PE20030303A1 - FORMULACIONES DE INTERFERON ß HUMANO - Google Patents
FORMULACIONES DE INTERFERON ß HUMANOInfo
- Publication number
- PE20030303A1 PE20030303A1 PE2002000613A PE2002000613A PE20030303A1 PE 20030303 A1 PE20030303 A1 PE 20030303A1 PE 2002000613 A PE2002000613 A PE 2002000613A PE 2002000613 A PE2002000613 A PE 2002000613A PE 20030303 A1 PE20030303 A1 PE 20030303A1
- Authority
- PE
- Peru
- Prior art keywords
- ifnß
- interferon
- formulations
- human
- solubilizers
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONSISTE ESENCIALMENTE DE: i)0,25mg/ml A 25mg/ml DE INTERFERON ß IFNß-1b BIOLOGICAMENTE ACTIVO NO GLICOSILADO QUE SE PRODUCE EN UN HUESPED BACTERIANO; ii)AMORTIGUADOR QUE CONTIENE DE 1mM A 100mM DE GLICINA, HCl; iii)AGUA, ESTERIL; CARACTERIZADA POR pH DE 2 A 4, ESTAR LIBRE DE ESTABILIZADORES CONVENCIONALES COMO ALBUMINA DE SUERO, NO CONTENER UNA CANTIDAD DETECTABLE DE SOLUBILIZADORES TAL COMO DETERGENTE. EL IFNß PUEDE SER UTIL PARA EL TRATAMIENTO DE ESCLEROSIS MULTIPLE
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30339501P | 2001-07-09 | 2001-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030303A1 true PE20030303A1 (es) | 2003-06-21 |
Family
ID=23171889
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002000613A PE20030303A1 (es) | 2001-07-09 | 2002-07-09 | FORMULACIONES DE INTERFERON ß HUMANO |
Country Status (7)
Country | Link |
---|---|
US (2) | US20030118548A1 (es) |
JP (1) | JP2004538275A (es) |
AR (1) | AR034749A1 (es) |
PE (1) | PE20030303A1 (es) |
TW (1) | TWI241193B (es) |
UY (1) | UY27373A1 (es) |
WO (1) | WO2003006053A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6887462B2 (en) * | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
US20070148171A1 (en) * | 2002-09-27 | 2007-06-28 | Xencor, Inc. | Optimized anti-CD30 antibodies |
TWI272948B (en) * | 2003-05-01 | 2007-02-11 | Ares Trading Sa | HSA-free stabilized interferon liquid formulations |
US20050008616A1 (en) * | 2003-07-11 | 2005-01-13 | Schering Aktiengesellschaft | Recombinant human interferon-beta-1b polypeptides |
WO2006033453A1 (ja) * | 2004-09-22 | 2006-03-30 | Juntendo Educational Foundation | インターフェロン作用物質の活性増強剤 |
CN101056890B (zh) * | 2004-11-10 | 2012-05-09 | 诺华疫苗和诊断公司 | 脱酰胺基干扰素-β |
US20070179113A1 (en) * | 2005-05-19 | 2007-08-02 | Schering Aktiengesellachaft | GM-CSF gene therapy for Crohn's disease using an improved regulated expression system |
DOP2006000116A (es) * | 2005-05-19 | 2007-01-31 | Schering Ag | Sistema mejorado de expresión regulada y sus usos. |
EP1891224A1 (en) * | 2005-05-19 | 2008-02-27 | Bayer Schering Pharma Aktiengesellschaft | Interferon-beta gene therapy using an improved, regulated expression system |
US20080076729A1 (en) * | 2005-05-19 | 2008-03-27 | Schering Aktiengesellachaft | Interferon-beta gene therapy using an improved, regulated expression system |
MX2008001396A (es) * | 2005-07-29 | 2008-04-16 | Novartis Ag | Metodo y sistema para plegado in vitro de proteinas. |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7404589A (nl) * | 1974-04-03 | 1975-10-07 | Stichting Rega V Z W | Werkwijze voor het stabiliseren van interferon. |
DE2916711A1 (de) * | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
US4289689A (en) * | 1980-03-14 | 1981-09-15 | Hoffmann-La Roche Inc. | Preparation of homogeneous human fibroblast interferon |
DE2943016C2 (de) * | 1979-10-24 | 1984-09-06 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Verfahren zur Reinigung von Interferon |
JPS5651995A (en) * | 1979-10-05 | 1981-05-09 | Green Cross Corp:The | Preparation of interferon |
NL7907791A (nl) * | 1979-10-23 | 1981-04-27 | Stichting Rega V Z W | Werkwijze voor het zuiveren van interferon. |
US4315852A (en) * | 1980-11-26 | 1982-02-16 | Schering Corporation | Extraction of interferon from bacteria |
JPS5821691A (ja) * | 1981-07-29 | 1983-02-08 | Mochida Pharmaceut Co Ltd | α−及びβ−インタ−フェロンの精製方法 |
EP0082481B2 (en) * | 1981-12-23 | 1990-09-12 | Schering Corporation | Stabilised alpha-interferon formulations and their preparation |
US4450103A (en) * | 1982-03-01 | 1984-05-22 | Cetus Corporation | Process for recovering human IFN-β from a transformed microorganism |
AU1234383A (en) * | 1982-03-17 | 1983-09-22 | Inter-Yeda Ltd. | Interferon stabilised with polyvinyl-pyrrolidone |
US5643566A (en) * | 1982-09-23 | 1997-07-01 | Cetus Corporation | Formulation processes for lipophilic proteins |
US4462940A (en) * | 1982-09-23 | 1984-07-31 | Cetus Corporation | Process for the recovery of human β-interferon-like polypeptides |
US4588585A (en) * | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
IL90047A (en) * | 1982-10-19 | 1992-12-01 | Cetus Oncology Corp | Cysteine-depleted biologically active muteins other than interferon - ' |
US4485017A (en) * | 1982-12-22 | 1984-11-27 | Cetus Corporation | Isolation of human interferon by immunosorbent and high performance liquid chromatography |
JPS60243028A (ja) * | 1984-04-28 | 1985-12-03 | Kyowa Hakko Kogyo Co Ltd | インタ−フエロンの可溶化方法 |
US4643566A (en) * | 1984-07-20 | 1987-02-17 | Canon Kabushiki Kaisha | Particle analyzing apparatus |
DE3628468A1 (de) * | 1986-08-21 | 1988-03-03 | Thomae Gmbh Dr K | Neue applikationsformen fuer (alpha)-interferone |
US5004605A (en) * | 1987-12-10 | 1991-04-02 | Cetus Corporation | Low pH pharmaceutical compositions of recombinant β-interferon |
FR2687843A1 (fr) * | 1992-02-24 | 1993-08-27 | Motorola Semiconducteurs | Transistor bipolaire lateral pnp et procede de fabrication. |
US5358708A (en) * | 1993-01-29 | 1994-10-25 | Schering Corporation | Stabilization of protein formulations |
IT1272252B (it) * | 1994-05-16 | 1997-06-16 | Applied Research Systems | Formulazioni liquide di interferone beta |
JP3466765B2 (ja) * | 1994-07-27 | 2003-11-17 | キッコーマン株式会社 | ビオチン化ホタルルシフェラーゼ、ビオチン化ホタルルシフェラーゼ遺伝子、新規な組み換え体dna、ビオチン化ホタルルシフェラーゼの製造法及び生物発光分析法 |
US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5814485A (en) * | 1995-06-06 | 1998-09-29 | Chiron Corporation | Production of interferon-β (IFN-β) in E. coli |
EE04266B1 (et) * | 1996-12-24 | 2004-04-15 | Biogen, Incorporated | Interferooni stabiilne vedelkompositsioon |
US6887462B2 (en) * | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
-
2002
- 2002-07-08 UY UY27373A patent/UY27373A1/es not_active Application Discontinuation
- 2002-07-08 AR ARP020102558A patent/AR034749A1/es unknown
- 2002-07-09 PE PE2002000613A patent/PE20030303A1/es not_active Application Discontinuation
- 2002-07-09 WO PCT/US2002/021464 patent/WO2003006053A1/en active Application Filing
- 2002-07-09 JP JP2003511859A patent/JP2004538275A/ja active Pending
- 2002-07-09 TW TW091115171A patent/TWI241193B/zh not_active IP Right Cessation
- 2002-07-09 US US10/190,838 patent/US20030118548A1/en not_active Abandoned
-
2005
- 2005-02-24 US US11/063,597 patent/US20050163752A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2003006053A1 (en) | 2003-01-23 |
US20050163752A1 (en) | 2005-07-28 |
TWI241193B (en) | 2005-10-11 |
US20030118548A1 (en) | 2003-06-26 |
UY27373A1 (es) | 2003-02-28 |
JP2004538275A (ja) | 2004-12-24 |
AR034749A1 (es) | 2004-03-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |