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PE20081315A1 - Derivados de benzimidazol como antagonistas de vr-1 - Google Patents

Derivados de benzimidazol como antagonistas de vr-1

Info

Publication number
PE20081315A1
PE20081315A1 PE2007001076A PE2007001076A PE20081315A1 PE 20081315 A1 PE20081315 A1 PE 20081315A1 PE 2007001076 A PE2007001076 A PE 2007001076A PE 2007001076 A PE2007001076 A PE 2007001076A PE 20081315 A1 PE20081315 A1 PE 20081315A1
Authority
PE
Peru
Prior art keywords
ethyl
halogen
methyl
antagonists
benzimidazole derivatives
Prior art date
Application number
PE2007001076A
Other languages
English (en)
Inventor
William L Brown
Shawn Johnstone
Denis Labrecque
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39033277&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081315(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20081315A1 publication Critical patent/PE20081315A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE BENZIMIDAZOL DE FORMULA (I) DONDE R1 ES CN, HALOGENO, C(=)CH3; R2 ES METILO O H; R3 ES H O HALOGENO, R4 Y R5 SON INDEPENDIENTEMENTE METILO O ETILO, O JUNTOS AL ATOMO C AL QUE ESTAN UNIDOS FORMAN CICLOALQUILO DE 3 A 6 MIEMBROS O HETEROCICLO DE 5 A 6 MIEMBROS; R6 Y R7 SON INDEPENDIENTEMENTE H, HALOGENO, METILO O ETILO. SON SELECCIONADOS: (S)(-)-2-(7-CIANO-1H-BENZIMIDAZOL-1-IL)-N-{1-[4-(1-CIANO-1-METILETIL)FENIL]ETIL}ACETAMIDA, (S)(-)-N-{1-[4-(1-CIANO-1-METILETIL)FENIL]ETIL}-2-(7-FLUORO-1H-BENZIMIDAZOL-1-IL)ACETAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE VR1 (RECEPTOR VANILLOIDE 1) SIENDO UTILES EN EL TRATAMIENTO DEL DOLOR
PE2007001076A 2006-08-11 2007-08-10 Derivados de benzimidazol como antagonistas de vr-1 PE20081315A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83724906P 2006-08-11 2006-08-11

Publications (1)

Publication Number Publication Date
PE20081315A1 true PE20081315A1 (es) 2008-11-08

Family

ID=39033277

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001076A PE20081315A1 (es) 2006-08-11 2007-08-10 Derivados de benzimidazol como antagonistas de vr-1

Country Status (25)

Country Link
US (2) US7906654B2 (es)
EP (1) EP2051967B1 (es)
JP (1) JP5140077B2 (es)
KR (1) KR101412881B1 (es)
CN (2) CN101522637A (es)
AR (1) AR062299A1 (es)
AU (1) AU2007282186B2 (es)
BR (1) BRPI0715746B8 (es)
CA (1) CA2660529C (es)
CL (1) CL2007002343A1 (es)
CO (1) CO6150176A2 (es)
ES (1) ES2533971T3 (es)
IL (1) IL196672A0 (es)
MX (1) MX2009001496A (es)
MY (1) MY147649A (es)
NO (1) NO20091054L (es)
NZ (1) NZ575416A (es)
PE (1) PE20081315A1 (es)
RU (1) RU2458055C2 (es)
SG (1) SG173360A1 (es)
TW (1) TWI433839B (es)
UA (1) UA96764C2 (es)
UY (1) UY30533A1 (es)
WO (1) WO2008018827A1 (es)
ZA (1) ZA200900961B (es)

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SE0301446D0 (sv) 2003-05-16 2003-05-16 Astrazeneca Ab New Compounds
AR058705A1 (es) 2005-12-23 2008-02-20 Astrazeneca Ab Compuestos de bencimidazol como inhibidores del receptor vaniloide 1 (vr1)
TWI433839B (zh) * 2006-08-11 2014-04-11 Neomed Inst 新穎的苯并咪唑衍生物290
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
KR101252334B1 (ko) 2008-04-18 2013-04-08 주식회사 대웅제약 신규 벤조옥사진 벤즈이미다졸 유도체, 이를 포함하는 약학 조성물 및 이의 용도
KR101293384B1 (ko) 2010-10-13 2013-08-05 주식회사 대웅제약 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
US8716226B2 (en) 2012-07-18 2014-05-06 Saint Louis University 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
EP2875021B1 (en) 2012-07-18 2017-08-23 Saint Louis University Beta amino acid derivatives as integrin antagonists
JO3719B1 (ar) 2014-11-20 2021-01-31 Takeda Pharmaceuticals Co 4- أوكسو-4،3- داي هيدرو-3،2،1- بنزوترايازينات كمواد ضابطة لأجل gpr139
KR102546020B1 (ko) 2014-12-08 2023-06-20 롬 앤드 하아스 컴패니 폴리올레핀 첨가제, 처짐 저항성 폴리올레핀 및 이를 제조하는 방법
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EP3294716B1 (en) 2015-12-30 2020-04-15 Saint Louis University Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
US20220089550A1 (en) * 2019-01-08 2022-03-24 Neomed Institute - Institut Neomed Crystalline forms of (s)-2-(7-cyano-1h-benzimidazol-1 yl)-n-{1-[4-(1-cyano-1-methylethyl)phenyl]ethyl}acetamide
RU2755206C1 (ru) 2020-05-20 2021-09-14 Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) Средство пролонгированного анальгетического действия и лекарственный препарат на его основе

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TWI433839B (zh) * 2006-08-11 2014-04-11 Neomed Inst 新穎的苯并咪唑衍生物290

Also Published As

Publication number Publication date
CA2660529C (en) 2014-10-21
TW200817338A (en) 2008-04-16
BRPI0715746A2 (pt) 2013-07-16
CL2007002343A1 (es) 2008-04-04
ZA200900961B (en) 2010-07-28
JP5140077B2 (ja) 2013-02-06
KR20090035701A (ko) 2009-04-10
US20110137045A1 (en) 2011-06-09
IL196672A0 (en) 2009-11-18
UA96764C2 (ru) 2011-12-12
CA2660529A1 (en) 2008-02-14
BRPI0715746B8 (pt) 2021-05-25
EP2051967B1 (en) 2014-12-31
US20080221188A1 (en) 2008-09-11
RU2009103675A (ru) 2010-09-20
CN101792436A (zh) 2010-08-04
JP2010500345A (ja) 2010-01-07
NO20091054L (no) 2009-03-09
CN101522637A (zh) 2009-09-02
ES2533971T3 (es) 2015-04-16
WO2008018827A8 (en) 2009-02-19
UY30533A1 (es) 2008-03-31
BRPI0715746B1 (pt) 2020-09-24
KR101412881B1 (ko) 2014-06-26
AU2007282186A1 (en) 2008-02-14
NZ575416A (en) 2011-10-28
US8093402B2 (en) 2012-01-10
AR062299A1 (es) 2008-10-29
MY147649A (en) 2012-12-31
WO2008018827A1 (en) 2008-02-14
RU2458055C2 (ru) 2012-08-10
CO6150176A2 (es) 2010-04-20
AU2007282186B2 (en) 2011-07-07
TWI433839B (zh) 2014-04-11
SG173360A1 (en) 2011-08-29
EP2051967A4 (en) 2011-06-29
EP2051967A1 (en) 2009-04-29
MX2009001496A (es) 2009-02-18
US7906654B2 (en) 2011-03-15

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