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PE20090449A1 - Agonistas de receptor acoplado a proteina g gpr119 de piridona - Google Patents

Agonistas de receptor acoplado a proteina g gpr119 de piridona

Info

Publication number
PE20090449A1
PE20090449A1 PE2008001197A PE2008001197A PE20090449A1 PE 20090449 A1 PE20090449 A1 PE 20090449A1 PE 2008001197 A PE2008001197 A PE 2008001197A PE 2008001197 A PE2008001197 A PE 2008001197A PE 20090449 A1 PE20090449 A1 PE 20090449A1
Authority
PE
Peru
Prior art keywords
gpr119
protein
piridone
receptor agonists
coupled receptor
Prior art date
Application number
PE2008001197A
Other languages
English (en)
Inventor
Dean A Wacker
Karen A Rossi
Ying Wang
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20090449A1 publication Critical patent/PE20090449A1/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, IA, DONDE G, Q, X SON CADA UNO CH, N CON LA CONDICION QUE Q, X NO SON AMBOS N; Y ES CH2, CO, O, S, ENTRE OTROS; n1, n2, n3 SON CADA UNO 0-2; R1 ES ARILO MONOCICLICO DE 6 MIEMBROS SUSTITUIDO O NO, HETEROARILO MONOCICLICO DE 5-6 MIEMBROS SUSTITUIDO O NO; R2 ES CICLOALQUILO, ARILO, HETEROARILO, HETEROCICLILO, ENTRE OTROS; R20 Y R21 SON CADA UNO H, ALQUILO, HALOALQUILO, CICLOALQUILO, HALO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-(1-(4-(METILSULFONIL)FENIL)-2-OXO-1,2-DIHIDROPIRIDIN-4-ILOXI)PIPERIDIN-1-CARBOXILATO DE TERC-BUTILO; 4-(1-(4-METOXIBENZOIL)PIPERIDIN-4-ILOXI)-1-(4-(METILSULFONIL)FENIL)PIRIDIN-2H(1H)-ONA; ENTRE OTROS. DICHOS COMPUESTO SON MODULADORES DE LA ACTIVIDAD DEL RECEPTOR ACOPLADOA PROTEINA G GPR119 UTILES EN EL TRATAMIENTO DE DIABETES, HIPERGLUCEMIA, NEUROPATIA, ATEROSCLEROSIS, ENTRE OTRAS
PE2008001197A 2007-07-17 2008-07-16 Agonistas de receptor acoplado a proteina g gpr119 de piridona PE20090449A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95016207P 2007-07-17 2007-07-17

Publications (1)

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PE20090449A1 true PE20090449A1 (es) 2009-04-18

Family

ID=39864683

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2008001196A PE20090888A1 (es) 2007-07-17 2008-07-16 Compuestos heterociclicos como agentes moduladores del receptor acoplado a la proteina g gpr119
PE2008001197A PE20090449A1 (es) 2007-07-17 2008-07-16 Agonistas de receptor acoplado a proteina g gpr119 de piridona

Family Applications Before (1)

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PE2008001196A PE20090888A1 (es) 2007-07-17 2008-07-16 Compuestos heterociclicos como agentes moduladores del receptor acoplado a la proteina g gpr119

Country Status (27)

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US (6) US7928230B2 (es)
EP (2) EP2173737B1 (es)
JP (3) JP5301539B2 (es)
KR (2) KR20100045471A (es)
CN (3) CN103550218A (es)
AR (2) AR067568A1 (es)
AT (2) ATE540945T1 (es)
AU (2) AU2008276055B2 (es)
BR (2) BRPI0814428A2 (es)
CA (2) CA2693439A1 (es)
CL (2) CL2008002111A1 (es)
CO (1) CO6160315A2 (es)
CY (2) CY1112151T1 (es)
DK (2) DK2170864T3 (es)
EA (2) EA018709B1 (es)
ES (2) ES2378914T3 (es)
HK (2) HK1136298A1 (es)
HR (2) HRP20110806T1 (es)
IL (1) IL228120A0 (es)
NZ (2) NZ582661A (es)
PE (2) PE20090888A1 (es)
PL (2) PL2173737T3 (es)
PT (2) PT2173737E (es)
SI (2) SI2170864T1 (es)
TW (2) TW200904440A (es)
WO (2) WO2009012277A1 (es)
ZA (2) ZA201000151B (es)

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