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PE20130376A1 - [1,8]naftiridinas sustituidas por 2,4-diarilo como inhibidores de quinasas para uso contra el cancer - Google Patents

[1,8]naftiridinas sustituidas por 2,4-diarilo como inhibidores de quinasas para uso contra el cancer

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Publication number
PE20130376A1
PE20130376A1 PE2012002514A PE2012002514A PE20130376A1 PE 20130376 A1 PE20130376 A1 PE 20130376A1 PE 2012002514 A PE2012002514 A PE 2012002514A PE 2012002514 A PE2012002514 A PE 2012002514A PE 20130376 A1 PE20130376 A1 PE 20130376A1
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PE
Peru
Prior art keywords
naphthyridine
diaryll
naphthyridines
substituted
fluoro
Prior art date
Application number
PE2012002514A
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English (en)
Inventor
Dieter Dorsch
Alfred Jonczyk
Guenter Hoelzemann
Christiane Amendt
Frank Zenke
Original Assignee
Merck Patent Gmbh
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44487155&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20130376(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PE20130376A1 publication Critical patent/PE20130376A1/es

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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE [1,8]NAFTIRIDINA DE FORMULA (I) DONDE W1, W2, W3, W4 Y W5 SON CADA UNO N O CR3, EN DONDE R3 ES H, OY, NYY, ENTRE OTROS; Y ES H O A, DONDE A ES ALQUILO(C1-C10) O CICLOALQUILO(C3-C8); Z ES C=C, C=N, O, S, CH, ENTRE OTROS; R1 ES ARILO(C5-C10) O HETEROARILO; R2 ES H, NO2, CN, CHO, ENTRE OTROS; R5 ES H, A, OY, NYY O HETEROCICLO; p Y q SON CADA UNO DE 0 A 3. SON COMPUESTOS PREFERIDOS: 2-(5-CLORO-2-FLUORO-FENIL)-4-(1H-PIRROLO[2,3-c]PIRIDIN-3-IL)-[1,8]NAFTIRIDINA; 2-(5-CLORO-2-FLUORO-FENIL)-4-ISOQUINOLIN-5-IL-[1,8]NAFTIRIDINA; 2-(2-FLUORO-5-TRIFLUOROMETIL-FENIL)-4-(1H-PIRROLO[2,3-c]PIRIDIN-3-IL)-[1,8]NAFTIRIDINA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE PROTEINAS CONSUMIDORAS DE ATP TAL COMO TAK1, PDK1, MINK1, HER4, ENTRE OTROS, SIENDO UTILES EN EL TRATAMIENTO DE CANCER, SARCOMA, GLIOMA
PE2012002514A 2010-06-28 2011-05-31 [1,8]naftiridinas sustituidas por 2,4-diarilo como inhibidores de quinasas para uso contra el cancer PE20130376A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10006683 2010-06-28

Publications (1)

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PE20130376A1 true PE20130376A1 (es) 2013-03-30

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ID=44487155

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PE2012002514A PE20130376A1 (es) 2010-06-28 2011-05-31 [1,8]naftiridinas sustituidas por 2,4-diarilo como inhibidores de quinasas para uso contra el cancer

Country Status (21)

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US (1) US8791113B2 (es)
EP (1) EP2585461B1 (es)
JP (1) JP5826261B2 (es)
KR (1) KR20130038336A (es)
CN (1) CN102958930B (es)
AR (1) AR081994A1 (es)
AU (1) AU2011273931B2 (es)
BR (1) BR112012033241A2 (es)
CA (1) CA2803665C (es)
CL (1) CL2012003680A1 (es)
CO (1) CO6612243A2 (es)
EA (1) EA201300052A1 (es)
EC (1) ECSP13012408A (es)
ES (1) ES2792799T3 (es)
IL (1) IL223496A (es)
MX (1) MX2012014549A (es)
NZ (1) NZ603456A (es)
PE (1) PE20130376A1 (es)
PH (1) PH12012502391A1 (es)
SG (1) SG186855A1 (es)
WO (1) WO2012000595A1 (es)

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