PE20090362A1 - Derivados de piperidina/piperazina como moduladores de dgat - Google Patents
Derivados de piperidina/piperazina como moduladores de dgatInfo
- Publication number
- PE20090362A1 PE20090362A1 PE2008000972A PE2008000972A PE20090362A1 PE 20090362 A1 PE20090362 A1 PE 20090362A1 PE 2008000972 A PE2008000972 A PE 2008000972A PE 2008000972 A PE2008000972 A PE 2008000972A PE 20090362 A1 PE20090362 A1 PE 20090362A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- dgat
- piperidine
- nrx
- modulators
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 2
- 102100036869 Diacylglycerol O-acyltransferase 1 Human genes 0.000 title 1
- 108050004099 Diacylglycerol O-acyltransferase 1 Proteins 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
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- C07D295/26—Sulfur atoms
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- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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Abstract
REFERIDA A UN DERIVADO DE PIPERIDINA O PIPERAZINA DE FORMULA (I), DONDE A ES CH O N; LA LINEA PUNTEADA REPRESENTA UN ENLACE; X ES C(=O), O-C(=O), C(=O)-C(=O), ENTRE OTROS; Y ES NRx-C(=O)-Z2, NRx-C(=O)-Z2-O, NRx-C(=O)-Z2-O-C(=O), ENTRE OTROS; Z2 ES ALCANDIILO C1-C6, ALQUENDIILO C2-C6, ALQUINDIILO C2-C6, ENTRE OTROS; Rx ES H O LAQUILO C1-C4; R1 ES ALQUILO C1-C12, ALQUILOXI C1-C4, ALQUENILO C2-C6, ENTRE OTROS; R2 ES H, ALQUILO C1-C12, ALQUENILO C2-C6. SON COMPUESTOS PREFERIDOS: (a), (b), ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS INHIBEN LA ENZIMA DIACILGLICEROL ACILTRANSFERASA (DGAT) Y SON UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE PARKINSON, DE ALZHEIMER, APOPLEJIA, ENTRE OTROS
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EP07109868 | 2007-06-08 | ||
EP07115805 | 2007-09-06 |
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PE20090362A1 true PE20090362A1 (es) | 2009-04-04 |
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US (1) | US8981094B2 (es) |
EP (1) | EP2152270B1 (es) |
JP (1) | JP5385263B2 (es) |
CN (1) | CN101678019B (es) |
AR (1) | AR066911A1 (es) |
AU (1) | AU2008258487B2 (es) |
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RU (1) | RU2470017C2 (es) |
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- 2008-06-06 PA PA20088783601A patent/PA8783601A1/es unknown
- 2008-06-06 WO PCT/EP2008/057060 patent/WO2008148868A1/en active Application Filing
- 2008-06-06 EP EP08760634.9A patent/EP2152270B1/en active Active
- 2008-06-06 TW TW097121019A patent/TWI426070B/zh not_active IP Right Cessation
- 2008-06-06 US US12/663,013 patent/US8981094B2/en active Active
- 2008-06-06 BR BRPI0813331-0A2A patent/BRPI0813331A2/pt not_active Application Discontinuation
- 2008-06-06 CL CL2008001671A patent/CL2008001671A1/es unknown
- 2008-06-06 RU RU2009148320/04A patent/RU2470017C2/ru active
- 2008-06-06 ES ES08760634.9T patent/ES2536406T3/es active Active
Also Published As
Publication number | Publication date |
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CN101678019A (zh) | 2010-03-24 |
PA8783601A1 (es) | 2009-01-23 |
CA2687754A1 (en) | 2008-12-11 |
US20100190789A1 (en) | 2010-07-29 |
JP2010529089A (ja) | 2010-08-26 |
CN101678019B (zh) | 2016-03-30 |
EP2152270A1 (en) | 2010-02-17 |
JP5385263B2 (ja) | 2014-01-08 |
BRPI0813331A2 (pt) | 2014-12-23 |
TWI426070B (zh) | 2014-02-11 |
RU2009148320A (ru) | 2011-07-20 |
TW200911771A (en) | 2009-03-16 |
ES2536406T3 (es) | 2015-05-25 |
MX2009013335A (es) | 2010-01-20 |
AU2008258487A1 (en) | 2008-12-11 |
WO2008148868A8 (en) | 2009-03-05 |
AU2008258487B2 (en) | 2012-11-15 |
US8981094B2 (en) | 2015-03-17 |
CA2687754C (en) | 2015-12-08 |
CL2008001671A1 (es) | 2009-07-17 |
RU2470017C2 (ru) | 2012-12-20 |
AR066911A1 (es) | 2009-09-23 |
EP2152270B1 (en) | 2015-03-04 |
WO2008148868A1 (en) | 2008-12-11 |
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