PE20070647A1 - 3-ALKYLAZETHYL DINE DERIVATIVES SUBSTITUTED WITH HETEROCICLES AS ANTAGONISTS OF CANABINOID RECEPTOR 1 (CB1) - Google Patents
3-ALKYLAZETHYL DINE DERIVATIVES SUBSTITUTED WITH HETEROCICLES AS ANTAGONISTS OF CANABINOID RECEPTOR 1 (CB1)Info
- Publication number
- PE20070647A1 PE20070647A1 PE2006001495A PE2006001495A PE20070647A1 PE 20070647 A1 PE20070647 A1 PE 20070647A1 PE 2006001495 A PE2006001495 A PE 2006001495A PE 2006001495 A PE2006001495 A PE 2006001495A PE 20070647 A1 PE20070647 A1 PE 20070647A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- alkylazethyl
- antagonists
- fluoro
- heterocicles
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 abstract 9
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 7
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical group [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE 3-ALQUILAZETIDINA DE FORMULA (I) DONDE X ES HIDROXI, NH2, METILO O METOXI; R2 Y R3 SON CADA UNO H, METILO, TRIFLUOROMETILO, ENTRE OTROS; R8 ES H, HALOGENO, METILO, ENTRE OTROS; R9 ES H, F, CN, ENTRE OTROS; R10 ES H, CF3, CN, METILO, ENTRE OTROS. SON COMPUESTOS PRERERIDOS: 3-[(S)-(4-CLOROFENIL)(3-{(1S)-2-FLUORO-1-[3-FLUORO-5-(5-OXO-4,5-DIHIDRO-1,3,4-OXADIAZOL-2-IL)FENIL]-2-METILPROPIL}AZETIDIN-1-IL)METIL]BENZONITRILO, 3-[(S)-(4-CLOROFENIL)(3-{(1S)-2-FLUORO-1-[3-FLUORO-5-(1,3,4-OXADIAZOL-2-IL)FENIL]-2-METILPROPIL}AZETIDIN-1-IL)METIL]BENZONITRILO, 3-[(S)-(3-{(1S)-1-[3-(5-AMINO-1,3,4-OXADIAZOL-2-IL)-5-FLUOROFENIL]-2-FLUORO-2-METILPROPIL}AZETIDIN-1-IL)(4-CLOROFENIL)METIL]BENZONITRILO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR CANABINOIDE 1 (CB1) SIENDO UTILES PARA EL TRATAMIENTO DE PSICOSIS, ENFERMEDAD DE ALZHEIMER, MIGRANA, NEUROPATIA, ESCLEROSIS MULTIPLEREFERS TO COMPOUNDS DERIVED FROM 3-ALKYLAZETHYL DINE OF FORMULA (I) WHERE X IS HYDROXY, NH2, METHYL OR METHOXY; R2 AND R3 ARE EACH H, METHYL, TRIFLUOROMETHYL, AMONG OTHERS; R8 IS H, HALOGEN, METHYL, AMONG OTHERS; R9 IS H, F, CN, AMONG OTHERS; R10 IS H, CF3, CN, METHYL, AMONG OTHERS. THE PRERED COMPOUNDS ARE: 3 - [(S) - (4-CHLOROPHENYL) (3 - {(1S) -2-FLUORO-1- [3-FLUORO-5- (5-OXO-4,5-DIHYDRO-1, 3,4-OXADIAZOL-2-IL) PHENYL] -2-METHYLPROPYL} AZETIDIN-1-IL) METHYL] BENZONITRILE, 3 - [(S) - (4-CHLOROPHENYL) (3 - {(1S) -2-FLUORINE -1- [3-FLUORO-5- (1,3,4-OXADIAZOL-2-IL) PHENYL] -2-METHYLPROPYL} AZETIDIN-1-IL) METHYL] BENZONITRILE, 3 - [(S) - (3- {(1S) -1- [3- (5-AMINO-1,3,4-OXADIAZOL-2-IL) -5-FLUOROPHENYL] -2-FLUORO-2-METHYLPROPYL} AZETIDIN-1-IL) (4- CHLOROPHENYL) METHYL] BENZONITRILE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE CANABINOID RECEPTOR 1 (CB1) ANTAGONISTS, BEING USEFUL FOR THE TREATMENT OF PSYCHOSIS, ALZHEIMER'S DISEASE, MIGRANA, NEUROPATHY, MULTIPLE SCLEROSIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74018305P | 2005-11-28 | 2005-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070647A1 true PE20070647A1 (en) | 2007-08-11 |
Family
ID=37779312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001495A PE20070647A1 (en) | 2005-11-28 | 2006-11-23 | 3-ALKYLAZETHYL DINE DERIVATIVES SUBSTITUTED WITH HETEROCICLES AS ANTAGONISTS OF CANABINOID RECEPTOR 1 (CB1) |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1954692A1 (en) |
| KR (1) | KR20080073721A (en) |
| AR (1) | AR058199A1 (en) |
| BR (1) | BRPI0619018A2 (en) |
| CR (1) | CR10014A (en) |
| DO (1) | DOP2006000261A (en) |
| EC (1) | ECSP088477A (en) |
| IL (1) | IL191586A0 (en) |
| MA (1) | MA30086B1 (en) |
| NO (1) | NO20082919L (en) |
| PE (1) | PE20070647A1 (en) |
| RU (1) | RU2008126248A (en) |
| SV (1) | SV2009002917A (en) |
| TW (1) | TW200804317A (en) |
| WO (1) | WO2007062193A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7906652B2 (en) | 2005-11-28 | 2011-03-15 | Merck Sharp & Dohme Corp. | Heterocycle-substituted 3-alkyl azetidine derivatives |
| EP2025674A1 (en) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs |
| US20100292282A1 (en) * | 2007-10-24 | 2010-11-18 | Campos Kevin R | Synthesis and crystalline forms of cb-1 antagonist/inverse agonist |
| EP2611788B1 (en) | 2010-09-03 | 2017-04-12 | University of Florida Research Foundation, Incorporated | Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use |
| EP2683704B1 (en) | 2011-03-08 | 2014-12-17 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120054A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2805817B1 (en) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | PHARMACEUTICAL COMPOSITIONS CONTAINING AZETIDINE DERIVATIVES, NOVEL AZETIDINE DERIVATIVES AND THEIR PREPARATION |
| FR2805810B1 (en) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | PHARMACEUTICAL COMPOSITIONS CONTAINING 3- AMINO-AZETIDINE DERIVATIVES, THE NEW DERIVATIVES AND THEIR PREPARATION |
| FR2805818B1 (en) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | AZETIDINE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| KR20060019587A (en) * | 2003-06-11 | 2006-03-03 | 머크 앤드 캄파니 인코포레이티드 | Substituted 3-alkyl and 3-alkenyl azetidine derivatives |
| CN101426500A (en) * | 2005-05-02 | 2009-05-06 | 默克公司 | Combination of dipeptidyl peptidase-iv inhibitor and a cannabinoid cb1 receptor antagonist for the treatment of diabetes and obesity |
-
2006
- 2006-11-20 AR ARP060105076A patent/AR058199A1/en unknown
- 2006-11-22 TW TW095143274A patent/TW200804317A/en unknown
- 2006-11-22 RU RU2008126248/04A patent/RU2008126248A/en not_active Application Discontinuation
- 2006-11-22 EP EP06838347A patent/EP1954692A1/en not_active Withdrawn
- 2006-11-22 BR BRPI0619018A patent/BRPI0619018A2/en not_active IP Right Cessation
- 2006-11-22 KR KR1020087012880A patent/KR20080073721A/en not_active Withdrawn
- 2006-11-22 WO PCT/US2006/045328 patent/WO2007062193A1/en active Application Filing
- 2006-11-23 DO DO2006000261A patent/DOP2006000261A/en unknown
- 2006-11-23 PE PE2006001495A patent/PE20070647A1/en not_active Application Discontinuation
-
2008
- 2008-05-20 IL IL191586A patent/IL191586A0/en unknown
- 2008-05-22 CR CR10014A patent/CR10014A/en not_active Application Discontinuation
- 2008-05-27 EC EC2008008477A patent/ECSP088477A/en unknown
- 2008-05-28 SV SV2008002917A patent/SV2009002917A/en not_active Application Discontinuation
- 2008-06-25 MA MA31075A patent/MA30086B1/en unknown
- 2008-06-27 NO NO20082919A patent/NO20082919L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR058199A1 (en) | 2008-01-23 |
| NO20082919L (en) | 2008-08-27 |
| ECSP088477A (en) | 2008-06-30 |
| RU2008126248A (en) | 2010-01-10 |
| MA30086B1 (en) | 2008-12-01 |
| CR10014A (en) | 2008-07-29 |
| TW200804317A (en) | 2008-01-16 |
| EP1954692A1 (en) | 2008-08-13 |
| DOP2006000261A (en) | 2007-07-15 |
| SV2009002917A (en) | 2009-02-19 |
| WO2007062193A1 (en) | 2007-05-31 |
| KR20080073721A (en) | 2008-08-11 |
| IL191586A0 (en) | 2008-12-29 |
| BRPI0619018A2 (en) | 2016-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |