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PE20090762A1 - Compuestos organicos - Google Patents

Compuestos organicos

Info

Publication number
PE20090762A1
PE20090762A1 PE2008000936A PE2008000936A PE20090762A1 PE 20090762 A1 PE20090762 A1 PE 20090762A1 PE 2008000936 A PE2008000936 A PE 2008000936A PE 2008000936 A PE2008000936 A PE 2008000936A PE 20090762 A1 PE20090762 A1 PE 20090762A1
Authority
PE
Peru
Prior art keywords
ona
dioxo
hydroxy
compounds
tiazolidin
Prior art date
Application number
PE2008000936A
Other languages
English (en)
Inventor
David Barnes
Gary Mark Coppola
Travis Stams
Sidney Wolf Topiol
James Richard Wareing
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39720401&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090762(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20090762A1 publication Critical patent/PE20090762A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

REFERIDO A LOS COMPUESTOS: 5-(3-HIDROXI-7-METOXI-NAFTALEN-2-IL)-1,1-DIOXO-[1,2,5]-TIAZOLIDIN-3-ONA, 5-(3-HIDROXI-7-PROPOXI-NAFTALENL-2-IL)-1,1-DIOXO-[1,2,5]]-TIAZOLIDIN-3-ONA Y 5-(3-HIDROXI-7-METIL-NAFTALEN-2-IL)-1,1-DIOXO-[1,2,5]-TIAZOLIDIN-3-ONA Y SUS SALES POTASICAS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE LOS COMPRENDE. DICHOS COMPUESTOS SON INHIBIDORES DE LAS FOSFATASAS DE PROTEINA TIROSINA(PTPasas) Y SON UTILES PARA EL TRATAMIENTO DE LAS CONDICIONES MEDIADAS POR LA ACTIVIDAD DE PTPasA TAL COMO RESISTENCIA A LA INSULINA ASOCIADA CON LA OBESIDAD, INTOLERANCIA A LA GLUCOSA, DIABETES MELLITUS, ENTRE OTROS
PE2008000936A 2007-06-04 2008-06-03 Compuestos organicos PE20090762A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94176807P 2007-06-04 2007-06-04

Publications (1)

Publication Number Publication Date
PE20090762A1 true PE20090762A1 (es) 2009-07-09

Family

ID=39720401

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000936A PE20090762A1 (es) 2007-06-04 2008-06-03 Compuestos organicos

Country Status (9)

Country Link
US (1) US20100197744A1 (es)
EP (1) EP2155704A1 (es)
JP (1) JP2010529075A (es)
CN (1) CN101687828A (es)
AR (1) AR066820A1 (es)
CL (1) CL2008001612A1 (es)
PE (1) PE20090762A1 (es)
TW (1) TW200911769A (es)
WO (1) WO2008148744A1 (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006321904A1 (en) * 2005-12-08 2007-06-14 Novartis Ag 1, 1, 3-trioxo-1 , 2 , 5-thiadiazolidines and their use as PTP-ases inhibitors
US8119666B2 (en) * 2005-12-08 2012-02-21 Novartis Ag 1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (PTPase)
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN105287531A (zh) * 2015-11-11 2016-02-03 朱忠良 一种抗糖尿病的口服药物组合物
CN105213387A (zh) * 2015-11-11 2016-01-06 朱忠良 一种抗糖尿病的口服药物组合物
CN105193797A (zh) * 2015-11-11 2015-12-30 朱忠良 一种抗糖尿病的口服药物组合物
CN105193801A (zh) * 2015-11-11 2015-12-30 朱忠良 一种抗糖尿病的口服药物组合物
CN105193821A (zh) * 2015-11-11 2015-12-30 朱忠良 一种抗糖尿病的口服药物组合物
CN105213379A (zh) * 2015-11-11 2016-01-06 朱忠良 一种抗糖尿病的口服药物组合物
CN105193796A (zh) * 2015-11-11 2015-12-30 朱忠良 一种抗糖尿病的口服药物组合物
CN105213380A (zh) * 2015-11-11 2016-01-06 朱忠良 一种抗糖尿病的口服药物组合物
CN105232545A (zh) * 2015-11-11 2016-01-13 朱忠良 一种抗糖尿病的口服药物组合物
CN105213386A (zh) * 2015-11-11 2016-01-06 朱忠良 一种抗糖尿病的口服药物组合物
CN105287535A (zh) * 2015-11-11 2016-02-03 朱忠良 一种抗糖尿病的口服药物组合物
CN105232544A (zh) * 2015-11-11 2016-01-13 朱忠良 一种抗糖尿病的口服药物组合物
CN105232546A (zh) * 2015-11-11 2016-01-13 朱忠良 一种抗糖尿病的口服药物组合物
CN105232547A (zh) * 2015-11-11 2016-01-13 朱忠良 一种抗糖尿病的口服药物组合物
CN105287534A (zh) * 2015-11-11 2016-02-03 朱忠良 一种抗糖尿病的口服药物组合物
CN105476990A (zh) * 2015-11-11 2016-04-13 朱忠良 一种抗糖尿病的口服药物组合物
CN105287533A (zh) * 2015-11-11 2016-02-03 朱忠良 一种抗糖尿病的口服药物组合物
CN105193800A (zh) * 2015-11-11 2015-12-30 朱忠良 一种抗糖尿病的口服药物组合物
CN105213385A (zh) * 2015-11-11 2016-01-06 朱忠良 一种抗糖尿病的口服药物组合物
CN105232552A (zh) * 2015-11-11 2016-01-13 朱忠良 一种抗糖尿病的口服药物组合物
CN105213383A (zh) * 2015-11-11 2016-01-06 朱忠良 一种抗糖尿病的口服药物组合物
CN105412095A (zh) * 2015-11-11 2016-03-23 朱忠良 一种抗糖尿病的口服药物组合物
CN105213384A (zh) * 2015-11-11 2016-01-06 朱忠良 一种抗糖尿病的口服药物组合物
CN105434433A (zh) * 2015-11-11 2016-03-30 朱忠良 一种抗糖尿病的口服药物组合物
CN105232543A (zh) * 2015-11-11 2016-01-13 朱忠良 一种抗糖尿病的口服药物组合物
CN105434434A (zh) * 2015-11-11 2016-03-30 朱忠良 一种抗糖尿病的口服药物组合物
CN105213381A (zh) * 2015-11-11 2016-01-06 朱忠良 一种抗糖尿病的口服药物组合物
CN105250276A (zh) * 2015-11-11 2016-01-20 朱忠良 一种抗糖尿病的口服药物组合物
CN105520943A (zh) * 2015-11-11 2016-04-27 朱忠良 一种抗糖尿病的口服药物组合物
CN105213382A (zh) * 2015-11-11 2016-01-06 朱忠良 一种抗糖尿病的口服药物组合物
CN105287532A (zh) * 2015-11-11 2016-02-03 朱忠良 一种抗糖尿病的口服药物组合物
CN105250277A (zh) * 2015-11-11 2016-01-20 朱忠良 一种抗糖尿病的口服药物组合物
EP3455219A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
EP3454862B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
EP4491236A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
CN113453679A (zh) 2018-12-20 2021-09-28 C4医药公司 靶向蛋白降解
KR20230074822A (ko) * 2019-03-14 2023-05-31 칼리코 라이프 사이언시스 엘엘씨 단백질 티로신 포스파타제 억제제 및 이의 사용 방법

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003082841A1 (en) * 2002-04-03 2003-10-09 Novartis Ag 5-substituted 1,1-dioxo-`1,2,5!thiazolidine-3-one derivatives as ptpase 1b inhibitors
GB0225986D0 (en) * 2002-11-07 2002-12-11 Astrazeneca Ab Chemical compounds
GB0227813D0 (en) * 2002-11-29 2003-01-08 Astrazeneca Ab Chemical compounds
UA94724C2 (en) * 2005-12-08 2011-06-10 Новартис Аг Thiadiazolidinone derivatives as antidiabetic agents

Also Published As

Publication number Publication date
AR066820A1 (es) 2009-09-16
WO2008148744A1 (en) 2008-12-11
US20100197744A1 (en) 2010-08-05
CN101687828A (zh) 2010-03-31
TW200911769A (en) 2009-03-16
EP2155704A1 (en) 2010-02-24
CL2008001612A1 (es) 2009-05-15
JP2010529075A (ja) 2010-08-26

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