PE20081795A1 - HTRA1-PDZ AND HTRA3-PDZ MODULATORS - Google Patents
HTRA1-PDZ AND HTRA3-PDZ MODULATORSInfo
- Publication number
- PE20081795A1 PE20081795A1 PE2008000341A PE2008000341A PE20081795A1 PE 20081795 A1 PE20081795 A1 PE 20081795A1 PE 2008000341 A PE2008000341 A PE 2008000341A PE 2008000341 A PE2008000341 A PE 2008000341A PE 20081795 A1 PE20081795 A1 PE 20081795A1
- Authority
- PE
- Peru
- Prior art keywords
- pdz
- htra3
- htra1
- sequence
- polypeptide
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical group CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 2
- 239000004475 Arginine Chemical group 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical group NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical group OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical group OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical group OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical group C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Chemical group 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Chemical group NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Chemical group OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Chemical group OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Chemical group CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
- 229960000310 isoleucine Drugs 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Chemical group OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Gyroscopes (AREA)
- Compression, Expansion, Code Conversion, And Decoders (AREA)
- Digital Transmission Methods That Use Modulated Carrier Waves (AREA)
Abstract
SE REFIERE A UN POLIPEPTIDO QUE SE UNE A UN DOMINIO PDZ DE HtrA1 QUE COMPRENDE LA SECUENCIA DIETWLL (IDENTIFICADOR DE SECUENCIA Nº 3), GWKTWIL (IDENTIFICADOR DE SECUENCIA Nº 4), DSRIWWV (IDENTIFICADOR DE SECUENCIA Nº 5) O WDKIWHV (IDENTIFICADOR DE SECUENCIA Nº 6). DONDE DICHO POLIPEPTIDO COMPRENDE UNA SECUENCIA CON UNA LEUCINA O VALINA EN LA POSICION 0; UN TRIPTOFANO, ISOLEUCINA O FENILALANINA EN LA POSICION 1; UNA TREONINA O ISOLEUCINA EN LA POSICION 3; Y ACIDO GLUTAMICO, LISINA, ARGININA O ACIDO ASPARTICO EN LA POSICION 4. SE REFIERE TAMBIEN A UN POLIPEPTIDO QUE SE UNE A UN DOMINIO PDZ DE HtrA3 Y A UN METODO PARA IDENTIFICAR UN COMPUESTO CON CAPACIDAD PARA MODULAR LA INTERACCION ENTRE UN LIGANDO Y UN DOMINIO PDZ DE HtrA1 O UN DOMINIO PDZ DE HtrA3REFERS TO A POLYPEPTIDE JOINING A PDZ DOMAIN OF HtrA1 THAT INCLUDES THE SEQUENCE DIETWLL (SEQUENCE IDENTIFIER # 3), GWKTWIL (SEQUENCE IDENTIFIER # 4), DSRIWWV (SEQUENCE IDENTIFIER # 5) OR WDKIWHV No. 6). WHERE SAID POLYPEPTIDE INCLUDES A SEQUENCE WITH A LEUCINE OR VALINE IN THE 0 POSITION; A TRYPTOPHAN, ISOLEUCIN OR PHENYLALANINE IN POSITION 1; A THREONINE OR ISOLEUCINE IN POSITION 3; AND GLUTAMIC ACID, LYSINE, ARGININE OR ASPARTIC ACID IN POSITION 4. ALSO REFERS TO A POLYPEPTIDE THAT IS JOINED TO A PDZ DOMAIN OF HtrA3 AND TO A METHOD TO IDENTIFY A COMPOUND WITH CAPACITY TO MODULATE THE INTERACTION BETWEEN A LIG PD DOMAIN FROM HtrA1 OR A PDZ DOMAIN FROM HtrA3
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89042807P | 2007-02-16 | 2007-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081795A1 true PE20081795A1 (en) | 2009-01-08 |
Family
ID=39590928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000341A PE20081795A1 (en) | 2007-02-16 | 2008-02-15 | HTRA1-PDZ AND HTRA3-PDZ MODULATORS |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2111413A2 (en) |
| AR (1) | AR065370A1 (en) |
| CL (1) | CL2008000493A1 (en) |
| PE (1) | PE20081795A1 (en) |
| TW (1) | TW200846358A (en) |
| WO (1) | WO2008101160A2 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| EP1994155B2 (en) | 2006-02-13 | 2022-05-04 | Daiichi Sankyo Company, Limited | Polynucleotide and polypeptide sequences involved in the process of bone remodeling |
| EA201490778A1 (en) | 2011-10-14 | 2014-09-30 | Дженентек, Инк. | ANTIBODIES AGAINST HtrA1 AND METHODS OF APPLICATION |
| IN2014KN02933A (en) | 2012-07-19 | 2015-05-08 | Alethia Biotherapeutics Inc | |
| KR102440160B1 (en) | 2015-10-30 | 2022-09-02 | 제넨테크, 인크. | Anti-HtrA1 antibodies and methods of use thereof |
| JP2019513698A (en) | 2016-03-04 | 2019-05-30 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Novel trifluoromethylpropanamide derivatives as HTRA1 inhibitors |
| EP3423467B1 (en) | 2016-03-04 | 2021-04-28 | F. Hoffmann-La Roche AG | New difluoroketamide derivatives as htra1 inhibitors |
| WO2018015240A1 (en) | 2016-07-18 | 2018-01-25 | F. Hoffmann-La Roche Ag | New difluoroketamide derivatives as htra1 inhibitors |
| CN109563084A (en) | 2016-08-23 | 2019-04-02 | 豪夫迈·罗氏有限公司 | Novel trifluoromethyl propanamide derivative as HTRA1 inhibitor |
| JP2019526563A (en) | 2016-08-23 | 2019-09-19 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Novel difluoroketamide derivatives as HTRA1 inhibitors |
| WO2018206816A1 (en) * | 2017-05-12 | 2018-11-15 | Universität Duisburg-Essen | Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors |
| WO2020083916A1 (en) * | 2018-10-22 | 2020-04-30 | University Of Copenhagen | Virally expressed inhibitors of pdz domains, such as pick1 and uses thereof |
| KR20220150313A (en) * | 2020-03-06 | 2022-11-10 | 유니버시티 오브 코펜하겐 | Lipid conjugated peptide inhibitor of PICK1 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090087878A9 (en) * | 1999-05-06 | 2009-04-02 | La Rosa Thomas J | Nucleic acid molecules associated with plants |
-
2008
- 2008-02-15 CL CL200800493A patent/CL2008000493A1/en unknown
- 2008-02-15 WO PCT/US2008/054081 patent/WO2008101160A2/en active Application Filing
- 2008-02-15 TW TW097105456A patent/TW200846358A/en unknown
- 2008-02-15 AR ARP080100656A patent/AR065370A1/en unknown
- 2008-02-15 PE PE2008000341A patent/PE20081795A1/en not_active Application Discontinuation
- 2008-02-15 EP EP08729968A patent/EP2111413A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008101160A2 (en) | 2008-08-21 |
| AR065370A1 (en) | 2009-06-03 |
| WO2008101160A3 (en) | 2009-02-19 |
| EP2111413A2 (en) | 2009-10-28 |
| TW200846358A (en) | 2008-12-01 |
| CL2008000493A1 (en) | 2008-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |