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PE20070122A1 - Proceso para preparar derivados de piperazina azindoloxoacetica sustituida con triazol y nuevas formas de sal producidas de los mismos - Google Patents

Proceso para preparar derivados de piperazina azindoloxoacetica sustituida con triazol y nuevas formas de sal producidas de los mismos

Info

Publication number
PE20070122A1
PE20070122A1 PE2006000714A PE2006000714A PE20070122A1 PE 20070122 A1 PE20070122 A1 PE 20070122A1 PE 2006000714 A PE2006000714 A PE 2006000714A PE 2006000714 A PE2006000714 A PE 2006000714A PE 20070122 A1 PE20070122 A1 PE 20070122A1
Authority
PE
Peru
Prior art keywords
azindoloxoacetica
triazole
piperazine
substituted
new forms
Prior art date
Application number
PE2006000714A
Other languages
English (en)
Inventor
Nachimuthu Soundararajan
Yuping Qiu
Wenhao Hu
Pierre Sirard
Roberto Droghini
Xinhua Qian
Shawn K Pack
Michael G Fakes
Feng Qian
Shan-Ming Kuang
Chiajen Lai
Blisse J Vakkalagadda
Qi Gao
Erquing Tang
Natalie
Ramakrishnan Chidambaram
Jean Lajeunesse
David R Kronenthal
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20070122A1 publication Critical patent/PE20070122A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA A, B, C, D ENTRE OTROS DONDE R18 ES H, ALQUILO; R1, R2 Y R3 SON CADA UNO H, HALOGENO, CIANO, NITRO, ENTRE OTROS. UN COMPUESTO PREFERIDO ES II. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A PROCEDIMIENTOS DE PREPRACION DE LOS COMPUESTOS MENCIONADOS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DEL SIDA
PE2006000714A 2005-06-22 2006-06-22 Proceso para preparar derivados de piperazina azindoloxoacetica sustituida con triazol y nuevas formas de sal producidas de los mismos PE20070122A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69300405P 2005-06-22 2005-06-22

Publications (1)

Publication Number Publication Date
PE20070122A1 true PE20070122A1 (es) 2007-03-11

Family

ID=37460063

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000714A PE20070122A1 (es) 2005-06-22 2006-06-22 Proceso para preparar derivados de piperazina azindoloxoacetica sustituida con triazol y nuevas formas de sal producidas de los mismos

Country Status (11)

Country Link
US (2) US7601715B2 (es)
EP (1) EP1907389B1 (es)
JP (1) JP5010593B2 (es)
CN (1) CN101243085A (es)
AR (1) AR055801A1 (es)
AT (1) ATE517898T1 (es)
ES (1) ES2368788T3 (es)
NO (1) NO341136B1 (es)
PE (1) PE20070122A1 (es)
TW (1) TW200740807A (es)
WO (1) WO2007002308A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601715B2 (en) * 2005-06-22 2009-10-13 Bristol-Myers Squibb Company Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
US7598380B2 (en) * 2005-08-03 2009-10-06 Bristol-Myers Squibb Company Method of preparation of azaindole derivatives
US20100010044A1 (en) * 2008-07-08 2010-01-14 Forest Laboratories Holdings Limited Novel crystalline form of 2-[4-(4-fluoro-benzyl)-piperidine-1-yl]-2-oxo-n-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-acetamide
PT2323633E (pt) * 2008-09-04 2012-05-29 Bristol Myers Squibb Co Composição farmacêutica estável para a administração optimizada de um inibidor de união de hiv
MX2012010666A (es) 2010-03-31 2012-10-05 Actelion Pharmaceuticals Ltd Derivados de isoquinolin-3-ilurea antibacterianos.
AR080908A1 (es) * 2010-04-16 2012-05-16 Novartis Ag Formulaciones de un piridazin -bipirazinilo
US20110263701A1 (en) * 2010-04-21 2011-10-27 Sigal Blau Gabapentin enacarbil compositions
CN102372707B (zh) * 2010-08-16 2015-08-19 上海药明康德新药开发有限公司 6-甲基-4-溴-1,6-二氢吡咯[2,3-c]吡啶-7-酮的合成方法
US8436168B2 (en) * 2011-01-31 2013-05-07 Bristol-Myers Squibb Company Methods of making HIV attachment inhibitor prodrug compound and intermediates
CN102993109A (zh) * 2012-12-03 2013-03-27 浙江工业大学 一种脒化合物的制备方法
CN105793263B (zh) 2013-12-05 2019-08-23 豪夫迈·罗氏有限公司 一种苯并[e]薁化合物及其晶型的合成
AR099677A1 (es) 2014-03-07 2016-08-10 Sumitomo Chemical Co Compuesto heterocíclico fusionado y su uso para el control de plagas
CN108863917A (zh) * 2017-05-16 2018-11-23 穆云 一种2,5-二甲氧基吡啶的制备方法
US12157753B2 (en) 2019-01-17 2024-12-03 ViiV Healthcare UK (No.4) Limited Process for preparing Fostemsavir

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3545461B2 (ja) 1993-09-10 2004-07-21 エーザイ株式会社 二環式ヘテロ環含有スルホンアミド誘導体
ZA949293B (en) 1993-12-08 1995-08-17 Nihon Nohyaku Co Ltd Hydrazine derivatives and uses thereof
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
US20020061892A1 (en) 2000-02-22 2002-05-23 Tao Wang Antiviral azaindole derivatives
RU2303038C2 (ru) 2001-02-02 2007-07-20 Бристол-Маерс Сквибб Компани Азаиндолоксоуксусные производные пиперазины и фармацевтическая композиция на их основе
US20030207910A1 (en) 2001-02-02 2003-11-06 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US20040110785A1 (en) 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US20040063744A1 (en) 2002-05-28 2004-04-01 Tao Wang Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
US7745625B2 (en) * 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7601715B2 (en) * 2005-06-22 2009-10-13 Bristol-Myers Squibb Company Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein

Also Published As

Publication number Publication date
NO20076575L (no) 2008-03-18
JP2008546795A (ja) 2008-12-25
ES2368788T3 (es) 2011-11-22
EP1907389B1 (en) 2011-07-27
WO2007002308A9 (en) 2007-03-01
WO2007002308A3 (en) 2007-07-12
NO341136B1 (no) 2017-08-28
WO2007002308A2 (en) 2007-01-04
TW200740807A (en) 2007-11-01
CN101243085A (zh) 2008-08-13
AR055801A1 (es) 2007-09-05
JP5010593B2 (ja) 2012-08-29
US20100076191A1 (en) 2010-03-25
US7601715B2 (en) 2009-10-13
US20060293304A1 (en) 2006-12-28
EP1907389A2 (en) 2008-04-09
US7968718B2 (en) 2011-06-28
ATE517898T1 (de) 2011-08-15

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