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PE20070209A1 - Encapsulacion de formulaciones lipidicas en polimeros entericos - Google Patents

Encapsulacion de formulaciones lipidicas en polimeros entericos

Info

Publication number
PE20070209A1
PE20070209A1 PE2006000900A PE2006000900A PE20070209A1 PE 20070209 A1 PE20070209 A1 PE 20070209A1 PE 2006000900 A PE2006000900 A PE 2006000900A PE 2006000900 A PE2006000900 A PE 2006000900A PE 20070209 A1 PE20070209 A1 PE 20070209A1
Authority
PE
Peru
Prior art keywords
lipid
phthalate
refers
encapsulation
medium
Prior art date
Application number
PE2006000900A
Other languages
English (en)
Inventor
Stephen M Mcallister
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20070209A1 publication Critical patent/PE20070209A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

SE REFIERE A UNA MICROCAPSULA CON UNA FORMULACION QUE COMPRENDE: A) UN NUCLEO LIPIDICO QUE CONTIENE AL MENOS UN VEHICULO LIPIDICO QUE FORMA UNA DISPERSION MOLECULAR LIQUIDA Y UNO O MAS INGREDIENTES ACTIVOS POCO SOLUBLES EN AGUA EN UNA CANTIDAD DE 0,01% A 20% DEL PESO TOTAL DEL NUCLEO LIPIDICO; ADEMAS COMPRENDE ESTERES DE ACIDOS GRASOS DE CADENA MEDIA O LARGA; TENSIOACTIVOS LIPIDICOS O MEJORADORES DE LA SOLUBILIZACION; LOS CUALES SE ENCAPSULAN DENTRO DE B) UNA CUBIERTA DE UN POLIMERO ENTERICO FORMADO POR UNO O MAS DE LOS POLIMEROS SELECCIONADOS DE ACETATO-FTALATO DE CELULOSA, FTALATO DE HIDROXIPROPILMETILCELULOSA, ALGINATOS, ENTRE OTROS; O COMBINACIONES; ADEMAS PUEDE COMPREDER UN PLASTIFICANTE Y UN PIGMENTO; DICHA CUBIERTA PRESENTA UNA DISOLUCION DESPRECIABLE EN MEDIO ACIDO PERO PUEDEN DISOLVERSE RAPIDAMNTE EN MEDIO ALCALINO. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION DE DICHAS MICROCAPSULAS POR EXCITACION VIBRATORIA CON DOBLE BOQUILLA
PE2006000900A 2005-07-26 2006-07-25 Encapsulacion de formulaciones lipidicas en polimeros entericos PE20070209A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70266905P 2005-07-26 2005-07-26

Publications (1)

Publication Number Publication Date
PE20070209A1 true PE20070209A1 (es) 2007-03-03

Family

ID=37507589

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000900A PE20070209A1 (es) 2005-07-26 2006-07-25 Encapsulacion de formulaciones lipidicas en polimeros entericos

Country Status (7)

Country Link
US (1) US20080199516A1 (es)
EP (1) EP1906940A2 (es)
JP (1) JP2009502841A (es)
AR (1) AR055587A1 (es)
PE (1) PE20070209A1 (es)
TW (1) TW200800305A (es)
WO (1) WO2007012478A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
CN101677964A (zh) 2007-04-04 2010-03-24 希格默伊德药业有限公司 他克莫司药物组合物
CA2942083C (en) * 2007-04-26 2019-01-29 Sigmoid Pharma Limited Manufacture of multiple minicapsules
DE102007048070A1 (de) * 2007-10-05 2009-04-09 Lanxess Deutschland Gmbh Verfahren zur Detektion von Oberflächenänderungen
CN102470106B (zh) 2009-05-18 2015-09-23 希格默伊德药业有限公司 包含油滴的组合物
EP2464341B1 (en) 2009-08-12 2022-07-06 Sublimity Therapeutics Limited Immunomodulatory compositions comprising a polymer matrix and an oil phase
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
GB201113775D0 (en) 2011-08-10 2011-09-21 British American Tobacco Co Capsule formation
GB201113776D0 (en) 2011-08-10 2011-09-21 British American Tobacco Co Capsule formation
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201304662D0 (en) 2013-03-14 2013-05-01 Sigmoid Pharma Ltd Compositions
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
PT3215127T (pt) 2014-11-07 2021-02-10 Sublimity Therapeutics Ltd Composições que compreendem ciclosporina
WO2019129454A1 (en) 2017-12-29 2019-07-04 Unilever N.V. Non-spherical microcapsule
CN113293129B (zh) * 2021-03-29 2022-06-17 浙江大学舟山海洋研究中心 一种促进成骨前体细胞增殖的功能肽混合粉及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6144810A (ja) * 1984-08-09 1986-03-04 Taisho Pharmaceut Co Ltd 腸溶性軟カプセル
AU591248B2 (en) * 1986-03-27 1989-11-30 Kinaform Technology, Inc. Sustained-release pharaceutical preparation
FR2663222A1 (fr) * 1990-06-13 1991-12-20 Medgenix Group Sa Microcapsule de liquide huileux.
DE4125133C2 (de) * 1991-07-30 1993-09-30 Nukem Gmbh Verfahren und Vorrichtung zur Herstellung von Alginatkugeln
US5430021A (en) * 1994-03-18 1995-07-04 Pharmavene, Inc. Hydrophobic drug delivery systems
JP3759986B2 (ja) * 1995-12-07 2006-03-29 フロイント産業株式会社 シームレスカプセルおよびその製造方法
JP4309045B2 (ja) * 1997-10-30 2009-08-05 森下仁丹株式会社 不飽和脂肪酸またはその誘導体を内容物とするカプセル製剤およびその製造法
WO2001024780A2 (en) * 1999-10-01 2001-04-12 Natco Pharma Limited Soft gel capsule resistant to gastric juices
US6759058B1 (en) * 2001-04-25 2004-07-06 Western Center For Drug Development College Of Pharmacy Western University Of Health Sciences Enteric-coated proliposomal formulations for poorly water soluble drugs
DE10164110A1 (de) * 2001-12-24 2003-07-10 Dragoco Gerberding Co Ag Mononuklear gefüllte Mikrokapseln
EP1362583A1 (de) * 2002-05-15 2003-11-19 CUM Taste Masking AG Verfahren zur Geschmacksmaskierung von Substanzen durch Mikroverkapselung
WO2004000201A1 (ja) * 2002-06-24 2003-12-31 Chugai Seiyaku Kabushiki Kaisha 非球形シームレスカプセルの製造方法及び製造装置
CA2520660C (en) * 2003-03-28 2013-08-20 Sigmoid Biotechnologies Limited Solid oral dosage form containing seamless microcapsules
EP1708687A1 (en) * 2004-01-16 2006-10-11 Glaxo Group Limited Encapsulation of lipid-based formulations in enteric polymers

Also Published As

Publication number Publication date
WO2007012478A3 (en) 2007-04-05
TW200800305A (en) 2008-01-01
WO2007012478A2 (en) 2007-02-01
EP1906940A2 (en) 2008-04-09
JP2009502841A (ja) 2009-01-29
AR055587A1 (es) 2007-08-29
US20080199516A1 (en) 2008-08-21

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