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PE20081566A1 - Compuestos y composiciones como inhibidores de proteasa activadora de canal - Google Patents

Compuestos y composiciones como inhibidores de proteasa activadora de canal

Info

Publication number
PE20081566A1
PE20081566A1 PE2008000105A PE2008000105A PE20081566A1 PE 20081566 A1 PE20081566 A1 PE 20081566A1 PE 2008000105 A PE2008000105 A PE 2008000105A PE 2008000105 A PE2008000105 A PE 2008000105A PE 20081566 A1 PE20081566 A1 PE 20081566A1
Authority
PE
Peru
Prior art keywords
alkyl
inhibitors
compounds
compositions
activating protease
Prior art date
Application number
PE2008000105A
Other languages
English (en)
Inventor
David C Tully
Arnab K Chatterjee
Agnes Vidal
Badry Bursulaya
Glen Spraggon
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of PE20081566A1 publication Critical patent/PE20081566A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)

Abstract

REFERIDA UN DERIVADO DE PIRROLIDINA DE FORMULA (1), DONDE J ES UN ANILLO CARBOCICLICO MONOCICLICO O FUSIONADO DE 5 A 12 MIEMBROS, UN ANILLO HETEROCICLICO QUE COMPRENDE N, O O S, UN ANILLO ARILO O HETEROARILO; B ES R3-Y-NH-C(H)[(CR2)m-R4]- O (CR2)k-R5; Y ES UN ENLACE, SO2, NHCO, O-(CO); R1 ES HALOGENO, -(CR2)l-NR6R7, ENTRE OTROS; R3 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS; R2, R4 Y R5 SON UN ANILLO CARBOCICLICO DE 5 A 12 MIEMBROS, UN ANILLO HETEROCICLICO, ARILO, ENTRE OTROS; R6 Y R7 SON H, ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS; l ES UN ENTERO DE 0 A 6; k, m, n Y p SON UN ENTERO DE 1 A 6. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE PROTEASA ACTIVADORA DEL CANAL (CAP) Y SON UTILES EN EL TRATAMIENTO DE FIBROSIS QUISTICA, CARCINOMA PULMONAR, BRONQUITIS CRONICA, ASMA, ENTRE OTROS
PE2008000105A 2007-01-10 2008-01-10 Compuestos y composiciones como inhibidores de proteasa activadora de canal PE20081566A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88433407P 2007-01-10 2007-01-10
US89147407P 2007-02-23 2007-02-23

Publications (1)

Publication Number Publication Date
PE20081566A1 true PE20081566A1 (es) 2008-12-14

Family

ID=39148650

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000105A PE20081566A1 (es) 2007-01-10 2008-01-10 Compuestos y composiciones como inhibidores de proteasa activadora de canal

Country Status (33)

Country Link
US (1) US20080176901A1 (es)
EP (2) EP2279777A2 (es)
JP (1) JP2010515729A (es)
KR (1) KR101084787B1 (es)
AR (1) AR064841A1 (es)
AT (1) ATE493174T1 (es)
AU (1) AU2007342223B2 (es)
BR (1) BRPI0720799A2 (es)
CA (1) CA2673803A1 (es)
CL (1) CL2008000060A1 (es)
CO (1) CO6190626A2 (es)
CU (1) CU23762B7 (es)
CY (1) CY1111340T1 (es)
DE (1) DE602007011670D1 (es)
DK (1) DK2104535T3 (es)
EA (1) EA016199B1 (es)
EC (1) ECSP099517A (es)
GT (1) GT200900196A (es)
HK (1) HK1129860A1 (es)
HN (1) HN2009001282A (es)
HR (1) HRP20110201T1 (es)
MA (1) MA31037B1 (es)
MX (1) MX2009007476A (es)
NO (1) NO20092817L (es)
NZ (1) NZ577939A (es)
PE (1) PE20081566A1 (es)
PL (1) PL2104535T3 (es)
PT (1) PT2104535E (es)
RS (1) RS51644B (es)
SV (1) SV2009003330A (es)
TN (1) TN2009000294A1 (es)
TW (1) TW200845981A (es)
WO (1) WO2008085608A1 (es)

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EA200900920A1 (ru) 2010-02-26
TW200845981A (en) 2008-12-01
AR064841A1 (es) 2009-04-29
AU2007342223B2 (en) 2011-02-24
CY1111340T1 (el) 2015-08-05
MX2009007476A (es) 2009-07-22
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