PE20061134A1 - COMPOUNDS DERIVED FROM PYRIMIDINE FUSED AS INHIBITORS OF TYROSINE KINASE - Google Patents
COMPOUNDS DERIVED FROM PYRIMIDINE FUSED AS INHIBITORS OF TYROSINE KINASEInfo
- Publication number
- PE20061134A1 PE20061134A1 PE2005001389A PE2005001389A PE20061134A1 PE 20061134 A1 PE20061134 A1 PE 20061134A1 PE 2005001389 A PE2005001389 A PE 2005001389A PE 2005001389 A PE2005001389 A PE 2005001389A PE 20061134 A1 PE20061134 A1 PE 20061134A1
- Authority
- PE
- Peru
- Prior art keywords
- inhibitors
- tyrosine kinase
- pyrrolo
- pyrimidin
- chloro
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 title abstract 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- -1 {3-CHLORO-4 - [(3-FLUOROBENZYL) OXY] PHENYL} AMINO Chemical class 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE W ES C(R1) O N, DONDE R1 ES H, O UN GRUPO OPCIONALMENTE SUSTITUIDO UNIDO A TRAVES DE UN C, N U O; A ES ARILO(C6-C18) O HETEROARILO(C5-C6) OPCIONALMENTE SUSTITUIDO; X1 ES O, S, SO, SO2, ENTRE OTROS; R2 ES H, GRUPO OPCIONALMENTE SUSTITUIDO UNIDO A TRAVES DE UN C O S, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-{2-[4-({3-CLORO-4-[(3-FLUOROBENCIL)OXI]FENIL}AMINO)-5H-PIRROLO[3,2-d]PIRIMIDIN-5-IL]ETOXI}ETANOL, 2-{2-[4-({3-CLORO-4-[3-(TRIFLUOROMETIL)FENOXI]FENIL}AMINO)-5H-PIRROLO[3,2-d]PIRIMIDIN-5-IL]ETOXI}ETANOL, N-{2-[4-({3-CLORO-4-[3-(TRIFLUOROMETIL)FENOXI]FENIL}AMINO)-5H-PIRROLO[3,2-d]PIRIMIDIN-5-IL]ETIL}-3-HIDROXI-3-METILBUTANAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE TIROSINA QUINASA SIENDO UTILES EN EL TRATAMIENTO DE CANCERREFERS TO A COMPOUND OF FORMULA (I) WHERE W IS C (R1) O N, WHERE R1 IS H, OR AN OPTIONALLY SUBSTITUTE GROUP JOINED THROUGH A C, N OR O; A IS ARYL (C6-C18) OR HETEROARYL (C5-C6) OPTIONALLY SUBSTITUTED; X1 IS O, S, SO, SO2, AMONG OTHERS; R2 IS H, OPTIONALLY SUBSTITUTED GROUP JOINED THROUGH A C OR S, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 2- {2- [4 - ({3-CHLORO-4 - [(3-FLUOROBENZYL) OXY] PHENYL} AMINO) -5H-PYRROLO [3,2-d] PYRIMIDIN-5-IL] ETOXY } ETHANOL, 2- {2- [4 - ({3-CHLORO-4- [3- (TRIFLUORomethyl) PHENOXY] PHENYL} AMINO) -5H-PYRROLO [3,2-d] PYRIMIDIN-5-IL] ETHOXY} ETHANOL, N- {2- [4 - ({3-CHLORO-4- [3- (TRIFLUORomethyl) PHENOXY] PHENYL} AMINO) -5H-PYRROLO [3,2-d] PYRIMIDIN-5-IL] ETHYL} - 3-HYDROXY-3-METHYLBUTANAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SAID COMPOUNDS ARE INHIBITORS OF TYROSINE KINASE, BEING USEFUL IN THE TREATMENT OF CANCER
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005058231 | 2005-03-02 | ||
| PCT/JP2005/010451 WO2005118588A1 (en) | 2004-06-02 | 2005-06-01 | Fused heterocyclic compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061134A1 true PE20061134A1 (en) | 2006-12-14 |
Family
ID=37715933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001389A PE20061134A1 (en) | 2005-03-02 | 2005-11-30 | COMPOUNDS DERIVED FROM PYRIMIDINE FUSED AS INHIBITORS OF TYROSINE KINASE |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR051782A1 (en) |
| PE (1) | PE20061134A1 (en) |
-
2005
- 2005-11-30 AR ARP050105009A patent/AR051782A1/en not_active Application Discontinuation
- 2005-11-30 PE PE2005001389A patent/PE20061134A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR051782A1 (en) | 2007-02-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20080538A1 (en) | FUSED HETEROCYCLIC DERIVATIVE AND ITS USE | |
| PE20081806A1 (en) | IMIDAZO- AND SUBSTITUTE TRIAZOLOPYRIMIDINES | |
| NO20071290L (en) | Enantiomerically pure amino heteroaryl compounds as protein kinase inhibitors | |
| PE20091243A1 (en) | FUSED HETEROCYCLIC COMPOUND | |
| IL276946B (en) | Antiproliferative compounds and methods of use | |
| EA200600317A1 (en) | DERIVATIVES OF OMEGA-CARBOXYaryldiphenylmoleum (OPTIONS), PHARMACEUTICAL COMPOSITION (OPTIONS) AND METHOD OF TREATMENT AND PREVENTION OF DISEASES AND STATES WITH THEIR USE (OPTIONS) | |
| PE20091955A1 (en) | DERIVATIVES OF QUINOXALIN- AND QUINOLIN-CARBOXAMIDE | |
| PE20061067A1 (en) | PYRIMIDINE DERIVATIVES | |
| PE20070113A1 (en) | QUINOLINE AND QUINAZOLINE DERIVATIVES AS INHIBITORS OF FLT3 AND TRKB TYROSINQUINASES | |
| CY1109299T1 (en) | Methanesulfonic SALT 3 - [(2 - {[4-hexyloxycarbonylamino-imino-methyl) -phenylamino] -methyl} -1-methyl-1H-benzimidazole-5-carbonyl) -pyridin-2-yl-amino] -propionic acid ethyl ester and USE THIS AS MEDICINAL | |
| PE20070593A1 (en) | PYRROLOPYRIMIDINE COMPOUNDS AS SYK INHIBITORS | |
| AR051735A1 (en) | PIRROLIC INHIBITORS OF THE PROTEIN QUINASA ERK, SYNTHESIS AND INTERMEDIARIES OF THE SAME. | |
| PE20051046A1 (en) | DIARYL-UREA DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | |
| PE20090837A1 (en) | NEW CHEMICALS | |
| EA200701470A1 (en) | METHODS OF OBTAINING DERIVATIVES OF 4- (FENOXY-5-METHYLPYRIMIDIN-4-ILOXI) PIPERIDIN-1-CARBIC ACID AND RELATED COMPOUNDS | |
| ATE431345T1 (en) | AZABICYCLO-(3,1,0)-HEXANE DERIVATIVES SUITABLE AS MODULATORS OF DOPAMINE D3 RECEPTORS | |
| PE20080069A1 (en) | BICYCLE COMPOUNDS AS AGONISTS OF THE RECEPTOR 40 COUPLED TO PROTEIN G (GPR40) | |
| PE20070218A1 (en) | AMINO-HYDANTOIN CYCLOALKYL COMPOUNDS AND USE OF THESE FOR THE MODULATION OF ß-SECRETASE | |
| RU2012110882A (en) | 6-AMINOCHINAZOLINE OR 3-CYANOCHINOLINE DERIVATIVES, METHODS FOR THEIR PRODUCTION AND THEIR PHARMACEUTICAL APPLICATIONS | |
| PE20081059A1 (en) | DERIVATIVES OF PYRIMIDINES AS INHIBITORS OF THE ACTIVITY OF BRUTON'S TYROSINE KINASE (BTK) | |
| EA200800728A1 (en) | POLYMORPHES OF BENZOATIC SALT 2 - [[6 - [(3R) -3-AMINO-1-PIPERIDINYL] -3,4-DIHYDRO-3-METHYL-2,4-DIOXO-1 (2H) -PYRIMIDINYL] METHYL] BENZONITRIL AND METHODS OF THEIR APPLICATION | |
| RU2006147267A (en) | CONDENSED HETEROCYCLIC COMPOUND | |
| RU2008123839A (en) | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | |
| BRPI0709007A2 (en) | 8-heteroarylpurine mnk2 inhibitors for treatment of metabolic disorders | |
| PE20120814A1 (en) | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |