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PE20091101A1 - AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO - Google Patents

AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO

Info

Publication number
PE20091101A1
PE20091101A1 PE2008002071A PE2008002071A PE20091101A1 PE 20091101 A1 PE20091101 A1 PE 20091101A1 PE 2008002071 A PE2008002071 A PE 2008002071A PE 2008002071 A PE2008002071 A PE 2008002071A PE 20091101 A1 PE20091101 A1 PE 20091101A1
Authority
PE
Peru
Prior art keywords
substituted
tetracine
imidazo
dihydro
oxo
Prior art date
Application number
PE2008002071A
Other languages
English (en)
Inventor
Malcolm Francis
David Cousin
Sharon Jennings
Andrew James Mccarroll
John Gareth Williams
Marc Geoffrery Hummerson
Jihong Zhang
Original Assignee
Pharminox Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharminox Ltd filed Critical Pharminox Ltd
Publication of PE20091101A1 publication Critical patent/PE20091101A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/10Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 3-TEMOZOLOMIDE AMIDA DE ACIDO 3-SUSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d][1,2,3,5]TETRACINA-8-CARBOXILICO DE FORMULA , DONDE Q ES INDEPENDIENTEMENTE (*); Ar1 ES FENILO O HETEROARILO C5-C6 SUSTITUIDO O NO; J1 ES ALQUILENO C1-C4. SON COMPUESTOS PREFERIDOS: 3-CICLOHEXILMETILO-8-CARBAMOILIMIDAZOTETRACINA-4-ONA, 3-ISOPROPILO-8-CARBAILIMIDAZOTETRACINA-4-ONA, 3-CICLOPENTILO-8-CARBAMOILIMIDAZOTETRACINA-4-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A UN METODO DE PREPRACION PARA UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO INHIBE LA PROLIFERACION CELULAR, SIENDO UTIL EN EL TRATAMIENTO DEL CANCER
PE2008002071A 2007-12-18 2008-12-12 AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO PE20091101A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1452007P 2007-12-18 2007-12-18

Publications (1)

Publication Number Publication Date
PE20091101A1 true PE20091101A1 (es) 2009-07-26

Family

ID=40427129

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008002071A PE20091101A1 (es) 2007-12-18 2008-12-12 AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO

Country Status (12)

Country Link
US (2) US8450479B2 (es)
EP (2) EP2698370A3 (es)
JP (1) JP2011506588A (es)
CN (1) CN101945874A (es)
AR (1) AR071548A1 (es)
AU (1) AU2008337261A1 (es)
CA (1) CA2709749A1 (es)
IL (1) IL206453A0 (es)
PE (1) PE20091101A1 (es)
TW (1) TW200934782A (es)
WO (1) WO2009077741A2 (es)
ZA (1) ZA201004554B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
CA2763766A1 (en) 2009-06-23 2010-12-29 Pharminox Limited 3-substituted-8-substituted-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-one compounds and their use
EP2542553A1 (en) 2010-03-01 2013-01-09 Pharminox Ltd Methods and intermediates for the synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines
WO2012085501A1 (en) 2010-12-20 2012-06-28 Pharminox Limited 8 - sulfo - imidazotetrazin- 4 - one compounds and their use as anticancer drug
RU2545458C2 (ru) * 2013-08-01 2015-03-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" ПРОТИВОТУБЕРКУЛЕЗНОЕ ЛЕКАРСТВЕННОЕ СРЕДСТВО: КОМПОЗИЦИЯ ИМИДАЗО[1,2-b]ТЕТРАЗИНА С ПИРАЗИНАМИДОМ
CN108276415B (zh) * 2018-02-08 2019-07-05 台州职业技术学院 一种烷氧化三唑并四嗪类化合物及其制备方法和应用
WO2020033880A1 (en) * 2018-08-09 2020-02-13 The Board Of Trustees Of The University Of Illinois Imidazotetrazine compounds
US12263171B2 (en) 2018-11-30 2025-04-01 Merck Sharp & Dohme Llc 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use
JOP20210117A1 (ar) 2018-11-30 2023-01-30 Merck Sharp & Dohme مشتقات أمينو ترايازولو كوينازولين بها استبدال في الموضع-9 كمضادات مستقبل أدينوزين، تركيبات صيدلانية واستخدامها
GB201907813D0 (en) 2019-05-31 2019-07-17 Univ Nottingham Therapeutic compounds
KR102571751B1 (ko) 2020-03-24 2023-08-25 삼성에스디아이 주식회사 리튬 이차 전지의 전해질용 첨가제, 리튬 이차 전지용 전해질 및 이를 포함하는 리튬 이차 전지
WO2022266468A1 (en) * 2021-06-18 2022-12-22 Yale University Anti-cancer compounds and methods of use
WO2023049806A1 (en) * 2021-09-23 2023-03-30 Yale University Compounds and methods for treating cancers that are mgmt deficient regardless of mmr status
US20250129083A1 (en) * 2022-02-01 2025-04-24 The Board Of Trustees Of The University Of Illinois Imidazotetrazine compounds and treatment of tmz-resistant cancers
US20250066371A1 (en) * 2023-08-04 2025-02-27 Modifi Biosciences, Inc. Fluoroalkoxyalkylene-dihydroimidazo[5,1-d]tetrazinone compounds and related compounds and their use in treating medical conditions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA07174A (fr) * 1981-08-24 1984-04-30 May & Baker Ltd Nouvelles imidazotétrazionones, leur préparation et les médicaments qui les contiennent.
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
GB2125402B (en) 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
US4504475A (en) 1983-05-24 1985-03-12 Warner Lambert Company 3-(Haloethyl)-4-oxopyrazolo[5,1-D]-1,2,3,5-tetrazine-8-carboxamide compounds
GB9504361D0 (en) 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
CA2434308C (en) 2001-01-18 2010-09-21 Schering Corporation Synthesis of temozolomide and analogs
CN1742723A (zh) 2004-09-02 2006-03-08 天津倍方科技发展有限公司 含有替莫唑胺-8-羧酸酯的药物组合物以及该类化合物用于制备抗肿瘤药物的用途
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
GB0807103D0 (en) 2008-04-18 2008-05-21 Univ Bradford The Compounds
CA2763766A1 (en) 2009-06-23 2010-12-29 Pharminox Limited 3-substituted-8-substituted-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-one compounds and their use

Also Published As

Publication number Publication date
EP2698370A3 (en) 2014-07-16
ZA201004554B (en) 2011-09-28
US8450479B2 (en) 2013-05-28
CA2709749A1 (en) 2009-06-25
TW200934782A (en) 2009-08-16
WO2009077741A3 (en) 2009-12-03
AR071548A1 (es) 2010-06-30
IL206453A0 (en) 2010-12-30
AU2008337261A1 (en) 2009-06-25
US20100286088A1 (en) 2010-11-11
WO2009077741A2 (en) 2009-06-25
US20130338104A1 (en) 2013-12-19
EP2698370A2 (en) 2014-02-19
JP2011506588A (ja) 2011-03-03
CN101945874A (zh) 2011-01-12
EP2229393A2 (en) 2010-09-22

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