PE20120007A1 - Sintesis de estirilpiridinas radiomarcadas con 18f a partir de precursores de tosilato y composiciones farmaceuticas estables de estas - Google Patents
Sintesis de estirilpiridinas radiomarcadas con 18f a partir de precursores de tosilato y composiciones farmaceuticas estables de estasInfo
- Publication number
- PE20120007A1 PE20120007A1 PE2011001294A PE2011001294A PE20120007A1 PE 20120007 A1 PE20120007 A1 PE 20120007A1 PE 2011001294 A PE2011001294 A PE 2011001294A PE 2011001294 A PE2011001294 A PE 2011001294A PE 20120007 A1 PE20120007 A1 PE 20120007A1
- Authority
- PE
- Peru
- Prior art keywords
- radiomaged
- tomography
- styrilpyridines
- synthesis
- oligal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Abstract
SE REFIERE A UNA COMPOSICION RADIOFARMACEUTICA QUE COMPRENDE: A) UNA CANTIDAD EFECTIVA DE UN COMPUESTO RADIOMARCADO CON 18F TAL COMO UN DERIVADO DE ESTIRILPIRIDINA O DIHIDROTETRABENAZINA QUE ES ((E)-4-(2-(6-(2-(2-(2-[18F] FLUOROETOXI)ETOXI)ETOXI)PIRIDINA-3-IL)VINIL)-N-METILBENCENAMINA) Y (2R,3R,11bR)-9-(3-[18F]FLUOROPROPOXI)-3-ISOPROPIL-10-METOXI-11b-METIL-2,3,4,6,7,11b-HEXAHIDRO-1H-PIRIDO[2,1-a]ISOQUINOLIN-2-OL; B) DE 1% A 15% (v/v) DE ALCOHOL ETILICO EN LA COMPOSICION TOTAL; C) DE 0.1% A 1% (p/v) DE ACIDO ASCORBICO O UNA SAL DEL MISMO EN LA COMPOSICION TOTAL. DICHA COMPOSICION RADIOFARMACEUTICA TIENE UN PH ENTRE 4,5 A 8,0 SIENDO UTIL PARA OBTENER IMAGENES POR TOMOGRAFIA POR EMISION DE POSITRONES (PET) DE ENFERMEDADES NEURODEGENERATIVAS DEL CEREBRO, EN DONDE LA DIANA PATOLOGICA COMPRENDE CONCENTRACIONES ANORMALES DE PROTEINA, PEPTIDO U OLIGONUCLEOTIDO TAL COMO B-AMILOIDE, a-SINUCLEINA, TRANSPORTADOR VESICULAR DE MONOAMINAS 2
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14188508P | 2008-12-31 | 2008-12-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20120007A1 true PE20120007A1 (es) | 2012-01-16 |
Family
ID=42310197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011001294A PE20120007A1 (es) | 2008-12-31 | 2009-12-29 | Sintesis de estirilpiridinas radiomarcadas con 18f a partir de precursores de tosilato y composiciones farmaceuticas estables de estas |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US20100172836A1 (es) |
| EP (1) | EP2381967B1 (es) |
| JP (1) | JP5717650B2 (es) |
| KR (1) | KR20110119670A (es) |
| CN (1) | CN102271716B (es) |
| AU (1) | AU2009335049B2 (es) |
| BR (1) | BRPI0923890A2 (es) |
| CA (1) | CA2748705C (es) |
| CO (1) | CO6341578A2 (es) |
| CR (1) | CR20110410A (es) |
| CY (1) | CY1118658T1 (es) |
| DK (1) | DK2381967T3 (es) |
| DO (1) | DOP2011000210A (es) |
| EA (1) | EA023014B1 (es) |
| EC (1) | ECSP11011242A (es) |
| ES (1) | ES2620402T3 (es) |
| HK (1) | HK1162951A1 (es) |
| HN (1) | HN2011001810A (es) |
| HR (1) | HRP20170453T1 (es) |
| HU (1) | HUE033649T2 (es) |
| IL (1) | IL213674A (es) |
| LT (1) | LT2381967T (es) |
| MA (1) | MA33004B1 (es) |
| MX (1) | MX2011007063A (es) |
| MY (1) | MY162312A (es) |
| NZ (1) | NZ593848A (es) |
| PE (1) | PE20120007A1 (es) |
| PL (1) | PL2381967T3 (es) |
| PT (1) | PT2381967T (es) |
| RS (1) | RS55674B1 (es) |
| SG (1) | SG172439A1 (es) |
| SI (1) | SI2381967T1 (es) |
| TN (1) | TN2011000318A1 (es) |
| UA (1) | UA105914C2 (es) |
| WO (1) | WO2010078370A1 (es) |
| ZA (1) | ZA201104824B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010039815A1 (en) * | 2008-09-30 | 2010-04-08 | Case Western Reserve University | Molecular probes for imaging of myelin |
| TWI504414B (zh) * | 2010-06-04 | 2015-10-21 | Bayer Schering Pharma Ag | 生產Ｆ－１８標記之Ａβ配位體之方法 |
| CN103269724B (zh) | 2010-06-04 | 2017-06-23 | 皮拉马影像股份公司 | 生产F‑18标记的β‑淀粉样蛋白配体的方法 |
| EP2575898B8 (en) * | 2010-06-04 | 2021-04-21 | Life Molecular Imaging SA | Method for production of f-18 labeled amyloid beta ligand |
| CN106729771A (zh) | 2011-04-21 | 2017-05-31 | 加利福尼亚大学董事会 | 官能化磁性纳米颗粒及在淀粉样沉积物和神经原纤维缠结成像中用途 |
| CN105833303A (zh) * | 2011-06-21 | 2016-08-10 | 皮拉莫尔影像股份公司 | 适用于pet成像的氟化茋的制剂 |
| AU2012324940A1 (en) | 2011-10-19 | 2014-04-17 | Piramal Imaging Sa | Improved method for production of F-18 labeled Abeta ligands |
| CN102432529B (zh) * | 2011-11-14 | 2014-03-26 | 江苏省原子医学研究所 | 一种苯乙烯基吡啶二硫二氮衍生物的制备方法 |
| CN104136420A (zh) * | 2011-12-15 | 2014-11-05 | 通用电气健康护理有限公司 | 作为tau病理学的成像探针的杂环化合物 |
| CN102526765B (zh) * | 2011-12-31 | 2014-07-30 | 郑州泰基鸿诺药物科技有限公司 | 一种Aβ斑块显像剂及其制备方法 |
| CN103965105A (zh) * | 2013-01-29 | 2014-08-06 | 中山大学 | 苯乙烯基喹啉衍生物及其在治疗阿尔茨海默病症中的应用 |
| CN103645254B (zh) * | 2013-11-28 | 2015-01-07 | 江苏省原子医学研究所 | 一种Aβ斑块显像剂前体AV45的含量分析方法 |
| WO2017014599A1 (ko) * | 2015-07-22 | 2017-01-26 | 주식회사 씨코헬스케어 | [18f]플루오로-도파의 방사화학적 순도를 안정화시키는 조성물 및 이의 제조방법 |
| CA3003884C (en) * | 2015-11-13 | 2020-04-21 | Eli Lilly And Company | Azetidine derivatives for tau imaging |
| WO2017156303A1 (en) * | 2016-03-09 | 2017-09-14 | Case Western Reserve University | Radioligands for myelin |
| CN107198780A (zh) * | 2016-03-18 | 2017-09-26 | 南京江原安迪科正电子研究发展有限公司 | 放射性药物组合物及其制备方法、应用 |
| CN106018575B (zh) * | 2016-05-05 | 2018-10-19 | 江苏省原子医学研究所 | 一种PET显像剂前体TsOP-(+)-DTBZ及其光学异构体的分离测定方法 |
| US10695450B2 (en) * | 2016-07-26 | 2020-06-30 | Laboratoires Cyclopharma | Synthesis of a radioactive agent composition |
| WO2018089491A1 (en) * | 2016-11-08 | 2018-05-17 | The Regents Of The University Of California | Methods for multi-dose synthesis of [f-18]fddnp for clinical settings |
| TW201906818A (zh) * | 2017-05-31 | 2019-02-16 | 美商５１１製藥公司 | 新穎氘取代之正子發射斷層掃描（ｐｅｔ）顯影劑及其藥理應用 |
| EA202091766A1 (ru) * | 2018-01-24 | 2021-02-18 | Ац Иммуне Са | Композиции для диагностики для пэт-визуализации, способ получения композиции для диагностики и ее применение в диагностике |
| CN111499570B (zh) * | 2019-01-31 | 2023-05-16 | 中国医学科学院放射医学研究所 | 一种av-45中间体的合成方法 |
| CN111499544B (zh) * | 2019-01-31 | 2022-12-02 | 中国医学科学院放射医学研究所 | 一种一锅法制备N-Boc-N-甲基-4-氨基苯乙烯的合成方法 |
| US20220175973A1 (en) * | 2019-03-29 | 2022-06-09 | National Institutes for Quantum Science and Technology | Method for producing radiopharmaceutical and radiopharmaceutical |
| CN115403434A (zh) * | 2021-05-26 | 2022-11-29 | 汉中汉核医疗科技有限公司 | 一种放射性药物的合成方法 |
| CN115400232A (zh) * | 2021-05-26 | 2022-11-29 | 汉中汉核医疗科技有限公司 | 一种放射性药物合成方法 |
| CN113582885B (zh) * | 2021-08-30 | 2023-04-21 | 南京克米斯璀新能源科技有限公司 | 一种烷基磺酸钠的生产方法 |
| CN114805190A (zh) * | 2022-06-08 | 2022-07-29 | 吉林大学第一医院 | 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法 |
| WO2024107620A1 (en) * | 2022-11-14 | 2024-05-23 | Eli Lilly And Company | Polymorphic forms of florbetapir precursor av-105 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007525211A (ja) * | 2004-01-19 | 2007-09-06 | テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド | パーキンソン病の診断検査 |
| CA2591534C (en) * | 2004-12-17 | 2013-08-06 | The Trustees Of The University Of Pennsylvania | Stilbene derivatives and their use for binding and imaging amyloid plaques |
| JP5290954B2 (ja) * | 2006-03-30 | 2013-09-18 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | スチリルピリジン誘導体及びアミロイド斑を結合させ画像化するためのその使用 |
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2009
- 2009-12-29 ES ES09837135.4T patent/ES2620402T3/es active Active
- 2009-12-29 SG SG2011048055A patent/SG172439A1/en unknown
- 2009-12-29 PT PT98371354T patent/PT2381967T/pt unknown
- 2009-12-29 DK DK09837135.4T patent/DK2381967T3/en active
- 2009-12-29 EA EA201170911A patent/EA023014B1/ru not_active IP Right Cessation
- 2009-12-29 UA UAA201109307A patent/UA105914C2/uk unknown
- 2009-12-29 CA CA2748705A patent/CA2748705C/en active Active
- 2009-12-29 CN CN200980153414.5A patent/CN102271716B/zh active Active
- 2009-12-29 LT LTEP09837135.4T patent/LT2381967T/lt unknown
- 2009-12-29 EP EP09837135.4A patent/EP2381967B1/en active Active
- 2009-12-29 MA MA34065A patent/MA33004B1/fr unknown
- 2009-12-29 AU AU2009335049A patent/AU2009335049B2/en active Active
- 2009-12-29 BR BRPI0923890-5A patent/BRPI0923890A2/pt active Search and Examination
- 2009-12-29 NZ NZ593848A patent/NZ593848A/xx unknown
- 2009-12-29 JP JP2011543721A patent/JP5717650B2/ja active Active
- 2009-12-29 SI SI200931600A patent/SI2381967T1/sl unknown
- 2009-12-29 MY MYPI2011003056A patent/MY162312A/en unknown
- 2009-12-29 HU HUE09837135A patent/HUE033649T2/en unknown
- 2009-12-29 KR KR1020117017636A patent/KR20110119670A/ko not_active Ceased
- 2009-12-29 RS RS20170117A patent/RS55674B1/sr unknown
- 2009-12-29 MX MX2011007063A patent/MX2011007063A/es active IP Right Grant
- 2009-12-29 PE PE2011001294A patent/PE20120007A1/es not_active Application Discontinuation
- 2009-12-29 PL PL09837135T patent/PL2381967T3/pl unknown
- 2009-12-29 US US12/648,869 patent/US20100172836A1/en not_active Abandoned
- 2009-12-29 WO PCT/US2009/069741 patent/WO2010078370A1/en active Application Filing
-
2011
- 2011-06-20 IL IL213674A patent/IL213674A/en active IP Right Grant
- 2011-06-24 TN TN2011000318A patent/TN2011000318A1/fr unknown
- 2011-06-29 ZA ZA2011/04824A patent/ZA201104824B/en unknown
- 2011-06-29 DO DO2011000210A patent/DOP2011000210A/es unknown
- 2011-06-29 HN HN2011001810A patent/HN2011001810A/es unknown
- 2011-07-11 CO CO11086470A patent/CO6341578A2/es active IP Right Grant
- 2011-07-29 CR CR20110410A patent/CR20110410A/es unknown
- 2011-07-29 EC EC2011011242A patent/ECSP11011242A/es unknown
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2012
- 2012-04-12 HK HK12103613.7A patent/HK1162951A1/xx not_active IP Right Cessation
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2017
- 2017-02-24 CY CY20171100253T patent/CY1118658T1/el unknown
- 2017-03-20 HR HRP20170453TT patent/HRP20170453T1/hr unknown
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