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PE20080668A1 - Compuestos heterociclicos como inhibidores de la cinasa-2 de proteina activada por cinasa de proteina activada por mitogeno - Google Patents

Compuestos heterociclicos como inhibidores de la cinasa-2 de proteina activada por cinasa de proteina activada por mitogeno

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Publication number
PE20080668A1
PE20080668A1 PE2007001155A PE2007001155A PE20080668A1 PE 20080668 A1 PE20080668 A1 PE 20080668A1 PE 2007001155 A PE2007001155 A PE 2007001155A PE 2007001155 A PE2007001155 A PE 2007001155A PE 20080668 A1 PE20080668 A1 PE 20080668A1
Authority
PE
Peru
Prior art keywords
protein kinase
activated protein
amino
alkyl
inhibitors
Prior art date
Application number
PE2007001155A
Other languages
English (en)
Inventor
Lazlo Revesz
Achim Schlapbach
Rudolf Walchli
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37836874&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080668(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20080668A1 publication Critical patent/PE20080668A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

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Abstract

SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) DONDE R1 ES HALOGENO, CN, HIDROXILO, MERCAPTO, ENTRE OTROS; X ES O, S O NOH; R2 ES -C(A)(Q)-Y EN DONDE Q ES H O ALQUILO(C1-C6); A ES H O ALQUILO(C1-C6); Y ES AMINO, AMINO-OXILO, HIDROXILO, ALCOXILO(C1-C6), ENTRE OTROS; R3 ES -OH, -OR4 O -NHR4 DONDE R4 ES H O ALQUILO(C1-C6); O R2 Y R3 SE UNEN PARA FORMAR UN ANILLO DE 5 A 7 MIEMBROS; R7 ES H O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON AMINO, HIDROXILO, HALOGENO O CARBOXILO. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DEL ACIDO 2-AMINO-METIL-8-((E)-ESTIRIL)-1H-PIRROLO-[2,3-f]-ISOQUINOLIN-3-CARBOXILICO, 2-((E)-ESTIRIL)-9,10-DIHIDRO-8H-3,8,10-TRIAZA-PENTALEN-[2,1-a]-NAFTALEN-7-ONA, CLORHIDRATO DEL ACIDO 2-AMINO-METIL-8-CLORO-1H-PIRROLO-[2,3-f]-ISOQUINOLIN-3-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA CINASA-2 DE PROTEINA ACTIVADA POR CINASA DE PROTEINA ACTIVADA POR MITOGENO (MAPKAPK2) SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, ANEMIA HEMOLITICA, ESPONDILITIS ANQUILOSANTE, GASTRITIS, LUPUS ERITEMATOSO SISTEMICO
PE2007001155A 2006-08-30 2007-08-27 Compuestos heterociclicos como inhibidores de la cinasa-2 de proteina activada por cinasa de proteina activada por mitogeno PE20080668A1 (es)

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CL2007002499A1 (es) 2006-08-30 2008-03-14 Phenomix Corp Sales citrato y tartrato de compuestos derivados de acido pirrolidinilaminoacetilpirrolidinboronico, inhibidores de dpp-iv; metodo de preparacion; forma solida; combinacion farmaceutica, util para el tratamiento de diabetes.
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
CA2710477A1 (en) 2007-12-20 2009-07-09 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
ES2445896T3 (es) * 2009-03-20 2014-03-05 Nerviano Medical Sciences S.R.L. Uso de un inhibidor de quinasa para el tratamiento del timoma
CN103930165B (zh) * 2011-09-02 2018-05-25 纽约市哥伦比亚大学理事会 用以治疗肥胖症的代谢紊乱的CaMKII、IP3R、钙调神经磷酸酶、P38和MK2/3抑制剂
JP2016518316A (ja) 2013-03-15 2016-06-23 セルジーン アビロミクス リサーチ， インコーポレイテッド Ｍｋ２阻害剤およびそれらの使用
EP3046905A4 (en) 2013-09-17 2017-03-22 Pharmakea Inc. Vinyl autotaxin inhibitor compounds
US9951026B2 (en) 2013-09-17 2018-04-24 Pharmakea, Inc. Heterocyclic vinyl autotaxin inhibitor compounds
CN104140393B (zh) * 2013-12-10 2016-09-21 郑州泰基鸿诺医药股份有限公司 一种芳环/芳杂环叔丁醇酯类化合物的制备方法
CN107082780B (zh) * 2017-04-14 2020-08-14 山东省医学科学院药物研究所 一种具有吡咯骈异喹啉结构的生物碱及其制备方法与应用

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AU2007291575B2 (en) 2011-02-10
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RU2009111382A (ru) 2010-10-10
CA2660980A1 (en) 2008-03-06
BRPI0716198A2 (pt) 2013-11-12
KR20090046891A (ko) 2009-05-11
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