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PE20081806A1 - Imidazo- y triazolopirimidinas sustituidas - Google Patents

Imidazo- y triazolopirimidinas sustituidas

Info

Publication number
PE20081806A1
PE20081806A1 PE2008000448A PE2008000448A PE20081806A1 PE 20081806 A1 PE20081806 A1 PE 20081806A1 PE 2008000448 A PE2008000448 A PE 2008000448A PE 2008000448 A PE2008000448 A PE 2008000448A PE 20081806 A1 PE20081806 A1 PE 20081806A1
Authority
PE
Peru
Prior art keywords
imidazo
amino
pyrimidin
trifluoromethyl
triazolopyrimidines
Prior art date
Application number
PE2008000448A
Other languages
English (en)
Inventor
Stephan Siegel
Andreas Wilmen
Susanne Rohrig
Niels Svenstrup
Mark Jean Gnoth
Stefan Heitmeier
Ulrich Rester
Dmitry Zuvov
Jochen Straley
Michael Sperzel
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of PE20081806A1 publication Critical patent/PE20081806A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE IMIDAZO Y TRIAZOLOPIRIMIDINAS SUSTITUIDAS DE FORMULA (I) DONDE A ES N O CR15, EN DONDE R15 ES H, Br O Cl; R1 ES H, HIDROXI, NH2, TRIFLUOROMETILO, CN, ALQUILO(C1-C4), ENTRE OTROS; R2 ES ARILO(C6-C10) O HETEROARILO DE 5 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDO CON HIDROXI, NH2, HALOGENO, CN, ENTRE OTROS; R4 ES H, HALOGENO, CN, TRIFLUOROMETILO, ENTRE OTROS; R16 ES UN COMPUESTO DE FORMULA (i), (ii), ENTRE OTROS, DONDE R3 ES 2-PIRIDILO, PIRIMID-2-ILO, 2-CICLOPROPILAMINOPIRIMID-4-ILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-[(2-{[7-(2,4-DICLOROFENIL)IMIDAZO[1,2-c]PIRIMIDIN-5-IL]AMINO}ETIL)AMINO]-NICOTINONITRILO, N-[7-(2,4-DICLOROFENIL)IMIDAZO[1,2-c]PIRIMIDIN-5-IL]-N'-[5-(TRIFLUOROMETIL)PIRIDIN-2-IL]ETANO-1,2-DIAMINA, 1-{6-[(2-{[7-(2,4-DICLOROFENIL)IMIDAZO[1,2-c]PIRIMIDIN-5-IL]AMINO}ETIL)AMINO]PIRIDIN-3-IL}ETANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA GLICOGENO SINTASA QUINASA 3B (GSK3B) SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS HEMATOLOGICOS TALES COMO LEUCOPENIAS Y NEUTROPENIAS
PE2008000448A 2007-03-16 2008-03-10 Imidazo- y triazolopirimidinas sustituidas PE20081806A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007012645A DE102007012645A1 (de) 2007-03-16 2007-03-16 Substituierte Imidazo- und Triazolopyrimidine

Publications (1)

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PE20081806A1 true PE20081806A1 (es) 2009-02-07

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ID=39688187

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Application Number Title Priority Date Filing Date
PE2008000448A PE20081806A1 (es) 2007-03-16 2008-03-10 Imidazo- y triazolopirimidinas sustituidas

Country Status (13)

Country Link
US (2) US8273752B2 (es)
EP (1) EP2137188B1 (es)
JP (1) JP5400626B2 (es)
AR (1) AR065719A1 (es)
CA (1) CA2680697C (es)
CL (1) CL2008000703A1 (es)
DE (1) DE102007012645A1 (es)
ES (1) ES2387223T3 (es)
PA (1) PA8772101A1 (es)
PE (1) PE20081806A1 (es)
TW (1) TW200904819A (es)
UY (1) UY30956A1 (es)
WO (1) WO2008113469A2 (es)

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DE102007012645A1 (de) 2007-03-16 2008-09-18 Bayer Healthcare Ag Substituierte Imidazo- und Triazolopyrimidine
DE102008023801A1 (de) * 2008-05-15 2009-11-19 Bayer Schering Pharma Aktiengesellschaft Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine
DE102008035552A1 (de) * 2008-07-30 2010-02-04 Bayer Schering Pharma Aktiengesellschaft Substituierte Pyridine und ihre Verwendung
CN102361872B (zh) * 2009-02-13 2014-12-03 拜耳知识产权有限责任公司 作为akt抑制剂的稠合嘧啶
JP5503930B2 (ja) * 2009-09-18 2014-05-28 住友化学株式会社 ３−アミノ−１−ｔｅｒｔ−ブトキシカルボニルピペリジンの精製方法およびそのクエン酸塩
CA2770087C (en) * 2009-09-24 2014-09-09 F. Hoffmann-La Roche Ag Imidazopyridine or imidazopyrimidine derivatives as phosphodiesterase 1oa inhibitors
WO2011044637A1 (en) * 2009-10-15 2011-04-21 Monash University Affinity ligands and methods for protein purification
ES2627703T3 (es) 2010-01-22 2017-07-31 Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii Inhibidores de PI3·quinasa
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
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WO2011141713A1 (en) 2010-05-13 2011-11-17 Centro Nacional De Investigaciones Oncologicas (Cnio) New bicyclic compounds as pi3-k and mtor inhibitors
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TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
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