+

PE20030137A1 - Derivados antimicrobianos de quinolona - Google Patents

Derivados antimicrobianos de quinolona

Info

Publication number
PE20030137A1
PE20030137A1 PE2001001284A PE2001001284A PE20030137A1 PE 20030137 A1 PE20030137 A1 PE 20030137A1 PE 2001001284 A PE2001001284 A PE 2001001284A PE 2001001284 A PE2001001284 A PE 2001001284A PE 20030137 A1 PE20030137 A1 PE 20030137A1
Authority
PE
Peru
Prior art keywords
alkyl
quinolone
ona
carboxi
alcoxy
Prior art date
Application number
PE2001001284A
Other languages
English (en)
Inventor
Mikhail Gordeev
Michael R Barbachyn
Dinesh V Patel
James R Gage
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20030137A1 publication Critical patent/PE20030137A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A UNA QUINOLONA DE FORMULA I DONDE Y1 ES CH, N; Y2, Y3, Y4 SON C Y N; L ES UNA UNION O UN ENLACE HACIA UN CARBONO EN LA POSICION SIETE DEL ANILLO DE QUINOLONA O UN N EN LA POSICION UNO DEL ANILLO DE QUINOLONA; m ES 0-1; n ES 0-3; Q ES EL GRUPO a, GRUPO b, ENTRE OTROS. R1 ES H, ALQUILO C1-C4, CICLOALQUILO C3-C5, HALOALQUILO C1-C4, ENTRE OTROS; R2 ES NULO CUANDO Y2 ES N, H, ALQUILO, ALCOXI C1-C2, ENTRE OTROS; R3 ES H, F CUANDO Y2 ES C, O R3 ES NULO CUANDO Y3 ES N; R4 ES H, CH3, AMINO, F; R5 ES H, CH3, OH, HALO; R6 ES H, CH3, OH, HALO; R7 ES H, ALQUILO C1-C4, ENTRE OTROS; R8 ES H, ALQUILO C1-C4, ENTRE OTROS; R9 ES ES H, ALQUILO C1-C4, ENTRE OTROS; R10 ES OH, ALCOXI, ARILOXI, NHC(=Z)R11, ENTRE OTROS. SON COMPUESTOS PREFERIDO 7-[4-[(5-(S)-ACETAMIDOMETILOXAZOLIDINA-2-ONA-3-IL)-2-FLUOROFENIL]PIPERAZINA-1-IL]-3-CARBOXI-1-CICLOPROPIL-6-FLUORO-1,4-DIHIDROQUINOLA-4-ONA, 10-[4-[(5-(S)-ACETAMIDOMETILOXAZOLIDINA-2-ONA-3-IL)-2-FLUOROFENIL]PIPERAZINA-1-IL]-6-CARBOXI-9-FLUORO-2,3-DIHIDRO-3-METIL-7-OXO-7H-PIRIDO-[1,2,3-d]-1,4-BENZOXAZINA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCESO PARA LA PREPARACION Y UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON DERIVADOS DE QUINOLONA Y SON UTILES COMO AGENTES ANTIBACTERIANOS
PE2001001284A 2000-12-21 2001-12-20 Derivados antimicrobianos de quinolona PE20030137A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25790400P 2000-12-21 2000-12-21

Publications (1)

Publication Number Publication Date
PE20030137A1 true PE20030137A1 (es) 2003-03-08

Family

ID=22978270

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001284A PE20030137A1 (es) 2000-12-21 2001-12-20 Derivados antimicrobianos de quinolona

Country Status (9)

Country Link
US (2) US6689769B2 (es)
EP (1) EP1349853B1 (es)
JP (1) JP2004518677A (es)
AT (1) ATE319710T1 (es)
CA (1) CA2424402A1 (es)
DE (1) DE60117861T2 (es)
ES (1) ES2256331T3 (es)
PE (1) PE20030137A1 (es)
WO (1) WO2002059116A2 (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
WO2003031441A1 (en) * 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
WO2003031443A1 (en) * 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
US6875784B2 (en) * 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
AU2003294565A1 (en) * 2002-12-04 2004-06-23 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
WO2004069832A2 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Antibacterial agents
EP1594494A1 (en) * 2003-02-07 2005-11-16 Warner-Lambert Company LLC Oxazolidinone derivatives n-substituted by a bicyclic ring, for use as antibacterial agents
BRPI0409955A (pt) * 2003-04-30 2006-04-25 Morphochem Ag Komb Chemie uso de antibióticos hìbridos de oxazolidinona - quinolina para o tratamento de antrax e outras infecções
MXPA06000228A (es) 2003-07-02 2006-06-27 Merck & Co Inc Antibioticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos.
US20070185132A1 (en) * 2003-07-02 2007-08-09 Yasumichi Fukuda Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
EP1557416A1 (en) * 2004-01-23 2005-07-27 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
ATE401326T1 (de) * 2003-12-18 2008-08-15 Morphochem Ag Komb Chemie Oxazolidinon-chinolon hybrid antibiotika
CA2561621A1 (en) * 2004-03-31 2005-10-20 Bayer Pharmaceuticals Corporation Quinolone carboxylic acid derivatives for treatment of hyperproliferative conditions
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
US7838532B2 (en) * 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8524734B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
AR054608A1 (es) * 2005-08-08 2007-06-27 Actelion Pharmaceuticals Ltd Derivados de oxazolidinona enlazados a quinolonas como antibacterianos
CA2642264A1 (en) * 2006-02-13 2007-08-30 Trustees Of Boston University Reca inhibitors with antibiotic activity, compositions and methods of use
US20070197548A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US20070196398A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone fatty acid salt compositions
US20100234348A1 (en) * 2006-08-04 2010-09-16 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
BRPI0718862B8 (pt) * 2006-11-10 2021-05-25 Actelion Pharmaceuticals Ltd composto, composição farmacêutica que o contém e uso do composto
US8124623B2 (en) * 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
MX2010011918A (es) * 2008-05-09 2010-11-26 Actelion Pharmaceuticals Ltd Derivados de 5-hidroximetil-oxazolidin-2-ona para el tratamiento de enfermedades intestinales bacteriales.
KR100980681B1 (ko) 2008-09-16 2010-09-07 한국과학기술연구원 디플루오로페닐 유도체를 갖는 신규한 옥사졸리디논 유도체또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 하는 항생제 조성물
HUE038428T2 (hu) 2008-10-07 2018-10-29 Horizon Orphan Llc Aeroszol fluorokinolon készítmények javított farmakokinetika érdekében
EP2346509B1 (en) 2008-10-07 2020-05-13 Horizon Orphan LLC Inhalation of levofloxacin for reducing lung inflammation
KR20120100904A (ko) 2009-09-04 2012-09-12 엠펙스 파마슈티컬즈, 인코포레이티드 낭포성 섬유증을 치료하기 위한 에어로졸화된 레보플록사신의 용도
CN102040591B (zh) * 2009-10-15 2013-12-11 山东轩竹医药科技有限公司 7-苯基喹诺酮类化合物
US20120065170A1 (en) 2010-09-10 2012-03-15 Micurx Pharmaceuticals, Inc. Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections
ES2726828T3 (es) 2013-05-28 2019-10-09 Morphochem Gmbh Administración de antibacterianos híbridos de oxazolidinona-quinolona
CA2912728C (en) 2013-05-28 2021-04-13 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
EP3328856A2 (en) 2015-07-28 2018-06-06 Vyome Biosciences Pvt. Ltd. Antibacterial therapeutics and prophylactics
US10995097B2 (en) 2016-03-11 2021-05-04 The Board Of Trustees Of The University Of Illinois Small molecules active against gram-negative bacteria
CN107286182A (zh) * 2016-04-12 2017-10-24 李靖 新型噁唑烷酮‑氟喹诺酮衍生物及用途
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
WO2018237140A1 (en) 2017-06-23 2018-12-27 The Board Of Trustees Of The University Of Illinois TOPOISOMERASE INHIBITORS HAVING ANTIBACTERIAL ACTIVITY AND ANTI-CANCER ACTIVITY

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL137326C (es) 1967-08-26
US3669965A (en) 1969-12-29 1972-06-13 Lilly Co Eli 1-lower alkyl or alkylene substituted-6,7-methylenedioxy-4(1h)-oxocinnoline-3-carboxylic acids and methods for making and using same
US4000155A (en) 1975-12-11 1976-12-28 Eli Lilly And Company Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones]
US4283403A (en) 1976-06-14 1981-08-11 Eli Lilly And Company Substituted isoxazolines for control of plant phytopathogens
IL51092A0 (en) * 1976-12-10 1977-02-28 Abic Ltd Naphthyridine derivatives and their preparation
JPS5746986A (en) 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
US4620007A (en) 1980-09-03 1986-10-28 Bayer Aktiengesellschaft 6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
DE3142854A1 (de) 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS5788182A (en) 1980-11-21 1982-06-01 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazinecarboxylic acid derivative
JPS5872589A (ja) 1981-10-28 1983-04-30 Dai Ichi Seiyaku Co Ltd ピリド〔１，２，３−ｄｅ〕〔１，４〕ベンゾオキサジン誘導体
DE3248507A1 (de) 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
DE3248505A1 (de) 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(4- (oxoalkyl)-1-piperazinyl/-3-chinolincarbonsaeuren und ihre derivate, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4705799A (en) 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
NO166131C (no) 1985-06-20 1991-06-05 Daiichi Seiyaku Co Analogifremgangsmaate for fremstilling av s(-)-pyridobenzoksazinforbindelser.
US4801600A (en) 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4977173A (en) 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US5254577A (en) 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5130316A (en) 1988-07-29 1992-07-14 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazlidinyl arylbenzene derivatives useful as antibacterial agents
US4948801A (en) 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
JPH0269478A (ja) * 1988-09-05 1990-03-08 Sagami Chem Res Center キノロンカルボン酸誘導体
US5164510A (en) 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
US5153203A (en) * 1989-03-30 1992-10-06 Wakunaga Seiyaku Kabushiki Kaisha Quinolone derivatives and salts thereof, preparation processes thereof, and antibacterial agents containing the same
DE69216251T2 (de) 1991-11-01 1997-05-15 Pharmacia & Upjohn Co., Kalamazoo, Mich. Substituierte aryl- und heteroaryl-phenyloxazolidinone
EP0673370B1 (en) * 1992-12-08 1998-01-07 PHARMACIA & UPJOHN COMPANY Tropone-substituted phenyloxazolidinone antibacterial agents
DE4425609A1 (de) 1994-07-20 1996-01-25 Bayer Ag Benzofuranyl- und Benzothienyloxazolidinone
DE4425613A1 (de) 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE4425612A1 (de) 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE19514313A1 (de) 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
US6124334A (en) * 1995-02-03 2000-09-26 Pharmacia & Upjohn Company Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials
DE19601265A1 (de) * 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
DE69716925T2 (de) 1996-08-21 2003-09-11 Pharmacia & Upjohn Co., Kalamazoo Isoxazoline derivate und ihre verwendung als antimikroben
WO1999041244A1 (en) 1998-02-13 1999-08-19 Pharmacia & Upjohn Company Substituted aminophenyl isoxazoline derivatives useful as antimicrobials
TW572757B (en) 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents

Also Published As

Publication number Publication date
DE60117861T2 (de) 2006-11-02
ATE319710T1 (de) 2006-03-15
CA2424402A1 (en) 2002-08-01
WO2002059116A3 (en) 2002-12-05
DE60117861D1 (de) 2006-05-04
US20040215017A1 (en) 2004-10-28
WO2002059116A2 (en) 2002-08-01
US6689769B2 (en) 2004-02-10
EP1349853B1 (en) 2006-03-08
US6869965B2 (en) 2005-03-22
US20030013737A1 (en) 2003-01-16
EP1349853A2 (en) 2003-10-08
JP2004518677A (ja) 2004-06-24
ES2256331T3 (es) 2006-07-16

Similar Documents

Publication Publication Date Title
PE20030137A1 (es) Derivados antimicrobianos de quinolona
PE20020592A1 (es) Quinolonas como agentes antimicrobianos
RS49850B (sr) Derivati 1,4-benzotiazepin-1,1-dioksida supstituisani radikalima šećera, postupak za njihovu proizvodnju, lekovi koji sadrže ova jedinjenja i njihova primena
AR035892A1 (es) Derivados de oxazol, proceso para su preparacion, composiciones farmaceuticas que los comprenden, y el uso de dichos compuestos en la preparacion de medicamentos
PE20010964A1 (es) Derivados de tiazolilamida
AR045260A1 (es) Compuestos que contienen imidazo-oxima sustituidos
AR036492A1 (es) Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos inhibidores para la elaboracion de un medicamento para el tratamiento de enfermedades androgeno dependientes
PE20020544A1 (es) Derivados de indolilmaleimida
PE20040164A1 (es) Mimeticos de glucocorticoides, procedimientos para su preparacion y composiciones farmaceuticas
AR035436A1 (es) Una benzofenona o derivado farmaceuticamente aceptable, sales, formas salinas, composiciones farmaceuticas, usos para la fabricacion de un medicamento, y proceso para la preparacion de una benzofenona
AR049331A1 (es) Derivados de imidazopiridinas, imidazoquinolinas e iimidazonaftiridinas sustituidas con amidas como moduladores de biosintesis de citoquinas. composiciones farmaceuticas.
UY26872A1 (es) Derivados de la 4- fenil piridina
PE20040479A1 (es) Inhibidores de proteasa del vih y composiciones que los contienen
PE20011001A1 (es) Compuestos heterociclicos como inhibidores del intercambio de sodio/protones
PE20040772A1 (es) Composicion y actividad antiviral de derivados de piperazina azaindoloxoaceticos
TW200500360A (en) Hydroxymethyl compounds
PE20070051A1 (es) Serin-amidas sustituidas con heteroaroilo
AR046046A1 (es) Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.
PE20030471A1 (es) Compuesto de imidazopiridin como moduladores del receptor 5-ht4
AR023152A1 (es) Compuesto tienopirimidina, procedimiento para producirlo, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar dichacomposicion
AR037907A1 (es) Derivados de azaindolilalquilamina como ligandos de 5-hidroxitriptamina-6
YU52403A (sh) Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
AR019789A2 (es) Compuestos derivados de la eritromicina, composiciones que los contienen, uso de los mismos para preparar un medicamento
CO4810375A1 (es) Derivados de 9-amino-3-ceto eritromicina
PA8495101A1 (es) Derivados de 13-metileritromicina

Legal Events

Date Code Title Description
FC Refusal
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载