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PE20060336A1 - Compuestos derivados de 1-amino-ftalazina como moduladores de mch1 - Google Patents

Compuestos derivados de 1-amino-ftalazina como moduladores de mch1

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Publication number
PE20060336A1
PE20060336A1 PE2005000413A PE2005000413A PE20060336A1 PE 20060336 A1 PE20060336 A1 PE 20060336A1 PE 2005000413 A PE2005000413 A PE 2005000413A PE 2005000413 A PE2005000413 A PE 2005000413A PE 20060336 A1 PE20060336 A1 PE 20060336A1
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PE
Peru
Prior art keywords
alkyl
halogen
naftilmetil
alkylene
amine
Prior art date
Application number
PE2005000413A
Other languages
English (en)
Inventor
Jean Michel Augereau
Gilles Courtemanche
Michel Geslin
Original Assignee
Sanofi Aventis
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Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20060336A1 publication Critical patent/PE20060336A1/es

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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

REFERIDA A UN COMPUESTO DERIVADO DE 1-AMINO-FTALAZINA DE FORMULA I, DONDE A ES ALQUILENO C1-C4 EVENTUALMENTE SUSTITUIDOS POR UNO O MAS GRUPOS R9; B ES ALQUILENO C1-C4 EVENTUALMENTE SUSTITUIDO POR UNO O MAS GRUPOS R10; R9 Y R10 SON H O ALQUILO C1-C5, ENTRE OTROS; L ES UN ENLACE SIMPLE O ALQUILENO C1-C2, -CH=CH-, ENTRE OTROS; R1 ES ARILO O HETEROARILO, QUE PUEDEN ESTAR EVENTUALMENTE SUSTITUIDOS POR UNO O MAS RADICALES Z; R2 Y R3 SON H, ALQUILO C1-C3, ENTRE OTROS; R4 ES H, ALQUILO C1-C3, ENTRE OTROS; R5 ES H, HALOGENO, ALQUILO C1-C5, ENTRE OTROS; R6 ES H, HALOGENO, ALQUILO C1-C5, ENTRE OTROS; R7 ES H, HALOGENO, ALQUILO C1-C5, ENTRE OTROS; R8 ES H, HALOGENO, ALQUILO C1-C5, ENTRE OTROS; Z ES H, HALOGENO, ALQUILO C1-C5, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION Y UN PROCEDIMIENTO DE PREPARACION. SON COMPUESTOS PREFERIDOS: 7-METOXI-4-(4-METOXIFENIL)-N-[8-(2-NAFTILMETIL)-8-AZABICILO[3.2.1]OCT-3-IL]FTALAZIN-1-AMINA, 7-METOXI-4-(4-METOXIFENIL)-N-[1-(2-NAFTILMETIL)-PIPERIDIN-4-IL]FTALAZIN-1-AMINA, 7-METOXI-4-(3-METOXIFENIL)-N-[1-(2-NAFTILMETIL)-PIPERIDIN-4-IL]FTALAZIN-1-AMINA, ENTRE OTROS. DICHOS COMPUESTOS MODULAN SELECTIVAMENTE LA ACTIVIDAD DEL RECEPTOR 1 DE LA HORMONA CONCENTRADORA DE MELANINA (MCH1) Y SON UTILES PARA EL TRATAMIENTO DE LAS ENFERMEDADES QUE PRESENTAN TRASTORNOS DE LA REGULACION DEL EQUILIBRIO ENERGETICO ASI COMO TAMBIEN PARA EL TRATAMIENTO DE LA OBESIDAD, ENTRE OTRAS
PE2005000413A 2004-04-13 2005-04-13 Compuestos derivados de 1-amino-ftalazina como moduladores de mch1 PE20060336A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0403806A FR2868780B1 (fr) 2004-04-13 2004-04-13 Derives de la 1-amino-phthalazine, leur preparation et leur application en therapeutique

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PE20060336A1 true PE20060336A1 (es) 2006-05-15

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US (1) US7423030B2 (es)
EP (1) EP1737840B1 (es)
JP (1) JP4918477B2 (es)
KR (1) KR20070007361A (es)
CN (1) CN1953972A (es)
AR (1) AR049543A1 (es)
AT (1) ATE372998T1 (es)
AU (1) AU2005235766A1 (es)
BR (1) BRPI0509910A (es)
CA (1) CA2562100A1 (es)
DE (1) DE602005002470T2 (es)
DO (1) DOP2005000062A (es)
FR (1) FR2868780B1 (es)
GT (1) GT200500089A (es)
IL (1) IL178402A0 (es)
MA (1) MA28575B1 (es)
MX (1) MXPA06011829A (es)
NO (1) NO20065184L (es)
PE (1) PE20060336A1 (es)
RU (1) RU2006139952A (es)
SV (1) SV2005002083A (es)
TW (1) TW200607800A (es)
UY (1) UY28855A1 (es)
WO (1) WO2005103033A1 (es)

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JP5149009B2 (ja) * 2004-09-20 2013-02-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体
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BRPI0515477A (pt) * 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos bicìclicos e o uso dos mesmos como inibidores de estaroil-coa-desaturase (scd)
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FR2891828B1 (fr) * 2005-10-12 2007-12-21 Sanofi Aventis Sa Derives de la 1-amino-phtalazine substituee, leur preparation et leur application en therapeutique
FR2891825B1 (fr) * 2005-10-12 2007-12-14 Sanofi Aventis Sa Derives de la 1-amino-isoquinoline, leur preparation et leur application en therapeutique
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AU2010288523A1 (en) 2009-08-26 2012-03-15 Sanofi Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
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WO2012120051A1 (de) 2011-03-08 2012-09-13 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
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EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
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AU2005235766A1 (en) 2005-11-03
ATE372998T1 (de) 2007-09-15
FR2868780B1 (fr) 2008-10-17
DOP2005000062A (es) 2006-10-15
UY28855A1 (es) 2005-11-30
MXPA06011829A (es) 2007-01-16
NO20065184L (no) 2007-01-11
GT200500089A (es) 2005-10-31
RU2006139952A (ru) 2008-05-20
EP1737840B1 (fr) 2007-09-12
EP1737840A1 (fr) 2007-01-03
JP4918477B2 (ja) 2012-04-18
CA2562100A1 (fr) 2005-11-03
US7423030B2 (en) 2008-09-09
DE602005002470T2 (de) 2008-06-12
IL178402A0 (en) 2007-02-11
US20070099895A1 (en) 2007-05-03
TW200607800A (en) 2006-03-01
WO2005103033A1 (fr) 2005-11-03
MA28575B1 (fr) 2007-05-02
AR049543A1 (es) 2006-08-16
DE602005002470D1 (de) 2007-10-25
CN1953972A (zh) 2007-04-25
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