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PE20060186A1 - SELECTED CGRP ANTAGONISTS, PROCEDURES FOR THEIR PREPARATION AS WELL AS THEIR USE AS A MEDICINE - Google Patents

SELECTED CGRP ANTAGONISTS, PROCEDURES FOR THEIR PREPARATION AS WELL AS THEIR USE AS A MEDICINE

Info

Publication number
PE20060186A1
PE20060186A1 PE2005000434A PE2005000434A PE20060186A1 PE 20060186 A1 PE20060186 A1 PE 20060186A1 PE 2005000434 A PE2005000434 A PE 2005000434A PE 2005000434 A PE2005000434 A PE 2005000434A PE 20060186 A1 PE20060186 A1 PE 20060186A1
Authority
PE
Peru
Prior art keywords
piperidin
oxo
methyl
benzodiazepin
piperazin
Prior art date
Application number
PE2005000434A
Other languages
Spanish (es)
Inventor
Stephan Georg Muller
Klaus Rudolf
Dirk Stenkamp
Fabio Paleari
Kirsten Arndt
Henri Doods
Gerhard Schaenzle
Marco Santagostino
Phillip Lusteberger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20060186A1 publication Critical patent/PE20060186A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE A ES O, S; X ES O, S; Q ES UN HETEROCICLO CONSISTENTE EN 2 O3 ANILLOS CONDENSADOS, EN CADA CASO DE 4-8 MIEMBROS, SATURADOS, PARCIAL O TOTALMENTE INSATURADOS INDEPENDIENTEMENTE UNO DE OTRO, DONDE EL HETEROCICLO PRESENTA 1-5 HETEROATOMOS, SELECCIONADOS ENTRE O, N, S; R1 ES HETEROCICLO AZA, DIAZA, OXAZA, S,S-DIOXIDO-TIADIAZA, ENTRE OTROS; R2 ES H, FENILMETILO, ALQUILO C2-C7 SUSTIUTIDO, ENTRE OTROS; R3 ES H, ALQUILO C1-C3 SUSTITUIDO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ESTER (R)-1-(7-METIL-1H-INDAZOL-5-ILMETIL)-2-[4-(4-METIL-PIPERAZIN-1-IL)-PIPERIDIN-1-IL]-2-OXO-ETILICO DE ACIDO 4-(2-OXO-1,2,4,5-TETRAHIDRO-1,3-BENZODIAZEPIN-3-IL)PIPERIDIN-1-CARBOXILICO; ESTER (R)-1-(4-AMINO-3-METIL-5-NITRO-BENCIL)-2-[4-(4-METIL-PIPERAZIN-1-IL)-PIPERIDIN-1-IL]-2-OXO-ETILICO DE ACIDO 4-(2-OXO-1,2,4,5-TETRAHIDRO-1,3-BENZODIAZEPIN-3-IL)PIPERIDIN-1-CARBOXILICO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS DE CGRP UTILES EN EL TRATAMIENTO AGUDO O PROFILACTICO DE CEFALEAS, ENFERMEDADES CARDIOVASCULARES, ARTRITIS, ENTRE OTROSREFERS TO A COMPOUND OF FORMULA I, WHERE A IS O, S; X IS O, S; Q IS A HETEROCYCLE CONSISTENT OF 2 OR 3 CONDENSED RINGS, IN EACH CASE OF 4-8 MEMBERS, SATURATED, PARTIALLY OR TOTALLY INSATURATED, INDEPENDENTLY ONE OF THE OTHER, WHERE THE HETEROCYCLE PRESENTS 1-5 HETEROATOMS, SELECTED AMONG O, N, S; R1 IS HETEROCICLO AZA, DIAZA, OXAZA, S, S-DIOXIDO-TIADIAZA, AMONG OTHERS; R2 IS H, PHENYLMETHYL, SUBSTITUTED C2-C7 ALKYL, AMONG OTHERS; R3 IS H, C1-C3 ALKYL SUBSTITUTED, AMONG OTHERS. PREFERRED COMPOUNDS ARE: ESTER (R) -1- (7-METHYL-1H-INDAZOL-5-ILMETYL) -2- [4- (4-METHYL-PIPERAZIN-1-IL) -PIPERIDIN-1-IL] -2 -OXO-ETHYL OF 4- (2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL) PIPERIDIN-1-CARBOXYL ACID; ESTER (R) -1- (4-AMINO-3-METHYL-5-NITRO-BENZYL) -2- [4- (4-METHYL-PIPERAZIN-1-IL) -PIPERIDIN-1-IL] -2-OXO - 4- (2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL) PIPERIDIN-1-CARBOXYL ACID ETHYL; AMONG OTHERS. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS ARE USEFUL ANTAGONISTS OF CGRP IN THE ACUTE OR PROPHYLACTIC TREATMENT OF HEADACHES, CARDIOVASCULAR DISEASES, ARTHRITIS, AMONG OTHERS

PE2005000434A 2004-04-22 2005-04-20 SELECTED CGRP ANTAGONISTS, PROCEDURES FOR THEIR PREPARATION AS WELL AS THEIR USE AS A MEDICINE PE20060186A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004019492A DE102004019492A1 (en) 2004-04-22 2004-04-22 Selected CGRP antagonists, process for their preparation and their use as pharmaceuticals

Publications (1)

Publication Number Publication Date
PE20060186A1 true PE20060186A1 (en) 2006-04-18

Family

ID=35140095

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000434A PE20060186A1 (en) 2004-04-22 2005-04-20 SELECTED CGRP ANTAGONISTS, PROCEDURES FOR THEIR PREPARATION AS WELL AS THEIR USE AS A MEDICINE

Country Status (9)

Country Link
EP (1) EP1740577A2 (en)
JP (1) JP2007533689A (en)
AR (1) AR049422A1 (en)
CA (1) CA2565219A1 (en)
DE (1) DE102004019492A1 (en)
PE (1) PE20060186A1 (en)
TW (1) TW200606151A (en)
UY (1) UY28859A1 (en)
WO (1) WO2005103037A2 (en)

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US7842808B2 (en) 2002-06-05 2010-11-30 Bristol-Myers Squibb Company Anti-migraine spirocycles
US7220862B2 (en) 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
US7595312B2 (en) 2002-10-25 2009-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
DE10250082A1 (en) 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Selected CGRP antagonists, process for their preparation and their use as pharmaceuticals
TW200524601A (en) 2003-12-05 2005-08-01 Bristol Myers Squibb Co Heterocyclic anti-migraine agents
DE102004015723A1 (en) 2004-03-29 2005-10-20 Boehringer Ingelheim Pharma Selected CGRP antagonists, process for their preparation and their use as pharmaceuticals
TW200533398A (en) 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
US7384930B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384931B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
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DE102004063752A1 (en) * 2004-12-29 2006-07-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of selected CGRP antagonists to combat menopausal hot flashes
DE102004063753A1 (en) * 2004-12-29 2006-07-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of selected CGRP antagonists in combination with other migraine medicines for the treatment of migraine
EP1770091A1 (en) * 2005-09-29 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP-antagonists, process for their preparation as well as their use as medicaments
DE102005038831A1 (en) * 2005-08-17 2007-02-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg New N-acylalkoxycarbonyl-piperidine derivatives, useful as CGRP antagonists, for treating e.g. headaches, cardiovascular disease, skin disorders, morphine tolerance, and inflammatory diseases such as osteoarthritis and allergic rhinitis
US7834007B2 (en) 2005-08-25 2010-11-16 Bristol-Myers Squibb Company CGRP antagonists
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US9108948B2 (en) * 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
EP2099767A1 (en) 2006-11-01 2009-09-16 Brystol-Myers Squibb Company Modulators of glucocorticoid receptor, ap-1, and/or nf- b activity and use thereof
CA2702503A1 (en) 2007-10-18 2009-04-23 Boehringer Ingelheim International Gmbh Cgrp-antagonists
EP2065381A1 (en) 2007-10-18 2009-06-03 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP antagonists
US8829006B2 (en) 2007-11-22 2014-09-09 Boehringer Ingelheim International Gmbh Compounds
CN103108873A (en) * 2010-07-16 2013-05-15 皮拉马尔企业有限公司 Substituted imidazoquinoline derivatives as kinase inhibitors
TN2016000121A1 (en) 2013-10-07 2017-10-06 Bayer Pharma AG Cyclic thienouracil-carboxamides and use thereof
GB201519194D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP receptor antagonists
GB201519196D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP Receptor Antagonists
GB201519195D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP Receptor Antagonists
US10730850B2 (en) 2016-03-03 2020-08-04 Boehringer Ingelheim International Gmbh Pyridinylmethyl carbamimidoylcarbamate derivatives and their use as AOC3 inhibitors
JP6695441B2 (en) 2016-03-03 2020-05-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 4-Cyano-benzylcarbamimidoylcarbamate derivatives and their use as AOC3 inhibitors

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TW200533398A (en) * 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine

Also Published As

Publication number Publication date
CA2565219A1 (en) 2005-11-03
TW200606151A (en) 2006-02-16
DE102004019492A1 (en) 2005-11-10
WO2005103037A3 (en) 2006-01-12
EP1740577A2 (en) 2007-01-10
WO2005103037A2 (en) 2005-11-03
UY28859A1 (en) 2005-11-30
AR049422A1 (en) 2006-08-02
JP2007533689A (en) 2007-11-22

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