PE20040644A1 - Nuevos derivados de quinuclidina-amina - Google Patents
Nuevos derivados de quinuclidina-aminaInfo
- Publication number
- PE20040644A1 PE20040644A1 PE2003000662A PE2003000662A PE20040644A1 PE 20040644 A1 PE20040644 A1 PE 20040644A1 PE 2003000662 A PE2003000662 A PE 2003000662A PE 2003000662 A PE2003000662 A PE 2003000662A PE 20040644 A1 PE20040644 A1 PE 20040644A1
- Authority
- PE
- Peru
- Prior art keywords
- azabicycle
- oct
- hydroxy
- quinuclidine
- phenyl
- Prior art date
Links
- IGNPOXGBNFMJHE-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octan-2-amine Chemical class C1CN2C(N)CC1CC2 IGNPOXGBNFMJHE-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 PHENETHYL Chemical group 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- OZCJTNLELXWUTQ-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octane-2-carboxamide Chemical compound C1CN2C(C(=O)N)CC1CC2 OZCJTNLELXWUTQ-UHFFFAOYSA-N 0.000 abstract 1
- FHTSIFHJYGMMMD-UHFFFAOYSA-N [C]1=CC=CO1 Chemical group [C]1=CC=CO1 FHTSIFHJYGMMMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
REFERIDO AL PROCEDIMIENTO DE PREPARACION DE COMPOSICIONES FARMACEUTICAS ANTAGONISTAS DE RECEPTORES MUSCARINICOS M3 QUE CONTIENEN UN COMPUESTO DERIVADO DE QUINUCLIDINA-AMIDA DE FORMULA I DONDE R1 ES H, ALQUILO INFERIOR LINEAL O RAMIFICADO; R2 ES (A) Y (B); R3 ES FENILO, 2-FURILO, 2-TIENILO, ENTRE OTROS; R4 ES FENILO, FENETILO, CICLOALQUILMETILO, ENTRE OTROS; R5 ES H, HIDROXI, METILO, ENTRE OTROS; P ES 1-2; Q ES ENLACE SENCILLO, -CH2-, -O-, ENTRE OTROS. TAMBIEN SE REFIERE A SU SAL CUATERNARIA. SON COMPUESTOS PREFERIDOS: N-(1-AZABICICLO[2.2.2]OCT-3-IL)-2-HIDROXI-2,2-DITIEN-2-ILACETAMIDA; N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-2-HIDROXI-2-TIEN-2-ILPENT-4-ENAMIDA Y N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-2,3-DIFENILPROPANAMIDA, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN TRASTORNOS UROLOGICOS, GASTROINSTITNALES Y RESPIRATORIOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200201539A ES2204295B1 (es) | 2002-07-02 | 2002-07-02 | Nuevos derivados de quinuclidina-amida. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040644A1 true PE20040644A1 (es) | 2004-09-18 |
Family
ID=30011350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000662A PE20040644A1 (es) | 2002-07-02 | 2003-06-30 | Nuevos derivados de quinuclidina-amina |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7488735B2 (es) |
| EP (1) | EP1519933B1 (es) |
| JP (1) | JP2005533826A (es) |
| CN (1) | CN100404533C (es) |
| AR (1) | AR040351A1 (es) |
| AT (1) | ATE467631T1 (es) |
| AU (1) | AU2003242757B2 (es) |
| BR (1) | BR0312216A (es) |
| CA (1) | CA2492535A1 (es) |
| DE (1) | DE60332534D1 (es) |
| EC (1) | ECSP045519A (es) |
| ES (1) | ES2204295B1 (es) |
| IL (1) | IL165923A (es) |
| MX (1) | MXPA04012271A (es) |
| MY (1) | MY130803A (es) |
| NO (1) | NO20050164L (es) |
| NZ (1) | NZ537341A (es) |
| PE (1) | PE20040644A1 (es) |
| RU (1) | RU2314306C2 (es) |
| TW (1) | TW200402420A (es) |
| UA (1) | UA80832C2 (es) |
| UY (1) | UY27870A1 (es) |
| WO (1) | WO2004005285A1 (es) |
| ZA (1) | ZA200410404B (es) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| CN1298717C (zh) | 2000-12-22 | 2007-02-07 | 阿尔米雷尔普罗迪斯制药有限公司 | 奎宁环氨基甲酸酯衍生物及其作为m3拮抗剂的应用 |
| ES2203327B1 (es) | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
| TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
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| ES2239546B1 (es) * | 2004-03-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos esteres de quinuclidina cuaternizados. |
| UY28871A1 (es) * | 2004-04-27 | 2005-11-30 | Glaxo Group Ltd | Antagonistas del receptor de acetilcolina muscarinico |
| EP1747219A4 (en) * | 2004-05-13 | 2010-05-26 | Glaxo Group Ltd | Antagonists of muscarinic acetylcholine receptor |
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| ES2246170B1 (es) * | 2004-07-29 | 2007-04-01 | Almirall Prodesfarma, S.A. | Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio. |
| DE602004027555D1 (de) * | 2004-09-15 | 2010-07-15 | Shuqiang Zhao | Chinuclidinverbindungen mit quaternärer ammoniumgruppe, verfahren zu ihrer herstellung und ihre verwendung als acetylcholinblockierende mittel |
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| GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
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| AU2008218962B2 (en) * | 2007-02-23 | 2013-03-14 | Theravance Biopharma R&D Ip, Llc | Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists |
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| CN101939054B (zh) | 2007-12-10 | 2014-10-29 | 诺华股份有限公司 | 有机化合物 |
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| EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
| KR20140019409A (ko) * | 2011-04-29 | 2014-02-14 | 키에시 파르마슈티시 엣스. 피. 에이. | 알칼로이드 에스텔 및 카바메이트 유도체와 그들의 의약조성물 |
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| WO2013038373A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
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| JP6165733B2 (ja) | 2011-09-16 | 2017-07-19 | ノバルティス アーゲー | Ｎ−置換ヘテロシクリルカルボキサミド類 |
| CN104363914A (zh) | 2011-11-23 | 2015-02-18 | 因特利凯有限责任公司 | 使用mTOR抑制剂的增强的治疗方案 |
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| CN110507654A (zh) | 2012-04-03 | 2019-11-29 | 诺华有限公司 | 有酪氨酸激酶抑制剂的组合产品和其应用 |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| WO2014151147A1 (en) | 2013-03-15 | 2014-09-25 | Intellikine, Llc | Combination of kinase inhibitors and uses thereof |
| CN105431432B (zh) * | 2013-07-13 | 2018-01-09 | 北京硕佰医药科技有限责任公司 | 奎宁类化合物、其光学异构体及其制备方法和医药用途 |
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| CN106458966B (zh) | 2014-04-24 | 2019-05-07 | 诺华股份有限公司 | 作为磷脂酰肌醇3-激酶抑制剂的吡嗪衍生物 |
| BR112016024484A2 (pt) | 2014-04-24 | 2017-08-15 | Novartis Ag | derivados de aminopiridina como inibidores de fosfatidilinositol 3-quinase |
| CA2945212A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
| JP6836502B2 (ja) * | 2014-05-30 | 2021-03-03 | スプハエラ ファーマ ピーヴィーティー リミテッド | 抗結核薬としての新規な化合物 |
| WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
| CA2954862A1 (en) | 2014-07-31 | 2016-02-04 | Novartis Ag | Combination therapy |
| CN113891744A (zh) | 2019-06-10 | 2022-01-04 | 诺华股份有限公司 | 用于治疗cf、copd和支气管扩张的吡啶和吡嗪衍生物 |
| PE20220346A1 (es) | 2019-08-28 | 2022-03-14 | Novartis Ag | Derivados de 1,3-fenil heteroarilo sustituidos y su uso en el tratamiento de enfermedades |
| CN110759904B (zh) * | 2019-10-21 | 2023-03-14 | 河南科技大学 | 9r-酰氧基奎宁类衍生物及其制备方法、奎宁或其衍生物的应用、植物源杀虫剂 |
| TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法 |
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|---|---|---|---|---|
| US2762796A (en) | 1956-09-11 | Iminodibenzyl derivative | ||
| GB1219606A (en) | 1968-07-15 | 1971-01-20 | Rech S Et D Applic Scient Soge | Quinuclidinol derivatives and preparation thereof |
| GB1246606A (en) | 1969-04-28 | 1971-09-15 | Starogardzkie Zakl Farma | Dibenzo-azepine derivatives |
| IL72788A (en) | 1984-08-28 | 1989-07-31 | Israel State | Bis quaternary oxy-bis methylene(or trimethylene)bis-n-quinuclidines,pyridines and piperidines,their preparation and antidotes against organophosphorus and carbamate poisoning containing them |
| GB2225574B (en) | 1987-12-24 | 1991-04-24 | Wyeth John & Brother Ltd | Heterocyclic compounds |
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| GB8923590D0 (en) | 1989-10-19 | 1989-12-06 | Pfizer Ltd | Antimuscarinic bronchodilators |
| GB9201751D0 (en) | 1992-01-28 | 1992-03-11 | Smithkline Beecham Plc | Compounds |
| GB9202443D0 (en) * | 1992-02-05 | 1992-03-18 | Fujisawa Pharmaceutical Co | A novel substituted-acetamide compound and a process for the preparation thereof |
| WO1995006635A1 (fr) * | 1993-09-02 | 1995-03-09 | Yamanouchi Pharmaceutical Co., Ltd. | Derive de carbamate et medicament le contenant |
| KR970701174A (ko) * | 1994-02-10 | 1997-03-17 | 오노다 마사요시 | 신규한 카바메이트 유도체 및 이의 의약 조성물(Novel carbamate derivative and medicinal composition containing the same) |
| NO2005012I1 (no) | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
| AU7145996A (en) | 1995-10-13 | 1997-04-30 | Banyu Pharmaceutical Co., Ltd. | Substituted heteroaromatic derivatives |
| AUPN862996A0 (en) | 1996-03-13 | 1996-04-04 | Fujisawa Pharmaceutical Co., Ltd. | A novel substituted-acetamide compound |
| PE92198A1 (es) * | 1996-08-01 | 1999-01-09 | Banyu Pharma Co Ltd | Derivados de 1,4-piperidina disustituida que contienen fluor |
| ES2165768B1 (es) * | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| AU6610001A (en) | 2000-06-27 | 2002-01-08 | S A L V A T Lab Sa | Carbamates derived from arylalkylamines |
| CN1298717C (zh) | 2000-12-22 | 2007-02-07 | 阿尔米雷尔普罗迪斯制药有限公司 | 奎宁环氨基甲酸酯衍生物及其作为m3拮抗剂的应用 |
| RU2282629C2 (ru) * | 2000-12-28 | 2006-08-27 | Альмиралль Продесфарма Аг | Производные хинуклидина, способ их получения и фармацевтическая композиция на их основе |
| CA2470956C (en) | 2001-12-20 | 2011-08-02 | Laboratorios S.A.L.V.A.T., S.A. | 1-alkyl-1-azoniabicyclo[2.2.2]octane carbamate derivatives and their use as muscarinic receptor antagonists |
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-
2002
- 2002-07-02 ES ES200201539A patent/ES2204295B1/es not_active Expired - Fee Related
-
2003
- 2003-06-25 WO PCT/EP2003/006708 patent/WO2004005285A1/en active Application Filing
- 2003-06-25 EP EP03762514A patent/EP1519933B1/en not_active Expired - Lifetime
- 2003-06-25 MX MXPA04012271A patent/MXPA04012271A/es active IP Right Grant
- 2003-06-25 JP JP2004518575A patent/JP2005533826A/ja active Pending
- 2003-06-25 AU AU2003242757A patent/AU2003242757B2/en not_active Ceased
- 2003-06-25 DE DE60332534T patent/DE60332534D1/de not_active Expired - Fee Related
- 2003-06-25 US US10/518,714 patent/US7488735B2/en not_active Expired - Fee Related
- 2003-06-25 CA CA002492535A patent/CA2492535A1/en not_active Abandoned
- 2003-06-25 RU RU2005102585/04A patent/RU2314306C2/ru not_active IP Right Cessation
- 2003-06-25 AT AT03762514T patent/ATE467631T1/de not_active IP Right Cessation
- 2003-06-25 NZ NZ537341A patent/NZ537341A/xx unknown
- 2003-06-25 UA UAA200500839A patent/UA80832C2/uk unknown
- 2003-06-25 BR BR0312216-6A patent/BR0312216A/pt not_active IP Right Cessation
- 2003-06-25 CN CNB03820648XA patent/CN100404533C/zh not_active Expired - Fee Related
- 2003-06-27 UY UY27870A patent/UY27870A1/es not_active Application Discontinuation
- 2003-06-30 PE PE2003000662A patent/PE20040644A1/es not_active Application Discontinuation
- 2003-06-30 MY MYPI20032447A patent/MY130803A/en unknown
- 2003-06-30 AR ARP030102368A patent/AR040351A1/es unknown
- 2003-07-02 TW TW092118081A patent/TW200402420A/zh unknown
-
2004
- 2004-12-22 IL IL165923A patent/IL165923A/en not_active IP Right Cessation
- 2004-12-23 ZA ZA200410404A patent/ZA200410404B/xx unknown
- 2004-12-29 EC EC2004005519A patent/ECSP045519A/es unknown
-
2005
- 2005-01-12 NO NO20050164A patent/NO20050164L/no not_active Application Discontinuation
-
2008
- 2008-01-08 US US11/970,698 patent/US7718670B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MY130803A (en) | 2007-07-31 |
| US20080234316A1 (en) | 2008-09-25 |
| MXPA04012271A (es) | 2005-04-08 |
| UY27870A1 (es) | 2003-10-31 |
| ES2204295B1 (es) | 2005-08-01 |
| ES2204295A1 (es) | 2004-04-16 |
| IL165923A0 (en) | 2006-01-15 |
| US7718670B2 (en) | 2010-05-18 |
| NZ537341A (en) | 2006-04-28 |
| ATE467631T1 (de) | 2010-05-15 |
| CN100404533C (zh) | 2008-07-23 |
| BR0312216A (pt) | 2005-04-12 |
| UA80832C2 (en) | 2007-11-12 |
| EP1519933A1 (en) | 2005-04-06 |
| IL165923A (en) | 2010-06-30 |
| EP1519933B1 (en) | 2010-05-12 |
| US7488735B2 (en) | 2009-02-10 |
| DE60332534D1 (de) | 2010-06-24 |
| NO20050164L (no) | 2005-04-04 |
| AR040351A1 (es) | 2005-03-30 |
| JP2005533826A (ja) | 2005-11-10 |
| ECSP045519A (es) | 2005-03-10 |
| AU2003242757B2 (en) | 2009-01-08 |
| CN1678610A (zh) | 2005-10-05 |
| AU2003242757A1 (en) | 2004-01-23 |
| RU2005102585A (ru) | 2005-10-10 |
| ZA200410404B (en) | 2005-09-05 |
| RU2314306C2 (ru) | 2008-01-10 |
| TW200402420A (en) | 2004-02-16 |
| WO2004005285A1 (en) | 2004-01-15 |
| US20060167042A1 (en) | 2006-07-27 |
| CA2492535A1 (en) | 2004-01-15 |
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