PE20030356A1 - Isoxazolopiridinona - Google Patents
IsoxazolopiridinonaInfo
- Publication number
- PE20030356A1 PE20030356A1 PE2002000734A PE2002000734A PE20030356A1 PE 20030356 A1 PE20030356 A1 PE 20030356A1 PE 2002000734 A PE2002000734 A PE 2002000734A PE 2002000734 A PE2002000734 A PE 2002000734A PE 20030356 A1 PE20030356 A1 PE 20030356A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- alkyl
- dialkyl
- pidyridin
- ilo
- Prior art date
Links
- XDWKYQRZDNGJNB-UHFFFAOYSA-N chembl246652 Chemical compound C1=2C(=O)NC(C=3C=CC=CC=3)=CC=2ON=C1C1=CC=CC=C1 XDWKYQRZDNGJNB-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 4-DIMETHYLAMINOMETHYL-PHENYL Chemical class 0.000 abstract 1
- OFINVCCMFOYTMR-UHFFFAOYSA-N CC1C=C(NO1)C2=CC=CC=C2C3=CC=C(C=C3)COCCOC Chemical compound CC1C=C(NO1)C2=CC=CC=C2C3=CC=C(C=C3)COCCOC OFINVCCMFOYTMR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE REFIERE A ISOXAZOLOPIRIDINONA DE FORMULA I DONDE X ES O; Y ES N O BIEN X ES N E Y ES O; R1 ES H, ALQUILO C1-C4, CICLOALQUILO C3-C7, CARBONO-ALQUILO C1-C4, DIALQUILO C1-C4, ENTRE OTROS; R2 ES ALQUILO C1-C4, CICLOALQUILO C3-C7, BENZO[1,3]DIOXOL-5-ILO, BENZO[1,2,5]OXADIAZOL-5-ILO, ENTRE OTROS; R3 ES H, HALO, ALQUILO C1-C4, DIALQUILO C1-C4, CARBONO-AMINOALQUILO C1-C4, DIALQUILO C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 6-(4-DIMETILAMINOMETIL-FENIL)-3-FENIL-5H-ISOXAZOLO[4,5-c]PIDIRIDIN-4-ONA EN FORMA DE BASE LIBRE O DE SAL DE ADICION DE ACIDO, 6-(4-(2-METOXI-ETOXIMETIL)-FENIL)-5-METIL-3-FENIL-5H-ISOXAZOLO[4,5-c]PIDIRIDIN-4-ONA EN FORMA DE BASE LIBRE O DE SAL DE ADICION DE ACIDO. SE REFIERE TAMBIEN A UN PROCESO PARA LA PREPARACION Y UNA COMPOSICION FARMACEUTICA UTIL PARA EL TRATAMIENTO DE PARKINSON
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0119911.6A GB0119911D0 (en) | 2001-08-15 | 2001-08-15 | Organic Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030356A1 true PE20030356A1 (es) | 2003-05-14 |
Family
ID=9920454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000734A PE20030356A1 (es) | 2001-08-15 | 2002-08-14 | Isoxazolopiridinona |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7087756B2 (es) |
| EP (1) | EP1418912B1 (es) |
| JP (1) | JP2005501847A (es) |
| KR (1) | KR20040029429A (es) |
| CN (1) | CN100384418C (es) |
| AR (1) | AR036351A1 (es) |
| AT (1) | ATE355059T1 (es) |
| BR (1) | BR0211903A (es) |
| CA (1) | CA2454762A1 (es) |
| CO (1) | CO5560566A2 (es) |
| DE (1) | DE60218484T2 (es) |
| EC (1) | ECSP044971A (es) |
| ES (1) | ES2282467T3 (es) |
| GB (1) | GB0119911D0 (es) |
| HU (1) | HUP0401325A3 (es) |
| IL (1) | IL160018A0 (es) |
| MX (1) | MXPA04001419A (es) |
| NO (1) | NO20040659D0 (es) |
| PE (1) | PE20030356A1 (es) |
| PL (1) | PL366848A1 (es) |
| PT (1) | PT1418912E (es) |
| RU (1) | RU2004107847A (es) |
| WO (1) | WO2003015780A2 (es) |
| ZA (1) | ZA200400525B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2002102807A1 (ja) * | 2001-06-14 | 2004-09-30 | 萬有製薬株式会社 | 新規イソキサゾロピリドン誘導体及びその用途 |
| CN1984894A (zh) * | 2004-05-14 | 2007-06-20 | Irm责任有限公司 | 作为ppar调节剂的化合物和组合物 |
| AU2007217892A1 (en) * | 2006-02-16 | 2007-08-30 | The Mclean Hospital Corporation | Methods and compositions for the treatment of Parkinson's Disease |
| CA2659155A1 (en) | 2006-07-20 | 2008-01-24 | Amgen Inc. | Substituted azole aromatic heterocycles as inhibitors of 11.beta.-hsd-1 |
| FR2906250B1 (fr) * | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
| FR2933609B1 (fr) * | 2008-07-10 | 2010-08-27 | Fournier Lab Sa | Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson. |
| WO2010083218A1 (en) | 2009-01-13 | 2010-07-22 | Van Andel Research Institute | Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids |
| FR2950053B1 (fr) | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
| FR2955110A1 (fr) | 2010-01-08 | 2011-07-15 | Fournier Lab Sa | Nouveaux derives de type pyrrolopyridine benzoique |
| DE102011085038A1 (de) | 2011-10-21 | 2013-04-25 | Tesa Se | Verfahren zur Kapselung einer elektronischen Anordnung |
| AU2014324961A1 (en) | 2013-09-25 | 2016-04-14 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Highly potent glucocorticoids |
| KR20170033630A (ko) | 2015-09-17 | 2017-03-27 | (주)다올 | 도로용 경계블럭 |
| JP7146750B2 (ja) | 2016-10-14 | 2022-10-04 | ヴァン アンデル リサーチ インスティテュート | 非常に強力な糖質コルチコイドの構造およびデザインのための機構 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7602542L (sv) | 1975-03-14 | 1976-09-15 | Sandoz Ag | 3-(alfa-iminobensyl)-4-hydroxi-2(lh)-pyridoner |
| US4064251A (en) | 1976-06-25 | 1977-12-20 | Sandoz, Inc. | Substituted hydroxy pyridones |
| US4049813A (en) | 1976-07-15 | 1977-09-20 | Sandoz, Inc. | Substituted isoxazolo pyridinones |
| US4238616A (en) | 1977-01-19 | 1980-12-09 | Sandoz, Inc. | 3-(Substituted)phenyl-5-(β-hydroxyphenethyl)-N-(alkyl)-isoxazole-4-carboxamides |
| DE2801190A1 (de) | 1977-01-19 | 1978-07-20 | Sandoz Ag | 3-(alpha-iminobenzyl)-4-hydroxy-2(1h)- pyridon-derivat |
| US4113727A (en) * | 1977-04-26 | 1978-09-12 | Sandoz, Inc. | Process for the preparation of substituted isoxazolo[4,5-c]pyridin-4-(5H)-ones |
| JPWO2002102807A1 (ja) * | 2001-06-14 | 2004-09-30 | 萬有製薬株式会社 | 新規イソキサゾロピリドン誘導体及びその用途 |
-
2001
- 2001-08-15 GB GBGB0119911.6A patent/GB0119911D0/en not_active Ceased
-
2002
- 2002-08-13 AR ARP020103046A patent/AR036351A1/es unknown
- 2002-08-14 BR BR0211903-0A patent/BR0211903A/pt not_active IP Right Cessation
- 2002-08-14 HU HU0401325A patent/HUP0401325A3/hu unknown
- 2002-08-14 IL IL16001802A patent/IL160018A0/xx unknown
- 2002-08-14 KR KR10-2004-7002124A patent/KR20040029429A/ko not_active Ceased
- 2002-08-14 PL PL02366848A patent/PL366848A1/xx not_active Application Discontinuation
- 2002-08-14 MX MXPA04001419A patent/MXPA04001419A/es unknown
- 2002-08-14 RU RU2004107847/15A patent/RU2004107847A/ru not_active Application Discontinuation
- 2002-08-14 CA CA002454762A patent/CA2454762A1/en not_active Abandoned
- 2002-08-14 ES ES02772157T patent/ES2282467T3/es not_active Expired - Lifetime
- 2002-08-14 JP JP2003520739A patent/JP2005501847A/ja not_active Withdrawn
- 2002-08-14 DE DE60218484T patent/DE60218484T2/de not_active Expired - Lifetime
- 2002-08-14 WO PCT/EP2002/009134 patent/WO2003015780A2/en active IP Right Grant
- 2002-08-14 CN CNB028159268A patent/CN100384418C/zh not_active Expired - Fee Related
- 2002-08-14 AT AT02772157T patent/ATE355059T1/de not_active IP Right Cessation
- 2002-08-14 PT PT02772157T patent/PT1418912E/pt unknown
- 2002-08-14 US US10/486,569 patent/US7087756B2/en not_active Expired - Fee Related
- 2002-08-14 PE PE2002000734A patent/PE20030356A1/es not_active Application Discontinuation
- 2002-08-14 EP EP02772157A patent/EP1418912B1/en not_active Expired - Lifetime
-
2004
- 2004-01-23 ZA ZA200400525A patent/ZA200400525B/en unknown
- 2004-02-03 EC EC2004004971A patent/ECSP044971A/es unknown
- 2004-02-13 NO NO20040659A patent/NO20040659D0/no not_active Application Discontinuation
- 2004-03-12 CO CO04023011A patent/CO5560566A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR036351A1 (es) | 2004-09-01 |
| ATE355059T1 (de) | 2006-03-15 |
| EP1418912B1 (en) | 2007-02-28 |
| GB0119911D0 (en) | 2001-10-10 |
| PT1418912E (pt) | 2007-05-31 |
| CN100384418C (zh) | 2008-04-30 |
| US20040248893A1 (en) | 2004-12-09 |
| DE60218484D1 (de) | 2007-04-12 |
| PL366848A1 (en) | 2005-02-07 |
| ES2282467T3 (es) | 2007-10-16 |
| KR20040029429A (ko) | 2004-04-06 |
| HUP0401325A3 (en) | 2005-09-28 |
| CO5560566A2 (es) | 2005-09-30 |
| JP2005501847A (ja) | 2005-01-20 |
| IL160018A0 (en) | 2004-06-20 |
| CN1635889A (zh) | 2005-07-06 |
| NO20040659L (no) | 2004-02-13 |
| RU2004107847A (ru) | 2005-05-10 |
| WO2003015780A2 (en) | 2003-02-27 |
| WO2003015780A3 (en) | 2003-11-13 |
| WO2003015780A8 (en) | 2004-05-21 |
| DE60218484T2 (de) | 2007-11-15 |
| BR0211903A (pt) | 2004-09-21 |
| MXPA04001419A (es) | 2004-05-27 |
| ECSP044971A (es) | 2004-03-23 |
| NO20040659D0 (no) | 2004-02-13 |
| US7087756B2 (en) | 2006-08-08 |
| HUP0401325A2 (hu) | 2004-10-28 |
| CA2454762A1 (en) | 2003-02-27 |
| EP1418912A2 (en) | 2004-05-19 |
| ZA200400525B (en) | 2005-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |