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PE20080067A1 - DERIVADOS DE TRIAZOLOPIRAZINA COMO MODULADORES DEL RECEPTOR DEL FACTOR DE CRECIMIENTO DE HEPATOCITO (c-MET O HGFR) - Google Patents

DERIVADOS DE TRIAZOLOPIRAZINA COMO MODULADORES DEL RECEPTOR DEL FACTOR DE CRECIMIENTO DE HEPATOCITO (c-MET O HGFR)

Info

Publication number
PE20080067A1
PE20080067A1 PE2007000559A PE2007000559A PE20080067A1 PE 20080067 A1 PE20080067 A1 PE 20080067A1 PE 2007000559 A PE2007000559 A PE 2007000559A PE 2007000559 A PE2007000559 A PE 2007000559A PE 20080067 A1 PE20080067 A1 PE 20080067A1
Authority
PE
Peru
Prior art keywords
hgfr
modulators
receptor
met
growth factor
Prior art date
Application number
PE2007000559A
Other languages
English (en)
Inventor
Hengmiao Cheng
Jingrong Jean Cui
Jacqui Elizabeth Hoffman
Lei Jia
Mary Catherine Johnson
Robert Steven Kania
Phuong Thi Quy Le
Mitchell David Nambu
Mason Alan Pairish
Hong Shen
Michelle Bich Tran-Dube
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20080067A1 publication Critical patent/PE20080067A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE TRIAZOLOPIRAZINA DE FORMULA (I) DONDE R1 Y R2 SON CADA UNO H, F, ALQUILO(C1-C6), CICLOALQUILO(C3-C8), ALQUENILO(C2-C6), ENTRE OTROS; R3 ES UN COMPUESTO DE FORMULA (i) DONDE R5, R6, R7, R8 Y R9 SON CADA UNO H, CN, NO2, ARILO(C6-C10), ALQUINILO(C2-C6), ENTRE OTROS; R4 ES H, F, ALQUILO(C1-C6) O ARILO(C6-C12). SON COMPUESTOS PREFERIDOS: 6-((6-(1-METIL-1H-PIRAZOL-4-IL)-1H-[1,2,3]TRIAZOLO[4,5-b]PIRAZIN-1-IL)METIL)QUINOLINA, N-(PIPERIDIN-4-IL)-4-(3-(QUINOLIN-6-ILMETIL)-3H-[1,2,3]TRIAZOLO[4,5-b]PIRAZIN-5-IL)BENZAMIDA, N-(2-AMINOETIL)-4-(3-(QUINOLIN-6-ILMETIL)-3H-[1,2,3]TRIAZOLO[4,5-b]PIRAZIN-5-IL)BENZAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR DEL FACTOR DE CRECIMIENTO DE HEPATOCITO (c-MET O HGFR) SIENDO UTILES EN EL TRATAMIENTO DE CANCER DE MAMA, GLIOMA, MELANOMA, LEUCEMIA
PE2007000559A 2006-05-11 2007-05-09 DERIVADOS DE TRIAZOLOPIRAZINA COMO MODULADORES DEL RECEPTOR DEL FACTOR DE CRECIMIENTO DE HEPATOCITO (c-MET O HGFR) PE20080067A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79996606P 2006-05-11 2006-05-11
US89323107P 2007-03-06 2007-03-06

Publications (1)

Publication Number Publication Date
PE20080067A1 true PE20080067A1 (es) 2008-03-10

Family

ID=38441445

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000559A PE20080067A1 (es) 2006-05-11 2007-05-09 DERIVADOS DE TRIAZOLOPIRAZINA COMO MODULADORES DEL RECEPTOR DEL FACTOR DE CRECIMIENTO DE HEPATOCITO (c-MET O HGFR)

Country Status (32)

Country Link
US (2) US7732604B2 (es)
EP (1) EP2018383B1 (es)
JP (1) JP4377962B2 (es)
KR (1) KR101099161B1 (es)
CN (1) CN101443331A (es)
AP (1) AP2008004674A0 (es)
AR (1) AR060994A1 (es)
AT (1) ATE532785T1 (es)
AU (1) AU2007251283A1 (es)
BR (1) BRPI0711809A2 (es)
CA (1) CA2651363C (es)
CR (1) CR10383A (es)
EA (1) EA016204B1 (es)
EC (1) ECSP088871A (es)
ES (1) ES2376913T3 (es)
GE (1) GEP20115174B (es)
GT (1) GT200700039A (es)
HN (1) HN2007015177A (es)
IL (1) IL194813A0 (es)
MA (1) MA30411B1 (es)
ME (1) MEP36508A (es)
MX (1) MX2008014399A (es)
NL (1) NL2000613C2 (es)
NO (1) NO20085060L (es)
NZ (1) NZ572361A (es)
PE (1) PE20080067A1 (es)
RS (1) RS20080533A (es)
TN (1) TNSN08445A1 (es)
TW (1) TWI346115B (es)
UY (1) UY30334A1 (es)
WO (1) WO2007132308A1 (es)
ZA (1) ZA200809020B (es)

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CN102459283B (zh) * 2009-05-28 2014-11-12 沃泰克斯药物股份有限公司 C-met 蛋白激酶的氨基吡唑三唑并噻二唑抑制剂
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Also Published As

Publication number Publication date
MEP36508A (en) 2011-02-10
CR10383A (es) 2008-11-11
JP4377962B2 (ja) 2009-12-02
CA2651363C (en) 2011-07-12
TW200804384A (en) 2008-01-16
WO2007132308A1 (en) 2007-11-22
US7732604B2 (en) 2010-06-08
JP2009536636A (ja) 2009-10-15
HN2007015177A (es) 2010-06-09
ATE532785T1 (de) 2011-11-15
TNSN08445A1 (fr) 2010-04-14
ES2376913T3 (es) 2012-03-20
NL2000613C2 (nl) 2007-11-20
US20100105656A1 (en) 2010-04-29
AU2007251283A1 (en) 2007-11-22
TWI346115B (en) 2011-08-01
US20070265272A1 (en) 2007-11-15
KR20090006187A (ko) 2009-01-14
CA2651363A1 (en) 2007-11-22
EA016204B1 (ru) 2012-03-30
BRPI0711809A2 (pt) 2011-12-06
CN101443331A (zh) 2009-05-27
EP2018383B1 (en) 2011-11-09
ZA200809020B (en) 2009-12-30
AP2008004674A0 (en) 2008-12-31
EP2018383A1 (en) 2009-01-28
GEP20115174B (en) 2011-03-10
ECSP088871A (es) 2008-12-30
IL194813A0 (en) 2009-08-03
AR060994A1 (es) 2008-07-30
UY30334A1 (es) 2008-01-02
GT200700039A (es) 2008-06-02
MX2008014399A (es) 2008-11-27
NO20085060L (no) 2008-12-03
RS20080533A (en) 2009-09-08
KR101099161B1 (ko) 2011-12-27
EA200870423A1 (ru) 2009-04-28
NZ572361A (en) 2012-02-24
MA30411B1 (fr) 2009-05-04

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