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PE20040785A1 - Compuestos de amida como antagonistas de la hormona concentradora de melanina (mch) - Google Patents

Compuestos de amida como antagonistas de la hormona concentradora de melanina (mch)

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Publication number
PE20040785A1
PE20040785A1 PE2003001094A PE2003001094A PE20040785A1 PE 20040785 A1 PE20040785 A1 PE 20040785A1 PE 2003001094 A PE2003001094 A PE 2003001094A PE 2003001094 A PE2003001094 A PE 2003001094A PE 20040785 A1 PE20040785 A1 PE 20040785A1
Authority
PE
Peru
Prior art keywords
phenyl
compounds
mch
antagonists
alkyl
Prior art date
Application number
PE2003001094A
Other languages
English (en)
Inventor
Ralf R H Lotz
Klaus Rudolf
Philipp Lustenberger
Kirsten Arndt
Dirk Stenkamp
Gerald J Roth
Thorsten Lehmann-Lintz
Martin Lenter
Stephan G Muller
Heike-Andrea Wieland
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20040785A1 publication Critical patent/PE20040785A1/es

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Abstract

SE REFIERE A COMPUESTOS DE AMIDA DE FORMULA I DONDE R1 Y R2 SON H, ALQUILO C1-C8, CICLOALQUILO C3-C7, ENTRE OTROS; R1 Y R2 FORMAN UN PUENTE ALQUILENO C2-C8 EN EL CUAL UNO O DOS GRUPOS DE CH2 PUEDEN HABER SIDO REEMPLAZADOS POR -CH=N-, -CH=CH-, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, ENTRE OTROS; X ES UN PUENTE DE ALQUILENO C1-C8 EN EL CUAL UN GRUPO DE CH2 PUEDE HABER SIDO REEMPLAZADOS POR -CH=CH-, -C///C-, ENTRE OTROS; W ES -CR6aR6b-O-, ENTRE OTROS; Z ES UN ENLACE SENCILLO, ALQUILENO C1-C4 DONDE DOS ATOMOS DE C CONTIGUOS PUEDEN ESTAR UNIDOS ENTRE SI CON UN PUENTE ALQUILENO C1-C4; Y, A, B, ES Cy; b ES 0-1; Cy ES UN GRUPO CARBO O HETEROCICLICO SELECCIONADO DE UN GRUPO CARBOCICLICO SATURADO DE 3 A 7 ESLABONES, FENILO, HETEROCICLICO, ENTRE OTROS; R6a,R6b ES H, ALQUILO C1-C4, CF3. NO ESTAN INCLUIDOS LOS COMPUESTOS N-[4-(2-DIETILAMINO-ETOXI)-FENIL]-3-FENIL-PROPIONAMIDA, N-[4-(2-MORFOLIN-4-ILETOXI)-FENIL]-3-FENIL-PROPIONAMIDA, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N-[3-CLORO-4-(2-PIPERIDIN-1-ILETOXI)-FENIL]-2-(2-CLORO-4-TRIFLUOROMETIL-FENOXI)-ACETAMIDA, 2-(2-CLORO-4-TRIFLUOROMETIL-FENOXI)-N-[3-CIANO-4-(2-DIETILAMINO-ETOXI)-FENIL]ACETAMIDA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON ANTAGONISTAS DE LA HORMONA CONCENTRADORA DE MELANINA (MCH) Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS METABOLICOS Y/O TRASTORNOS DE LA ALIMENTACION
PE2003001094A 2002-10-31 2003-10-29 Compuestos de amida como antagonistas de la hormona concentradora de melanina (mch) PE20040785A1 (es)

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