PE20070332A1 - Compuestos heteroaril-nitrilos sustituidos como inhibidores de cisteina proteasas - Google Patents
Compuestos heteroaril-nitrilos sustituidos como inhibidores de cisteina proteasasInfo
- Publication number
- PE20070332A1 PE20070332A1 PE2006001056A PE2006001056A PE20070332A1 PE 20070332 A1 PE20070332 A1 PE 20070332A1 PE 2006001056 A PE2006001056 A PE 2006001056A PE 2006001056 A PE2006001056 A PE 2006001056A PE 20070332 A1 PE20070332 A1 PE 20070332A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- heteroaryl
- inhibitors
- alkylen
- phenyl
- Prior art date
Links
- 102000005927 Cysteine Proteases Human genes 0.000 title abstract 2
- 108010005843 Cysteine Proteases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 201000004792 malaria Diseases 0.000 abstract 2
- 241000223960 Plasmodium falciparum Species 0.000 abstract 1
- 101000977048 Streptomyces cinnamonensis Uncharacterized protein in mutB 3'region Proteins 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 244000045947 parasite Species 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A COMPUESTOS HETEROARIL-NITRILOS SUSTITUIDOS DE FORMULA (I) EN DONDE R4 ES HALOGENO; R2 ES FENIL-ALQUILEN(C1-C3)-X, PIRIDIL-FENIL-ALQUILEN(C1-C3)-X O FENIL-ALQUILEN(C1-C3)-X-RJ; RJ ES Z -ALQUILEN(C1-C3)-Z O -C(O)Z; X E Y SON INDEPENDIENTEMENTE UN GRUPO HIDROCARBONADO SATURADO MONOCICLICO DE 6 MIEMBROS QUE CONTIENE 1 A 2 ATOMOS DE NITROGENO Y OPCIONALMENTE UN OXIGENO OPCIONALMENTE SUSTITUIDOS CON ALQUILO(C1-C4), OH, ALQUIL(C1-C4)OH, ENTRE OTROS. SON PREFERIDOS: N'-(5-BROMO-2-CIANO-4-PIRIMIDINIL)-N'-(CICLOPENTILMETIL)-4-[(4-METIL-1-PIPERAZINIL)METIL]BENZOHIDRAZIDA, N'-(5-BROMO-2-CIANO-4-PIRIMIDINIL)-N'-(CICLOPENTILMETIL)-4-[(4-HIDROXI-1-PIPERIDINIL)METIL]BENZOHIDRAZIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE CISTEINA PROTEASA HALLADAS EN EL PARASITO DEL PALUDISMO PLASMODIUM FALCIPARUM POR LO QUE SON UTILES EN EL TRATAMIENTO DE MALARIA
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05381043 | 2005-09-02 | ||
| EP06110666 | 2006-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070332A1 true PE20070332A1 (es) | 2007-05-11 |
Family
ID=37770277
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001057A PE20070612A1 (es) | 2005-09-02 | 2006-08-31 | Nuevos inhibidores de cisteina proteasas |
| PE2006001056A PE20070332A1 (es) | 2005-09-02 | 2006-08-31 | Compuestos heteroaril-nitrilos sustituidos como inhibidores de cisteina proteasas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001057A PE20070612A1 (es) | 2005-09-02 | 2006-08-31 | Nuevos inhibidores de cisteina proteasas |
Country Status (4)
| Country | Link |
|---|---|
| AR (2) | AR057110A1 (es) |
| PE (2) | PE20070612A1 (es) |
| TW (2) | TW200804351A (es) |
| WO (3) | WO2007025776A2 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20081471A1 (es) * | 2006-10-30 | 2008-12-31 | Glaxo Group Ltd | Derivados de heteroarilnitrilo como inhibidores de cisteina proteasa |
| EP2030621A1 (en) * | 2007-08-21 | 2009-03-04 | Glaxo Group Limited | Novel substituted pyrimidines as cysteine protease inhibitors |
| EP2168600A1 (en) | 2007-06-08 | 2010-03-31 | Nippon Chemiphar Co., Ltd. | Therapeutic or prophylactic agent for cerebral aneurysm |
| EP2216047A4 (en) | 2007-10-24 | 2011-12-28 | Nat Univ Corp Tokyo Med & Dent | Regulator for signaling of toll-like receptor, which comprises cathepsin inhibitor as active ingredient |
| DE102008063561A1 (de) * | 2008-12-18 | 2010-08-19 | Bayer Cropscience Ag | Hydrazide, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Insektizide |
| CN102267964B (zh) * | 2011-06-15 | 2014-06-18 | 浙江师范大学 | 3-羟基-2,3-二氢苯并呋喃衍生物及其合成方法和应用 |
| EP3778576B1 (en) * | 2018-03-28 | 2024-04-17 | Hanlim Pharmaceutical Co., Ltd. | 2-cyanopyrimidin-4-yl carbamate or urea derivative or salt thereof, and pharmaceutical composition including same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR036375A1 (es) * | 2001-08-30 | 2004-09-01 | Novartis Ag | Compuestos pirrolo [2,3-d] pirimidina -2- carbonitrilo, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de medicamentos |
-
2006
- 2006-08-31 AR ARP060103809A patent/AR057110A1/es not_active Application Discontinuation
- 2006-08-31 WO PCT/EP2006/008580 patent/WO2007025776A2/en active Application Filing
- 2006-08-31 PE PE2006001057A patent/PE20070612A1/es not_active Application Discontinuation
- 2006-08-31 TW TW095132087A patent/TW200804351A/zh unknown
- 2006-08-31 TW TW095132088A patent/TW200804352A/zh unknown
- 2006-08-31 WO PCT/EP2006/008578 patent/WO2007025774A2/en active Application Filing
- 2006-08-31 AR ARP060103810A patent/AR055624A1/es not_active Application Discontinuation
- 2006-08-31 PE PE2006001056A patent/PE20070332A1/es not_active Application Discontinuation
- 2006-08-31 WO PCT/EP2006/008579 patent/WO2007025775A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| TW200804352A (en) | 2008-01-16 |
| AR055624A1 (es) | 2007-08-29 |
| WO2007025774A2 (en) | 2007-03-08 |
| PE20070612A1 (es) | 2007-06-23 |
| AR057110A1 (es) | 2007-11-14 |
| WO2007025775A2 (en) | 2007-03-08 |
| WO2007025774A3 (en) | 2007-04-26 |
| TW200804351A (en) | 2008-01-16 |
| WO2007025776A3 (en) | 2007-05-03 |
| WO2007025776A2 (en) | 2007-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |