+

PE20081313A1 - Pirrolidinona anilinas como moduladores de los receptores de progesterona - Google Patents

Pirrolidinona anilinas como moduladores de los receptores de progesterona

Info

Publication number
PE20081313A1
PE20081313A1 PE2007001055A PE2007001055A PE20081313A1 PE 20081313 A1 PE20081313 A1 PE 20081313A1 PE 2007001055 A PE2007001055 A PE 2007001055A PE 2007001055 A PE2007001055 A PE 2007001055A PE 20081313 A1 PE20081313 A1 PE 20081313A1
Authority
PE
Peru
Prior art keywords
methyl
modulators
anilines
pyrrolidinone
progesterone receptors
Prior art date
Application number
PE2007001055A
Other languages
English (en)
Inventor
David G Washburn
Scott Kevin Thompson
Marlys Hammond
James S Frazee
Tram H Hoang
Latisha C Johnson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20081313A1 publication Critical patent/PE20081313A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPUESTOS DE PIRROLIDINA ANILINAS DE FORMULA (I) EN DONDE X ES H, HALO OCF3; R1 ES H, ALQUILO(C1-C6), ALCOXI(C1-C6)CARBONIL-(CH2)o, ENTRE OTROS SIENDO PREFERIDO BENCILO; R2 ES ALQUILO(C1-C5), CICLOALQUILO(C3-C6), ENTRE OTROS, SIENDO PREFERIDO FENIL-(R3')n, DONDE n ES 0 A 2; Y X ES CLORO. SON SELECCIONADOS: 2-CLORO-4-{[(3S)-1-METIL-5-OXO-3-PIRROLIDINIL][(2-METILFENIL)METIL]AMINO}BENZONITRILO, 2-CLORO-4-{[(2-FLUOROFENIL)METIL][(3S)-1-METIL-5-OXO-3-PIRROLIDINIL]AMINO}BENZONITRILO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON MODULADORES DE RECEPTORES DE PROGESTERONA SIENDO UTILES EN EL TRATAMIENTO DE FIBROMAS UTERINO, DISMENORREA, ANTICONCEPCION, TERAPIA HORMONAL
PE2007001055A 2006-08-09 2007-08-08 Pirrolidinona anilinas como moduladores de los receptores de progesterona PE20081313A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82184106P 2006-08-09 2006-08-09

Publications (1)

Publication Number Publication Date
PE20081313A1 true PE20081313A1 (es) 2008-11-15

Family

ID=39082895

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001055A PE20081313A1 (es) 2006-08-09 2007-08-08 Pirrolidinona anilinas como moduladores de los receptores de progesterona

Country Status (16)

Country Link
US (2) US7816395B2 (es)
EP (1) EP2049104B1 (es)
JP (1) JP5205379B2 (es)
KR (1) KR20090035695A (es)
CN (1) CN101522190A (es)
AR (1) AR062233A1 (es)
AU (1) AU2007284161A1 (es)
BR (1) BRPI0715355A2 (es)
CA (1) CA2660397A1 (es)
CL (1) CL2007002293A1 (es)
EA (1) EA200970189A1 (es)
ES (1) ES2393632T3 (es)
MX (1) MX2009001442A (es)
PE (1) PE20081313A1 (es)
TW (1) TW200825051A (es)
WO (1) WO2008021796A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2611776T3 (en) 2010-09-03 2017-01-09 Lg Life Sciences Ltd Method for producing intermediate for synthesis of drug
KR101185583B1 (ko) * 2011-12-27 2012-09-24 김영재 매듭짓는 작업이 필요 없는 봉합사 및 이를 포함하는 키트
TW201534586A (zh) * 2013-06-11 2015-09-16 Orion Corp 新穎ｃｙｐ１７抑制劑／抗雄激素劑

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959482A (en) * 1988-09-26 1990-09-25 Biofor, Ltd. Pyrrolidinone compounds and pharamaceutical compositions containing same
GB9113031D0 (en) 1991-06-17 1991-08-07 Smithkline Beecham Plc Compounds
US20060148893A1 (en) * 2003-06-10 2006-07-06 Blanc Jean-Baptiste E Chemical compounds
JP2007505164A (ja) * 2003-06-10 2007-03-08 スミスクライン ビーチャム コーポレーション アンドロゲン、グルココルチコイド、ミネラルコルチコイドおよびプロゲステロン受容体のモジュレーターとしての１−アミノナフタレン類
WO2005085185A1 (en) * 2004-03-03 2005-09-15 Smithkline Beecham Corporation Aniline derivatives as selective androgen receptor modulators
JP2008515998A (ja) * 2004-10-13 2008-05-15 スミスクライン ビーチャム コーポレーション 化合物
WO2006113552A2 (en) 2005-04-15 2006-10-26 Smithkline Beecham Corporation Cyanoarylamines
EP1888512A2 (en) * 2005-06-06 2008-02-20 Smithkline Beecham Corporation Chemical compounds
EP1954133A4 (en) * 2005-11-30 2010-11-24 Glaxosmithkline Llc PYRROLIDINANILINE
WO2008077089A1 (en) 2006-12-19 2008-06-26 Smithkline Beecham Corporation Pyrrolidinanilines

Also Published As

Publication number Publication date
AU2007284161A1 (en) 2008-02-21
ES2393632T3 (es) 2012-12-26
CN101522190A (zh) 2009-09-02
EA200970189A1 (ru) 2009-08-28
JP2010500366A (ja) 2010-01-07
EP2049104A4 (en) 2009-09-09
US20080039517A1 (en) 2008-02-14
AR062233A1 (es) 2008-10-22
TW200825051A (en) 2008-06-16
JP5205379B2 (ja) 2013-06-05
EP2049104B1 (en) 2012-09-19
CL2007002293A1 (es) 2008-02-22
US20100210706A1 (en) 2010-08-19
US7816395B2 (en) 2010-10-19
WO2008021796A3 (en) 2008-07-10
EP2049104A2 (en) 2009-04-22
WO2008021796A2 (en) 2008-02-21
CA2660397A1 (en) 2008-02-21
BRPI0715355A2 (pt) 2013-06-18
KR20090035695A (ko) 2009-04-10
MX2009001442A (es) 2009-02-18

Similar Documents

Publication Publication Date Title
PE20080997A1 (es) Compuestos n-fenilmetil-5-oxo-prolina-2-amida como moduladores de receptores p2x7
TNSN08311A1 (en) Indole sulfonamide modulators of progesterone receptors
PE20060401A1 (es) Derivados de n-(2-bencil)-2-fenil-butanamidas y propanamidas como moduladores del receptor de androgeno
PE20090816A1 (es) Derivados de pirrolopirimidinona como agentes ligandos de los receptores p2x3
DK1768625T3 (da) Sammensætninger med vedvarende frigørelse indeholdende progesteron-receptormodulatorer
UA84146C2 (ru) Амиды пирролопиридин-2-карбоновой кислоты как ингибиторы гликогенфосфорилазы, способ их получения, фармацевтическая композиция и их применение как терапевтических агентов для лечения заболеваний
PE20020084A1 (es) N-(glicilo sustituido)-2-ciano-pirrolidinas como inhibidores de la dipeptidilpeptidasa-iv
GEP20074197B (en) 5ht2c receptor modulators
GEP20135907B (en) L-(piperidin-4-yl)-pyrazole derivatives as gpr 119 modulators
PE20090057A1 (es) Compuestos y composiciones como moduladores de la actividad gpr119
PE20060777A1 (es) Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
PE20071095A1 (es) Derivados policiclicos de indazol como inhibidores de erk
PE20061084A1 (es) Compuestos derivados de 2-ciano-3-(halo)alcoxi-bencenosulfonamida
EA200970811A1 (ru) Новые производные бензамида в качестве модуляторов фолликулостимулирующего гормона
TW200716137A (en) Tanaproget compositions containing ethinyl estradiol
MX2007010964A (es) Formas cristalinas de 2-(3-fluoro-4-hidroxifenil)-7-vinil-1,3- benzoxazol-5-ol y su uso como moduladores del receptor estrogenico.
PE20051054A1 (es) Compuestos heterociclicos utiles como secretagogos de la hormona de crecimiento
TW200731969A (en) Use of progesterone receptor modulators
DE602004011394D1 (en) Thiazolderivate
PE20130401A1 (es) Heteroaril-ciclohexil-tetraazabenzo[e]azulenos
ATE467632T1 (de) Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors
PE20090712A1 (es) Moduladores de la gamma secretasa
DE602006017837D1 (de) Azabicycloä3.1.0ühexan-derivate als modulatoren des dopamin-d3-rezeptors
PE20021083A1 (es) Moduladores de los receptores estrogenos
TW200728274A (en) Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof

Legal Events

Date Code Title Description
FC Refusal
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载