PE20080178A1 - Oxindoldioxanos, sintesis de los mismos, y compuestos intermedios - Google Patents
Oxindoldioxanos, sintesis de los mismos, y compuestos intermediosInfo
- Publication number
- PE20080178A1 PE20080178A1 PE2007000641A PE2007000641A PE20080178A1 PE 20080178 A1 PE20080178 A1 PE 20080178A1 PE 2007000641 A PE2007000641 A PE 2007000641A PE 2007000641 A PE2007000641 A PE 2007000641A PE 20080178 A1 PE20080178 A1 PE 20080178A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- formula
- group
- base
- halogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 13
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- -1 PHENYL RING Chemical group 0.000 abstract 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 2
- 102000004980 Dopamine D2 Receptors Human genes 0.000 abstract 1
- 108090001111 Dopamine D2 Receptors Proteins 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 150000007942 carboxylates Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003291 dopaminomimetic effect Effects 0.000 abstract 1
- 150000002148 esters Chemical group 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052697 platinum Inorganic materials 0.000 abstract 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
REFERIDA UN METODO DE PREPARACION DE UN COMPUESTO DE FORMULA (I), QUE COMPRENDE: a) HACER REACCIONAR UN COMPUESTO DE FORMULA E CON UN COMPUESTO DE FORMULA R1-CH2-CN EN PRESENCIA DE UNA BASE, DONDE R1 ES HALOGENO O UN GRUPO FENOXI DONDE EL ANILLO DE FENILO ESTA OPCIONALMENTE SUSTITUIDO CON UNO O MAS GRUPOS HALOGENO, NITRO O ESTER Y LA BASE ES UNA BASE FUERTE TAL COMO TER-BUTOXIDO DE POTASIO, PARA OBTENER UN COMPUESTO DE FORMULA D, b) CONVERTIR LA PORCION HIDROXILO LIBRE DE D EN UN GRUPO SALIENTE EN PRESENCIA DE UNA BASE TAL COMO TRIETILAMINA PARA DAR UN COMPUESTO DE FORMULA C, DONDE LG2 ES TOSILO, c) TRATAR EL COMPUESTO DE FORMULA C CON BENCILAMINA PARA DAR UN COMPUESTO DE FORMULA B, d) HIDROLIZAR EL GRUPO NITRILO DEL COMPUESTO B PARA FORMAR UN COMPUESTO DE FORMULA A, DONDE R2 ES UN GRUPO CARBOXILATO Y e) REDUCIR EL GRUPO NITRO DEL COMPUESTO A MEDIANTE HIDROGENACION EN PRESENCIA DE UN CATALIZADOR DE PLATINO, Fe/HCl O Sn/HCl PARA FORMAR UN COMPUESTO DE FORMULA (I). DICHOS COMPUESTOS DE FORMULA (I) SON AGONISTAS DELOS RECEPTORES DE DOPAMINA D2 Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DOPAMINERGICOS TALES COMO ESQUIZOFRENIA, PARKINSON, SINDROME DE TOURETTE, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80839406P | 2006-05-25 | 2006-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080178A1 true PE20080178A1 (es) | 2008-04-16 |
Family
ID=38569786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000641A PE20080178A1 (es) | 2006-05-25 | 2007-05-23 | Oxindoldioxanos, sintesis de los mismos, y compuestos intermedios |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7662979B2 (es) |
| EP (1) | EP2046771B1 (es) |
| JP (1) | JP5295103B2 (es) |
| CN (1) | CN101448814B (es) |
| AR (1) | AR061125A1 (es) |
| AU (1) | AU2007267799B2 (es) |
| BR (1) | BRPI0712608B8 (es) |
| CA (1) | CA2652800C (es) |
| CL (1) | CL2007001498A1 (es) |
| ES (1) | ES2387901T3 (es) |
| IL (1) | IL195226A0 (es) |
| MX (1) | MX2008014789A (es) |
| PE (1) | PE20080178A1 (es) |
| TW (1) | TW200811182A (es) |
| WO (1) | WO2007139998A2 (es) |
| ZA (1) | ZA200809966B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GT200400218A (es) | 2003-10-29 | 2005-06-06 | Formulaciones de liberacion sostenida. | |
| US8466296B2 (en) * | 2007-03-26 | 2013-06-18 | Ligand Pharmaceuticals | Compounds and processes for preparing substituted aminomethyl-2,3,8,9-tetrahydro-7H-1,4-dioxino[2,3-e]indol-8-ones |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4314944A (en) * | 1980-08-22 | 1982-02-09 | Smithkline Corporation | 4-Aminoalkyl-7-hydroxy-2(3H)-indolones |
| CA2075057A1 (en) | 1990-03-15 | 1991-09-16 | Pharmacia & Upjohn Company Llc | Therapeutically useful heterocyclic indole compounds |
| US5166367A (en) * | 1991-06-21 | 1992-11-24 | American Home Products Corporation | Antipsychotic benzodioxan derivatives |
| US5189171A (en) * | 1991-06-21 | 1993-02-23 | American Home Products Corporation | Antipsychotic benzodioxan derivatives |
| US5126366A (en) * | 1991-06-21 | 1992-06-30 | American Home Products Corporation | Aminophenoxyalkyl derivatives of benzodioxan |
| DE4135474A1 (de) | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-aminomethyl-chromane |
| DE4140540A1 (de) * | 1991-12-09 | 1993-06-17 | Bayer Ag | Neue azaheterocyclylmethyl-chromane |
| US5235055A (en) * | 1992-09-02 | 1993-08-10 | American Home Products Corporation | Antipsychotic quinoline derivatives of benzodioxanmethylamine |
| US5245051A (en) * | 1992-09-03 | 1993-09-14 | American Home Products Corporation | Antipsychotic chroman derivatives of benzodioxanmethylamine |
| DE69325698T2 (de) * | 1992-12-21 | 2000-01-27 | Duphar International Research B.V., Weesp | Enzymatisches Verfahren zur stereoselektiven Herstellung einem Enantiomer aus einem hetero bicyclischen Alkohols |
| EP1123933A1 (en) | 1994-10-14 | 2001-08-16 | MERCK PATENT GmbH | 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chromane as CNS active agent |
| AR004523A1 (es) | 1995-11-06 | 1998-12-16 | American Home Prod | 2-(AMINOMETIL)-3,4,7,9-TETRAHIDRO-2H-PIRANO-[2,3e] INDOL-8-ONAS Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN |
| US5756532A (en) * | 1995-11-06 | 1998-05-26 | American Home Products Corporation | Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives |
| US5869490A (en) * | 1996-10-15 | 1999-02-09 | American Home Products Corporation | Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one |
| US5750556A (en) * | 1996-10-30 | 1998-05-12 | American Home Products Corporation | 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano- 2,3-E!indol-8-ones and derivatives |
| EP1432695A1 (en) * | 2001-10-05 | 2004-06-30 | Wyeth | A process for the stereoselective synthesis of 2-hydroxymethyl-chromans |
| WO2003031428A1 (en) * | 2001-10-05 | 2003-04-17 | Wyeth | Stereospecific process for the synthesis of 2-yl chroman derivatives |
| US7135479B2 (en) * | 2002-09-12 | 2006-11-14 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans |
| ES2277546B1 (es) | 2005-11-21 | 2008-06-16 | Natraceutical, S.A. | Procedimiento microbiano de produccion de isomeros especificos de acidos linoleicos conjugados. |
-
2007
- 2007-05-16 TW TW096117352A patent/TW200811182A/zh unknown
- 2007-05-23 PE PE2007000641A patent/PE20080178A1/es not_active Application Discontinuation
- 2007-05-24 CL CL2007001498A patent/CL2007001498A1/es unknown
- 2007-05-24 AR ARP070102253A patent/AR061125A1/es unknown
- 2007-05-25 US US11/807,257 patent/US7662979B2/en active Active
- 2007-05-25 JP JP2009512182A patent/JP5295103B2/ja active Active
- 2007-05-25 EP EP07795426A patent/EP2046771B1/en active Active
- 2007-05-25 CN CN2007800183180A patent/CN101448814B/zh active Active
- 2007-05-25 ES ES07795426T patent/ES2387901T3/es active Active
- 2007-05-25 CA CA2652800A patent/CA2652800C/en active Active
- 2007-05-25 MX MX2008014789A patent/MX2008014789A/es active IP Right Grant
- 2007-05-25 BR BRPI0712608A patent/BRPI0712608B8/pt active IP Right Grant
- 2007-05-25 WO PCT/US2007/012622 patent/WO2007139998A2/en active Application Filing
- 2007-05-25 AU AU2007267799A patent/AU2007267799B2/en active Active
-
2008
- 2008-11-11 IL IL195226A patent/IL195226A0/en active IP Right Grant
- 2008-11-24 ZA ZA200809966A patent/ZA200809966B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2007001498A1 (es) | 2008-01-18 |
| IL195226A0 (en) | 2009-08-03 |
| BRPI0712608B1 (pt) | 2020-09-08 |
| BRPI0712608A2 (pt) | 2012-08-14 |
| ZA200809966B (en) | 2009-09-30 |
| ES2387901T3 (es) | 2012-10-03 |
| JP2009538324A (ja) | 2009-11-05 |
| CA2652800A1 (en) | 2007-12-06 |
| MX2008014789A (es) | 2008-11-28 |
| JP5295103B2 (ja) | 2013-09-18 |
| EP2046771B1 (en) | 2012-07-11 |
| TW200811182A (en) | 2008-03-01 |
| BRPI0712608B8 (pt) | 2021-05-25 |
| WO2007139998A3 (en) | 2008-01-31 |
| AU2007267799B2 (en) | 2013-09-12 |
| AR061125A1 (es) | 2008-08-06 |
| US20070293686A1 (en) | 2007-12-20 |
| BRPI0712608A8 (pt) | 2018-12-11 |
| US7662979B2 (en) | 2010-02-16 |
| CA2652800C (en) | 2014-05-13 |
| CN101448814B (zh) | 2013-04-24 |
| CN101448814A (zh) | 2009-06-03 |
| EP2046771A2 (en) | 2009-04-15 |
| AU2007267799A1 (en) | 2007-12-06 |
| WO2007139998A2 (en) | 2007-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |