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PE20090708A1 - Compuestos y composiciones como moduladores de la actividad gpr119 - Google Patents

Compuestos y composiciones como moduladores de la actividad gpr119

Info

Publication number
PE20090708A1
PE20090708A1 PE2008001646A PE2008001646A PE20090708A1 PE 20090708 A1 PE20090708 A1 PE 20090708A1 PE 2008001646 A PE2008001646 A PE 2008001646A PE 2008001646 A PE2008001646 A PE 2008001646A PE 20090708 A1 PE20090708 A1 PE 20090708A1
Authority
PE
Peru
Prior art keywords
compounds
alkyl
modulators
piperidin
carboxylate
Prior art date
Application number
PE2008001646A
Other languages
English (en)
Inventor
Phillip B Alper
Mihai Azimioara
Christopher Cow
Robert Epple
Songchun Jiang
Gerald Lelais
Pierre-Yves Michellys
Daniel Mutnick
Victor Nikulin
Lucas Westcott-Baker
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of PE20090708A1 publication Critical patent/PE20090708A1/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

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  • Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
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  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
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Abstract

REFERIDA A COMPUESTOS DE FORMULA (I) DONDE Q ES RADICAL DIVALENTE O TRIVALENTE DE ARILO C6-C10, CICLOALQLUILO C3-C8, HETEROCICLOALQUILO C3-C8, ENTRE OTROS; W1 Y W2 SON CADA UNO CR21 Y N; R21 ES H, CN, ALQUILO C1-C6, ENTRE OTROS; L ES ALQUILENO C1-C6, -(CH2)nO-, -OC(O)(CH2)n-, ENTRE OTROS; n ES DE 0-5; m Y q SON CADA UNO DE 0-4; t1, t2, t3 y t4 SON CADA UNO DE 0-2; R1 ES DE PREFERENCIA METILSULFONILPIPERAZIN-1-IL; R2 Y R3 SON CADA UNO H, HALO, OH, ALQUILO(C1-C4), ENTRE OTROS; R4 ES R8 O -C(O)OR8; R8 ES ALQUILO C1-C6, ARILO C6-C10, CICLOALQUILO C3-C8, ENTRE OTROS; R5 ES H, ALQUILO C1-C6, ALCOXI(C1-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-METILCICLOPROPIL-4-((5-(4-(METILSULFONIL)PIPERAZIN-1-IL)PIRAZIN-2-ILOXI)METIL)PIPERIDIN-1-CARBOXILATO, ISOPROPIL 4-((4-((4-METANOSULFONILPIPERAZIN)-1-IL)FENOXI)METIL)PIPERIDIN-1-CARBOXILATO, ISOPROPIL 4-(2-(4-(4-(METANOSULFONIL)PIPERAZIN-1-IL)FENOXI)ETIL)PIPERIDIN-1-CARBOXILATO, ENTRE OTROS. DICHOS COMPUESTOS SON MODULADORES DE LA ACTIVIDAD DEL GPR119, UTILES EN EL TRATAMIENTO DE LA HIPERLIPIDEMIA, DIABETES TIPO I Y II, DIABETES DE LA GESTACION, DISLIPIDEMIA, ENTRE OTROS
PE2008001646A 2007-09-20 2008-09-19 Compuestos y composiciones como moduladores de la actividad gpr119 PE20090708A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97406407P 2007-09-20 2007-09-20
US4526308P 2008-04-15 2008-04-15

Publications (1)

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PE20090708A1 true PE20090708A1 (es) 2009-07-15

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Family Applications (1)

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PE2008001646A PE20090708A1 (es) 2007-09-20 2008-09-19 Compuestos y composiciones como moduladores de la actividad gpr119

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US (3) US8153635B2 (es)
EP (1) EP2197873B1 (es)
JP (1) JP5465177B2 (es)
KR (1) KR20100055536A (es)
CN (1) CN101801954B (es)
AR (1) AR068496A1 (es)
AU (1) AU2008302570B2 (es)
BR (1) BRPI0817211A2 (es)
CA (1) CA2697551C (es)
CL (1) CL2008002787A1 (es)
CO (1) CO6270362A2 (es)
CR (1) CR11292A (es)
EC (1) ECSP10010042A (es)
ES (1) ES2499018T3 (es)
MA (1) MA31764B1 (es)
MX (1) MX2010003117A (es)
NZ (1) NZ583495A (es)
PE (1) PE20090708A1 (es)
RU (1) RU2443699C2 (es)
TN (1) TN2010000122A1 (es)
TW (1) TWI368618B (es)
WO (1) WO2009038974A1 (es)

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