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PE20081878A1 - Compuestos derivados de 1-(4-hidroxifenil sustituido)-4-ol-indazol - Google Patents

Compuestos derivados de 1-(4-hidroxifenil sustituido)-4-ol-indazol

Info

Publication number
PE20081878A1
PE20081878A1 PE2008000434A PE2008000434A PE20081878A1 PE 20081878 A1 PE20081878 A1 PE 20081878A1 PE 2008000434 A PE2008000434 A PE 2008000434A PE 2008000434 A PE2008000434 A PE 2008000434A PE 20081878 A1 PE20081878 A1 PE 20081878A1
Authority
PE
Peru
Prior art keywords
indazole
hydroxyphenil
substituted
compounds derived
hydroxyphenyl
Prior art date
Application number
PE2008000434A
Other languages
English (en)
Inventor
Christopher Norbert Johnson
David G Jones
Xi Liang
David Timothy Macpherson
Aaron B Miller
Antoinette Naylor
Steven James Stanway
Andrew Kenneth Takle
Giancarlo Trani
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20081878A1 publication Critical patent/PE20081878A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE Ra, Rb Y Rc SON CADA UNO HALO, ALCOXI C1-C4, ALQUILO C1-C4, CF3, CN, ENTRE OTROS; m ES 0-3; n ES 0-1; p ES 0-4. SON COMPUESTOS PREFERIDOS: 1-(3-FLUORO-4-HIDROXIFENIL)-1H-INDAZOL-4-OL; 1-(3-FLUORO-4HIDROXIFENIL)-6-METI-1H-INDAZOL-4-OL; 1-(3,5-DIFLUORO-4-HIDROXIFENIL)-4-HIDROXI-1H-INDAZOL-6-CARBONITRILO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SE UNENAL RECEPTOR ERBETHA UTILES EN EL TRATAMIENTO DE DOLOR, ENFERMEDADES AUTOINMUNES, TRASTORNOS METABOLICOS O TRASTORNOS DEL APETITO
PE2008000434A 2007-03-07 2008-03-05 Compuestos derivados de 1-(4-hidroxifenil sustituido)-4-ol-indazol PE20081878A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0704407.6A GB0704407D0 (en) 2007-03-07 2007-03-07 Compounds

Publications (1)

Publication Number Publication Date
PE20081878A1 true PE20081878A1 (es) 2009-03-05

Family

ID=37988543

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000434A PE20081878A1 (es) 2007-03-07 2008-03-05 Compuestos derivados de 1-(4-hidroxifenil sustituido)-4-ol-indazol

Country Status (16)

Country Link
US (1) US7960563B2 (es)
EP (1) EP2118068A1 (es)
JP (1) JP2010520259A (es)
KR (1) KR20090118998A (es)
CN (1) CN101679288A (es)
AR (1) AR065605A1 (es)
AU (1) AU2008223850A1 (es)
BR (1) BRPI0808464A2 (es)
CA (1) CA2680109A1 (es)
CL (1) CL2008000647A1 (es)
EA (1) EA200970835A1 (es)
GB (1) GB0704407D0 (es)
MX (1) MX2009009581A (es)
PE (1) PE20081878A1 (es)
TW (1) TW200848025A (es)
WO (1) WO2008107455A1 (es)

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WO2012062750A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
EP2828243B1 (en) 2012-03-20 2018-10-17 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
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Also Published As

Publication number Publication date
CA2680109A1 (en) 2008-09-12
US7960563B2 (en) 2011-06-14
KR20090118998A (ko) 2009-11-18
CL2008000647A1 (es) 2009-01-02
AU2008223850A1 (en) 2008-09-12
JP2010520259A (ja) 2010-06-10
AR065605A1 (es) 2009-06-17
EA200970835A1 (ru) 2010-04-30
TW200848025A (en) 2008-12-16
GB0704407D0 (en) 2007-04-18
EP2118068A1 (en) 2009-11-18
CN101679288A (zh) 2010-03-24
US20100087502A1 (en) 2010-04-08
MX2009009581A (es) 2009-09-16
WO2008107455A1 (en) 2008-09-12
BRPI0808464A2 (pt) 2014-07-15

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