PE20081608A1 - Derivados indolicos con anillo unido en las posiciones 4,5 y sus metodos de uso - Google Patents
Derivados indolicos con anillo unido en las posiciones 4,5 y sus metodos de usoInfo
- Publication number
- PE20081608A1 PE20081608A1 PE2008000053A PE2008000053A PE20081608A1 PE 20081608 A1 PE20081608 A1 PE 20081608A1 PE 2008000053 A PE2008000053 A PE 2008000053A PE 2008000053 A PE2008000053 A PE 2008000053A PE 20081608 A1 PE20081608 A1 PE 20081608A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- positions
- methods
- cycloalkyl
- aryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE INDOL DE FORMULA (I) DONDE EL ANILLO Z ES CICLOPENTILO, HETEROCICLOALQUILO DE 5 MIEMBROS, HETEROARILO DE 5 MIEMBROS, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON HALO, OH, CN, ENTRE OTROS; R1 ES UN ENLACE, -[C(R12)2]r-, -[C(R12)2]r-O-[C(R12)2]q-, -[C(R12)2]q-CH=CH-[C(R12)2]q-, ENTRE OTROS, DONDE R12 ES H, HALO, ALQUILO(C1-C20), CICLOALQUILO(C3-C10), CICLOALQUENILO(C3-C10), ENTRE OTROS; q ES DE 0 A 4; r ES DE 1 A 4; R2 ES -C(O)R9, -C(O)OR9, -C(O)OCH2OR9, -C(O)N(R9)2, ENTRE OTROS, DONDE R9 ES H, ALQUILO(C1-C20), ALQUENILO(C2-C15), ALQUINILO(C2-C15), HALOALQUILO(C1-C20), ENTRE OTROS; R3 ES H, -[C(R12)2]q-ALQUILO(C1-C20), -[C(R12)2]q-ARILO(C6-C14), -[C(R12)2]q-CICLOALQUILO(C3-C10), ENTRE OTROS; R6 Y R7 SON CADA UNO H, ALQUILO(C1-C20), ALQUENILO(C2-C15), ALQUINILO(C2-C15), ARILO(C6-C14), ENTRE OTROS; R10 ES H, CICLOALQUILO(C3-C10), CICLOALQUENILO(C3-C10), ARILO(C6-C14), ENTRE OTROS. SON COMPUESTOS PREFERIDOS LOS DE FORMULA (i), (ii), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA REPLICACION DEL VIRUS DE LA HEPATITIS C (VHC)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87687706P | 2006-12-22 | 2006-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081608A1 true PE20081608A1 (es) | 2008-11-12 |
Family
ID=39186835
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000053A PE20081608A1 (es) | 2006-12-22 | 2008-01-02 | Derivados indolicos con anillo unido en las posiciones 4,5 y sus metodos de uso |
Country Status (18)
Country | Link |
---|---|
US (1) | US8557848B2 (es) |
EP (1) | EP2064180B1 (es) |
JP (1) | JP5079818B2 (es) |
KR (1) | KR20090094154A (es) |
CN (1) | CN101631773A (es) |
AR (1) | AR064428A1 (es) |
AU (1) | AU2007339382B2 (es) |
BR (1) | BRPI0720625A2 (es) |
CA (1) | CA2673249C (es) |
CL (1) | CL2007003686A1 (es) |
CO (1) | CO6190515A2 (es) |
EC (1) | ECSP099447A (es) |
MX (1) | MX2009006880A (es) |
NO (1) | NO20092742L (es) |
PE (1) | PE20081608A1 (es) |
RU (1) | RU2009127855A (es) |
TW (1) | TW200831496A (es) |
WO (1) | WO2008082484A1 (es) |
Families Citing this family (40)
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KR20090106539A (ko) | 2006-12-22 | 2009-10-09 | 쉐링 코포레이션 | Hcv 및 관련 바이러스 감염을 치료 또는 예방하기 위한 4,5-환 환상 인돌 유도체 |
MX2009006880A (es) | 2006-12-22 | 2009-07-03 | Schering Corp | Derivados indolicos con anillo unido en las posiciones 4,5 para tratar o prevenir infecciones virales por virus de la hepatitis c e infecciones virales relacionadas. |
ATE543808T1 (de) | 2006-12-22 | 2012-02-15 | Schering Corp | 5,6-ring-annelierte indolderivate und ihre verwendung |
MX2010002318A (es) | 2007-08-29 | 2010-03-22 | Schering Corp | Derivados azaindol 2,3-sustituidos para tratar infecciones virales. |
AU2008295476B2 (en) * | 2007-08-29 | 2013-08-01 | Merck Sharp & Dohme Corp. | 2, 3-Substituted Indole Derivatives for treating viral infections |
TW200924780A (en) * | 2007-08-29 | 2009-06-16 | Schering Corp | 2-carboxy substituted indole derivatives and methods of use thereof |
CA2705586A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-heterocyclic substituted indole derivatives and methods of use thereof |
CN102317285A (zh) | 2007-11-16 | 2012-01-11 | 先灵公司 | 3-氨基磺酰基取代的吲哚衍生物及其使用方法 |
CA2727620A1 (en) * | 2008-06-13 | 2009-12-17 | Schering Corporation | Tricyclic indole derivatives and methods of use thereof |
BRPI0920513A2 (pt) * | 2008-09-26 | 2019-09-24 | F Hoffamann La Roche Ag | derivados de pirina ou pirazina para tratar hcv |
JP2012513434A (ja) | 2008-12-22 | 2012-06-14 | エフ.ホフマン−ラ ロシュ アーゲー | 複素環式抗ウイルス化合物 |
JP2012519661A (ja) * | 2009-03-06 | 2012-08-30 | エフ.ホフマン−ラ ロシュ アーゲー | 抗ウイルス性複素環化合物 |
EP2435424B1 (en) | 2009-05-29 | 2015-01-21 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
WO2011000566A2 (en) * | 2009-06-30 | 2011-01-06 | Savira Pharmaceuticals Gmbh | Compounds and pharmaceutical compositions for the treatment of negative-sense ssrna virus infections |
JP2013512246A (ja) | 2009-11-25 | 2013-04-11 | メルク・シャープ・アンド・ドーム・コーポレーション | ウイルス疾患治療に有用な縮合型三環式化合物およびその誘導体 |
EP2516430B1 (en) | 2009-12-22 | 2014-11-05 | Merck Sharp & Dohme Corp. | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases |
MA34147B1 (fr) | 2010-03-09 | 2013-04-03 | Merck Sharp & Dohme | Composes tricycliques fusionnes de silyle et leurs methodes d'utilisation dans le cadre du traitement de maladies virales |
EP2598149A4 (en) | 2010-07-26 | 2014-09-10 | Merck Sharp & Dohme | SUBSTITUTED BIPHENYLENE COMPOUNDS AND METHOD FOR USE THEREOF FOR THE TREATMENT OF VIRUS DISEASES |
JP2013540122A (ja) | 2010-09-29 | 2013-10-31 | メルク・シャープ・エンド・ドーム・コーポレイション | 縮合四環式化合物誘導体およびウィルス疾患治療のためのそれの使用方法 |
WO2012142075A1 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
JP2014515023A (ja) | 2011-04-13 | 2014-06-26 | メルク・シャープ・アンド・ドーム・コーポレーション | 2’−置換ヌクレオシド誘導体およびウイルス疾患の処置のためのその使用方法 |
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WO2013033901A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
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EP3063140A4 (en) | 2013-10-30 | 2017-11-08 | Merck Sharp & Dohme Corp. | Pseudopolymorphs of an hcv ns5a inhibitor and uses thereof |
CN106810557B (zh) * | 2015-11-27 | 2021-05-04 | 南京圣和药物研发有限公司 | 杂环化合物及其应用 |
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WO2018044986A1 (en) * | 2016-08-30 | 2018-03-08 | The Rockefeller University | Triazinoindole-based chemical inhibitors of eukaryotic ribosome biogenesis |
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CA2727620A1 (en) | 2008-06-13 | 2009-12-17 | Schering Corporation | Tricyclic indole derivatives and methods of use thereof |
-
2007
- 2007-12-17 MX MX2009006880A patent/MX2009006880A/es unknown
- 2007-12-17 RU RU2009127855/04A patent/RU2009127855A/ru not_active Application Discontinuation
- 2007-12-17 JP JP2009542835A patent/JP5079818B2/ja not_active Expired - Fee Related
- 2007-12-17 CA CA2673249A patent/CA2673249C/en active Active
- 2007-12-17 EP EP07862998.7A patent/EP2064180B1/en active Active
- 2007-12-17 KR KR1020097015298A patent/KR20090094154A/ko not_active Ceased
- 2007-12-17 BR BRPI0720625-9A2A patent/BRPI0720625A2/pt not_active Application Discontinuation
- 2007-12-17 AU AU2007339382A patent/AU2007339382B2/en not_active Ceased
- 2007-12-17 WO PCT/US2007/025754 patent/WO2008082484A1/en active Application Filing
- 2007-12-17 CN CN200780051419A patent/CN101631773A/zh active Pending
- 2007-12-17 US US12/519,715 patent/US8557848B2/en active Active
- 2007-12-18 AR ARP070105705A patent/AR064428A1/es not_active Application Discontinuation
- 2007-12-18 TW TW096148504A patent/TW200831496A/zh unknown
- 2007-12-18 CL CL200703686A patent/CL2007003686A1/es unknown
-
2008
- 2008-01-02 PE PE2008000053A patent/PE20081608A1/es not_active Application Discontinuation
-
2009
- 2009-06-18 CO CO09063496A patent/CO6190515A2/es not_active Application Discontinuation
- 2009-06-19 EC EC2009009447A patent/ECSP099447A/es unknown
- 2009-07-21 NO NO20092742A patent/NO20092742L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2010513490A (ja) | 2010-04-30 |
US8557848B2 (en) | 2013-10-15 |
EP2064180B1 (en) | 2016-07-13 |
TW200831496A (en) | 2008-08-01 |
US20100098661A1 (en) | 2010-04-22 |
MX2009006880A (es) | 2009-07-03 |
KR20090094154A (ko) | 2009-09-03 |
CL2007003686A1 (es) | 2008-06-27 |
NO20092742L (no) | 2009-09-21 |
BRPI0720625A2 (pt) | 2014-03-25 |
CN101631773A (zh) | 2010-01-20 |
CA2673249A1 (en) | 2008-07-10 |
WO2008082484A1 (en) | 2008-07-10 |
EP2064180A1 (en) | 2009-06-03 |
ECSP099447A (es) | 2009-07-31 |
AU2007339382A1 (en) | 2008-07-10 |
RU2009127855A (ru) | 2011-01-27 |
CA2673249C (en) | 2013-04-30 |
AR064428A1 (es) | 2009-04-01 |
JP5079818B2 (ja) | 2012-11-21 |
AU2007339382B2 (en) | 2013-05-02 |
CO6190515A2 (es) | 2010-08-19 |
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