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PE20080360A1 - Derivados 4-bencilftalazinona 2-sustituidos como antagonistas de histaminas h1 y h3 - Google Patents

Derivados 4-bencilftalazinona 2-sustituidos como antagonistas de histaminas h1 y h3

Info

Publication number
PE20080360A1
PE20080360A1 PE2007000478A PE2007000478A PE20080360A1 PE 20080360 A1 PE20080360 A1 PE 20080360A1 PE 2007000478 A PE2007000478 A PE 2007000478A PE 2007000478 A PE2007000478 A PE 2007000478A PE 20080360 A1 PE20080360 A1 PE 20080360A1
Authority
PE
Peru
Prior art keywords
benzylftalazinone
histamines
antagonists
methyl
substituted
Prior art date
Application number
PE2007000478A
Other languages
English (en)
Inventor
Paul Martin Gore
Ashley Paul Hancock
Simon Teanby Hodgson
Leanda Jane Kindon
Panayiotis Alexandrou Procopiou
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0607839A external-priority patent/GB0607839D0/en
Priority claimed from GB0706160A external-priority patent/GB0706160D0/en
Priority claimed from GB0706176A external-priority patent/GB0706176D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20080360A1 publication Critical patent/PE20080360A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS 4-BENCILFTALAZINONA 2-SUSTITUIDOS DE FORMULA (I), EN DONDE A ES N Y CH; R1 Y R2 SON INDEPENDIENTEMENTE HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-C6), HIDROXILO O TRIFLUOROMETILO; y Y z SON INDEPENDIENTEMENTE DE 0,1 O 2; R3 ES -(CH2)aNR4R5, O UN GRUPO DE FORMULA i); R4 ES H O ALQUILO(C1-C6); R5 Y R6 SON INDEPENDIENTEMENTE UN GRUPO a), b) O c). SON SELECCIONADOS 4-[(4-CLOROFENIL)METIL]-2-(2-{[4-(4-{[2-(HEXAHIDRO-1H-AZEPIN-1-IL)PROPIL]OXI}-FENIL)BUTIL]AMINO}ETIL)-1(2H)-FTALAZINONA, 4-[(4-CLOROFENIL)METIL]-2-({(2R)-1-[4-(4-{3-(HEXAHIDRO-1H-AZEPIN-1-IL)PROPIL]OXI}FENIL)BUTIL]-2-PIRROLIDINIL}METIL)-1(2H)-FTALAZINONA. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCESO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS DE HISTAMINAS H1 Y H3, POR LO QUE SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y/O ALERGICAS DEL TRACTO RESPIRATORIO
PE2007000478A 2006-04-20 2007-04-18 Derivados 4-bencilftalazinona 2-sustituidos como antagonistas de histaminas h1 y h3 PE20080360A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0607839A GB0607839D0 (en) 2006-04-20 2006-04-20 Compounds
GB0706160A GB0706160D0 (en) 2007-03-29 2007-03-29 Compounds
GB0706176A GB0706176D0 (en) 2007-03-29 2007-03-29 Compounds

Publications (1)

Publication Number Publication Date
PE20080360A1 true PE20080360A1 (es) 2008-05-22

Family

ID=38226516

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000478A PE20080360A1 (es) 2006-04-20 2007-04-18 Derivados 4-bencilftalazinona 2-sustituidos como antagonistas de histaminas h1 y h3

Country Status (19)

Country Link
US (2) US20090105225A1 (es)
EP (1) EP2007735B1 (es)
JP (1) JP4489143B2 (es)
KR (1) KR20090007604A (es)
AR (1) AR060535A1 (es)
AT (1) ATE486063T1 (es)
AU (1) AU2007242842A1 (es)
BR (1) BRPI0710156A2 (es)
CA (1) CA2649029A1 (es)
CO (1) CO6140030A2 (es)
CR (1) CR10356A (es)
DE (1) DE602007010118D1 (es)
EA (1) EA200801996A1 (es)
MA (1) MA30405B1 (es)
MX (1) MX2008013406A (es)
NO (1) NO20084363L (es)
PE (1) PE20080360A1 (es)
TW (1) TW200811116A (es)
WO (1) WO2007122156A1 (es)

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TW200730498A (en) 2005-12-20 2007-08-16 Glaxo Group Ltd Compounds
ES2341813T3 (es) * 2006-12-20 2010-06-28 Glaxo Group Limited 4-bencil-1 (2h)-ftalazinonas como antagonistas del receptor h1.
TW200932243A (en) * 2007-10-16 2009-08-01 Glaxo Group Ltd Pharmaceutical compositions
US8772495B2 (en) 2008-05-23 2014-07-08 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein inhibitor
GB0811447D0 (en) * 2008-06-20 2008-07-30 Glaxo Group Ltd Formulations
WO2010094643A1 (en) 2009-02-17 2010-08-26 Glaxo Group Limited Quinoline derivatives and their uses for rhinitis and urticaria
US20120157446A1 (en) * 2009-06-29 2012-06-21 Glaxo Group Limited Medical use
WO2011144656A1 (en) 2010-05-19 2011-11-24 Sandoz Ag Preparation of posaconazole intermediates
BR112012029225B1 (pt) 2010-05-19 2020-10-27 Sandoz Ag processo para a preparação de um composto quiral, composto quiral e uso de um composto quiral
BR112012029228A2 (pt) * 2010-05-19 2021-08-03 Sandoz Ag processo para a preparação de um sal de cloreto de hidrogênio, sal de cloreto de hidrogênio, sal de cloreto de hidrogênio cristalino, uso de um sal e uso do processo
WO2012045729A1 (en) 2010-10-05 2012-04-12 Glaxo Group Limited Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists
WO2012072512A1 (en) 2010-11-29 2012-06-07 Glaxo Group Limited N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists
WO2012139963A1 (en) 2011-04-11 2012-10-18 Glaxo Group Limited N- cyclobutyl - imidazopyridine - methylamine as trpv1 antagonists
CN108329303A (zh) 2011-06-16 2018-07-27 桑多斯股份公司 制备手性化合物的方法
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
AU2015260841A1 (en) 2014-05-12 2016-12-01 Glaxosmithkline Intellectual Property (No. 2) Limited Pharmaceutical compositions comprising danirixin for treating infectious diseases
BR112022019245A2 (pt) 2020-03-26 2022-11-16 Glaxosmithkline Ip Dev Ltd Inibidores de catepsina para prevenir ou tratar infecções virais
KR20240013792A (ko) * 2021-05-27 2024-01-30 슈뢰딩거, 인크. 헤테로시클릭 화합물 및 사용 방법

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CH572914A5 (es) * 1971-01-22 1976-02-27 Asta Werke Ag Chem Fab
US3813384A (en) * 1972-01-17 1974-05-28 Asta Werke Ag Chem Fab Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
ATE49205T1 (de) * 1984-09-14 1990-01-15 Asta Pharma Ag Substituierte benzylphthalazinon-derivate.
DE3677322D1 (de) * 1985-11-11 1991-03-07 Asta Pharma Ag 4-benzyl-1-(2h)-phthalazinon-derivate.
EP0289939A1 (de) * 1987-05-08 1988-11-09 ASTA Pharma AG Neue 4-Benzyl-1-(2H)-phthalazinon-Derivate mit einem Aminosäurerest
CZ199593A3 (en) * 1992-10-02 1994-04-13 Asta Medica Ag Phthalazinone derivatives exhibiting anti-arrhythmic and analgesic activity and eliminating resistance to a plurality of medicaments (mdr)
DK0997474T3 (da) * 1998-08-14 2004-02-09 Pfizer Antithrombotiske midler
US6180629B1 (en) * 1998-08-14 2001-01-30 Cell Pathways, Inc. [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia
GB0224084D0 (en) * 2002-10-16 2002-11-27 Glaxo Group Ltd Novel compounds
JP2006520783A (ja) * 2003-03-18 2006-09-14 メルク　エンド　カムパニー　インコーポレーテッド ケモカイン受容体活性のアミノシクロブチルアミド調節物質
US7595316B2 (en) * 2003-06-27 2009-09-29 Banyu Pharmaceutical Co., Ltd. Heteroaryloxy nitrogenous saturated heterocyclic derivative

Also Published As

Publication number Publication date
US20080039444A1 (en) 2008-02-14
EA200801996A1 (ru) 2009-04-28
MX2008013406A (es) 2008-11-04
US20090105225A1 (en) 2009-04-23
WO2007122156A1 (en) 2007-11-01
TW200811116A (en) 2008-03-01
JP4489143B2 (ja) 2010-06-23
WO2007122156A9 (en) 2008-01-24
BRPI0710156A2 (pt) 2012-06-05
EP2007735A1 (en) 2008-12-31
ATE486063T1 (de) 2010-11-15
EP2007735B1 (en) 2010-10-27
KR20090007604A (ko) 2009-01-19
AU2007242842A1 (en) 2007-11-01
CA2649029A1 (en) 2007-11-01
JP2009534351A (ja) 2009-09-24
DE602007010118D1 (de) 2010-12-09
CO6140030A2 (es) 2010-03-19
CR10356A (es) 2008-11-26
AR060535A1 (es) 2008-06-25
MA30405B1 (fr) 2009-05-04
NO20084363L (no) 2008-11-17

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