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PE20080318A1 - Derivados de diceto-piperazina y piperidina como agentes antivirales - Google Patents

Derivados de diceto-piperazina y piperidina como agentes antivirales

Info

Publication number
PE20080318A1
PE20080318A1 PE2007000513A PE2007000513A PE20080318A1 PE 20080318 A1 PE20080318 A1 PE 20080318A1 PE 2007000513 A PE2007000513 A PE 2007000513A PE 2007000513 A PE2007000513 A PE 2007000513A PE 20080318 A1 PE20080318 A1 PE 20080318A1
Authority
PE
Peru
Prior art keywords
phenyl
alkyl
diceto
piperazine
diona
Prior art date
Application number
PE2007000513A
Other languages
English (en)
Inventor
Tao Wang
John F Kadow
Zhongxing Zhang
Zhiwei Yin
Nicholas A Meanwell
Alicia Regueiro-Ren
Jacob Swidorski
Ying Han
David J Carini
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20080318A1 publication Critical patent/PE20080318A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

REFERIDA A UN DERIVADO DE DICETO-PIPERAZINA O PIPERIDINA DE FORMULA (I), DONDE A SE SELECCIONA DE a), b), c), d) O e); LAS LINEAS PUNTEADAS REPRESENTAN UN ENLACE CARBONO-CARBONO O NO EXISTE; R1 ES H, ALQUILO C1-C4 O FLUOROALQUILO C1-C4; R2 ES H; R4, R5, R5 Y R7 SON H, OH, CIANO, NITRO, ALQUILO C1-C4, ENTRE OTROS; R4N NO EXISTE O ES O; Y ES FENILO, HETEROARILO BICICLICO C9-C10, CICLOALQUILO C5-C7, ENTRE OTROS; Z ES ALQUILO C1-C6, ALCOXI C1-C6, CICLOALQUILO C3-C7, ENTRE OTROS; R9, R10, R11, R12, R13, R14, R15, R16 SON H, ALQUILO C1-C6, ENTRE OTROS; X ES N O CH. SON COMPUESTOS PREFERIDOS: 1-(7-BROMO-4-FLUORO-1H-PIRROLO[2,3-c]PIRIDIN-3-IL)-2-(4-(1-FENIL-1H-TETRAZOL-5-IL)PIPERAZIN-1-IL)ETAN-DIONA, 1-(4-FLUORO-7-(3-METIL-1H-PIRAZOL-1-IL)-1H-PIRROLO[2,3-c]PIRIDIN-3-IL)-2-(4-(1-FENIL-1H-TETRAZOL-5-IL)PIPERAZIN-1-IL)ETAN-1,2-DIONA, 1-(4-FLUORO-7-(5-METIL-1H-PIRAZOL-1-IL)-1H-PIRROLO[2,3-c]PIRIDIN-3-IL)-2-(4-(1-FENIL-1H-TETRAZOL-5-IL)PIPERAZIN-1-IL)ETAN-1,2-DIONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGENTES ANTIVIRALES Y SON UTILES EN EL TRATAMIENTO DEL SIDA
PE2007000513A 2006-04-25 2007-04-25 Derivados de diceto-piperazina y piperidina como agentes antivirales PE20080318A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79470006P 2006-04-25 2006-04-25
US79470306P 2006-04-25 2006-04-25
US11/733,283 US7807671B2 (en) 2006-04-25 2007-04-10 Diketo-piperazine and piperidine derivatives as antiviral agents

Publications (1)

Publication Number Publication Date
PE20080318A1 true PE20080318A1 (es) 2008-04-10

Family

ID=38335673

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000513A PE20080318A1 (es) 2006-04-25 2007-04-25 Derivados de diceto-piperazina y piperidina como agentes antivirales

Country Status (17)

Country Link
US (2) US7807671B2 (es)
EP (1) EP2010525B1 (es)
JP (1) JP5214590B2 (es)
KR (1) KR101450349B1 (es)
AR (1) AR060658A1 (es)
AU (1) AU2007242989B2 (es)
BR (1) BRPI0710919A2 (es)
CA (1) CA2650382C (es)
EA (1) EA014957B1 (es)
ES (1) ES2432758T3 (es)
IL (1) IL194540A (es)
MX (1) MX2008013265A (es)
NO (1) NO341412B1 (es)
NZ (1) NZ571995A (es)
PE (1) PE20080318A1 (es)
TW (1) TWI394754B (es)
WO (1) WO2007127635A2 (es)

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US20080139572A1 (en) 2008-06-12
WO2007127635A3 (en) 2008-03-13
EP2010525A2 (en) 2009-01-07
JP2009535352A (ja) 2009-10-01
IL194540A (en) 2015-03-31
MX2008013265A (es) 2008-10-27
AU2007242989B2 (en) 2012-06-28
KR20090005393A (ko) 2009-01-13
JP5214590B2 (ja) 2013-06-19
KR101450349B1 (ko) 2014-10-14
TWI394754B (zh) 2013-05-01
CA2650382A1 (en) 2007-11-08
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US20070249579A1 (en) 2007-10-25
AR060658A1 (es) 2008-07-02
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US7807676B2 (en) 2010-10-05
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IL194540A0 (en) 2009-08-03
US7807671B2 (en) 2010-10-05
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AU2007242989A1 (en) 2007-11-08

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