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PE20050482A1 - DIHYDROBENZOFURANIL ALKANAMIDE DERIVATIVES - Google Patents

DIHYDROBENZOFURANIL ALKANAMIDE DERIVATIVES

Info

Publication number
PE20050482A1
PE20050482A1 PE2004001025A PE2004001025A PE20050482A1 PE 20050482 A1 PE20050482 A1 PE 20050482A1 PE 2004001025 A PE2004001025 A PE 2004001025A PE 2004001025 A PE2004001025 A PE 2004001025A PE 20050482 A1 PE20050482 A1 PE 20050482A1
Authority
PE
Peru
Prior art keywords
dihydrobenzofuranil
halogen
alkanamide derivatives
benzofuran
amine
Prior art date
Application number
PE2004001025A
Other languages
Spanish (es)
Inventor
Jonathan Laird Gross
Marla Jean Williams
Gary Paul Stack
Hong Gao
Dahui Zhou
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34576747&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20050482(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20050482A1 publication Critical patent/PE20050482A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I DONDE R Y R' SON CADA UNO H, ALQUILO C1-C6, CICLOALQUILO C1-C6, ENTRE OTROS; R1 Y R2 SON CADA UNO H, HALOGENO, HIDROXILO, ENTRE OTROS; R3a Y R3b SON CADA UNO H, HALOGENO, OH, ENTRE OTROS; R4, R5, R6 Y R7 SON CADA UNO H, HALOGENO, OH, CIANO, ENTRE OTROS; n ES 1-3. SON COMPUESTOS PREFERIDOS: (-)-{[(7-(2,3-DIMETOXIFENIL)-2,3-DIHIDRO-1-BENZOFURAN-2-IL]METIL}AMINA, (-)-{[(7-PIRIDIN-3-IL-2,3-DIHIDRO-1-BENZOFURAN-2-IL]METIL}AMINA, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ESQUIZOFRENIA, ENTRE OTROSREFERRING TO A COMPOUND OF FORMULA I WHERE R AND R 'ARE EACH H, C1-C6 ALKYL, C1-C6 CYCLOALKYL, AMONG OTHERS; R1 AND R2 ARE EACH H, HALOGEN, HYDROXYL, AMONG OTHERS; R3a AND R3b ARE EACH H, HALOGEN, OH, AMONG OTHERS; R4, R5, R6 AND R7 ARE EACH H, HALOGEN, OH, CYANE, AMONG OTHERS; n IS 1-3. PREFERRED COMPOUNDS ARE: (-) - {[(7- (2,3-DIMETOXIFENIL) -2,3-DIHIDRO-1-BENZOFURAN-2-IL] METIL} AMINE, (-) - {[(7-PIRIDIN- 3-IL-2,3-DIHYDRO-1-BENZOFURAN-2-IL] METHYL} AMINE, AMONG OTHERS SUCH COMPOUNDS ARE USEFUL IN THE TREATMENT OF SCHIZOPHRENIA, AMONG OTHERS

PE2004001025A 2003-10-24 2004-10-25 DIHYDROBENZOFURANIL ALKANAMIDE DERIVATIVES PE20050482A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51445403P 2003-10-24 2003-10-24
US10/970,714 US7435837B2 (en) 2003-10-24 2004-10-21 Dihydrobenzofuranyl alkanamine derivatives and methods for using same

Publications (1)

Publication Number Publication Date
PE20050482A1 true PE20050482A1 (en) 2005-10-13

Family

ID=34576747

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004001025A PE20050482A1 (en) 2003-10-24 2004-10-25 DIHYDROBENZOFURANIL ALKANAMIDE DERIVATIVES

Country Status (20)

Country Link
US (2) US7435837B2 (en)
EP (1) EP1675840A1 (en)
JP (1) JP2007509174A (en)
KR (1) KR20060092257A (en)
CN (1) CN1997635A (en)
AR (1) AR046309A1 (en)
AU (1) AU2004287809A1 (en)
BR (1) BRPI0415657A (en)
CA (1) CA2542878A1 (en)
CR (1) CR8349A (en)
EC (1) ECSP066520A (en)
IL (1) IL174953A0 (en)
MX (1) MXPA06004409A (en)
NO (1) NO20062139L (en)
PA (1) PA8615701A1 (en)
PE (1) PE20050482A1 (en)
RU (1) RU2006117789A (en)
TW (1) TW200526615A (en)
WO (1) WO2005044812A1 (en)
ZA (1) ZA200603233B (en)

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JP2008538571A (en) * 2005-04-22 2008-10-30 ワイス Dihydrobenzofuran derivatives and uses thereof
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US7402687B2 (en) * 2005-04-22 2008-07-22 Wyeth Dihydrobenzofuran derivatives and uses thereof
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