+

PE20090718A1 - Derivados de espiroindolinona - Google Patents

Derivados de espiroindolinona

Info

Publication number
PE20090718A1
PE20090718A1 PE2008000875A PE2008000875A PE20090718A1 PE 20090718 A1 PE20090718 A1 PE 20090718A1 PE 2008000875 A PE2008000875 A PE 2008000875A PE 2008000875 A PE2008000875 A PE 2008000875A PE 20090718 A1 PE20090718 A1 PE 20090718A1
Authority
PE
Peru
Prior art keywords
diona
tetrahydrospiro
indol
chlorophenyl
triazine
Prior art date
Application number
PE2008000875A
Other languages
English (en)
Inventor
Jin-Jun Liu
Zhuming Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20090718A1 publication Critical patent/PE20090718A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE X ES H, HALOGENO, CIANO, ENTRE OTROS; R1, R2, R3 Y R4 SON CADA UNO ALQUILO INFERIOR, ALQUENILO INFERIOR, ARILO, ENTRE OTROS; R ES H, ALQUILO INFERIOR SUSTITUIDO O NO. SON COMPUESTOS PREFERIDOS: (6'R,3R,8'S)-6-CLORO-8'-(3-CLOROFENIL)-6'-(5-FLUOR-2-METILFENIL)-2'-METIL-6',7',8',9'-TETRAHIDROESPIRO[3H-INDOL-3,7'-(2H-PIRIDO[2,1-c][1,2,4]TRIAZINA)]-2,3'(1H)-DIONA, (6'R,3R,8'S)-6-CLORO-8'-(3-CLOROFENIL)-2'-(3-DIMETILAMINO-PROPIL)-6'-(1-METILENO-PROPIL)-6', 7',8',9'-TETRAHIDROESPIRO-[3H-INDOL-3,7'-(2H-PIRIDO[2,1-c][1,2,4]TRIAZINA)-2,3'(1H)-DIONA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA FORMULACION PARA UNA SOLA UNIDAD DE DOSIFICACION ORAL. DICHOS COMPUESTOS TIENEN ACTIVIDAD INHIBIDORA DE LA INTERACCION MDM2-p53 Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS DE PROLIFERACION CELULAR COMO EL CANCER
PE2008000875A 2007-05-23 2008-05-21 Derivados de espiroindolinona PE20090718A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93136807P 2007-05-23 2007-05-23

Publications (1)

Publication Number Publication Date
PE20090718A1 true PE20090718A1 (es) 2009-06-20

Family

ID=39645560

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000875A PE20090718A1 (es) 2007-05-23 2008-05-21 Derivados de espiroindolinona

Country Status (16)

Country Link
US (1) US7834179B2 (es)
EP (1) EP2152714B1 (es)
JP (1) JP2010527954A (es)
KR (1) KR20090130319A (es)
CN (1) CN101679448A (es)
AR (1) AR066659A1 (es)
AT (1) ATE549340T1 (es)
AU (1) AU2008253117A1 (es)
BR (1) BRPI0812155A2 (es)
CA (1) CA2687160A1 (es)
ES (1) ES2382139T3 (es)
IL (1) IL202020A0 (es)
MX (1) MX2009012595A (es)
PE (1) PE20090718A1 (es)
TW (1) TW200901994A (es)
WO (1) WO2008141975A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776875B2 (en) * 2007-12-19 2010-08-17 Hoffman-La Roche Inc. Spiroindolinone derivatives
US7723372B2 (en) 2008-03-19 2010-05-25 Hoffman-La Roche Inc. Spiroindolinone derivatives
US8217051B2 (en) * 2009-02-17 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone derivatives
CN104876938A (zh) * 2009-11-12 2015-09-02 密歇根大学董事会 螺-吲哚酮mdm2拮抗剂
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
FR2967072B1 (fr) 2010-11-05 2013-03-29 Univ Dundee Procede pour ameliorer la production de virus et semences vaccinales influenza
JP2014500870A (ja) 2010-11-12 2014-01-16 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン スピロ−オキシインドールｍｄｍ２アンタゴニスト
MX342958B (es) 2011-03-10 2016-10-18 Daiichi Sankyo Co Ltd Derivados de diespiropirrolidina.
EP2707372B1 (en) 2011-05-11 2016-12-21 The Regents Of The University Of Michigan Spiro-oxindole mdm2 antagonists
JP6093770B2 (ja) 2011-09-27 2017-03-08 アムジエン・インコーポレーテツド 癌の治療のためのｍｄｍ２阻害剤としての複素環化合物
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
WO2014089904A1 (en) 2012-12-10 2014-06-19 Abbvie Inc. Triazinone compounds
ES2707305T3 (es) 2012-12-20 2019-04-03 Merck Sharp & Dohme Imidazopiridinas sustituidas como inhibidores de HDM2
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
MX368703B (es) 2013-02-28 2019-10-11 Amgen Inc Un inhibidor de mdm2 derivado de acido benzoico para el tratamiento del cancer.
CA2906538C (en) 2013-03-14 2021-02-02 Ana Gonzalez Buenrostro Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
CN103435621B (zh) * 2013-07-26 2015-11-04 中国林业科学研究院林产化学工业研究所 螺环喹唑啉衍生物及其制备方法
WO2016001376A1 (en) 2014-07-03 2016-01-07 Boehringer Ingelheim International Gmbh New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
JP6564449B2 (ja) 2015-02-20 2019-08-21 第一三共株式会社 がんの併用治療法
CN107530336B (zh) 2015-04-13 2020-09-25 第一三共株式会社 组合使用mdm2抑制剂和btk抑制剂的治疗方法
PL3359542T3 (pl) 2015-10-09 2021-09-20 Boehringer Ingelheim International Gmbh Związki i pochodne spiro[3h-indolo-3,2’-pirolidyno]-2(1h)-onowe jako inhibitory mdm2-p53
JP2019522633A (ja) 2016-05-20 2019-08-15 ジェネンテック， インコーポレイテッド Ｐｒｏｔａｃ抗体コンジュゲート及び使用方法
KR20190068544A (ko) 2016-10-17 2019-06-18 다이이찌 산쿄 가부시키가이샤 Mdm2 저해제와 dna 메틸트랜스페라아제 저해제의 병용 치료법
EP3511334A1 (en) * 2018-01-16 2019-07-17 Adamed sp. z o.o. 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds as therapeutic agents activating tp53
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA014445B1 (ru) * 2005-02-22 2010-12-30 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган Низкомолекулярные ингибиторы mdm2 и их применения
WO2007013691A1 (ja) * 2005-07-29 2007-02-01 Takeda Pharmaceutical Company Limited スピロ環化合物

Also Published As

Publication number Publication date
CA2687160A1 (en) 2008-11-27
US20080293723A1 (en) 2008-11-27
TW200901994A (en) 2009-01-16
BRPI0812155A2 (pt) 2019-09-24
AR066659A1 (es) 2009-09-02
IL202020A0 (en) 2010-06-16
US7834179B2 (en) 2010-11-16
EP2152714A1 (en) 2010-02-17
WO2008141975A1 (en) 2008-11-27
AU2008253117A1 (en) 2008-11-27
KR20090130319A (ko) 2009-12-22
EP2152714B1 (en) 2012-03-14
JP2010527954A (ja) 2010-08-19
MX2009012595A (es) 2009-12-07
ATE549340T1 (de) 2012-03-15
ES2382139T3 (es) 2012-06-05
CN101679448A (zh) 2010-03-24

Similar Documents

Publication Publication Date Title
PE20090718A1 (es) Derivados de espiroindolinona
PE20060531A1 (es) Derivados de piridazin-3-(2h)-ona como inhibidores de la fosfodiesterasa 4
PE20091095A1 (es) Moduladores de gamma secretasa
PE20081346A1 (es) Derivados de espiroindolinona como antagonistas de mdm2
PE20090279A1 (es) Derivados de 3,3-espiroindolinona como agentes antagonistas de mdm2
PE20080695A1 (es) Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
PE20091466A1 (es) Derivados de 4,5-dihidro-oxazol-2-il-amina
TW200720266A (en) Benzodioxane and benzodioxolan derivatives and uses thereof
PE20130012A1 (es) Derivados de pirazol como inhibidores de jak
TW200716595A (en) Chromane and chromene derivatives and uses thereof
TW200719886A (en) Dihydrobenzofuran derivatives and uses thereof
PE20070832A1 (es) Derivados de piridazinona como inhibidores de la tirosina quinasa
EA200400466A1 (ru) Производные пиперазина с антагонистической активностью к рецептору ccr1
PE20071177A1 (es) Derivados de 3,5-piridina como inhibidores de renina
CY1113642T1 (el) Γεφυρωμενες δικυκλικες ετεροαρυλ υποκατεστημενες τριαζολες, χρησιμες ως αναστολεις της axl
ATE384050T1 (de) Benzazepinderivate als histamin-h3-antagonisten
PE20070218A1 (es) COMPUESTOS DE CICLOALQUILO AMINO-HIDANTOINA Y USO DE ESTOS PARA LA MODULACION DE ß-SECRETASA
PE20081845A1 (es) Nuevos derivados de aminopirimidina como inhibidores de plk1
PE20060383A1 (es) Nuevos derivados amino de urea ciclicos como inhibidores de quinasa
BR0315547A (pt) Derivados de quinolina como antagonistas de crth2
EA200800018A1 (ru) Аминопиримидины в качестве модуляторов киназы
MXPA05010621A (es) Pirimidinonas sustituidas.
PE20060691A1 (es) Serinamidas sustituidas por benzoilo
PE20110671A1 (es) Derivados de diazabicicloalcanos como moduladores de la actividad de los receptores nicotinicos de la acetilcolina
ECSP10010429A (es) Derivados bicíclicos heterocíclicos o espirobicíclicos heterocíclicos enlazados, de pirazolo[1,5-a]pirimidinas, procedimientos para su preparación y usos de los mismos

Legal Events

Date Code Title Description
FA Abandonment or withdrawal
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载