PE20081761A1 - Agonistas de los receptores alfa2c adrenergicos funcionalmente selectivos - Google Patents
Agonistas de los receptores alfa2c adrenergicos funcionalmente selectivosInfo
- Publication number
- PE20081761A1 PE20081761A1 PE2008000304A PE2008000304A PE20081761A1 PE 20081761 A1 PE20081761 A1 PE 20081761A1 PE 2008000304 A PE2008000304 A PE 2008000304A PE 2008000304 A PE2008000304 A PE 2008000304A PE 20081761 A1 PE20081761 A1 PE 20081761A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halo
- alcoxy
- agonists
- compounds
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title abstract 2
- 108060003345 Adrenergic Receptor Proteins 0.000 title 1
- 102000017910 Adrenergic receptor Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 101000977048 Streptomyces cinnamonensis Uncharacterized protein in mutB 3'region Proteins 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE NAFTENO E INDANO DE FORMULA (I) DONDE J4 ES UN COMPUESTO DE FORMULA (a), (b) O (c), DONDE Z ES -[C(RC)(RC)]x- EN DONDE x ES DE 1 A 3; RC ES H O ALQUILO; A ES UN ANILLO HETEROARILO, HETEROCICLILO O HETEROCICLENILO DE 5 MIEMBROS; R4 ES H, CN, HALO, ALCOXI, ENTRE OTROS; R4' ES H, HALO, ALQUILO, CICLOALCOXI, ENTRE OTROS; R6 ES H, CN, CICLOALQUILO, ALCOXI, ENTRE OTROS; R13 ES H, ALQUILO, ALQUENILO, CICLOALQUILO, ENTRE OTROS; R14 ES H, ALQUILO, HALO, CN O ALCOXI; m ES 0 O 1; z ES DE 0 A 5; J1, J2 Y J3 SON CADA UNO -N-, -N(O)- O -C(R2)-, EN DONDE R2 ES H, OH, HALO, CN, NO2, ENTRE OTROS; === ES UN ENLACE SIMPLE O DOBLE; n Y w SON CADA UNO DE 1 A 3; R1 ES -[C(Ra)(Rb)]qNR7R7', -[C(Ra)(Rb)]qON=CR7R7', ENTRE OTROS, DONDE Ra Y Rb SON CADA UNO H, ALQUILO, ALCOXI O HALO; R7 ES H, ALQUILO, ALQUINILO, CICLOALQUILO, ENTRE OTROS; R7' ES H, ALQUILO, ARILO, ALQUENILO, ENTRE OTROS; q ES DE 0 A 10; R3 ES H, ALQUENILO, ALQUINILO, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS LOS COMPUESTOS DE FORMULA (i), (ii), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DE LOS RECEPTORES a2C SIENDO UTILES EN EL TRATAMIENTO DE LA RINITIS ALERGICA, CONGESTION, MIGRANA, GLAUCOMA, ISQUEMIA CARDIACA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90106407P | 2007-02-13 | 2007-02-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081761A1 true PE20081761A1 (es) | 2008-12-06 |
Family
ID=39590425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000304A PE20081761A1 (es) | 2007-02-13 | 2008-02-12 | Agonistas de los receptores alfa2c adrenergicos funcionalmente selectivos |
Country Status (11)
Country | Link |
---|---|
US (1) | US8017642B2 (es) |
EP (1) | EP2398776A1 (es) |
JP (1) | JP2010518163A (es) |
CN (1) | CN101657429A (es) |
AR (1) | AR065309A1 (es) |
CA (1) | CA2678072A1 (es) |
CL (1) | CL2008000431A1 (es) |
MX (1) | MX2009008776A (es) |
PE (1) | PE20081761A1 (es) |
TW (1) | TW200843745A (es) |
WO (1) | WO2008100480A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20090113326A (ko) | 2007-02-13 | 2009-10-29 | 쉐링 코포레이션 | 작용 선택적 알파2c 아드레날린성 수용체 효능제 |
CL2008000429A1 (es) | 2007-02-13 | 2008-08-18 | Schering Corp | Compuestos derivados de heterociclos condensados; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar afecciones asociadas con los receptores alfa2c adrenergicos, tales como congestion asociada a rinitis, polipos, resfrio |
CL2008000431A1 (es) | 2007-02-13 | 2008-08-18 | Schering Corp | Compuestos derivados de biciclos o heterociclos condensados; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar afecciones relacionadas con los a2c adrenegicos, tales como congestion relacionada con rinitis, polipos o re |
EP2257546B1 (en) | 2008-02-21 | 2012-08-15 | Merck Sharp & Dohme Corp. | Functionally selective alpha2c adrenoreceptor agonists |
EP2344491A2 (en) * | 2008-09-16 | 2011-07-20 | Schering Corporation | Functionally selective azanitrile alpha2c adrenoreceptor agonists |
EP2356106A1 (en) | 2008-10-07 | 2011-08-17 | Schering Corporation | Biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators |
CN112125790A (zh) * | 2020-10-27 | 2020-12-25 | 埃法姆药物研发(宁夏)有限公司 | 一种7-氯-1-萘醛的合成方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0445073A1 (de) | 1990-02-27 | 1991-09-04 | Ciba-Geigy Ag | Benzofurane |
GB9425211D0 (en) | 1994-12-14 | 1995-02-15 | Ucb Sa | Substituted 1H-imidazoles |
GB9520150D0 (en) | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
US6841684B2 (en) | 1997-12-04 | 2005-01-11 | Allergan, Inc. | Imidiazoles having reduced side effects |
SK8542000A3 (en) | 1997-12-04 | 2001-03-12 | Allergan Sales Inc | Substituted imidazole derivatives having agonist-like activity at alpha 2b or 2b/2c adrenergic receptors |
TWI283669B (en) | 1999-06-10 | 2007-07-11 | Allergan Inc | Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors |
FR2810979B1 (fr) | 2000-06-29 | 2002-08-23 | Adir | Nouveaux derives de diphenyluree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US7091232B2 (en) | 2002-05-21 | 2006-08-15 | Allergan, Inc. | 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds |
WO2005005781A1 (en) | 2003-07-14 | 2005-01-20 | Elthom Enterprises Limited | Volume screw machine of rotary type |
JP2009506047A (ja) | 2005-08-25 | 2009-02-12 | シェーリング コーポレイション | 機能的に選択的なα2Cアドレナリン受容体アゴニストとしてのイミダゾール誘導体 |
US8003624B2 (en) | 2005-08-25 | 2011-08-23 | Schering Corporation | Functionally selective ALPHA2C adrenoreceptor agonists |
RU2008110902A (ru) | 2005-08-25 | 2009-09-27 | Шеринг Корпорейшн (US) | Агонисты адренорецепторов альфа а2с |
US7700592B2 (en) | 2005-08-25 | 2010-04-20 | Schering Corporation | α2C adrenoreceptor agonists |
DE602007004949D1 (de) * | 2006-01-27 | 2010-04-08 | Hoffmann La Roche | Verwendung von 4-imidazol-derivaten für zns-erkrankungen |
CL2008000431A1 (es) | 2007-02-13 | 2008-08-18 | Schering Corp | Compuestos derivados de biciclos o heterociclos condensados; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar afecciones relacionadas con los a2c adrenegicos, tales como congestion relacionada con rinitis, polipos o re |
CL2008000429A1 (es) | 2007-02-13 | 2008-08-18 | Schering Corp | Compuestos derivados de heterociclos condensados; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar afecciones asociadas con los receptores alfa2c adrenergicos, tales como congestion asociada a rinitis, polipos, resfrio |
KR20090113326A (ko) | 2007-02-13 | 2009-10-29 | 쉐링 코포레이션 | 작용 선택적 알파2c 아드레날린성 수용체 효능제 |
-
2008
- 2008-02-11 CL CL200800431A patent/CL2008000431A1/es unknown
- 2008-02-11 CN CN200880011989A patent/CN101657429A/zh active Pending
- 2008-02-11 CA CA002678072A patent/CA2678072A1/en not_active Abandoned
- 2008-02-11 WO PCT/US2008/001808 patent/WO2008100480A1/en active Application Filing
- 2008-02-11 US US12/525,648 patent/US8017642B2/en not_active Expired - Fee Related
- 2008-02-11 EP EP08714249A patent/EP2398776A1/en not_active Withdrawn
- 2008-02-11 JP JP2009549604A patent/JP2010518163A/ja not_active Withdrawn
- 2008-02-11 MX MX2009008776A patent/MX2009008776A/es not_active Application Discontinuation
- 2008-02-12 PE PE2008000304A patent/PE20081761A1/es not_active Application Discontinuation
- 2008-02-12 TW TW097104892A patent/TW200843745A/zh unknown
- 2008-02-12 AR ARP080100595A patent/AR065309A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AR065309A1 (es) | 2009-05-27 |
MX2009008776A (es) | 2009-08-25 |
TW200843745A (en) | 2008-11-16 |
US8017642B2 (en) | 2011-09-13 |
EP2398776A1 (en) | 2011-12-28 |
CA2678072A1 (en) | 2008-08-21 |
JP2010518163A (ja) | 2010-05-27 |
WO2008100480A1 (en) | 2008-08-21 |
CN101657429A (zh) | 2010-02-24 |
CL2008000431A1 (es) | 2008-08-18 |
US20100144816A1 (en) | 2010-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |