PE20090318A1 - Macrociclos y sus usos - Google Patents
Macrociclos y sus usosInfo
- Publication number
- PE20090318A1 PE20090318A1 PE2008000935A PE2008000935A PE20090318A1 PE 20090318 A1 PE20090318 A1 PE 20090318A1 PE 2008000935 A PE2008000935 A PE 2008000935A PE 2008000935 A PE2008000935 A PE 2008000935A PE 20090318 A1 PE20090318 A1 PE 20090318A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- compounds
- alcoxyl
- oxo
- alkenyl
- Prior art date
Links
- 150000002678 macrocyclic compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 241000193163 Clostridioides difficile Species 0.000 abstract 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract 1
- 241000193998 Streptococcus pneumoniae Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A COMPUESTOS MACROCICLOS DE FORMULA (I) DONDE q ES DE 0 A 3; E ESTA AUSENTE O ES C(O), C(O)O, ENTRE OTROS; R1 ES H, ALQUILO(C1-C8), ALQUENILO(C2-C8), ALCOXILO(C1-C8), ENTRE OTROS; R2, R3 Y R6 SON CADA UNO H, HALOGENO, OH, OXO, ALCOXILO(C1-C8), ENTRE OTROS; R5 ES H, ALQUILO(C1-C8), ENTRE OTROS; R4 ES H, OXO, NH, COOH, CONH2, ENTRE OTROS; R7 ES H, OH, NH2, ALQUILO(C1-C8), ENTRE OTROS; R7a ES OR7b O N(R7b)2, EN DONDE R7b ES H, ALQUILO(C1-C8), ALQUENILO(C2-C8), ALQUINILO(C2-C8), ENTRE OTROS. SON COMPUESTOS PREFERIDOS LOS COMPUESTOS DE FORMULA (i), (ii), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTIBACTERIANOS SIENDO UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS PRODUCIDAS POR STAPHYLOCCOCUS AUREUS, STREPTOCOCCUS NEUMONIAE, MYCOBACTERIUM TUBERCULOSIS, CLOSTRIDIUM DIFFICILE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94177707P | 2007-06-04 | 2007-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090318A1 true PE20090318A1 (es) | 2009-04-17 |
Family
ID=40094226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000935A PE20090318A1 (es) | 2007-06-04 | 2008-06-03 | Macrociclos y sus usos |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US8476224B2 (es) |
| EP (1) | EP2170907A2 (es) |
| JP (1) | JP2010529076A (es) |
| KR (1) | KR101202483B1 (es) |
| CN (1) | CN101772506B (es) |
| AR (1) | AR066865A1 (es) |
| AU (1) | AU2008258639B2 (es) |
| BR (1) | BRPI0812340A2 (es) |
| CA (1) | CA2688621A1 (es) |
| CL (1) | CL2008001613A1 (es) |
| CO (1) | CO6270222A2 (es) |
| CR (1) | CR11158A (es) |
| EA (1) | EA200901613A1 (es) |
| EC (1) | ECSP099836A (es) |
| GT (1) | GT200900310A (es) |
| IL (1) | IL202285A0 (es) |
| MA (1) | MA31562B1 (es) |
| MX (1) | MX2009013214A (es) |
| NZ (1) | NZ581917A (es) |
| PE (1) | PE20090318A1 (es) |
| TN (1) | TN2009000495A1 (es) |
| TW (1) | TW200902540A (es) |
| WO (1) | WO2008148754A2 (es) |
| ZA (1) | ZA200908262B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA020205B1 (ru) | 2007-12-12 | 2014-09-30 | Новартис Аг | Аминотиазолы, фармацевтические композиции на их основе и способы лечения бактериальной инфекции |
| WO2018073269A1 (en) * | 2016-10-21 | 2018-04-26 | Xellia Pharmaceuticals Aps | Liquid formulations of daptomycin |
| CN109485617B (zh) * | 2018-12-11 | 2023-01-31 | 贵州永诺菲特生物制药有限公司 | 一种n-甲基-2-异丙基-4-噻唑甲胺的制备方法 |
| WO2024044751A2 (en) * | 2022-08-26 | 2024-02-29 | Wake Forest University Health Sciences | Peroxiredoxin 3 inhibitors and methods of use for treating cancer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE121459T1 (de) * | 1990-03-08 | 1995-05-15 | Lepetit Spa | Antibiotika ge 2270 faktoren b1, b2, c1, d1, d2, e und t. |
| DE9004073U1 (de) | 1990-04-07 | 1990-06-13 | Auto-Kabel Hausen GmbH & Co. Betriebs-KG, 79688 Hausen | Anschlußklemme für Akkumulator o.dgl. |
| IL100572A (en) | 1991-01-03 | 1997-01-10 | Lepetit Spa | Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them |
| ES2113391T3 (es) | 1991-08-30 | 1998-05-01 | Biosearch Italia Spa | Factor c2a de antibiotico ge 2270. |
| WO1997030078A1 (en) | 1996-02-14 | 1997-08-21 | Biosearch Italia S.P.A. | DERIVATIVES OF ANTIBIOTIC GE2270 FACTORS C2a, D2 AND E |
| JPH1059997A (ja) * | 1996-08-22 | 1998-03-03 | Microbial Chem Res Found | アミチアマイシンアミド誘導体 |
| PT1553967E (pt) * | 2002-06-17 | 2011-08-01 | Naicons S C A R L | Utilização de um derivado amídico do factor a3 do ge 2270 no tratamento da acne |
| US20050106159A1 (en) * | 2003-08-12 | 2005-05-19 | Thompson Stuart A. | Campylobacter jejuni outer membrane protein immunogenic composition |
| PE20121011A1 (es) | 2006-05-31 | 2012-08-25 | Novartis Ag | AMINOTIAZOLES COMO MODULADORES DEL FACTOR DE ELONGACION EF-Tu |
| BRPI0720542A2 (pt) * | 2006-12-20 | 2014-01-21 | Novartis Ag | Compostos antibacterianos e processos para a sua produção |
-
2008
- 2008-06-03 TW TW097120619A patent/TW200902540A/zh unknown
- 2008-06-03 US US12/132,377 patent/US8476224B2/en not_active Expired - Fee Related
- 2008-06-03 AU AU2008258639A patent/AU2008258639B2/en not_active Ceased
- 2008-06-03 EP EP08760422A patent/EP2170907A2/en not_active Withdrawn
- 2008-06-03 WO PCT/EP2008/056838 patent/WO2008148754A2/en active Application Filing
- 2008-06-03 JP JP2010510764A patent/JP2010529076A/ja active Pending
- 2008-06-03 CA CA002688621A patent/CA2688621A1/en not_active Abandoned
- 2008-06-03 CN CN200880101867.9A patent/CN101772506B/zh not_active Expired - Fee Related
- 2008-06-03 NZ NZ581917A patent/NZ581917A/en unknown
- 2008-06-03 MX MX2009013214A patent/MX2009013214A/es active IP Right Grant
- 2008-06-03 PE PE2008000935A patent/PE20090318A1/es not_active Application Discontinuation
- 2008-06-03 BR BRPI0812340-3A2A patent/BRPI0812340A2/pt not_active IP Right Cessation
- 2008-06-03 KR KR1020097027601A patent/KR101202483B1/ko not_active Expired - Fee Related
- 2008-06-03 EA EA200901613A patent/EA200901613A1/ru unknown
- 2008-06-03 CL CL2008001613A patent/CL2008001613A1/es unknown
- 2008-06-04 AR ARP080102381A patent/AR066865A1/es unknown
-
2009
- 2009-11-23 IL IL202285A patent/IL202285A0/en unknown
- 2009-11-23 ZA ZA200908262A patent/ZA200908262B/xx unknown
- 2009-11-26 TN TNP2009000495A patent/TN2009000495A1/fr unknown
- 2009-12-02 GT GT200900310A patent/GT200900310A/es unknown
- 2009-12-11 CR CR11158A patent/CR11158A/es not_active Application Discontinuation
- 2009-12-30 MA MA32463A patent/MA31562B1/fr unknown
- 2009-12-30 EC EC2009009836A patent/ECSP099836A/es unknown
- 2009-12-30 CO CO09149375A patent/CO6270222A2/es not_active Application Discontinuation
-
2013
- 2013-05-23 US US13/900,866 patent/US8691756B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008258639B2 (en) | 2012-07-05 |
| ECSP099836A (es) | 2010-01-29 |
| US20130252883A1 (en) | 2013-09-26 |
| TW200902540A (en) | 2009-01-16 |
| EP2170907A2 (en) | 2010-04-07 |
| KR101202483B1 (ko) | 2012-11-16 |
| ZA200908262B (en) | 2010-08-25 |
| CL2008001613A1 (es) | 2009-05-15 |
| CN101772506B (zh) | 2014-02-12 |
| MA31562B1 (fr) | 2010-08-02 |
| US8476224B2 (en) | 2013-07-02 |
| MX2009013214A (es) | 2010-01-15 |
| BRPI0812340A2 (pt) | 2015-01-27 |
| US20090186830A1 (en) | 2009-07-23 |
| WO2008148754A2 (en) | 2008-12-11 |
| WO2008148754A3 (en) | 2009-03-05 |
| AU2008258639A1 (en) | 2008-12-11 |
| CN101772506A (zh) | 2010-07-07 |
| EA200901613A1 (ru) | 2010-06-30 |
| CA2688621A1 (en) | 2008-12-11 |
| US8691756B2 (en) | 2014-04-08 |
| TN2009000495A1 (en) | 2011-03-31 |
| IL202285A0 (en) | 2010-06-16 |
| NZ581917A (en) | 2011-04-29 |
| KR20100021496A (ko) | 2010-02-24 |
| CO6270222A2 (es) | 2011-04-20 |
| JP2010529076A (ja) | 2010-08-26 |
| AR066865A1 (es) | 2009-09-16 |
| CR11158A (es) | 2010-01-20 |
| GT200900310A (es) | 2010-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |