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PE20030535A1 - Derivados de naftiridin como inhibidores de isoenzima fosfodiesterasa de nucleotido ciclica - Google Patents

Derivados de naftiridin como inhibidores de isoenzima fosfodiesterasa de nucleotido ciclica

Info

Publication number
PE20030535A1
PE20030535A1 PE2002001073A PE2002001073A PE20030535A1 PE 20030535 A1 PE20030535 A1 PE 20030535A1 PE 2002001073 A PE2002001073 A PE 2002001073A PE 2002001073 A PE2002001073 A PE 2002001073A PE 20030535 A1 PE20030535 A1 PE 20030535A1
Authority
PE
Peru
Prior art keywords
naphthyridin
cyclohexancarboxyl
phenyl
inhibitors
isoenzyme
Prior art date
Application number
PE2002001073A
Other languages
English (en)
Inventor
Alastair Denholm
Thomas Hugo Keller
Roger John Taylor
Neil John Press
Clive Mccarthy
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0126511A external-priority patent/GB0126511D0/en
Priority claimed from GB0209882A external-priority patent/GB0209882D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20030535A1 publication Critical patent/PE20030535A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

SE REFIERE A COMPUESTOS NAFTIRIDIN DE FORMULA I DONDE R1 ES UN GRUPO AROMATICO MONOVALENTE; R2 ES UN GRUPO CIOCLOALIFATICO. SON COMPUESTOS PREFERIDOS ETILESTER DEL ACIDO 4-[8-(3-CIANO-FENIL)-[1,7]NAFTIRIDIN-6-IL]-CICLOHEXANCARBOXILICO; ACIDO 4-[8-(3-CIANO-FENIL)-[1,7]-NAFTIRIDIN-6-IL]-CICLOHEXANCARBOXILICO; SAL POTASICA DEL ACIDO 4-[8-(3-CIANO-FENIL)-[1,7-NAFTIRIDIN-6-IL]-CICLOHEXANCARBOXILICO, ACIDO 4-[8-(3-CARBAMOIL-FENIL)-[1,7]NAFTIRIDIN-6-IL]-CICLOHEXANCARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON INHIBIDORES DE ISOENZIMA FOSFODIESTERASA DE NUCLEOTIDO CICLICA O INHIBEN LA LIBERACION DE TNP-O Y PUEDEN SER UTILES POR SUS PROPIEDADES ANTIINFLAMATORIAS, ANTI-HIPERACTIVIDAD DE VIAS RESPIRATORIAS Y BRONCODILATADORAS
PE2002001073A 2001-11-05 2002-11-04 Derivados de naftiridin como inhibidores de isoenzima fosfodiesterasa de nucleotido ciclica PE20030535A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0126511A GB0126511D0 (en) 2001-11-05 2001-11-05 Organic compounds
GB0209882A GB0209882D0 (en) 2002-04-30 2002-04-30 Organic compounds

Publications (1)

Publication Number Publication Date
PE20030535A1 true PE20030535A1 (es) 2003-07-11

Family

ID=26246741

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002001073A PE20030535A1 (es) 2001-11-05 2002-11-04 Derivados de naftiridin como inhibidores de isoenzima fosfodiesterasa de nucleotido ciclica

Country Status (26)

Country Link
US (1) US7273875B2 (es)
EP (1) EP1443925B8 (es)
JP (1) JP4150672B2 (es)
KR (1) KR100623548B1 (es)
CN (1) CN1298324C (es)
AR (1) AR037517A1 (es)
AT (1) ATE349209T1 (es)
BR (1) BR0213877A (es)
CA (1) CA2462211C (es)
CY (1) CY1107532T1 (es)
DE (1) DE60217160T2 (es)
DK (1) DK1443925T3 (es)
ES (1) ES2275935T3 (es)
HK (1) HK1069970A1 (es)
HU (1) HUP0402311A3 (es)
IL (2) IL161257A0 (es)
MX (1) MXPA04004264A (es)
MY (1) MY130622A (es)
NO (1) NO329093B1 (es)
NZ (1) NZ532586A (es)
PE (1) PE20030535A1 (es)
PL (1) PL368286A1 (es)
PT (1) PT1443925E (es)
RU (1) RU2296764C2 (es)
TW (1) TWI320784B (es)
WO (1) WO2003039544A1 (es)

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