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PE20060373A1 - Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 - Google Patents

Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2

Info

Publication number
PE20060373A1
PE20060373A1 PE2005000715A PE2005000715A PE20060373A1 PE 20060373 A1 PE20060373 A1 PE 20060373A1 PE 2005000715 A PE2005000715 A PE 2005000715A PE 2005000715 A PE2005000715 A PE 2005000715A PE 20060373 A1 PE20060373 A1 PE 20060373A1
Authority
PE
Peru
Prior art keywords
piperidinyl
carboxamide
inhibitors
indazol
kinase activity
Prior art date
Application number
PE2005000715A
Other languages
English (en)
Inventor
Jeffrey K Kerns
Christine Edwards
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20060373A1 publication Critical patent/PE20060373A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/16—Emollients or protectives, e.g. against radiation
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE Z ES ARILO O HETEROARILO SUSTITUIDO O NO CON HALO, ALQUILO C1-C6, CN, ENTRE OTROS; R1 ES H, HALO, WX; W ES UN ENLACE, ALQUILENO C1-C6; X ES ARILO, HETEROARILO, HETEROCICLOALQUILO, CICLOALQUILO C4-C7, ENTRE OTROS.SON COMPUESTOS PREFERIDOS: 4-[7-(AMINOCARBONIL)-5-FENIL-1H-INDAZOL-3-IL]-1-PIPERIDINCARBOXILATO DE 1,1-DIMETILETILO; HIDROCLORURO DE 5-FENIL-3-(4-PIPERIDINIL)-1H-INDAZOL-7-CARBOXAMIDA; 3-{1-[(1,2-DIMETIL-1H-IMIDAZOL-4-IL)SULFONIL]-4-PIPERIDINIL}-5FENIL-1H-INDAZOL-7-CARBOXAMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE IKK2, UTILES EN EL TRATAMIENTO DE TRASTORNOS INFLAMATORIOS Y DE REPARACION TISULAR TALES COMO ARTRITIS REUMATOIDE, ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA
PE2005000715A 2004-06-24 2005-06-22 Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 PE20060373A1 (es)

Applications Claiming Priority (1)

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US58265504P 2004-06-24 2004-06-24

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PE20060373A1 true PE20060373A1 (es) 2006-04-29

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US (1) US8501780B2 (es)
EP (1) EP1758578B1 (es)
JP (1) JP5017105B2 (es)
KR (1) KR20070043940A (es)
CN (1) CN101005836A (es)
AR (1) AR050253A1 (es)
AT (1) ATE493396T1 (es)
AU (1) AU2005258332A1 (es)
BR (1) BRPI0512533A (es)
CA (1) CA2571712A1 (es)
DE (1) DE602005025632D1 (es)
ES (1) ES2358579T3 (es)
IL (1) IL179747A0 (es)
MA (1) MA28727B1 (es)
MX (1) MXPA06014481A (es)
NO (1) NO20070076L (es)
PE (1) PE20060373A1 (es)
RU (1) RU2007102576A (es)
TW (1) TW200616967A (es)
WO (1) WO2006002434A2 (es)
ZA (1) ZA200609759B (es)

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US20070281933A1 (en) 2007-12-06
EP1758578A4 (en) 2009-05-27
JP5017105B2 (ja) 2012-09-05
DE602005025632D1 (de) 2011-02-10
ZA200609759B (en) 2007-10-31
TW200616967A (en) 2006-06-01
MA28727B1 (fr) 2007-07-02
ATE493396T1 (de) 2011-01-15
BRPI0512533A (pt) 2008-03-25
WO2006002434A2 (en) 2006-01-05
CN101005836A (zh) 2007-07-25
KR20070043940A (ko) 2007-04-26
CA2571712A1 (en) 2006-01-05
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MXPA06014481A (es) 2007-03-01
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