (en) | 2011-11-01 |
ECSP12012174A (es) | 2012-10-30 |
US8410117B2 (en) | 2013-04-02 |
EP2552918B1 (en) | 2014-06-11 |
JP5764196B2 (ja) | 2015-08-12 |
HK1173440A1 (en) | 2013-05-16 |
US20110237564A1 (en) | 2011-09-29 |
PH12012501772A1 (en) | 2017-07-26 |
NZ600927A (en) | 2013-08-30 |
CA2786213A1 (en) | 2011-09-29 |
CN102791714A (zh) | 2012-11-21 |
AU2011231668A1 (en) | 2012-07-19 |
ES2478448T3 (es) | 2014-07-22 |
RU2012143794A (ru) | 2014-05-10 |
MX2012010880A (es) | 2012-10-15 |
WO2011117264A1 (en) | 2011-09-29 |
BR112012024199A2 (pt) | 2016-07-05 |
MA34069B1 (fr) | 2013-03-05 |
JP2013523673A (ja) | 2013-06-17 |
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