PE20030129A1 - Imidazotriazinas - Google Patents
ImidazotriazinasInfo
- Publication number
- PE20030129A1 PE20030129A1 PE2002000536A PE2002000536A PE20030129A1 PE 20030129 A1 PE20030129 A1 PE 20030129A1 PE 2002000536 A PE2002000536 A PE 2002000536A PE 2002000536 A PE2002000536 A PE 2002000536A PE 20030129 A1 PE20030129 A1 PE 20030129A1
- Authority
- PE
- Peru
- Prior art keywords
- triazin
- imidazo
- dimethyl
- amine
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A IMIDAZOTRIAZINAS DE FORMULA I DONDE R1 ES ARILO C6-C10 CON HALOGENO, FORMILO, CARBAMOILO, -SO2NR5R6 DONDE R5 Y R6 SON H, ALQUILO C1-C6; R2 ES UN RESTO HIDROCARBURO DE 1 A 10 ATOMOS DE CARBONO; R3 ES METILO, ETILO; R7 ES H, ALQUILO C1-C6 CON ALCOXI C1-C3; E ES UN ENLACE O ALCANODIILO C1-C3; R4 ES ARILO C6-C10, HETEROARILO DE 5 A 10 MIEMBROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y COMPUESTOS INTERMEDIOS. SON COMPUESTOS PREFERIDOS 2-(3,4-DIMETOXIFENIL)-5,7-DIMETIL-N-(3,4,5-TRIMETOXIFENIL)IMIDAZO[5,1-f][1,2,4]TRIAZIN-4-AMINA, 2-(3,4-DIMETOXIFENIL)-5,7-DIMETIL-4-[(2-METIL-3-FURIL)SULFANIL]IMIDAZO[5,1-f][1,2,4]TRIAZIN-4-AMINA, N-(3,5-DIMETOXIBENCIL)-2-(3,4-DIMETOXIFENIL)-5,7-DIMETIL-IMIDAZO[5,1-f][1,2,4]TRIAZIN-4-AMINA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS COMO PARKINSON
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10130167A DE10130167A1 (de) | 2001-06-22 | 2001-06-22 | Imidazotriazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030129A1 true PE20030129A1 (es) | 2003-03-13 |
Family
ID=7689090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000536A PE20030129A1 (es) | 2001-06-22 | 2002-06-21 | Imidazotriazinas |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6936609B2 (es) |
| EP (1) | EP1404677A1 (es) |
| JP (1) | JP2004534827A (es) |
| AR (1) | AR036103A1 (es) |
| CA (1) | CA2451525A1 (es) |
| DE (1) | DE10130167A1 (es) |
| DO (1) | DOP2002000429A (es) |
| GT (1) | GT200200122A (es) |
| PE (1) | PE20030129A1 (es) |
| SV (1) | SV2003001107A (es) |
| WO (1) | WO2003000693A1 (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10230604A1 (de) * | 2002-07-08 | 2004-01-29 | Bayer Ag | Heterocyclisch substituierte Imidazotriazine |
| DE10230605A1 (de) | 2002-07-08 | 2004-01-29 | Bayer Ag | Substituierte Imidazotriazine |
| US8338420B1 (en) | 2002-12-04 | 2012-12-25 | Mitsubishi Tanabe Pharma Corporation | Treatment of Parkinson's disease and enhancement of dopamine signal using PDE 10 inhibitor |
| DE602005023333D1 (de) * | 2004-10-15 | 2010-10-14 | Takeda Pharmaceutical | Kinaseinhibitoren |
| US7576080B2 (en) * | 2004-12-23 | 2009-08-18 | Memory Pharmaceuticals Corporation | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| EP2275096A3 (en) | 2005-08-26 | 2011-07-13 | Braincells, Inc. | Neurogenesis via modulation of the muscarinic receptors |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| MX2009002496A (es) | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| RS54510B1 (en) | 2006-11-22 | 2016-06-30 | Incyte Holdings Corporation | IMIDAZOTRIAZINS AND IMIDAZOPYRIMIDINS AS KINASE INHIBITORS |
| US20080260643A1 (en) * | 2007-03-27 | 2008-10-23 | Omeros Corporation | Use of pde7 inhibitors for the treatment of movement disorders |
| US8637528B2 (en) * | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| DE102007032349A1 (de) | 2007-07-11 | 2009-01-15 | Bayer Healthcare Ag | Imidazo-, Pyrazolopyrazine und Imidazotriazine und ihre Verwendung |
| DE102008035209A1 (de) | 2008-07-29 | 2010-02-04 | Bayer Schering Pharma Aktiengesellschaft | Triazolotriazine und Triazolopyrazine und ihre Verwendung |
| DE102007060172A1 (de) | 2007-12-13 | 2009-06-25 | Bayer Healthcare Ag | Triazolotriazine und Triazolopyrazine und ihre Verwendung |
| DE102008023801A1 (de) | 2008-05-15 | 2009-11-19 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine |
| JP5290406B2 (ja) * | 2008-09-04 | 2013-09-18 | 田辺三菱製薬株式会社 | 三置換ピリミジン化合物及びそのｐｄｅ１０阻害薬としての使用 |
| ES2412780T3 (es) | 2008-09-10 | 2013-07-12 | Mitsubishi Tanabe Pharma Corporation | Compuestos aromáticos de anillo de 6 miembros que contiene nitrógeno y su uso |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| ES2627703T3 (es) | 2010-01-22 | 2017-07-31 | Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii | Inhibidores de PI3·quinasa |
| KR101478889B1 (ko) | 2010-02-26 | 2015-01-02 | 미쓰비시 타나베 파마 코퍼레이션 | 피라졸로피리미딘 화합물 및 ｐｄｅ10 억제제로서의 그의 용도 |
| US20130131057A1 (en) | 2010-05-13 | 2013-05-23 | Centro Nacional De Investigaciones Oncologicas (Cnio | New bicyclic compounds as pi3-k and mtor inhibitors |
| AR081428A1 (es) * | 2010-05-28 | 2012-08-29 | Biocryst Pharm Inc | Derivados heterociclicos condensados nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos para suprimir una respuesta inmune o tratar cancer. |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| AU2011326173B2 (en) | 2010-11-08 | 2015-08-27 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| WO2012112946A1 (en) | 2011-02-18 | 2012-08-23 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| PE20140236A1 (es) * | 2011-02-23 | 2014-03-14 | Pfizer | IMIDAZO[5,1-f][1,2,4]TRIAZINAS PARA EL TRATAMIENTO DE TRASTORNOS NEUROLOGICOS |
| JP2014231475A (ja) * | 2011-08-25 | 2014-12-11 | 田辺三菱製薬株式会社 | 新規化合物及びそのｐｄｅ１０阻害薬としての使用 |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| ES2723876T3 (es) | 2013-02-27 | 2019-09-03 | Mochida Pharm Co Ltd | Nuevos derivados de pirazol |
| DK2991989T3 (en) | 2013-05-02 | 2017-07-31 | Pfizer | IMIDAZO-TRIAZINE DERIVATIVES AS PDE10 INHIBITORS |
| US10039764B2 (en) | 2013-07-12 | 2018-08-07 | University Of South Alabama | Treatment and diagnosis of cancer and precancerous conditions using PDE10A inhibitors and methods to measure PDE10A expression |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| WO2015166370A1 (en) | 2014-04-28 | 2015-11-05 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| CN111825675B (zh) * | 2019-04-15 | 2023-08-01 | 武汉朗来科技发展有限公司 | Rock抑制剂及其制备方法和用途 |
| AU2023326563A1 (en) | 2022-08-18 | 2025-02-27 | Mitodicure Gmbh | Use of a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1457873A (en) * | 1973-01-04 | 1976-12-08 | Allen & Hanburys Ltd | Imidazotriazines |
| DK109578A (da) * | 1977-03-25 | 1978-09-26 | Allen & Hanburys Ltd | Fremgangsmaade til fremstilling af heterocycliske forbindelser |
| NZ504436A (en) * | 1997-11-12 | 2001-08-31 | Bayer Ag | 2-Phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
| AU7766300A (en) | 1999-10-07 | 2001-05-10 | Novaneuron Inc. | Gene necessary for striatal function, uses thereof, and compounds for modulatingsame |
-
2001
- 2001-06-22 DE DE10130167A patent/DE10130167A1/de not_active Withdrawn
-
2002
- 2002-06-10 US US10/481,281 patent/US6936609B2/en not_active Expired - Fee Related
- 2002-06-10 EP EP02747362A patent/EP1404677A1/de not_active Withdrawn
- 2002-06-10 CA CA002451525A patent/CA2451525A1/en not_active Abandoned
- 2002-06-10 WO PCT/EP2002/006322 patent/WO2003000693A1/de active Application Filing
- 2002-06-10 JP JP2003507096A patent/JP2004534827A/ja not_active Withdrawn
- 2002-06-17 GT GT200200122A patent/GT200200122A/es unknown
- 2002-06-21 SV SV2002001107A patent/SV2003001107A/es not_active Application Discontinuation
- 2002-06-21 AR ARP020102343A patent/AR036103A1/es not_active Application Discontinuation
- 2002-06-21 PE PE2002000536A patent/PE20030129A1/es not_active Application Discontinuation
- 2002-06-21 DO DO2002000429A patent/DOP2002000429A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2451525A1 (en) | 2003-01-03 |
| AR036103A1 (es) | 2004-08-11 |
| GT200200122A (es) | 2003-06-05 |
| WO2003000693A1 (de) | 2003-01-03 |
| SV2003001107A (es) | 2003-03-18 |
| EP1404677A1 (de) | 2004-04-07 |
| DE10130167A1 (de) | 2003-01-02 |
| US6936609B2 (en) | 2005-08-30 |
| JP2004534827A (ja) | 2004-11-18 |
| DOP2002000429A (es) | 2003-10-15 |
| US20040249148A1 (en) | 2004-12-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20030129A1 (es) | Imidazotriazinas | |
| PE20211795A1 (es) | Compuestos heteroaril tetraciclicos | |
| PE20130012A1 (es) | Derivados de pirazol como inhibidores de jak | |
| PE20050774A1 (es) | Pirazolopirimidinas como inhibidores de quinasa ciclina-dependientes | |
| PE20030292A1 (es) | Compuestos de heteroarilo biciclicos fusionados substituidos con heteroarilo como ligandos del receptor gabaa | |
| PE20030155A1 (es) | Azaindoles como inhibidores de quinasas | |
| AR072756A2 (es) | Intermediarios para la preparacion; derivados de triazolo[4,5-d]pirimidina, utiles como antitromboticos | |
| UY26086A1 (es) | Procedimientos e intermedios para preparar compuestos anticancerosos | |
| PE20100741A1 (es) | COMPUESTOS DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2(1H)-ONA COMO INHIBIDORES DE QUINASA p38 | |
| CY1109263T1 (el) | Ανταγωνιστες των α2α υποδοχεων αδενοσινης 2-alkynyl-kai 2-αλκενυλ-pyrazolo-[4,3-ε]-1,2,4-triazolo-[1,5-c]-pyrimidine | |
| PE20020406A1 (es) | 7-OXO-PIRIDO[2,3-d]PIRIMIDINAS 2,6-DISUSTITUIDAS COMO INHIBIDORES DE LAS PROTEINAS CINASAS | |
| UY25344A1 (es) | Procedimiento para la preparacion de derivados de la tienopirimidina y de la tienopiridina utiles como agentes anticancerigenos | |
| PT1159279E (pt) | 4-oxo-4,7-di-hidrotieno¬2,3-b|piridino-5-carboxamidas como agentes antivirais | |
| ATE443063T1 (de) | Ä1,2,4ütriazoloä4,3-aüpyridin-derivative zur behandlung hyperproliferativer erkrankungen | |
| PE20010629A1 (es) | Derivados de triazolpiridinamina como ligandos de receptores de adenosina | |
| PE20060775A1 (es) | Derivados de pirrolidilo de compuestos heteroaromaticos como inhibidores de fosfodiesterasa | |
| PE20061424A1 (es) | Compuestos triciclicos de base 1,6-dihidro-1-3,5,6-tetraaza-as-indaceno y composiciones farmaceuticas que comprenden los mismos | |
| EA200400236A1 (ru) | Производные замещенного 2-пиримидинил-6,7,8,9-тетрагидропиримидо[1,2-a]пиримидин-4-она и 7-пиримидинил-2,3-дигидроимидазо[1,2-a]пиримидин-5(1h)она для нейродегенеративных нарушений | |
| PE20100737A1 (es) | Nuevos compuestos | |
| PE20010638A1 (es) | Imidazo-5-il-aminas biciclicas, medicamentos que las contienen, su uso para la preparacion de medicamentos y procedimiento para su preparacion | |
| DE60216745D1 (de) | Carbolin Derivate als Hemmstoffe von Phospphodiesterase 5 (PDE5) zur Behandlung kardiovaskulärer Erkrankungen und der erektilen Dysfunktion | |
| MX2009006885A (es) | Derivados de pirrolo[3,2-a]piridina para inhibir la actividad de la proteina cinesina del huso. | |
| AR033753A1 (es) | Derivados de imidazo[1,5-a]pirimido[5,4-d]benzazepina | |
| PE20030761A1 (es) | Derivados del 7-amino-benzotiazol | |
| RU2012128551A (ru) | Производные этинила |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |