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PE20030127A1 - Derivados de acido sulfonico - Google Patents

Derivados de acido sulfonico

Info

Publication number
PE20030127A1
PE20030127A1 PE2002000520A PE2002000520A PE20030127A1 PE 20030127 A1 PE20030127 A1 PE 20030127A1 PE 2002000520 A PE2002000520 A PE 2002000520A PE 2002000520 A PE2002000520 A PE 2002000520A PE 20030127 A1 PE20030127 A1 PE 20030127A1
Authority
PE
Peru
Prior art keywords
alkyl
acid derivatives
sulphonic acid
piperazin
phenyl
Prior art date
Application number
PE2002000520A
Other languages
English (en)
Inventor
Matthew Merrill Hayward
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20030127A1 publication Critical patent/PE20030127A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
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  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
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  • Biomedical Technology (AREA)
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Abstract

SE REFIERE A DERIVADOS DE ACIDO SULFONICO DE FORMULA I DONDE a ES 0-5, b ES 0-2, c = 0-2, d = 0-4 Y X ES -O-, -S-, -CH2-, -NR6-; Y ES ARILO (C6-C10), HETEROARILO (C2-C9); R1 ES H, OH, FALO, ALQUIL (C1-C8), ENTRE OTROS; R2 Y R3 SON H, OXO, ALQUIL C1-C8 CON 1-3 ATOMOS DE FLUOR, ALQUIL (C1-C8), ENTRE OTROS; R4 ES H, OH, HALO, NC-, ENTRE OTROS; R5 ES ALQUIL (C1-C8). SON COMPUESTOS PREFERIDOS ACIDO (5-BROMO-2-{2-[4-(4-FLUOROBENCIL)-2R-METIL-PIPERAZIN-1-IL]-2-OXOETOXI}FENIL)METANOSULFONICO, ACIDO (5-CLORO-2-{2-[4-(4-CLOROBENCIL)-2R,5S-DIMETIL-PIPERAZIN-1-IL]-2-OXOETOXI}FENIL)METANOSULFONICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA UNION DE MIP-1O(CCL3) A SU RECEPTOR CCR1 UTILES PARA EL TRATAMIENTO DE ENFERMEDADES AUTOINMUNES COMO ARTRITIS, DIABETES, LUPUS
PE2002000520A 2001-06-20 2002-06-18 Derivados de acido sulfonico PE20030127A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29946101P 2001-06-20 2001-06-20

Publications (1)

Publication Number Publication Date
PE20030127A1 true PE20030127A1 (es) 2003-02-22

Family

ID=23154893

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000520A PE20030127A1 (es) 2001-06-20 2002-06-18 Derivados de acido sulfonico

Country Status (35)

Country Link
US (2) US6974817B2 (es)
EP (1) EP1430041A2 (es)
JP (2) JP3829136B2 (es)
KR (1) KR20040012956A (es)
CN (1) CN1529699A (es)
AP (1) AP1564A (es)
AR (1) AR036094A1 (es)
BG (1) BG108426A (es)
BR (1) BR0210531A (es)
CA (1) CA2447865C (es)
CZ (1) CZ20033455A3 (es)
DO (1) DOP2002000399A (es)
EA (1) EA006447B1 (es)
EC (1) ECSP034917A (es)
EE (1) EE200400023A (es)
GT (1) GT200200095A (es)
HR (1) HRP20030834A2 (es)
HU (1) HUP0400369A2 (es)
IL (1) IL158461A0 (es)
IS (1) IS6987A (es)
MA (1) MA27033A1 (es)
MX (1) MXPA03011954A (es)
NO (1) NO20035694D0 (es)
OA (1) OA12623A (es)
PA (1) PA8548501A1 (es)
PE (1) PE20030127A1 (es)
PL (1) PL366900A1 (es)
SK (1) SK15722003A3 (es)
SV (1) SV2003001099A (es)
TN (1) TNSN03140A1 (es)
UA (1) UA74266C2 (es)
UY (1) UY27338A1 (es)
WO (1) WO2002102787A2 (es)
YU (1) YU94103A (es)
ZA (1) ZA200307736B (es)

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JP2005504043A (ja) * 2001-08-10 2005-02-10 パラチン テクノロジーズ インク． 生物学的に活性な金属ペプチド類のペプチド模倣体類
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US7732451B2 (en) * 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7456184B2 (en) * 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
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US20040116441A1 (en) * 2002-10-30 2004-06-17 Pfizer Inc Methods of using sulfonic acid derivatives
EP1604981A4 (en) 2003-03-14 2008-12-24 Ono Pharmaceutical Co NITROGENIC HETEROCYCLIC DERIVATIVES AND MEDICAMENTS CONTAINING THEM AS AN ACTIVE SUBSTANCE
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US20050119275A1 (en) * 2003-06-24 2005-06-02 Pfizer Inc. Salt and crystal forms of (5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-phenyl)-methanesulfonic acid
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
ZA200700811B (en) 2004-08-06 2008-10-29 Otsuka Pharma Co Ltd Aromatic compound
SG146673A1 (en) 2004-09-13 2008-10-30 Ono Pharmaceutical Co Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient
KR101157004B1 (ko) 2005-12-05 2012-07-09 오쓰까 세이야꾸 가부시키가이샤 항종양제로서의 디아릴에테르 유도체
BRPI0708731A2 (pt) 2006-03-10 2011-06-07 Ono Pharmaceutical Co derivado heterocìclico nitrogenado, e agente farmacêutico compreendendo o derivado como ingrediente ativo
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
UA95978C2 (ru) 2006-10-02 2011-09-26 Оцука Фармас'Ютікел Ко., Лтд. Ингибитор активации stat3/5
US8716235B2 (en) * 2012-04-18 2014-05-06 Albert Einstein College Of Medicine Of Yeshiva University Method for inhibiting metastasis by using anti-CCL3 antibodies
FR3029112A1 (fr) * 2014-12-02 2016-06-03 Pf Medicament Dispersion solide a base de derives d'heteroarylsulfonamides a usage pharmaceutique

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IL158461A0 (en) * 2001-06-20 2004-05-12 Pfizer Prod Inc Novel sulfonic acid derivatives

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SK15722003A3 (sk) 2004-08-03
AP1564A (en) 2006-02-02
NO20035694D0 (no) 2003-12-19
US20030083335A1 (en) 2003-05-01
YU94103A (sh) 2006-03-03
UA74266C2 (uk) 2005-11-15
JP2006232846A (ja) 2006-09-07
JP3829136B2 (ja) 2006-10-04
PL366900A1 (en) 2005-02-07
SV2003001099A (es) 2003-03-18
EA006447B1 (ru) 2005-12-29
EA200301276A1 (ru) 2004-04-29
EE200400023A (et) 2004-06-15
TNSN03140A1 (fr) 2005-12-23
MXPA03011954A (es) 2004-03-26
CZ20033455A3 (en) 2004-06-16
AR036094A1 (es) 2004-08-11
WO2002102787A2 (en) 2002-12-27
CA2447865C (en) 2010-07-20
OA12623A (en) 2006-06-12
ZA200307736B (en) 2004-10-04
GT200200095A (es) 2003-02-27
BR0210531A (pt) 2004-06-22
KR20040012956A (ko) 2004-02-11
AP2002002560A0 (en) 2002-06-30
BG108426A (en) 2005-01-31
CN1529699A (zh) 2004-09-15
WO2002102787A3 (en) 2004-04-29
US6974817B2 (en) 2005-12-13
UY27338A1 (es) 2003-10-31
PA8548501A1 (es) 2003-05-14
ECSP034917A (es) 2004-02-26
MA27033A1 (fr) 2004-12-20
CA2447865A1 (en) 2002-12-27
HRP20030834A2 (en) 2004-08-31
EP1430041A2 (en) 2004-06-23
IS6987A (is) 2003-10-09
HUP0400369A2 (hu) 2004-12-28
IL158461A0 (en) 2004-05-12
DOP2002000399A (es) 2002-12-30
US20050250790A1 (en) 2005-11-10
JP2005511486A (ja) 2005-04-28

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